human-LCAT

Homo sapiens (Human) phosphatidylcholine-sterol acyltransferase. Lecithin-cholesterol acyltransferase

Comment

Lecithin:cholesterol acyltransferase (LCAT\; EC 2.3.1.43) is a soluble enzyme that converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high density lipoproteins. LCAT facilitates the removal of excess cholesterol from peripheral tissues to the liver. A lack of LCAT activity would be expected to lead to accumulation of free cholesterol in the tissues. The gene encoding LCAT on chromosome 16 is the site of the mutation in both lecithin-cholesterol acyltransferase deficiency (LCATD) (Norum disease) and fish-eye disease (FED)<\/A>. Two phenotypic forms are found: familial LCAT deficiency and fish-eye disease. Familial LCAT deficiency is associated with a complete absence of alpha and beta LCAT activities and results in esterification anomalies involving both HDL (alpha-LCAT activity) and LDL (beta-LCAT activity). It causes a typical triad of diffuse corneal opacities, target cell hemolytic anemia, and proteinuria with renal failure. In fish-eye disease, there is only a partial LCAT deficiency that affects only alpha-LCAT activity. It is characterized by low plasma HDL and corneal opacities due to accumulation of cholesterol deposits in the cornea ('fish-eye').there is a specific inability of LCAT to esterify cholesterol in HDL, a deficiency of alpha-LCAT function. See LCAT Mutation database<\/A>

Relationship

Family : PC-sterol_acyltransferase

Block : L

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Database

Sequence

Peptide

MGPPGSPWQW VTLLLGLLLP PAAPFWLLNV LFPPHTTPKA ELSNHTRPVI LVPGCLGNQL EAKLDKPDVV NWMCYRKTED FFTIWLDLNM FLPLGVDCWI DNTRVVYNRS SGLVSNAPGV QIRVPGFGKT YSVEYLDSSK LAGYLHTLVQ NLVNNGYVRD ETVRAAPYDW RLEPGQQEEY YRKLAGLVEE MHAAYGKPVF LIGHSLGCLH LLYFLLRQPQ AWKDRFIDGF ISLGAPWGGS IKPMLVLASG DNQGIPIMSS IKLKEEQRIT TTSPWMFPSR MAWPEDHVFI STPSFNYTGR DFQRFFADLH FEEGWYMWLQ SRDLLAGLPA PGVEVYCLYG VGLPTPRTYI YDHGFPYTDP VGVLYEDGDD TVATRSTELC GLWQGRQPQP VHLLPLHGIQ HLNMVFSNLT LEHINAILLG AYRQGPPASP TASPEPPPPE

References (53)

Title : A novel pathogenic variant in LCAT causing FLD. A case report - Goni Ros_2022_Acta.Clin.Belg_77_970
Author(s) : Goni Ros N , Gonzalez-Tarancon R , Sienes Bailo P , Salvador-Ruperez E , Puzo Bayod M , Puzo Foncillas J
Ref : Acta Clin Belg , 77 :970 , 2022
PubMedID: 34789074
Gene_locus related to this paper: human-LCAT

Title : Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol - Manthei_2018_Elife_7_
Author(s) : Manthei KA , Yang SM , Baljinnyam B , Chang L , Glukhova A , Yuan W , Freeman LA , Maloney DJ , Schwendeman A , Remaley AT , Jadhav A , Tesmer JJ
Ref : Elife , 7 : , 2018
PubMedID: 30479275
Gene_locus related to this paper: human-LCAT

Title : Depletion in LpA-I:A-II particles enhances HDL-mediated endothelial protection in familial LCAT deficiency - Gomaraschi_2017_J.Lipid.Res_58_994
Author(s) : Gomaraschi M , Ossoli A , Castelnuovo S , Simonelli S , Pavanello C , Balzarotti G , Arca M , Di Costanzo A , Sampietro T , Vaudo G , Baldassarre D , Veglia F , Franceschini G , Calabresi L
Ref : J Lipid Res , 58 :994 , 2017
PubMedID: 28351888
Gene_locus related to this paper: human-LCAT

Title : A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I - Manthei_2017_J.Biol.Chem_292_20313
Author(s) : Manthei KA , Ahn J , Glukhova A , Yuan W , Larkin C , Manett TD , Chang L , Shayman JA , Axley MJ , Schwendeman A , Tesmer JJG
Ref : Journal of Biological Chemistry , 292 :20313 , 2017
PubMedID: 29030428
Gene_locus related to this paper: human-LCAT

Title : Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31 - Freeman_2017_J.Pharmacol.Exp.Ther_362_306
Author(s) : Freeman LA , Demosky SJ, Jr. , Konaklieva M , Kuskovsky R , Aponte A , Ossoli AF , Gordon SM , Koby RF , Manthei KA , Shen M , Vaisman BL , Shamburek RD , Jadhav A , Calabresi L , Gucek M , Tesmer JJG , Levine RL , Remaley AT
Ref : Journal of Pharmacology & Experimental Therapeutics , 362 :306 , 2017
PubMedID: 28576974
Gene_locus related to this paper: human-LCAT

Title : A novel homozygous mutation causing lecithin-cholesterol acyltransferase deficiency in a proband of Romanian origin with a record of extreme gestational hyperlipidemia - Rial-Crestelo_2017_J.Clin.Lipidol_11_1475
Author(s) : Rial-Crestelo D , Santos-Recuero I , Julve J , Blanco-Vaca F , Torralba M
Ref : J Clin Lipidol , 11 :1475 , 2017
PubMedID: 28942093
Gene_locus related to this paper: human-LCAT

Title : [Lecithin:Cholesterol Acyltransferase Deficiency, from genes to therapy] - Lucca_2016_G.Ital.Nefrol_33_
Author(s) : Lucca F , Ossoli A , Boscutti G , Franceschini G , Calabresi L
Ref : G Ital Nefrol , 33 : , 2016
PubMedID: 27960011
Gene_locus related to this paper: human-LCAT

Title : Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism - Gunawardane_2016_J.Biol.Chem_291_2799
Author(s) : Gunawardane RN , Fordstrom P , Piper DE , Masterman S , Siu S , Liu D , Brown M , Lu M , Tang J , Zhang R , Cheng J , Gates A , Meininger D , Chan J , Carlson T , Walker N , Schwarz M , Delaney J , Zhou M
Ref : Journal of Biological Chemistry , 291 :2799 , 2016
PubMedID: 26644477
Gene_locus related to this paper: human-LCAT

Title : Familial lecithin:cholesterol acyltransferase deficiency: First-in-human treatment with enzyme replacement - Shamburek_2016_J.Clin.Lipidol_10_356
Author(s) : Shamburek RD , Bakker-Arkema R , Auerbach BJ , Krause BR , Homan R , Amar MJ , Freeman LA , Remaley AT
Ref : J Clin Lipidol , 10 :356 , 2016
PubMedID: 27055967
Gene_locus related to this paper: human-LCAT

Title : Safety and Tolerability of ACP-501, a Recombinant Human Lecithin:Cholesterol Acyltransferase, in a Phase 1 Single-Dose Escalation Study - Shamburek_2016_Circ.Res_118_73
Author(s) : Shamburek RD , Bakker-Arkema R , Shamburek AM , Freeman LA , Amar MJ , Auerbach B , Krause BR , Homan R , Adelman SJ , Collins HL , Sampson M , Wolska A , Remaley AT
Ref : Circulation Research , 118 :73 , 2016
PubMedID: 26628614
Gene_locus related to this paper: human-LCAT

Title : A case of acquired lecithin:cholesterol acyltransferase deficiency with sarcoidosis that remitted spontaneously - Akiko_2016_CEN.Case.Rep_5_192
Author(s) : Akiko T , Okura T , Nagao T , Kukida M , Enomoto D , Miyoshi KI , Higaki J , Kuroda M , Bujo H
Ref : CEN Case Rep , 5 :192 , 2016
PubMedID: 28508975
Gene_locus related to this paper: human-LCAT

Title : The high-resolution crystal structure of human LCAT - Piper_2015_J.Lipid.Res_56_1711
Author(s) : Piper DE , Romanow WG , Gunawardane RN , Fordstrom P , Masterman S , Pan O , Thibault ST , Zhang R , Meininger D , Schwarz M , Wang Z , King C , Zhou M , Walker NP
Ref : J Lipid Res , 56 :1711 , 2015
PubMedID: 26195816
Gene_locus related to this paper: human-LCAT

Title : Familial lecithin-cholesterol acyltransferase (LCAT) deficiency\; a differential of proteinuria - Althaf_2015_J.Nephropathol_4_25
Author(s) : Althaf MM , Almana H , Abdelfadiel A , Amer SM , Al-Hussain TO
Ref : J Nephropathol , 4 :25 , 2015
PubMedID: 25657982
Gene_locus related to this paper: human-LCAT

Title : Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase - Glukhova_2015_Nat.Commun_6_6250
Author(s) : Glukhova A , Hinkovska-Galcheva V , Kelly R , Abe A , Shayman JA , Tesmer JJ
Ref : Nat Commun , 6 :6250 , 2015
PubMedID: 25727495
Gene_locus related to this paper: human-LCAT

Title : Lipoprotein subfractions highly associated with renal damage in familial lecithin:cholesterol acyltransferase deficiency - Kuroda_2014_Arterioscler.Thromb.Vasc.Biol_34_1756
Author(s) : Kuroda M , Holleboom AG , Stroes ES , Asada S , Aoyagi Y , Kamata K , Yamashita S , Ishibashi S , Saito Y , Bujo H
Ref : Arterioscler Thromb Vasc Biol , 34 :1756 , 2014
PubMedID: 24876348
Gene_locus related to this paper: human-LCAT

Title : Amelioration of circulating lipoprotein profile and proteinuria in a patient with LCAT deficiency due to a novel mutation (Cys74Tyr) in the lid region of LCAT under a fat-restricted diet and ARB treatment - Naito_2013_Atherosclerosis_228_193
Author(s) : Naito S , Kamata M , Furuya M , Hayashi M , Kuroda M , Bujo H , Kamata K
Ref : Atherosclerosis , 228 :193 , 2013
PubMedID: 23522979
Gene_locus related to this paper: human-LCAT

Title : Recombinant human LCAT normalizes plasma lipoprotein profile in LCAT deficiency - Simonelli_2013_Biologicals_41_446
Author(s) : Simonelli S , Tinti C , Salvini L , Tinti L , Ossoli A , Vitali C , Sousa V , Orsini G , Nolli ML , Franceschini G , Calabresi L
Ref : Biologicals , 41 :446 , 2013
PubMedID: 24140107
Gene_locus related to this paper: human-LCAT

Title : Familial LCAT deficiency: from renal replacement to enzyme replacement - Stoekenbroek_2013_Neth.J.Med_71_29
Author(s) : Stoekenbroek RM , van den Bergh Weerman MA , Hovingh GK , Potter van Loon BJ , Siegert CE , Holleboom AG
Ref : Neth J Med , 71 :29 , 2013
PubMedID: 23412821
Gene_locus related to this paper: human-LCAT

Title : Nephrotic syndrome caused by immune-mediated acquired LCAT deficiency - Takahashi_2013_J.Am.Soc.Nephrol_24_1305
Author(s) : Takahashi S , Hiromura K , Tsukida M , Ohishi Y , Hamatani H , Sakurai N , Sakairi T , Ikeuchi H , Kaneko Y , Maeshima A , Kuroiwa T , Yokoo H , Aoki T , Nagata M , Nojima Y
Ref : J Am Soc Nephrol , 24 :1305 , 2013
PubMedID: 23620397
Gene_locus related to this paper: human-LCAT

Title : Novel missense variants in LCAT and APOB genes in an Italian kindred with familial lecithin:cholesterol acyltransferase deficiency and hypobetalipoproteinemia - Conca_2012_J.Clin.Lipidol_6_244
Author(s) : Conca P , Pileggi S , Simonelli S , Boer E , Boscutti G , Magnolo L , Tarugi P , Penco S , Franceschini G , Calabresi L , Gomaraschi M
Ref : J Clin Lipidol , 6 :244 , 2012
PubMedID: 22658148
Gene_locus related to this paper: human-LCAT

Title : Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations - Katayama_2011_NDT.Plus_4_299
Author(s) : Katayama A , Wada J , Kataoka HU , Yamasaki H , Teshigawara S , Terami T , Inoue K , Kanzaki M , Murakami K , Nakatsuka A , Sugiyama H , Koide N , Bujo H , Makino H
Ref : NDT Plus , 4 :299 , 2011
PubMedID: 25984174
Gene_locus related to this paper: human-LCAT

Title : Homozygous lecithin:cholesterol acyltransferase (LCAT) deficiency due to a new loss of function mutation and review of the literature - Roshan_2011_J.Clin.Lipidol_5_493
Author(s) : Roshan B , Ganda OP , Desilva R , Ganim RB , Ward E , Haessler SD , Polisecki EY , Asztalos BF , Schaefer EJ
Ref : J Clin Lipidol , 5 :493 , 2011
PubMedID: 22108153
Gene_locus related to this paper: human-LCAT

Title : Lecithin-cholesterol acyltransferase (LCAT) deficiency without mutations in the coding sequence: a case report and literature review - Shoji_2011_Clin.Nephrol_76_323
Author(s) : Shoji K , Morita H , Ishigaki Y , Rivard CJ , Takayasu M , Nakayama K , Nakayama T , Inoue Y , Ayaki M , Yoshimura A
Ref : Clin Nephrol , 76 :323 , 2011
PubMedID: 21955868
Gene_locus related to this paper: human-LCAT

Title : Lecithin: Cholesterol Acyltransferase (LCAT) Deficiency: renal lesions with early graft recurrence - Strom_2011_Ultrastruct.Pathol_35_139
Author(s) : Strom EH , Sund S , Reier-Nilsen M , Dorje C , Leren TP
Ref : Ultrastruct Pathol , 35 :139 , 2011
PubMedID: 21323422
Gene_locus related to this paper: human-LCAT

Title : A case of familial lecithin-cholesterol acyltransferase deficiency on hemodialysis for over 20 years - Tsuchiya_2011_Clin.Nephrol_76_492
Author(s) : Tsuchiya Y , Ubara Y , Hiramatsu R , Suwabe T , Hoshino J , Sumida K , Hasegawa E , Yamanouchi M , Hayami N , Marui Y , Sawa N , Hara S , Takaichi K , Oohashi K
Ref : Clin Nephrol , 76 :492 , 2011
PubMedID: 22105454
Gene_locus related to this paper: human-LCAT

Title : Molecular analysis of a novel LCAT mutation (Gly179 --> Arg) found in a patient with complete LCAT deficiency - Wang_2011_J.Atheroscler.Thromb_18_713
Author(s) : Wang XL , Osuga J , Tazoe F , Okada K , Nagashima S , Takahashi M , Ohshiro T , Bayasgalan T , Yagyu H , Ishibashi S
Ref : J Atheroscler Thromb , 18 :713 , 2011
PubMedID: 21597230
Gene_locus related to this paper: human-LCAT

Title : Proteinuria in early childhood due to familial LCAT deficiency caused by loss of a disulfide bond in lecithin:cholesterol acyl transferase - Holleboom_2011_Atherosclerosis_216_161
Author(s) : Holleboom AG , Kuivenhoven JA , van Olden CC , Peter J , Schimmel AW , Levels JH , Valentijn RM , Vos P , Defesche JC , Kastelein JJ , Hovingh GK , Stroes ES , Hollak CE
Ref : Atherosclerosis , 216 :161 , 2011
PubMedID: 21315357
Gene_locus related to this paper: human-LCAT

Title : Point mutation (C to T) of the LCAT gene resulting in R140C substitution - Hirashio_2010_J.Atheroscler.Thromb_17_1297
Author(s) : Hirashio S , Izumi K , Ueno T , Arakawa T , Naito T , Taguchi T , Yorioka N
Ref : J Atheroscler Thromb , 17 :1297 , 2010
PubMedID: 20938102
Gene_locus related to this paper: human-LCAT

Title : Two different allelic mutations in a Finnish family with lecithin:cholesterol acyltransferase deficiency - Miettinen_1995_Arterioscler.Thromb.Vasc.Biol_15_460
Author(s) : Miettinen H , Gylling H , Ulmanen I , Miettinen TA , Kontula K
Ref : Arterioscler Thromb Vasc Biol , 15 :460 , 1995
PubMedID: 7749857
Gene_locus related to this paper: human-LCAT

Title : Deficiency of lecithin:cholesterol acyltransferase due to compound heterozygosity of two novel mutations (Gly33Arg and 30 bp ins) in the LCAT gene -
Author(s) : Wiebusch H , Cullen P , Owen JS , Collins D , Sharp PS , Funke H , Assmann G
Ref : Hum Mol Genet , 4 :143 , 1995
PubMedID: 7711728
Gene_locus related to this paper: human-LCAT

Title : Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC\/electrospray mass spectrometry and sequential glycosidase digestion - Schindler_1995_Protein.Sci_4_791
Author(s) : Schindler PA , Settineri CA , Collet X , Fielding CJ , Burlingame AL
Ref : Protein Science , 4 :791 , 1995
PubMedID: 7613477
Gene_locus related to this paper: human-LCAT

Title : [Familial LCAT deficiency] - Kinoshita_1994_Nihon.Rinsho_52_3210
Author(s) : Kinoshita M
Ref : Nihon Rinsho , 52 :3210 , 1994
PubMedID: 7853712
Gene_locus related to this paper: human-LCAT

Title : Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. Six newly identified defective alleles further contribute to the structural heterogeneity in this disease - Funke_1993_J.Clin.Invest_91_677
Author(s) : Funke H , von Eckardstein A , Pritchard PH , Hornby AE , Wiebusch H , Motti C , Hayden MR , Dachet C , Jacotot B , Gerdes U , Faergeman O , Albers JJ , Colleoni N , Catapano A , Frohlich J , Assmann G
Ref : J Clinical Investigation , 91 :677 , 1993
PubMedID: 8432868
Gene_locus related to this paper: human-LCAT

Title : Lecithin:cholesterol acyltransferase deficiency: identification of a causative gene mutation and a co-inherited protein polymorphism - Hill_1993_Biochim.Biophys.Acta_1181_321
Author(s) : Hill JS , O K , Wang X , Pritchard PH
Ref : Biochimica & Biophysica Acta , 1181 :321 , 1993
PubMedID: 8318557
Gene_locus related to this paper: human-LCAT

Title : An amino acid exchange in exon I of the human lecithin: cholesterol acyltransferase (LCAT) gene is associated with fish eye disease - Skretting_1992_Biochem.Biophys.Res.Commun_182_583
Author(s) : Skretting G , Prydz H
Ref : Biochemical & Biophysical Research Communications , 182 :583 , 1992
PubMedID: 1571050
Gene_locus related to this paper: human-LCAT

Title : Two different allelic mutations in the lecithin-cholesterol acyltransferase gene associated with the fish eye syndrome. Lecithin-cholesterol acyltransferase (Thr123----Ile) and lecithin-cholesterol acyltransferase (Thr347----Met) - Klein_1992_J.Clin.Invest_89_499
Author(s) : Klein HG , Lohse P , Pritchard PH , Bojanovski D , Schmidt H , Brewer HB, Jr.
Ref : J Clinical Investigation , 89 :499 , 1992
PubMedID: 1737840
Gene_locus related to this paper: human-LCAT

Title : The genetic defect of the original Norwegian lecithin:cholesterol acyltransferase deficiency families. - Skretting_1992_FEBS.Lett_309_307
Author(s) : Skretting G , Blomhoff JP , Solheim J , Prydz H
Ref : FEBS Letters , 309 :307 , 1992
PubMedID: 1516702
Gene_locus related to this paper: human-LCAT

Title : Lecithin-cholesterol acyltransferase (LCAT) deficiency with a missense mutation in exon 6 of the LCAT gene - Maeda_1991_Biochem.Biophys.Res.Commun_178_460
Author(s) : Maeda E , Naka Y , Matozaki T , Sakuma M , Akanuma Y , Yoshino G , Kasuga M
Ref : Biochemical & Biophysical Research Communications , 178 :460 , 1991
PubMedID: 1859405
Gene_locus related to this paper: human-LCAT

Title : Differential phenotypic expression by three mutant alleles in familial lecithin:cholesterol acyltransferase deficiency - Gotoda_1991_Lancet_338_778
Author(s) : Gotoda T , Yamada N , Murase T , Sakuma M , Murayama N , Shimano H , Kozaki K , Albers JJ , Yazaki Y , Akanuma Y
Ref : Lancet , 338 :778 , 1991
PubMedID: 1681161
Gene_locus related to this paper: human-LCAT

Title : Lecithin cholesterol acyl transferase deficiency: molecular analysis of a mutated allele - Taramelli_1990_Hum.Genet_85_195
Author(s) : Taramelli R , Pontoglio M , Candiani G , Ottolenghi S , Dieplinger H , Catapano A , Albers J , Vergani C , McLean J
Ref : Hum Genet , 85 :195 , 1990
PubMedID: 2370048
Gene_locus related to this paper: human-LCAT

Title : Lecithin:cholesterol acyltransferase. Functional regions and a structural model of the enzyme - Yang_1987_J.Biol.Chem_262_3086
Author(s) : Yang CY , Manoogian D , Pao Q , Lee FS , Knapp RD , Gotto AM, Jr. , Pownall HJ
Ref : Journal of Biological Chemistry , 262 :3086 , 1987
PubMedID: 2880847
Gene_locus related to this paper: human-LCAT

Title : The isolation and characterisation of a cDNA clone for human lecithin:cholesterol acyl transferase and its use to analyse the genes in patients with LCAT deficiency and fish eye disease - Rogne_1987_Biochem.Biophys.Res.Commun_148_161
Author(s) : Rogne S , Skretting G , Larsen F , Myklebost O , Mevag B , Carlson LA , Holmquist L , Gjone E , Prydz H
Ref : Biochemical & Biophysical Research Communications , 148 :161 , 1987
PubMedID: 2823801
Gene_locus related to this paper: human-LCAT

Title : The isolation and characterisation of cDNA and genomic clones for human lecithin: cholesterol acyltransferase - Tata_1987_Biochim.Biophys.Acta_910_142
Author(s) : Tata F , Chaves ME , Markham AF , Scrace GD , Waterfield MD , McIntyre N , Williamson R , Humphries SE
Ref : Biochimica & Biophysica Acta , 910 :142 , 1987
PubMedID: 2823898
Gene_locus related to this paper: human-LCAT

Title : Alpha-lecithin:cholesterol acyltransferase deficiency. Lack of both phospholipase A2 and acyltransferase activities characteristic of high density lipoprotein lecithin:cholesterol acyltransferase in fish eye disease - Holmquist_1987_Acta.Med.Scand_222_23
Author(s) : Holmquist L , Carlson LA
Ref : Acta Med Scand , 222 :23 , 1987
PubMedID: 3630775
Gene_locus related to this paper: human-LCAT

Title : Inhibitory effect of normal high density lipoproteins on lecithin:cholesterol acyltransferase activity in fish eye disease plasma - Holmquist_1987_Acta.Med.Scand_222_15
Author(s) : Holmquist L , Carlson LA
Ref : Acta Med Scand , 222 :15 , 1987
PubMedID: 3630774
Gene_locus related to this paper: human-LCAT

Title : Cloning and expression of human lecithin-cholesterol acyltransferase cDNA - McLean_1986_Proc.Natl.Acad.Sci.U.S.A_83_2335
Author(s) : McLean J , Fielding C , Drayna D , Dieplinger H , Baer B , Kohr W , Henzel W , Lawn R
Ref : Proc Natl Acad Sci U S A , 83 :2335 , 1986
PubMedID: 3458198
Gene_locus related to this paper: human-LCAT

Title : Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression - McLean_1986_Nucleic.Acids.Res_14_9397
Author(s) : McLean J , Wion K , Drayna D , Fielding C , Lawn R
Ref : Nucleic Acids Research , 14 :9397 , 1986
PubMedID: 3797244
Gene_locus related to this paper: human-LCAT

Title : Evidence for deficiency of high density lipoprotein lecithin: cholesterol acyltransferase activity (alpha-LCAT) in fish eye disease - Carlson_1985_Acta.Med.Scand_218_189
Author(s) : Carlson LA , Holmquist L
Ref : Acta Med Scand , 218 :189 , 1985
PubMedID: 4061122
Gene_locus related to this paper: human-LCAT

Title : Evidence for the presence in human plasma of lecithin: cholesterol acyltransferase activity (beta-LCAT) specifically esterifying free cholesterol of combined pre-beta- and beta-lipoproteins. Studies of fish eye disease patients and control subjects - Carlson_1985_Acta.Med.Scand_218_197
Author(s) : Carlson LA , Holmquist L
Ref : Acta Med Scand , 218 :197 , 1985
PubMedID: 4061123
Gene_locus related to this paper: human-LCAT

Title : Effect of organophosphate pesticides on the activities of lecithin- cholesterol acyltransferase and cholinesterase in rat serum -
Author(s) : Nakagawa M , Kobayashi H , Katsuya M , Takada N , Kojima S
Ref : Chem Pharm Bull (Tokyo) , 30 :214 , 1982
PubMedID: 7083404
Gene_locus related to this paper: human-LCAT , ratno-lipli

Title : Renal failure in familial lecithin: cholesterol acyltransferase deficiency - Borysiewicz_1982_Q.J.Med_51_411
Author(s) : Borysiewicz LK , Soutar AK , Evans DJ , Thompson GR , Rees AJ
Ref : Q J Med , 51 :411 , 1982
PubMedID: 7156322
Gene_locus related to this paper: human-LCAT

Title : Lecithin: cholesterol acyl transferase (LCAT) - Frohlich_1982_Clin.Biochem_15_269
Author(s) : Frohlich J , McLeod R , Hon K
Ref : Clinical Biochemistry , 15 :269 , 1982
PubMedID: 6762928
Gene_locus related to this paper: human-LCAT

Title : Fish-eye disease. A new familial condition with massive corneal opacities and dyslipoproteinaemia - Carlson_1979_Lancet_2_922
Author(s) : Carlson LA , Philipson B
Ref : Lancet , 2 :922 , 1979
PubMedID: 91022
Gene_locus related to this paper: human-LCAT