PC-sterol_acyltransferase
Relationship
Comment
Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT), Lecithin-cholesterol acyltransferase, belong to this family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport, respectively. Whereas LPLA2 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease and familial LCAT deficiency. 
LACT also known as phosphatidylcholine-sterol acyltransferase (EC), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Defects in LACT cause Norum and Fish eye diseases. This family correspond to group XV phospholipase A2. Phospholipid:diacylglycerol acyltransferase (PDAT)(2.3.1.158) is involved in triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid. A group of bacterial enzymes was extracted in a new family : Bacterial_EstLip_FamXIV
Database
Interpro : IPR003386 Lecithin:cholesterol\/phospholipid:diacylglycerol acyltransferase LACT\/PDAT_acylTrfase
PIRSF : No PIRSF
Pdoc : PDOC00110
Pfam : PF02450 LACT-Lecithin:cholesterol acyltransferase LCAT
Prints : PR00821
EC Number : 2.3.1.43
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Structure | Name | Proteins |
|---|---|---|
| 6MTW | Crystal structure of Lysosomal Phospholipase A2 in complex with Zinc | human-PLA2G15 |
| 4X91 | Crystal structure of Lysosomal Phospholipase A2 in complex with Isopropyl dodec-11-enylfluorophosphonate (IDFP) | human-PLA2G15 |
| 4X90 | Crystal structure of Lysosomal Phospholipase A2 | human-PLA2G15 |
| 4X92 | Crystal structure of Lysosomal Phospholipase A2-S165A | human-PLA2G15 |
| 4X95 | Crystal structure of fully glycosylated Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP) | human-PLA2G15 |
| 4X93 | Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (tetragonal form) | human-PLA2G15 |
| 4X94 | Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (hexagonal form) | human-PLA2G15 |
| 5BV7 | Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody | human-LCAT |
| 6MVD | Crystal structure of human Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator supersedes 6DTJ | human-LCAT |
| 5TXF | Crystal structure of human Lecithin:cholesterol acyltransferase (LCAT) in a closed conformation | human-LCAT |
| 4XWG | Crystal Structure of human LCAT (C31Y) in complex with Fab1 Cholesterol Acyltransferase (LCAT (Cys31Tyr) | human-LCAT |
| 4XX1 | Low resolution structure of human LCAT in complex with Fab1. Lecithin:Cholesterol Acyltransferase (LCAT\; wild type) | human-LCAT |
| 4X96 | Low resolution crystal structure of human Lecithin:Cholesterol Acyltransferase (LCAT\; residues 21-397) | human-LCAT |
| 4X97 | Crystal structure of human Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP) | human-PLA2G15 |
| Gene_locus | Name | Species |
|---|---|---|
| pereae-PDAT1 | Persea americana (Avocado) phospholipid:diacylglycerol acyltransferase 1 (PDAT1) PaPDAT1 | Persea americana |
| anapl-lcat | Anas platyrhynchos (Domestic duck) lecithin cholesterol acyltransferase | Anas platyrhynchos |
| arath-At5g13640 | Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) at5g13640\/msh12_10 Phospholipid:diacylglycerol acyltransferase 1 PDAT1 | Arabidopsis thaliana |
| arath-LCAT2 | Arabidopsis thaliana (Mouse-ear cress) At1g04010 f21m11.5 Phospholipid--sterol O-acyltransferase PSAT | Arabidopsis thaliana |
| arath-PDAT2 | Arabidopsis thaliana (Mouse-ear cress) At3g44830 PDAT2 Putative phospholipid:diacylglycerol acyltransferase 2 | Arabidopsis thaliana |
| arath-LCAT1 | Arabidopsis thaliana (Mouse-ear cress) f17l21.27 (at1g27480\/f17l21_28) | Arabidopsis thaliana |
| arath-LCAT4 | Arabidopsis thaliana (Mouse-ear cress) Lecithin-cholesterol acyltransferase-like 4 | Arabidopsis thaliana |
| arath-LCAT3 | Arabidopsis thaliana (Mouse-ear cress) Phospholipase A(1) LCAT3 At3g03310 t21p5.27 | Arabidopsis thaliana |
| ashgo-q755k2 | Ashbya gossypii (Yeast) (Eremothecium gossypii) afl179cp | Ashbya gossypii |
| aspfu-q4wxl7 | Aspergillus fumigatus Af293 phospholipid:diacylglycerol acyltransferase, putative | Aspergillus fumigatus Af293 |
| aspor-q2ul81 | Aspergillus oryzae, Aspergillus flavus, lecithin:cholesterol acyltransferase | Aspergillus oryzae |
| bacan-BA3805 | Bacillus anthracis prophage lambdaba01, acyltransferase, putative | Bacillus anthracis |
| bacli-EST | Bacillus licheniformis esterase (EC 3.1.1.1) | Bacillus licheniformis |
| bovin-lcat | Bos taurus (Bovine) phosphatidylcholine-sterol acyltransferase | Bos taurus |
| bovin-LPLA2 | Bos taurus (Bovine) lysosomal phospholipase a2 ( lysophospholipase 3) | Bos taurus |
| caebr-A8Y168 | Caenorhabditis briggsae hypothetical protein cbg21934 | Caenorhabditis briggsae |
| caeel-M05B5.4 | Caenorhabditis elegans m05b5.4 protein | Caenorhabditis elegans |
| canal-q5abf2 | Candida albicans SC5314 hypothetical protein lro1 | Candida albicans SC5314 |
| canfa-q6xpz3 | Canis familiaris (Dog) lysosomal phospholipase a2 | Canis lupus familiaris |
| canga-q6fqj3 | Candida glabrata (Yeast) (Torulopsis glabrata) lro1 | Candida glabrata |
| cavpo-lcat | Cavia porcellus (Guinea pig) lecithin: cholesterol acyl-transferase (fragment) | Cavia porcellus |
| chick-lcat | Gallus gallus (Chicken) acyltransferase) (fragment) | Gallus gallus |
| citsi-q58fa2 | Citrus sinensis (Sweet orange) putative sterol esterification protein | Citrus sinensis |
| cryne-q5k8s0 | Cryptococcus neoformans (Filobasidiella neoformans) (and strain B-3501A) phospholipid:diacylglycerol acyltransferase, putative | Cryptococcus neoformans |
| danre-q6nyh6 | Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein pla2g15 | Danio rerio |
| debha-q6bsc3 | Debaryomyces hansenii (Yeast) (Torulaspora hansenii) similar to cagl0i05786g candida glabrata | Debaryomyces hansenii |
| drome-GH02384 | Drosophila melanogaster (Fruit fly) bcdna.gh02384 CG31683 CG18858 | Drosophila melanogaster |
| drops-q29ks6 | Drosophila pseudoobscura (Fruit fly) ga15103-pa (fragment) | Drosophila pseudoobscura |
| emeni-q5b388 | Aspergillus nidulans FGSC A4 hypothetical protein | Aspergillus nidulans FGSC A4 |
| enthi-b1n456 | Entamoeba histolytica, Entamoeba dispar, lecithin:cholesterol acyltransferase, putative | Entamoeba histolytica HM-1:IMSS |
| enthi-c4m0c3 | Entamoeba histolytica, Entamoeba dispar lecithin:cholesterol acyltransferase, putative | Entamoeba histolytica HM-1:IMSS |
| enthi-c4m2a9 | Entamoeba histolytica, Entamoeba dispar lecithin:cholesterol acyltransferase, putative | Entamoeba histolytica |
| enthi-c4m4l3 | Entamoeba histolytica, Entamoeba dispar lecithin:cholesterol acyltransferase, putative | Entamoeba histolytica HM-1:IMSS |
| enthi-c4m6k3 | Entamoeba histolytica, Entamoeba dispar, lecithin:cholesterol acyltransferase, putative | Entamoeba histolytica |
| enthi-c4m7v0 | Entamoeba histolytica HM-1:IMSS 1-o-acylceramide synthase, putative | Entamoeba histolytica HM-1:IMSS |
| enthi-q51a37 | Entamoeba histolytica HM-1:IMSS 1-o-acylceramide synthase, putative | Entamoeba histolytica HM-1:IMSS |
| enthi-q51aw6 | Entamoeba histolytica HM-1:IMSS 1-o-acylceramide synthase, putative | Entamoeba histolytica HM-1:IMSS |
| enthi-q51cz6 | Entamoeba histolytica HM-1:IMSS lecithin:cholesterol acyltransferase, putative | Entamoeba histolytica HM-1:IMSS |
| giala-q7qwm1 | Giardia lamblia ATCC 50803 glp_762_23988_17611 | Giardia lamblia ATCC 50803 |
| gibze-q4i8t3 | Gibberella zeae (Fusarium graminearum) hypothetical protein | Gibberella zeae |
| human-LCAT |  Homo sapiens (Human) phosphatidylcholine-sterol acyltransferase. Lecithin-cholesterol acyltransferase |
Homo sapiens |
| human-PLA2G15 | Homo sapiens (Human) Group XV phospholipase A2 lcat-like lysophospholipase (llpl) (unq341\/pro540) |
Homo sapiens |
| ipotf-q6jj42 | Ipomoea trifida (Morning glory) putative phosphatidylcholine-sterol acyltransferase | Ipomoea trifida |
| klula-q6cl20 | Kluyveromyces lactis (Yeast) 1140 of kluyveromyces lactis | Kluyveromyces lactis |
| leima-q4qhs0 | Leishmania major (EC 2.3.1.158) | Leishmania major |
| lyces-q71lx7 | Lycopersicon esculentum (Tomato) lecithine cholesterol acyltransferase-like protein | Lycopersicon esculentum |
| medtr-q1s687 | Medicago truncatula (Barrel medic) lecithin:cholesterol acyltransferase | Medicago truncatula |
| medtr-q6xsh3 | Medicago truncatula (Barrel medic) lecithine cholesterol acyltransferase-like protein | Medicago truncatula |
| medtr-Q8GZM5 | Medicago truncatula (Barrel medic) (Medicago tribuloides) putative phosphatidylcholine acyltransferase | Medicago truncatula |
| medtr-q71ce5 | Medicago truncatula (Barrel medic) lecithine cholesterol acyltransferase-like protein | Medicago truncatula |
| mouse-C87498 | Mus musculus (Mouse) similar to LCAT-like lysophospholipase (llpl) | Mus musculus |
| mouse-lcat | Mus musculus mRNA for phosphatidylcholine-sterol acyltransferase ( lecithin: cholesterol acyltransferase) | Mus musculus |
| neucr-q7s4e3 | Neurospora crassa hypothetical protein | Neurospora crassa |
| orysa-Q8S5X5 | Oryza sativa subsp. japonica subsp. indica (Rice) hypothetical 91.2 kda protein | Oryza sativa |
| orysa-Q851F0 | Oryza sativa (japonica cultivar-group) putative lecithin-cholesterol acyl transferase | Oryza sativa |
| orysa-Q8RYV9 | Oryza sativa subsp. japonica subsp. indica (Rice) p0614d08.29 protein | Oryza sativa |
| orysa-q6k3d9 | Oryza sativa subsp. japonica subsp. indica (Rice) phosphatidylcholine acyltransferase-like | Oryza sativa |
| orysa-q6yy42 | Oryza sativa subsp. japonica subsp. indica (Rice) putative acyltransferase (46.9 kd) (1h765) | Oryza sativa |
| orysa-q6yy78 | Oryza sativa (japonica cultivar-group) putative acyltransferase (46.9 kd) (1h765) | Oryza sativa |
| orysa-q7xts6 | Oryza sativa subsp. indica subsp. japonica (Rice) osjnba0008m17.7 protein | Oryza sativa |
| orysa-q67u60 | Oryza sativa (japonica cultivar-group) putative lecithin diacylglycerol cholesterol acyltransferase | Oryza sativa |
| orysa-Q94HP5 | Oryza sativa (Rice) hypothetical protein | Oryza sativa |
| papan-lcat | Papio anubis lecithin cholesterol acyltransferase | Papio anubis |
| pencw-b6hmd9 | Penicillium chrysogenum (strain ATCC 28089 \/ DSM 1075 \/ Wisconsin 54-1255) (Penicillium notatum) Pc21g08810 protein | Penicillium chrysogenum |
| phypa-Q8GU37 | Physcomitrella patens (Moss) putative phosphatidylcholine-sterol acetyltransferase (fragment) | Physcomitrella patens |
| plaba-q4z5z8 | Plasmodium berghei phosphatidylcholine-sterol acyltransferase, putative | Plasmodium berghei |
| plach-q4xsw6 | Plasmodium chabaudi phosphatidylcholine-sterol acyltransferase, putative (fragment) | Plasmodium chabaudi |
| plafa-MAL6P1.135 | Plasmodium falciparum (isolate 3D7) PF3D7_0629300 Phosphatidylcholine-sterol acyltransferase, putative (EC 2.3.1.43) PfPL | Plasmodium falciparum |
| playo-q7rh25 | Plasmodium yoelii yoelii lecithin:cholesterol acyltransferase, putative | Plasmodium yoelii yoelii |
| podan-Q875A3 | Podospora anserina hypothetical protein pa5d0027 | Podospora anserina |
| ponab-q5rai0 | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Putative uncharacterized protein DKFZp468N192 | Pongo abelii |
| rabit-lcat | Rabbit mRNA for lecithin-cholesterol acyltransferase | Oryctolagus cuniculus |
| ratno-lcat | Rattus norvegicus (Rat) Phosphatidylcholine-sterol acyltransfer | Rattus norvegicus |
| ratno-q675a5 | Rattus norvegicus (Rat) lysosomal phospholipase a2 | Rattus norvegicus |
| schja-q5dfm2 | Schistosoma japonicum (Blood fluke, platyhelminth) hypothetical protein | Schistosoma japonicum |
| schja-Q86F58 | Schistosoma japonicum (Blood fluke, platyhelminth) clone zzd1085 mrna sequence | Schistosoma japonicum |
| schpo-pdat | Schizosaccharomyces pombe (Fission yeast) (pdat) | Schizosaccharomyces pombe |
| strav-SAV4434 | Streptomyces avermitilis hypothetical protein | Streptomyces avermitilis |
| tetng-q4t6m1 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) | Tetraodon nigroviridis |
| tetts-q22b72 | Tetrahymena thermophila SB210 lecithin:cholesterol acyltransferase family protein | Tetrahymena thermophila SB210 |
| tobac-q71lw1 | Nicotiana tabacum (Common tobacco) phospholipase a1 | Nicotiana tabacum |
| tryb2-q382l4 | Trypanosoma brucei phospholipid:diacylglycerol acyltransferase-like protein | Trypanosoma brucei |
| trycr-q4dqa6 | Trypanosoma cruzi (EC 2.3.1.158) | Trypanosoma cruzi |
| tupch-lcat | Tupaia chinensis (Chinese tree shrew)\; Tupaia glis (Tree shrew) (Sorex glis). lecithin cholesterol acyltransferase | Tupaia chinensis |
| ustma-q4phu1 | Ustilago maydis (strain 521 \/ FGSC 9021) (Corn smut fungus) hypothetical protein | Ustilago maydis 521 |
| xenla-q66j38 | Xenopus laevis (African clawed frog) mgc82035 protein | Xenopus laevis |
| xenla-q566i0 | Xenopus laevis (African clawed frog) hypothetical protein | Xenopus laevis |
| xentr-q6dj79 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) lecithin-cholesterol acyltransferase | Xenopus tropicalis |
| yarli-q6c5m4 | Yarrowia lipolytica (Candida lipolytica) lipolytica. | Yarrowia lipolytica |
| yarli-q6c6m4 | Yarrowia lipolytica (Candida lipolytica) lipolytica. Similar to deha0e15411g debaryomyces hansenii (fragment) | Yarrowia lipolytica |
| yeast-pdat | Saccharomyces cerevisiae (Baker's yeast) phospholipid:diacylglycerol acyltransferase (EC 2.3.1.158) (pdat) LRO1 | Saccharomyces cerevisiae |
| yeast-yj68 | Saccharomyces cerevisiae (Baker's yeast) (and strain AWRI1631) hypothetical 74.1 kda protein in acr1-yuh1 intergenic region | Saccharomyces cerevisiae |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| akoto-lcat | Akodon torques lecithin cholesterol acyl transferase (LCAT) gene | Akodon torques |
| alheh-q0a9t5 | Alkalilimnicola ehrlichei (strain MLHE-1) hypothetical protein | Alkalilimnicola ehrlichei MLHE-1 |
| anoga-q7pwe9 | Anopheles gambiae str. PEST ensangp00000028095 ensangp00000019452 (fragment) | Anopheles gambiae |
| canfa-LCAT | Canis familiaris (Dog) lecithin:cholesterol acyltransferase (fragment) | Canis lupus familiaris |
| chagb-q2hh56 | Chaetomium globosum CBS 148.51 hypothetical protein | Chaetomium globosum CBS 148.51 |
| clegl-lcat | Clethrionomys glareolus (Bank vole) acyltransferase (fragment) | Clethrionomys glareolus |
| criga-LCAT | Cricetomys gambianus (Gambia rat) lecithin cholesterol acyl transferase (fragment) | Cricetomys gambianus |
| crimi-lcat | Cricetulus migratorius lecithin:cholesterol acyl transferase (LCAT) gene, partial cds | Cricetulus migratorius |
| croru-LCAT | Crocidura russula (White-toothed shrew) lecithin:cholesterol acyl-transferase (fragment) | Crocidura russula |
| decar-q479y4 | Dechloromonas aromatica (strain RCB) hypothetical protein | Dechloromonas aromatica |
| didma-LCAT | Didelphis marsupialis (Southern opossum) lecithin: cholesterol acyl-transferase (fragment) | Didelphis marsupialis |
| eliqu-lcat | Eliomys quercinus (Garden dormouse) acyltransferase (fragment) | Eliomys quercinus |
| geomg-q39wd7 | Geobacter metallireducens (strain GS-15 \/ ATCC 53774 \/ DSM 7210) hypothetical protein | Geobacter metallireducens |
| gerhe-lcat | Gerbillus henleyi (Pygmy gerbil) (Henley's gerbil) lecithin:cholesterol acyl transferase (LCAT) gene, partial cds | Gerbillus henleyi |
| marma-lcat | Marmota marmota (Alpine marmot) lecithin:cholesterol acyl transferase (LCAT) gene, partial cds | Marmota marmota |
| micmi-lcat | Micromys minutus lecithin-cholesterol acyl transferase (LCAT) gene, partial cds | Micromys minutus |
| nanle-lcat | Nannospalax leucodon (lesser mole rat) lecithin:cholesterol acyl transferase (LCAT) gene, partial cds | Nannospalax leucodon |
| orysa-q6yy82 | Oryza sativa subsp. japonica (Rice) putative lecithin-cholesterol acyl transferase | Oryza sativa |
| orysa-q6yy83 | Oryza sativa subsp. japonica (Rice) hypothetical protein osjnba0006o15.15 | Oryza sativa |
| ponpy-Q8HZA1 | Pongo pygmaeus (Orangutan) lecithin cholesterol acyltransferase (fragment) | Pongo pygmaeus |
| prudu-LCAT1 | Prunus dulcis (Almond) (Prunus amygdalus) lecithin-cholesterol acyl transferase (fragment) | Prunus dulcis |
| rhipr-LCAT | Rhizomys pruinosus (hoary bamboo rat) lecithin-cholesterol acyl transferase (fragment) | Rhizomys pruinosus |
| sacca-LCAT | Saccostomus campestris (pouched mouse) lecithin cholesterol acyl transferase (fragment) | Saccostomus campestris |
| schja-q5byt2 | Schistosoma japonicum (Blood fluke) hypothetical protein | Schistosoma japonicum |
| schja-q5dd45 | Schistosoma japonicum (Blood fluke, platyhelminth) hypothetical protein | Schistosoma japonicum |
| pig-lcat | Sus scrofa domestica (domestic pig) phosphatidylcholine-sterol acyltransferase | Sus scrofa |
| tatke-lcat | Tatera kempi gambiana lecithin-cholesterol acyl transferase (LCAT) gene, partial cds | Tatera kempi gambiana |
| tetng-q4t6m0 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome undetermined scaf8700, whole genome shotgun sequence | Tetraodon nigroviridis |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| Cholesterol | (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | staau-lipas |
| Dipalmitoylphosphatidylcholine | 2,3-di(hexadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate | legpn-i7i328 human-LCAT |
| 1-Stearoyl-2-arachidonylphosphatidylcholine | [2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy-3-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate | human-LCAT human-LIPC |
| 1-palmitoyl-2-linoleoylphosphatidylcholine | [3-hexadecanoyloxy-2-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate | arath-PLA12 human-LCAT human-LIPC human-LIPG |
| POPC | [(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate | 9entr-PLAA |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| ABP-C6 | Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate | mouse-hslip mouse-MGLL mouse-Abhd11 mouse-Ces1d mouse-ES10 mouse-lypla2 drome-CG18815 mouse-lypla1 mouse-Ces1c mouse-Ces1f mouse-Ces1g mouse-PPME1 mouse-apeh mouse-abhd5 mouse-lypl1 mouse-Ces2c mouse-Ces2a mouse-Ces2e mouse-aryla mouse-BCHE mouse-dpp2 mouse-dpp4 mouse-C87498 |
| Methyl-arachidonyl-fluorophosphonate | (5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene | human-PLA2G15 9eury-6QE2 human-ABHD4 |
| VX-Biotin | human-CTSA human-ACHE human-BCHE | |
| IDFP | 1-[fluoro(propan-2-yloxy)phosphoryl]dodecane | |
| IDFPen | 12-[fluoro(propan-2-yloxy)phosphoryl]dodec-1-ene | human-PLA2G15 human-LCAT |
References (8)
| Title : Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol - Manthei_2018_Elife_7_ |
| Author(s) : Manthei KA , Yang SM , Baljinnyam B , Chang L , Glukhova A , Yuan W , Freeman LA , Maloney DJ , Schwendeman A , Remaley AT , Jadhav A , Tesmer JJ |
| Ref : Elife , 7 : , 2018 |
| Abstract : |
| PubMedSearch : Manthei_2018_Elife_7_ |
| PubMedID: 30479275 |
| Gene_locus related to this paper: human-LCAT |
| Title : A thermostable esterase from Thermoanaerobacter tengcongensis opening up a new family of bacterial lipolytic enzymes - Rao_2011_Biochim.Biophys.Acta_1814_1695 |
| Author(s) : Rao L , Xue Y , Zhou C , Tao J , Li G , Lu JR , Ma Y |
| Ref : Biochimica & Biophysica Acta , 1814 :1695 , 2011 |
| Abstract : |
| PubMedSearch : Rao_2011_Biochim.Biophys.Acta_1814_1695 |
| PubMedID: 21907313 |
| Gene_locus related to this paper: thete-LIPA3 |
| Title : Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. - Zhang_2003_J.Biol.Chem_278_47145 |
| Author(s) : Zhang Q , Chieu HK , Low CP , Zhang S , Heng CK , Yang H |
| Ref : Journal of Biological Chemistry , 278 :47145\ , 2003 |
| Abstract : |
| PubMedSearch : Zhang_2003_J.Biol.Chem_278_47145 |
| PubMedID: 12963726 |
| Gene_locus related to this paper: schpo-pdat |
| Title : Deficiency of lecithin:cholesterol acyltransferase due to compound heterozygosity of two novel mutations (Gly33Arg and 30 bp ins) in the LCAT gene - |
| Author(s) : Wiebusch H , Cullen P , Owen JS , Collins D , Sharp PS , Funke H , Assmann G |
| Ref : Hum Mol Genet , 4 :143 , 1995 |
| PubMedID: 7711728 |
| Gene_locus related to this paper: human-LCAT |
| Title : Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. Six newly identified defective alleles further contribute to the structural heterogeneity in this disease - Funke_1993_J.Clin.Invest_91_677 |
| Author(s) : Funke H , von Eckardstein A , Pritchard PH , Hornby AE , Wiebusch H , Motti C , Hayden MR , Dachet C , Jacotot B , Gerdes U , Faergeman O , Albers JJ , Colleoni N , Catapano A , Frohlich J , Assmann G |
| Ref : J Clinical Investigation , 91 :677 , 1993 |
| Abstract : |
| PubMedSearch : Funke_1993_J.Clin.Invest_91_677 |
| PubMedID: 8432868 |
| Gene_locus related to this paper: human-LCAT |
| Title : Lecithin cholesterol acyl transferase deficiency: molecular analysis of a mutated allele - Taramelli_1990_Hum.Genet_85_195 |
| Author(s) : Taramelli R , Pontoglio M , Candiani G , Ottolenghi S , Dieplinger H , Catapano A , Albers J , Vergani C , McLean J |
| Ref : Hum Genet , 85 :195 , 1990 |
| Abstract : |
| PubMedSearch : Taramelli_1990_Hum.Genet_85_195 |
| PubMedID: 2370048 |
| Gene_locus related to this paper: human-LCAT |
| Title : Alpha-lecithin:cholesterol acyltransferase deficiency. Lack of both phospholipase A2 and acyltransferase activities characteristic of high density lipoprotein lecithin:cholesterol acyltransferase in fish eye disease - Holmquist_1987_Acta.Med.Scand_222_23 |
| Author(s) : Holmquist L , Carlson LA |
| Ref : Acta Med Scand , 222 :23 , 1987 |
| Abstract : |
| PubMedSearch : Holmquist_1987_Acta.Med.Scand_222_23 |
| PubMedID: 3630775 |
| Gene_locus related to this paper: human-LCAT |
| Title : Inhibitory effect of normal high density lipoproteins on lecithin:cholesterol acyltransferase activity in fish eye disease plasma - Holmquist_1987_Acta.Med.Scand_222_15 |
| Author(s) : Holmquist L , Carlson LA |
| Ref : Acta Med Scand , 222 :15 , 1987 |
| Abstract : |
| PubMedSearch : Holmquist_1987_Acta.Med.Scand_222_15 |
| PubMedID: 3630774 |
| Gene_locus related to this paper: human-LCAT |