Family: Dieckmann_Cyclase

Block: X

Parent Family: No family


Off-loading Dieckmann cyclase, NcmC, that installs the tetramate head group in nocamycin, a hybrid polyketide/nonribosomalpeptide natural product. A conserved thioesterase-like scaffold has been adapted to perform a new chemical reaction: heterocyclization. The catalytic triad for the cyclization reaction consists of Cys89, Asp116, and His254 in 9pseu-NcmC. Dieckmann cyclase (TrdC, SlgL, LipX2, KirHI,and FacH) last step which generate actinomycete-derived tetramic acid and pyridone natural products in the biosynthetic pathways for Tirandamycin, Streptolydigin, alpha-Lipomycin, Kirromycin, and Factumycin


Interpro : No interpro


Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

References (2)

Title : Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation - Cogan_2020_ACS.Chem.Biol_15_2783
Author(s) : Cogan DP , Ly J , Nair SK
Ref : ACS Chemical Biology , 15 :2783 , 2020
Abstract : Cogan_2020_ACS.Chem.Biol_15_2783
ESTHER : Cogan_2020_ACS.Chem.Biol_15_2783
PubMedSearch : Cogan_2020_ACS.Chem.Biol_15_2783
PubMedID: 33017142
Gene_locus related to this paper: 9pseu-NcmC

Title : Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis - Gui_2015_Org.Lett_17_628
Author(s) : Gui C , Li Q , Mo X , Qin X , Ma J , Ju J
Ref : Org Lett , 17 :628 , 2015
Abstract : Gui_2015_Org.Lett_17_628
ESTHER : Gui_2015_Org.Lett_17_628
PubMedSearch : Gui_2015_Org.Lett_17_628
PubMedID: 25621700

Structures (3)

Genes Proteins in Dieckmann_Cyclase family (89)

Fragments of genes in Dieckmann_Cyclase family (7)

Structures in Dieckmann_Cyclase family (3)

Substrates in Dieckmann_Cyclase family (3)

Inhibitors in Dieckmann_Cyclase family (1)