Family: PC-sterol_acyltransferase

Block: L

Parent Family: No family


Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT), Lecithin-cholesterol acyltransferase, belong to this family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport, respectively. Whereas LPLA2 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease and familial LCAT deficiency. LACT also known as phosphatidylcholine-sterol acyltransferase (EC), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Defects in LACT cause Norum and Fish eye diseases. This family correspond to group XV phospholipase A2. Phospholipid:diacylglycerol acyltransferase (PDAT)( is involved in triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid. A group of bacterial enzymes was extracted in a new family : Bacterial_EstLip_FamXIV



Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (14)

Genes Proteins in PC-sterol_acyltransferase family (92)

Fragments of genes in PC-sterol_acyltransferase family (28)

Structures in PC-sterol_acyltransferase family (14)

Substrates in PC-sterol_acyltransferase family (5)

Inhibitors in PC-sterol_acyltransferase family (5)

References (8)

Title : Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol - Manthei_2018_Elife_7_
Author(s) : Manthei KA , Yang SM , Baljinnyam B , Chang L , Glukhova A , Yuan W , Freeman LA , Maloney DJ , Schwendeman A , Remaley AT , Jadhav A , Tesmer JJ
Ref : Elife , 7 : , 2018
PubMedID: 30479275
Gene_locus related to this paper: human-LCAT

Title : A thermostable esterase from Thermoanaerobacter tengcongensis opening up a new family of bacterial lipolytic enzymes - Rao_2011_Biochim.Biophys.Acta_1814_1695
Author(s) : Rao L , Xue Y , Zhou C , Tao J , Li G , Lu JR , Ma Y
Ref : Biochimica & Biophysica Acta , 1814 :1695 , 2011
PubMedID: 21907313
Gene_locus related to this paper: thete-LIPA3

Title : Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. - Zhang_2003_J.Biol.Chem_278_47145
Author(s) : Zhang Q , Chieu HK , Low CP , Zhang S , Heng CK , Yang H
Ref : Journal of Biological Chemistry , 278 :47145\ , 2003
PubMedID: 12963726
Gene_locus related to this paper: schpo-pdat

Title : Deficiency of lecithin:cholesterol acyltransferase due to compound heterozygosity of two novel mutations (Gly33Arg and 30 bp ins) in the LCAT gene -
Author(s) : Wiebusch H , Cullen P , Owen JS , Collins D , Sharp PS , Funke H , Assmann G
Ref : Hum Mol Genet , 4 :143 , 1995
PubMedID: 7711728
Gene_locus related to this paper: human-LCAT

Title : Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. Six newly identified defective alleles further contribute to the structural heterogeneity in this disease - Funke_1993_J.Clin.Invest_91_677
Author(s) : Funke H , von Eckardstein A , Pritchard PH , Hornby AE , Wiebusch H , Motti C , Hayden MR , Dachet C , Jacotot B , Gerdes U , Faergeman O , Albers JJ , Colleoni N , Catapano A , Frohlich J , Assmann G
Ref : J Clinical Investigation , 91 :677 , 1993
PubMedID: 8432868
Gene_locus related to this paper: human-LCAT

Title : Lecithin cholesterol acyl transferase deficiency: molecular analysis of a mutated allele - Taramelli_1990_Hum.Genet_85_195
Author(s) : Taramelli R , Pontoglio M , Candiani G , Ottolenghi S , Dieplinger H , Catapano A , Albers J , Vergani C , McLean J
Ref : Hum Genet , 85 :195 , 1990
PubMedID: 2370048
Gene_locus related to this paper: human-LCAT

Title : Alpha-lecithin:cholesterol acyltransferase deficiency. Lack of both phospholipase A2 and acyltransferase activities characteristic of high density lipoprotein lecithin:cholesterol acyltransferase in fish eye disease - Holmquist_1987_Acta.Med.Scand_222_23
Author(s) : Holmquist L , Carlson LA
Ref : Acta Med Scand , 222 :23 , 1987
PubMedID: 3630775
Gene_locus related to this paper: human-LCAT

Title : Inhibitory effect of normal high density lipoproteins on lecithin:cholesterol acyltransferase activity in fish eye disease plasma - Holmquist_1987_Acta.Med.Scand_222_15
Author(s) : Holmquist L , Carlson LA
Ref : Acta Med Scand , 222 :15 , 1987
PubMedID: 3630774
Gene_locus related to this paper: human-LCAT