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PC-sterol_acyltransferase

Relationship

Family: PC-sterol_acyltransferase

Block: L

Parent Family: No family

Comment

Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT), Lecithin-cholesterol acyltransferase, belong to this family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport, respectively (in human human-LCAT phosphatidylcholine-sterol acyltransferase. Lecithin-cholesterol acyltransferase; human-PLA2G15 Group XV phospholipase A2 lcat-like lysophospholipase). Whereas LPLA2 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease and familial LCAT deficiency. LCAT also known as phosphatidylcholine-sterol acyltransferase (EC), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Defects in LACT cause Norum and Fish eye diseases. This family correspond to group XV phospholipase A2. Phospholipid:diacylglycerol acyltransferase (PDAT)(2.3.1.158) is involved in triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid. A group of bacterial enzymes was extracted in a new family : Bacterial_EstLip_FamXIV

Database

Interpro : IPR003386 Lecithin:cholesterol\/phospholipid:diacylglycerol acyltransferase LACT\/PDAT_acylTrfase

PIRSF : No PIRSF

Pdoc : PDOC00110

Pfam : PF02450 LACT-Lecithin:cholesterol acyltransferase LCAT

Prints : PR00821

EC Number : 2.3.1.43

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
4X90 Crystal structure of Lysosomal Phospholipase A2 human-PLA2G15
4X91 Crystal structure of Lysosomal Phospholipase A2 in complex with Isopropyl dodec-11-enylfluorophosphonate (IDFP) human-PLA2G15
4X92 Crystal structure of Lysosomal Phospholipase A2-S165A human-PLA2G15
4X93 Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (tetragonal form) human-PLA2G15
4X94 Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (hexagonal form) human-PLA2G15
4X95 Crystal structure of fully glycosylated Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP) human-PLA2G15
4X96 Low resolution crystal structure of human Lecithin:Cholesterol Acyltransferase (LCAT\; residues 21-397) human-LCAT
4X97 Crystal structure of human Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP) human-PLA2G15
4XWG Crystal Structure of human LCAT (C31Y) in complex with Fab1 Cholesterol Acyltransferase (LCAT (Cys31Tyr) human-LCAT
4XX1 Low resolution structure of human LCAT in complex with Fab1. Lecithin:Cholesterol Acyltransferase (LCAT\; wild type) human-LCAT
5BV7 Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody human-LCAT
5TXF Crystal structure of human Lecithin:cholesterol acyltransferase (LCAT) in a closed conformation human-LCAT
6MTW Crystal structure of Lysosomal Phospholipase A2 in complex with Zinc human-PLA2G15
6MVD Crystal structure of human Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator supersedes 6DTJ human-LCAT
9MXZ Lecithin:Cholesterol Acyltransferase Bound to Apolipoprotein A-I dimer in HDL human-LCAT

Gene_locus Name Species
9chlo-MiPDAT Lobosphaera incisa Phospholipid: diacylglycerol acyltransferase PDAT Lobosphaera incisa
9stra-w7tm55 Nannochloropsis gaditana Lecithin:cholesterol acyltransferase Nannochloropsis gaditana
9tele-a0a4w5p412 Hucho hucho (huchen). Phospholipid-cholesterol acyltransferase Hucho hucho
9zzzz-MGL.2 metagenome MGL-2 metagenome
ailme-a0a7n5jch2 Ailuropoda melanoleuca (Giant panda). Phospholipid-cholesterol acyltransferase Ailuropoda melanoleuca
ailme-d2h9g5 Ailuropoda melanoleuca (Giant panda). Phospholipid-cholesterol acyltransferase Ailuropoda melanoleuca
anapl-lcat Anas platyrhynchos (Domestic duck) lecithin cholesterol acyltransferase Anas platyrhynchos
arath-At5g13640 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) at5g13640\/msh12_10 Phospholipid:diacylglycerol acyltransferase 1 PDAT1 Arabidopsis thaliana
arath-LCAT1 Arabidopsis thaliana (Mouse-ear cress) f17l21.27 (at1g27480\/f17l21_28) Arabidopsis thaliana
arath-LCAT2 Arabidopsis thaliana (Mouse-ear cress) At1g04010 f21m11.5 Phospholipid--sterol O-acyltransferase PSAT Arabidopsis thaliana
arath-LCAT3 Arabidopsis thaliana (Mouse-ear cress) Phospholipase A(1) LCAT3 At3g03310 t21p5.27 Arabidopsis thaliana
arath-LCAT4 Arabidopsis thaliana (Mouse-ear cress) Lecithin-cholesterol acyltransferase-like 4 Arabidopsis thaliana
arath-PDAT2 Arabidopsis thaliana (Mouse-ear cress) At3g44830 PDAT2 Putative phospholipid:diacylglycerol acyltransferase 2 Arabidopsis thaliana
ashgo-q755k2 Ashbya gossypii (Yeast) (Eremothecium gossypii) afl179cp Ashbya gossypii
aspfu-q4wxl7 Aspergillus fumigatus Af293 phospholipid:diacylglycerol acyltransferase, putative Aspergillus fumigatus Af293
aspor-q2ul81 Aspergillus oryzae, Aspergillus flavus, lecithin:cholesterol acyltransferase Aspergillus oryzae
astmx-a0a8t2lkd9 Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). Phospholipid-cholesterol acyltransferase Astyanax mexicanus
avesa-AsPDAT Avena sativa (Oat) Phospholipid:diacylglycerol acyltransferase 1 PDAT1 Avena sativa
bacan-BA3805 Bacillus anthracis prophage lambdaba01, acyltransferase, putative Bacillus anthracis
bacli-EST Bacillus licheniformis esterase (EC 3.1.1.1) Bacillus licheniformis
balmu-a0a8b8vud3 Balaenoptera musculus (Blue whale). Phospholipid-cholesterol acyltransferase Balaenoptera musculus
bovin-LPLA2 Bos taurus (Bovine) lysosomal phospholipase a2 ( lysophospholipase 3) Bos taurus
bovin-lcat Bos taurus (Bovine)\; Bos mutus phosphatidylcholine-sterol acyltransferase Bos taurus
caebr-A8Y168 Caenorhabditis briggsae hypothetical protein cbg21934 Caenorhabditis briggsae
caeel-M05B5.4 Caenorhabditis elegans m05b5.4 protein Caenorhabditis elegans
camdr-a0a5n4dse3 Camelus dromedarius (Dromedary) (Arabian camel)\; Camelus bactrianus (Bactrian camel). Phospholipid-cholesterol acyltransferase Camelus dromedarius
camfr-a0a8b6yc42 Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). Phospholipid-cholesterol acyltransferase Camelus ferus
camsa-pdat Camelina sativa (False flax) (Myagrum sativum) phospholipid:diacylglycerol acyltransferase PDAT Camelina sativa
canal-q5abf2 Candida albicans SC5314 hypothetical protein lro1 Candida albicans SC5314
canfa-q6xpz3 Canis familiaris (Dog) lysosomal phospholipase a2 Canis lupus familiaris
canga-q6fqj3 Candida glabrata (Yeast) (Torulopsis glabrata) lro1 Candida glabrata
canlf-a0a8c0nj18 Canis lupus familiaris (Dog) (Canis familiaris)\; Canis lupus dingo (dingo)\; Vulpes vulpes (Red fox). Phospholipid-cholesterol acyltransferase Canis lupus familiaris
caphi-a0a452ej90 Capra hircus (Goat). Phospholipid-cholesterol acyltransferase Capra hircus
cavpo-lcat Cavia porcellus (Guinea pig) lecithin: cholesterol acyl-transferase (fragment) Cavia porcellus
chemy-m7anr2 Chelonia mydas (Green sea-turtle) (Chelonia agassizi). Phosphatidylcholine-sterol acyltransferase Chelonia mydas
chick-lcat Gallus gallus (Chicken) acyltransferase) (fragment) Gallus gallus
citsi-q58fa2 Citrus sinensis (Sweet orange) putative sterol esterification protein Citrus sinensis
cryne-q5k8s0 Cryptococcus neoformans (Filobasidiella neoformans) (and strain B-3501A) phospholipid:diacylglycerol acyltransferase, putative Cryptococcus neoformans
danre-a0a8m1p7r5 Danio rerio (Zebrafish) (Brachydanio rerio). Phospholipid-cholesterol acyltransferase Danio rerio
danre-q6nyh6 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein pla2g15 Danio rerio
debha-q6bsc3 Debaryomyces hansenii (Yeast) (Torulaspora hansenii) similar to cagl0i05786g candida glabrata Debaryomyces hansenii
drome-GH02384 Drosophila melanogaster (Fruit fly) bcdna.gh02384 CG31683 CG18858 Drosophila melanogaster
drops-q29ks6 Drosophila pseudoobscura (Fruit fly) ga15103-pa (fragment) Drosophila pseudoobscura
eleel-a0a4w4gb54 Electrophorus electricus (Electric eel) (Gymnotus electricus). Phospholipid-cholesterol acyltransferase Electrophorus electricus
emeni-q5b388 Aspergillus nidulans FGSC A4 hypothetical protein Aspergillus nidulans FGSC A4
enthi-b1n456 Entamoeba histolytica, Entamoeba dispar, lecithin:cholesterol acyltransferase, putative Entamoeba histolytica HM-1:IMSS
enthi-c4m0c3 Entamoeba histolytica, Entamoeba dispar lecithin:cholesterol acyltransferase, putative Entamoeba histolytica HM-1:IMSS
enthi-c4m2a9 Entamoeba histolytica, Entamoeba dispar lecithin:cholesterol acyltransferase, putative Entamoeba histolytica
enthi-c4m4l3 Entamoeba histolytica, Entamoeba dispar lecithin:cholesterol acyltransferase, putative Entamoeba histolytica HM-1:IMSS
enthi-c4m6k3 Entamoeba histolytica, Entamoeba dispar, lecithin:cholesterol acyltransferase, putative Entamoeba histolytica
enthi-c4m7v0 Entamoeba histolytica HM-1:IMSS 1-o-acylceramide synthase, putative Entamoeba histolytica HM-1:IMSS
enthi-q51a37 Entamoeba histolytica HM-1:IMSS 1-o-acylceramide synthase, putative Entamoeba histolytica HM-1:IMSS
enthi-q51aw6 Entamoeba histolytica HM-1:IMSS 1-o-acylceramide synthase, putative Entamoeba histolytica HM-1:IMSS
enthi-q51cz6 Entamoeba histolytica HM-1:IMSS lecithin:cholesterol acyltransferase, putative Entamoeba histolytica HM-1:IMSS
esolu-a0a3p8y174 Esox lucius (Northern pike). Phospholipid-cholesterol acyltransferase Esox lucius
giala-q7qwm1 Giardia lamblia ATCC 50803 glp_762_23988_17611 Giardia lamblia ATCC 50803
gibze-q4i8t3 Gibberella zeae (Fusarium graminearum) hypothetical protein Gibberella zeae
gorgo-g3qql2 Gorilla gorilla gorilla (Western lowland gorilla). Phospholipid-cholesterol acyltransferase Gorilla gorilla gorilla
horse-f6zjp9 Equus caballus (Horse)\; Equus asinus asinus\; Equus przewalskii. Phospholipid-cholesterol acyltransferase Equus caballus
human-LCAT Homo sapiens (Human) phosphatidylcholine-sterol acyltransferase. Lecithin-cholesterol acyltransferase Homo sapiens
human-PLA2G15 Homo sapiens (Human) Group XV phospholipase A2 lcat-like lysophospholipase (llpl) (unq341\/pro540) Homo sapiens
ipotf-q6jj42 Ipomoea trifida (Morning glory) putative phosphatidylcholine-sterol acyltransferase Ipomoea trifida
klula-q6cl20 Kluyveromyces lactis (Yeast) 1140 of kluyveromyces lactis Kluyveromyces lactis
leima-q4qhs0 Leishmania major (EC 2.3.1.158) Leishmania major
loxaf-g3uil7 Loxodonta africana (African elephant). Phospholipid-cholesterol acyltransferase Loxodonta africana
lyces-q71lx7 Lycopersicon esculentum (Tomato) lecithine cholesterol acyltransferase-like protein Lycopersicon esculentum
macfa-g7q1f6 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Phospholipid-cholesterol acyltransferase Macaca fascicularis
macmu-g7nq76 Macaca mulatta (Rhesus macaque). Phospholipid-cholesterol acyltransferase Macaca mulatta
marma-a0a8c5zm10 Marmota marmota marmota (Alpine marmot). Platelet-activating factor acetylhydrolase Marmota marmota marmota
medtr-Q8GZM5 Medicago truncatula (Barrel medic) (Medicago tribuloides) putative phosphatidylcholine acyltransferase Medicago truncatula
medtr-q1s687 Medicago truncatula (Barrel medic) lecithin:cholesterol acyltransferase Medicago truncatula
medtr-q6xsh3 Medicago truncatula (Barrel medic) lecithine cholesterol acyltransferase-like protein Medicago truncatula
medtr-q71ce5 Medicago truncatula (Barrel medic) lecithine cholesterol acyltransferase-like protein Medicago truncatula
mesau-a0abm2wnw4 Mesocricetus auratus (Golden hamster). Phosphatidylcholine-sterol acyltransferase isoform X1 Mesocricetus auratus
mondo-f7g613 Monodelphis domestica (Gray short-tailed opossum). Phospholipid-cholesterol acyltransferase Monodelphis domestica
mouse-C87498 Mus musculus (Mouse) similar to LCAT-like lysophospholipase (llpl) Mus musculus
mouse-lcat Mus musculus mRNA for phosphatidylcholine-sterol acyltransferase ( lecithin: cholesterol acyltransferase) Mus musculus
myomy-a0a7j7scg5 Myotis myotis (Greater mouse-eared bat) (Vespertilio myotis). Phospholipid-cholesterol acyltransferase Myotis myotis
neucr-q7s4e3 Neurospora crassa hypothetical protein Neurospora crassa
oncmy-a0a8c7nz26 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). Phospholipid-cholesterol acyltransferase Oncorhynchus mykiss
ornan-f7fus6 Ornithorhynchus anatinus (Duckbill platypus). Phospholipid-cholesterol acyltransferase Ornithorhynchus anatinus
orysa-Q851F0 Oryza sativa (japonica cultivar-group) putative lecithin-cholesterol acyl transferase Oryza sativa
orysa-Q8RYV9 Oryza sativa subsp. japonica subsp. indica (Rice) p0614d08.29 protein Oryza sativa
orysa-Q8S5X5 Oryza sativa subsp. japonica subsp. indica (Rice) hypothetical 91.2 kda protein Oryza sativa
orysa-Q94HP5 Oryza sativa (Rice) hypothetical protein Oryza sativa
orysa-q67u60 Oryza sativa (japonica cultivar-group) putative lecithin diacylglycerol cholesterol acyltransferase Oryza sativa
orysa-q6k3d9 Oryza sativa subsp. japonica subsp. indica (Rice) phosphatidylcholine acyltransferase-like Oryza sativa
orysa-q6yy42 Oryza sativa subsp. japonica subsp. indica (Rice) putative acyltransferase (46.9 kd) (1h765) Oryza sativa
orysa-q6yy78 Oryza sativa (japonica cultivar-group) putative acyltransferase (46.9 kd) (1h765) Oryza sativa
orysa-q7xts6 Oryza sativa subsp. indica subsp. japonica (Rice) osjnba0008m17.7 protein Oryza sativa
panpa-a0a2r9bd07 Pan paniscus (Pygmy chimpanzee) (Bonobo). Phospholipid-cholesterol acyltransferase Pan paniscus
pantr-h2qbd3 Pan troglodytes (Chimpanzee). Phospholipid-cholesterol acyltransferase Pan troglodytes
papan-lcat Papio anubis lecithin cholesterol acyltransferase Papio anubis
pencw-b6hmd9 Penicillium chrysogenum (strain ATCC 28089 \/ DSM 1075 \/ Wisconsin 54-1255) (Penicillium notatum) Pc21g08810 protein Penicillium chrysogenum
pereae-PDAT1 Persea americana (Avocado) phospholipid:diacylglycerol acyltransferase 1 (PDAT1) PaPDAT1 Persea americana
phatc-PDAT Phaeodactylum tricornutum (ASM15095v2) Phospholipid:diacylglycerol acyltransferase 1 PDAT1 Phaeodactylum tricornutum
phypa-Q8GU37 Physcomitrella patens (Moss) putative phosphatidylcholine-sterol acetyltransferase (fragment) Physcomitrella patens
pig-lcat Sus scrofa domestica (domestic pig) phosphatidylcholine-sterol acyltransferase Sus scrofa
plaba-q4z5z8 Plasmodium berghei phosphatidylcholine-sterol acyltransferase, putative Plasmodium berghei
plach-q4xsw6 Plasmodium chabaudi phosphatidylcholine-sterol acyltransferase, putative (fragment) Plasmodium chabaudi
plafa-MAL6P1.135 Plasmodium falciparum (isolate 3D7) PF3D7_0629300 Phosphatidylcholine-sterol acyltransferase, putative (EC 2.3.1.43) PfPL Plasmodium falciparum
playo-q7rh25 Plasmodium yoelii yoelii lecithin:cholesterol acyltransferase, putative Plasmodium yoelii yoelii
podan-Q875A3 Podospora anserina hypothetical protein pa5d0027 Podospora anserina
ponab-h2nr98 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). Phospholipid-cholesterol acyltransferase Pongo abelii
ponab-q5rai0 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Putative uncharacterized protein DKFZp468N192 Pongo abelii
rabit-lcat Rabbit mRNA for lecithin-cholesterol acyltransferase Oryctolagus cuniculus
ratno-lcat Rattus norvegicus (Rat) Phosphatidylcholine-sterol acyltransfer Rattus norvegicus
ratno-q675a5 Rattus norvegicus (Rat) lysosomal phospholipase a2 Rattus norvegicus
salsa-a0a1s3kmb6 Salmo salar (Atlantic salmon)\; Salmo trutta (Brown trout). Phospholipid-cholesterol acyltransferase Salmo salar
schja-Q86F58 Schistosoma japonicum (Blood fluke, platyhelminth) clone zzd1085 mrna sequence Schistosoma japonicum
schja-q5dfm2 Schistosoma japonicum (Blood fluke, platyhelminth) hypothetical protein Schistosoma japonicum
schpo-pdat Schizosaccharomyces pombe (Fission yeast) (pdat) Schizosaccharomyces pombe
sheep-c5is96 Ovis aries (Sheep)\; Ovis ammon polii. Phospholipid-cholesterol acyltransferase Ovis aries
strav-SAV4434 Streptomyces avermitilis hypothetical protein Streptomyces avermitilis
tetng-q4t6m1 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetts-q22b72 Tetrahymena thermophila SB210 lecithin:cholesterol acyltransferase family protein Tetrahymena thermophila SB210
tobac-q71lw1 Nicotiana tabacum (Common tobacco) phospholipase a1 Nicotiana tabacum
tryb2-q382l4 Trypanosoma brucei phospholipid:diacylglycerol acyltransferase-like protein Trypanosoma brucei
trycr-q4dqa6 Trypanosoma cruzi (EC 2.3.1.158) Trypanosoma cruzi
tupch-lcat Tupaia chinensis (Chinese tree shrew)\; Tupaia glis (Tree shrew) (Sorex glis). lecithin cholesterol acyltransferase Tupaia chinensis
ursma-a0a8m1g1a3 Ursus maritimus (Polar bear) (Thalarctos maritimus). Phospholipid-cholesterol acyltransferase Ursus maritimus
ustma-q4phu1 Ustilago maydis (strain 521 \/ FGSC 9021) (Corn smut fungus) hypothetical protein Ustilago maydis 521
vicpa-a0a6i9i841 Vicugna pacos (Alpaca) (Lama pacos). Phospholipid-cholesterol acyltransferase Vicugna pacos
wheat-pdat1 Triticum aestivum (Wheat) Lecithin-cholesterol acyltransferase-like 1 TaPDAT Triticum aestivum
xenla-q566i0 Xenopus laevis (African clawed frog) hypothetical protein Xenopus laevis
xenla-q66j38 Xenopus laevis (African clawed frog) mgc82035 protein Xenopus laevis
xentr-q6dj79 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) lecithin-cholesterol acyltransferase Xenopus tropicalis
yarli-q6c5m4 Yarrowia lipolytica (Candida lipolytica) lipolytica. Yarrowia lipolytica
yarli-q6c6m4 Yarrowia lipolytica (Candida lipolytica) lipolytica. Similar to deha0e15411g debaryomyces hansenii (fragment) Yarrowia lipolytica
yeast-pdat Saccharomyces cerevisiae (Baker's yeast) phospholipid:diacylglycerol acyltransferase (EC 2.3.1.158) (pdat) LRO1 Saccharomyces cerevisiae
yeast-yj68 Saccharomyces cerevisiae (Baker's yeast) (and strain AWRI1631) hypothetical 74.1 kda protein in acr1-yuh1 intergenic region Saccharomyces cerevisiae

Gene_locus_frgt Name Species
akoto-lcat Akodon torques lecithin cholesterol acyl transferase (LCAT) gene Akodon torques
alheh-q0a9t5 Alkalilimnicola ehrlichei (strain MLHE-1) hypothetical protein Alkalilimnicola ehrlichei MLHE-1
anoga-q7pwe9 Anopheles gambiae str. PEST ensangp00000028095 ensangp00000019452 (fragment) Anopheles gambiae
canfa-LCAT Canis familiaris (Dog) lecithin:cholesterol acyltransferase (fragment) Canis lupus familiaris
chagb-q2hh56 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
clegl-lcat Clethrionomys glareolus (Bank vole) acyltransferase (fragment) Clethrionomys glareolus
criga-LCAT Cricetomys gambianus (Gambia rat) lecithin cholesterol acyl transferase (fragment) Cricetomys gambianus
crimi-lcat Cricetulus migratorius lecithin:cholesterol acyl transferase (LCAT) gene, partial cds Cricetulus migratorius
croru-LCAT Crocidura russula (White-toothed shrew) lecithin:cholesterol acyl-transferase (fragment) Crocidura russula
decar-q479y4 Dechloromonas aromatica (strain RCB) hypothetical protein Dechloromonas aromatica
didma-LCAT Didelphis marsupialis (Southern opossum) lecithin: cholesterol acyl-transferase (fragment) Didelphis marsupialis
eliqu-lcat Eliomys quercinus (Garden dormouse) acyltransferase (fragment) Eliomys quercinus
geomg-q39wd7 Geobacter metallireducens (strain GS-15 \/ ATCC 53774 \/ DSM 7210) hypothetical protein Geobacter metallireducens
gerhe-lcat Gerbillus henleyi (Pygmy gerbil) (Henley's gerbil) lecithin:cholesterol acyl transferase (LCAT) gene, partial cds Gerbillus henleyi
marma-lcat Marmota marmota (Alpine marmot) lecithin:cholesterol acyl transferase (LCAT) gene, partial cds Marmota marmota
micmi-lcat Micromys minutus lecithin-cholesterol acyl transferase (LCAT) gene, partial cds Micromys minutus
nanle-lcat Nannospalax leucodon (lesser mole rat) lecithin:cholesterol acyl transferase (LCAT) gene, partial cds Nannospalax leucodon
orysa-q6yy82 Oryza sativa subsp. japonica (Rice) putative lecithin-cholesterol acyl transferase Oryza sativa
orysa-q6yy83 Oryza sativa subsp. japonica (Rice) hypothetical protein osjnba0006o15.15 Oryza sativa
ponpy-Q8HZA1 Pongo pygmaeus (Orangutan) lecithin cholesterol acyltransferase (fragment) Pongo pygmaeus
prudu-LCAT1 Prunus dulcis (Almond) (Prunus amygdalus) lecithin-cholesterol acyl transferase (fragment) Prunus dulcis
rhipr-LCAT Rhizomys pruinosus (hoary bamboo rat) lecithin-cholesterol acyl transferase (fragment) Rhizomys pruinosus
sacca-LCAT Saccostomus campestris (pouched mouse) lecithin cholesterol acyl transferase (fragment) Saccostomus campestris
schja-q5byt2 Schistosoma japonicum (Blood fluke) hypothetical protein Schistosoma japonicum
schja-q5dd45 Schistosoma japonicum (Blood fluke, platyhelminth) hypothetical protein Schistosoma japonicum
tatke-lcat Tatera kempi gambiana lecithin-cholesterol acyl transferase (LCAT) gene, partial cds Tatera kempi gambiana
tetng-q4t6m0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome undetermined scaf8700, whole genome shotgun sequence Tetraodon nigroviridis

Substrate Chemical Nomenclature Proteins
1-Stearoyl-2-arachidonylphosphatidylcholine [2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy-3-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate human-LCAT    human-LIPC
1-palmitoyl-2-linoleoylphosphatidylcholine [3-hexadecanoyloxy-2-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate arath-PLA12    human-LCAT    human-LIPC    human-LIPG
Cholesterol (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol staau-lipas
Dipalmitoylphosphatidylcholine 2,3-di(hexadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate legpn-i7i328    human-LCAT
NBD-DAG 1-palmitoyl-2-dodecanoyl-nitrobenzoxadiazole-sn-glycero-3-glycerol arath-At5g13640
POPC [(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate 9entr-PLAA    human-PLA2G15    human-LCAT

Inhibitor Chemical Nomenclature Proteins
ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-hslip    mouse-MGLL    mouse-Abhd11    mouse-Ces1d    mouse-ES10    mouse-lypla2    drome-CG18815    mouse-lypla1    mouse-Ces1c    mouse-Ces1f    mouse-Ces1g    mouse-PPME1    mouse-apeh    mouse-abhd5    mouse-lypl1    mouse-Ces2c    mouse-Ces2a    mouse-Ces2e    mouse-aryla    mouse-BCHE    mouse-dpp2    mouse-dpp4    mouse-C87498
IDFP 1-[fluoro(propan-2-yloxy)phosphoryl]dodecane
IDFPen 12-[fluoro(propan-2-yloxy)phosphoryl]dodec-1-ene human-PLA2G15    human-LCAT
Methyl-arachidonyl-fluorophosphonate (5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene human-PLA2G15    9eury-6QE2    human-ABHD4    human-ABHD2    human-MGLL
VX-Biotin human-CTSA    human-ACHE    human-BCHE

References (13)

Title : Synergistic mechanisms of DGAT and PDAT in shaping triacylglycerol diversity: evolutionary insights and metabolic engineering strategies - Cai_2025_Front.Plant.Sci_16_1598815
Author(s) : Cai WL , Yu SY , Hu YH
Ref : Front Plant Sci , 16 :1598815 , 2025
Abstract :
PubMedSearch : Cai_2025_Front.Plant.Sci_16_1598815
PubMedID: 40666298

Title : Physiological Functions of Phospholipid:Diacylglycerol Acyltransferases - Sah_2024_Plant.Cell.Physiol_65_863
Author(s) : Sah SK , Fan J , Blanford J , Shanklin J , Xu C
Ref : Plant Cell Physiol , 65 :863 , 2024
Abstract :
PubMedSearch : Sah_2024_Plant.Cell.Physiol_65_863
PubMedID: 37702708

Title : Characterization of the diversification of phospholipid:diacylglycerol acyltransferases in the green lineage - Falarz_2020_Plant.J_103_2025
Author(s) : Falarz LJ , Xu Y , Caldo KMP , Garroway CJ , Singer SD , Chen G
Ref : Plant J , 103 :2025 , 2020
Abstract :
PubMedSearch : Falarz_2020_Plant.J_103_2025
PubMedID: 32538516

Title : Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol - Manthei_2018_Elife_7_
Author(s) : Manthei KA , Yang SM , Baljinnyam B , Chang L , Glukhova A , Yuan W , Freeman LA , Maloney DJ , Schwendeman A , Remaley AT , Jadhav A , Tesmer JJ
Ref : Elife , 7 : , 2018
Abstract :
PubMedSearch : Manthei_2018_Elife_7_
PubMedID: 30479275
Gene_locus related to this paper: human-LCAT

Title : Genome-wide analysis of PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE (PDAT) genes in plants reveals the eudicot-wide PDAT gene expansion and altered selective pressures acting on the core eudicot PDAT paralogs - Pan_2015_Plant.Physiol_167_887
Author(s) : Pan X , Peng FY , Weselake RJ
Ref : Plant Physiol , 167 :887 , 2015
Abstract :
PubMedSearch : Pan_2015_Plant.Physiol_167_887
PubMedID: 25585619

Title : A thermostable esterase from Thermoanaerobacter tengcongensis opening up a new family of bacterial lipolytic enzymes - Rao_2011_Biochim.Biophys.Acta_1814_1695
Author(s) : Rao L , Xue Y , Zhou C , Tao J , Li G , Lu JR , Ma Y
Ref : Biochimica & Biophysica Acta , 1814 :1695 , 2011
Abstract :
PubMedSearch : Rao_2011_Biochim.Biophys.Acta_1814_1695
PubMedID: 21907313
Gene_locus related to this paper: thete-LIPA3

Title : Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. - Zhang_2003_J.Biol.Chem_278_47145
Author(s) : Zhang Q , Chieu HK , Low CP , Zhang S , Heng CK , Yang H
Ref : Journal of Biological Chemistry , 278 :47145\ , 2003
Abstract :
PubMedSearch : Zhang_2003_J.Biol.Chem_278_47145
PubMedID: 12963726
Gene_locus related to this paper: schpo-pdat

Title : Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants - Dahlqvist_2000_Proc.Natl.Acad.Sci.U.S.A_97_6487
Author(s) : Dahlqvist A , Stahl U , Lenman M , Banas A , Lee M , Sandager L , Ronne H , Stymne S
Ref : Proc Natl Acad Sci U S A , 97 :6487 , 2000
Abstract :
PubMedSearch : Dahlqvist_2000_Proc.Natl.Acad.Sci.U.S.A_97_6487
PubMedID: 10829075
Gene_locus related to this paper: yeast-pdat

Title : Deficiency of lecithin:cholesterol acyltransferase due to compound heterozygosity of two novel mutations (Gly33Arg and 30 bp ins) in the LCAT gene -
Author(s) : Wiebusch H , Cullen P , Owen JS , Collins D , Sharp PS , Funke H , Assmann G
Ref : Hum Mol Genet , 4 :143 , 1995
PubMedID: 7711728
Gene_locus related to this paper: human-LCAT

Title : Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. Six newly identified defective alleles further contribute to the structural heterogeneity in this disease - Funke_1993_J.Clin.Invest_91_677
Author(s) : Funke H , von Eckardstein A , Pritchard PH , Hornby AE , Wiebusch H , Motti C , Hayden MR , Dachet C , Jacotot B , Gerdes U , Faergeman O , Albers JJ , Colleoni N , Catapano A , Frohlich J , Assmann G
Ref : J Clinical Investigation , 91 :677 , 1993
Abstract :
PubMedSearch : Funke_1993_J.Clin.Invest_91_677
PubMedID: 8432868
Gene_locus related to this paper: human-LCAT

Title : Lecithin cholesterol acyl transferase deficiency: molecular analysis of a mutated allele - Taramelli_1990_Hum.Genet_85_195
Author(s) : Taramelli R , Pontoglio M , Candiani G , Ottolenghi S , Dieplinger H , Catapano A , Albers J , Vergani C , McLean J
Ref : Hum Genet , 85 :195 , 1990
Abstract :
PubMedSearch : Taramelli_1990_Hum.Genet_85_195
PubMedID: 2370048
Gene_locus related to this paper: human-LCAT

Title : Alpha-lecithin:cholesterol acyltransferase deficiency. Lack of both phospholipase A2 and acyltransferase activities characteristic of high density lipoprotein lecithin:cholesterol acyltransferase in fish eye disease - Holmquist_1987_Acta.Med.Scand_222_23
Author(s) : Holmquist L , Carlson LA
Ref : Acta Med Scand , 222 :23 , 1987
Abstract :
PubMedSearch : Holmquist_1987_Acta.Med.Scand_222_23
PubMedID: 3630775
Gene_locus related to this paper: human-LCAT

Title : Inhibitory effect of normal high density lipoproteins on lecithin:cholesterol acyltransferase activity in fish eye disease plasma - Holmquist_1987_Acta.Med.Scand_222_15
Author(s) : Holmquist L , Carlson LA
Ref : Acta Med Scand , 222 :15 , 1987
Abstract :
PubMedSearch : Holmquist_1987_Acta.Med.Scand_222_15
PubMedID: 3630774
Gene_locus related to this paper: human-LCAT