Family: Dieckmann_Cyclase

Block: X

Parent Family: No family


Off-loading Dieckmann cyclase, NcmC, that installs the tetramate head group in nocamycin, a hybrid polyketide/nonribosomalpeptide natural product. A conserved thioesterase-like scaffold has been adapted to perform a new chemical reaction: heterocyclization. The catalytic triad for the cyclization reaction consists of Cys89, Asp116, and His254 in 9pseu-NcmC. Dieckmann cyclase (TrdC, SlgL, LipX2, KirHI,and FacH) last step which generate actinomycete-derived tetramic acid and pyridone natural products in the biosynthetic pathways for Tirandamycin, Streptolydigin, alpha-Lipomycin, Kirromycin, and Factumycin


Interpro : No interpro


Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (3)

Genes Proteins in Dieckmann_Cyclase family (89)

Fragments of genes in Dieckmann_Cyclase family (7)

Structures in Dieckmann_Cyclase family (3)

Substrates in Dieckmann_Cyclase family (3)

Inhibitors in Dieckmann_Cyclase family (1)

References (2)

Title : Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation - Cogan_2020_ACS.Chem.Biol_15_2783
Author(s) : Cogan DP , Ly J , Nair SK
Ref : ACS Chemical Biology , 15 :2783 , 2020
PubMedID: 33017142
Gene_locus related to this paper: 9pseu-NcmC

Title : Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis - Gui_2015_Org.Lett_17_628
Author(s) : Gui C , Li Q , Mo X , Qin X , Ma J , Ju J
Ref : Org Lett , 17 :628 , 2015
PubMedID: 25621700