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Gliotactin

Relationship

Family: Gliotactin

Block: C

Parent Family: Non-catalytic_C

Comment

Gliotactin, a transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila. It is a marker of tricellular junctions, is necessary for septate junction development in Drosophila. Gliotactin and Discs large form a protein complex at the tricellular junction of polarized epithelial cells in Drosophila. The intracellular domain of gliotactin, is natively unfolded. Control of Gliotactin localization and levels by tyrosine phosphorylation and endocytosis is necessary for survival of polarized epithelia

Database

Interpro : IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : No Pdoc

Pfam : PF00135 COesterase

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Gene_locus Name Species
fashe-a0a4e0s092 Fasciola hepatica (Liver fluke) Gliotactin Fasciola hepatica
helvi-a0a2a4jbs1 Heliothis virescens (Tobacco budworm moth). COesterase domain-containing protein Heliothis virescens
trini-a0a7e5wd86 Trichoplusia ni (Cabbage looper).COesterase domain-containing protein Trichoplusia ni
spofr-a0a2h1vmr3 Spodoptera frugiperda (Fall armyworm) Spodoptera litura. COesterase domain-containing protein SFRICE014111.2 Spodoptera frugiperda
9hyme-e2a0n6 Camponotus floridanus (Florida carpenter ant) Neuroligin-4, X-linked Camponotus floridanus
9hyme-e2bc53 Harpegnathos saltator (Jerdon's jumping ant) Gliotactin Neuroligin-1 Harpegnathos saltator
acrec-f4w848 Acromyrmex echinatior (Panamanian leafcutter ant) Atta cephalotes (Leafcutter ant) Neuroligin-4, X-linked Acromyrmex echinatior
aedae-glita Aedes aegypti (Yellowfever mosquito) gliotactin Aedes aegypti
anoda-e3wmw1 Anopheles darlingi (Mosquito) Putative uncharacterized protein Anopheles darlingi
anoga-glita Anopheles gambiae\; A. coluzzii\; A. arabiensis\; A. christyi\; A. coluzzii\; A. culicifacies\; A. epiroticus\; A. funestus\; A. maculatus\; A. melas\; A. merus\; A. minimus\; A. quadriannulatus\; A. stephensi, CRA_x9P1GAV5CRW, gliotactin Anopheles gambiae
apime-h9k5b0 Apis mellifera (Honeybee) Uncharacterized protein Apis mellifera
ascsu-f1kxs8 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) Neuroligin-4, Y-linked Ascaris suum
bommo-h9j8g3 Bombyx mori (Silk moth) Uncharacterized protein Bombyx mori
bruma-a8nl88 Brugia malayi (Filarial nematode worm) Carboxylesterase family protein Brugia malayi
caebe-g0m892 Caenorhabditis brenneri (Nematode worm) CBN-GLIT-1 protein Caenorhabditis brenneri
caebr-a8xk46 Caenorhabditis briggsae CBR-GLIT-1 protein ENSCBRG-02843 CBG14528 Caenorhabditis briggsae
caeel-f55d10.3 Caenorhabditis elegans F55D10.3 GLIoTactin (Drosophila neuroligin-like) homolog glit-1 Caenorhabditis elegans
caeja-h2wj36 Caenorhabditis japonica Uncharacterized protein Caenorhabditis japonica
caere-e3lec6 Caenorhabditis remanei (Caenorhabditis vulgaris) Caenorhabditis sp. 23 AD-2012 CRE-GLIT-1 protein Caenorhabditis remanei
closi-h2kvp1 Clonorchis sinensis (Chinese liver fluke) Neuroligin-4 X-linked protein Clonorchis sinensis
culqu-b0w0b8 Culex quinquefasciatus (Southern house mosquito) Gliotactin Culex quinquefasciatus
danpl-g6dsv4 Danaus plexippus (Monarch butterfly) Gliotactin Danaus plexippus
dappu-e9h7w9 Daphnia pulex (Water flea)\; Daphnia magna, Putative uncharacterized protein Daphnia pulex
droan-b3ml20 Drosophila ananassae (Fruit fly) GF14975 Drosophila ananassae
droer-b3n612 Drosophila erecta (Fruit fly) GG24195 Drosophila erecta
drogr-b4jpc6 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) GH13495 Drosophila grimshawi
drome-glita Drosophila melanogaster (Fruit fly) CG3903 mRNA for gliotactin Drosophila melanogaster
dromo-b4kki1 Drosophila mojavensis (Fruit fly) GI17245 Drosophila mojavensis
drops-q29ke5 Drosophila pseudoobscura (Fruit fly) ga17762-pa (fragment) Drosophila pseudoobscura
drose-b4hxs9 Drosophila sechellia (Fruit fly) GM14210 Drosophila sechellia
drosi-b4q6h6 Drosophila simulans (Fruit fly) GD21942 Drosophila simulans
drovi-b4m918 Drosophila virilis (Fruit fly) GJ18005 Drosophila virilis
drowi-b4n023 Drosophila willistoni (Fruit fly) GK24272 Drosophila willistoni
droya-b4ny86 Drosophila yakuba (Fruit fly) GE19390 Drosophila yakuba
ixosc-b7q343 Ixodes scapularis (Black-legged tick) (Deer tick) Esterase, putative Ixodes scapularis
pedhc-e0w4c8 Pediculus humanus corporis (Body louse) Gliotactin, putative Pediculus humanus corporis
pripa-h3fnc0 Pristionchus pacificus Two genes concanated one piece missing Pristionchus pacificus
schma-g4vmf3 Schistosoma mansoni (Blood fluke, platyhelminth) Gliotactin Schistosoma mansoni
solin-e9iwj7 Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri) Putative uncharacterized protein Solenopsis invicta
trica-d6w7h2 Tribolium castaneum (Red flour beetle) Gliotactin Tribolium castaneum
trisp-e5s773 Trichinella spiralis (Trichina worm) Trichinella pseudospiralis, Putative uncharacterized protein Trichinella spiralis
acypi-j9jls9 Acyrthosiphon pisum (Pea aphid) Uncharacterized protein Acyrthosiphon pisum
cragi-k1qaj8 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) Neuroligin-4, Y-linked Crassostrea gigas
nasvi-k7inp9 Nasonia vitripennis (Parasitic wasp) Uncharacterized protein Nasonia vitripennis
ixori-v5ic82 Ixodes ricinus (Common tick) Putative gliotactin Ixodes ricinus
rhopr-t1hm41 Rhodnius prolixus (Triatomid bug) Uncharacterized protein Rhodnius prolixus
denpd-u4up38 Dendroctonus ponderosae (Mountain pine beetle) Uncharacterized protein Dendroctonus ponderosae
capte-r7uie6 Capitella teleta (Polychaete worm) Uncharacterized protein Capitella teleta
9dipt-u5euz8 Corethrella appendiculata (frog biting fly) Putative esterase and lipase Corethrella appendiculata
capte-r7ux79 Capitella teleta (Polychaete worm) Uncharacterized protein Capitella teleta
tetur-t1l0q5 Tetranychus urticae (Two-spotted spider mite) tetur30g01560 CCE62 COesterase domain-containing protein Gliotactin Tetranychus urticae
haeco-u6pe80 Haemonchus contortus (Barber pole worm) Carboxylesterase domain containing protein Haemonchus contortus
9bila-a0a085mja7 Trichuris suis (pig whipworm). Uncharacterized protein Trichuris suis
calsg-a0a068fbt9 Calliphora stygia (Common brown blowfly). Esterase Calliphora stygia
cerca-w8bv22 Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata). Neuroligin-4, Y-linked Ceratitis capitata
anoda-w5jd44 Anopheles darlingi (Mosquito)\; Anopheles albimanus (New world malaria mosquito). Uncharacterized protein Anopheles darlingi
9hyme-a0a022t684 Microplitis demolitor. Neuroligin-4, Y-linked-like protein Microplitis demolitor
cerbi-a0a026w5f6 Cerapachys biroi (Ant). Neuroligin-4, X-linked Cerapachys biroi
apime-a0a088a211 Apis mellifera (Honeybee). COesterase domain-containing protein Apis mellifera
zoone-a0a067rbc7 Zootermopsis nevadensis (Dampwood termite). Neuroligin-4, Y-linked Zootermopsis nevadensis
attce-w4x506 Atta cephalotes (Leafcutter ant). Uncharacterized protein Atta cephalotes
9trem-a0a074zx87 Opisthorchis viverrini. Uncharacterized protein Opisthorchis viverrini
9arac-a0a087szh2 Stegodyphus mimosarum. Neuroligin-4, X-linked Stegodyphus mimosarum
tritr-a0a077ywi3 Trichuris trichiura (Whipworm) (Trichocephalus trichiurus). Carboxylesterase Trichuris trichiura
9bila-a0a016s8z2 Ancylostoma ceylanicum. Uncharacterized protein Ancylostoma ceylanicum
oncvo-a0a044shd3 Onchocerca volvuluss\; Onchocerca ochengi (Filarial nematode worm). Uncharacterized protein Onchocerca volvulus
9arac-a0a087tq55 Stegodyphus mimosarum. Neuroligin-4, Y-linked Stegodyphus mimosarum
strrb-a0a090l236 Strongyloides ratti (Parasitic roundworm). Uncharacterized protein Strongyloides ratti
schha-a0a095ai61 Schistosoma haematobium (Blood fluke). Acetylcholinesterase Schistosoma haematobium
schha-a0a095ce64 Schistosoma haematobium (Blood fluke). Neuroligin-4, Y-linked Schistosoma haematobium
baccu-a0a0a1wyd8 Bactrocera cucurbitae (Melon fruit fly) (Dacus cucurbitae)\; Bactrocera latifrons (Malaysian fruit fly) (Chaetodacus latifrons). Neuroligin-4, Y-linked Bactrocera cucurbitae
lepde-a0a0a7eqk3 Leptinotarsa decemlineata (Colorado potato beetle) (Doryphora decemlineata). Putative gliotactin Leptinotarsa decemlineata
oesde-a0a0b1tpj8 Oesophagostomum dentatum (Nodular worm). Carboxylesterase Oesophagostomum dentatum
toxca-a0a0b2vha5 Toxocara canis (Canine roundworm). Neuroligin-4, Y-linked Toxocara canis
9eupu-a0a0b7a1j6 Arion vulgaris (Spanish slug) Uncharacterized protein Arion vulgaris
9hyme-a0a0c9ru21 Fopius arisanus. NLGN4X_6 protein Fopius arisanus
dicvi-a0a0d8xes7 Dictyocaulus viviparus (Bovine lungworm). Ribosomal protein L23 Dictyocaulus viviparus
lasni-a0a0j7kww4 Lasius niger Uncharacterized protein Lasius niger
strer-a0a0k0epi2 Strongyloides stercoralis (Threadworm) Uncharacterized protein Strongyloides stercoralis
9bila-a0a0k0flk3 Strongyloides venezuelensis (Intestinal threadworm) Uncharacterized protein Strongyloides venezuelensis
lyghe-a0a0k8sp43 Lygus hesperus (Western plant bug) Uncharacterized protein Lygus hesperus
bacla-a0a0k8uv44 Bactrocera latifrons (Malaysian fruit fly) (Chaetodacus latifrons) Uncharacterized protein Bactrocera latifrons
luccu-a0a0l0cgd1 Lucilia cuprina (Green bottle fly) (Australian sheep blowfly) Uncharacterized protein Lucilia cuprina
9neop-a0a0l7lfd9 Operophtera brumata (winter moth) Uncharacterized protein Operophtera brumata
9hyme-a0a0l7quz4 Habropoda laboriosa Uncharacterized protein Habropoda laboriosa
anisi-a0a0m3jxj3 Anisakis simplex (Herring worm) Uncharacterized protein Anisakis simplex
drobs-a0a0m4eps3 Drosophila busckii Uncharacterized protein Drosophila busckii
9hyme-a0a0n0bji7 Melipona quadrifasciata Uncharacterized protein Melipona quadrifasciata
papma-a0a0n0pbr0 Papilio machaon (Old World swallowtail butterfly) Uncharacterized protein Papilio machaon
brupa-a0a0n4tsl5 Brugia pahangi Uncharacterized protein Brugia pahangi
drame-a0a0n4udj3 Dracunculus medinensis Uncharacterized protein Dracunculus medinensis
entve-a0a0n4uyx5 Enterobius vermicularis (Human pinworm) Uncharacterized protein Enterobius vermicularis
haepc-a0a0n4vuk5 Haemonchus placei (Barber's pole worm) Uncharacterized protein Haemonchus placei
nipbr-a0a0n4xzi6 Nippostrongylus brasiliensis (Rat hookworm) Uncharacterized protein Nippostrongylus brasiliensis
parti-a0a0n4z6l7 Parastrongyloides trichosuri (Possum-specific nematode worm) Uncharacterized protein Parastrongyloides trichosuri
thecl-a0a0n5d0k9 Thelazia callipaeda (Oriental eyeworm) Uncharacterized protein Thelazia callipaeda
trimr-a0a0n5dhd4 Trichuris muris (Mouse whipworm) Uncharacterized protein Trichuris muris
9hemi-a0a0p4vns1 Rhodnius neglectus Uncharacterized protein Rhodnius neglectus
9crus-a0a0p4zgh5 Daphnia magna Uncharacterized protein Daphnia magna
angcs-a0a0r3pa83 Angiostrongylus costaricensis (Nematode worm). Uncharacterized protein Angiostrongylus costaricensis
9bila-a0a0r3rux8 Elaeophora elaphi. Uncharacterized protein Elaeophora elaphi
9bila-a0a0v0tgw4.2 Trichinella murrelli\; T. sp.\; T. pseudospiralis (Parasitic roundworm)\; T. patagoniensis\; T. spiralis (Trichina worm)\; T britovi\; T. zimbabwensi\; T nativa\;\; T papuae Gliotactin Trichinella murrelli
sarsc-a0a132a4p8 Sarcoptes scabiei (Itch mite) (Acarus scabiei), Neuroligin-4, Y-linked-like protein Sarcoptes scabiei
9hyme-a0a151x4g8 Trachymyrmex zeteki. Neuroligin-4, X-linked Trachymyrmex zeteki
9hyme-a0a154prb6 Dufourea novaeangliae. Neuroligin-4, Y-linked Dufourea novaeangliae
pladu-a0a2h5bfe9 Platynereis dumerilii (Dumeril's clam worm).Gliotactin Platynereis dumerilii
linun-a0a1s3h3d9 Lingula unguis. cholinesterase 1-like isoform X2 Lingula unguis
linun-a0a2r2mqd7 Lingula unguis. cholinesterase Lingula unguis

Gene_locus_frgt Name Species
9hemi-i6zmi5 Laodelphax striatella (small brown planthopper) Carboxylesterase Laodelphax striatella
drope-b4hbz3 Drosophila persimilis (Fruit fly) GL15437 Drosophila persimilis
loalo-e1fpk7 Loa loa (Eye worm) Carboxylesterase Loa loa
schja-q5c2x2 Schistosoma japonicum (Blood fluke, platyhelminth) sjchgc07451 protein (fragment) Schistosoma japonicum
wucba-j9alq0 Wuchereria bancrofti Uncharacterized protein Wuchereria bancrofti
wucba-j9ei09 Wuchereria bancrofti Carboxylesterase Wuchereria bancrofti
ixori-v5hjn7 Ixodes ricinus (Common tick) Putative gliotactin Ixodes ricinus
caebe-r9yvy7 Caenorhabditis brenneri (Nematode worm) GLIT-1 Caenorhabditis brenneri
anogl-v5gau3 Anoplophora glabripennis (Asian longhorn beetle) (Anoplophora nobilis) Neuroligin-4, Y-linked protein Anoplophora glabripennis
strmm-t1ihu4 Strigamia maritima (European centipede) (Geophilus maritimus) Uncharacterized protein Strigamia maritima
helro-t1eg65 Helobdella robusta (Californian leech) Uncharacterized protein Helobdella robusta
caebe-r9yve0 Caenorhabditis brenneri (Nematode worm) GLIT-1 Caenorhabditis brenneri
helro-t1fzg0 Helobdella robusta (Californian leech) Uncharacterized protein Helobdella robusta
lotgi-v3zwi4 Lottia gigantea (Giant owl limpet) Uncharacterized protein Lottia gigantea
anogl-v5iag5 Anoplophora glabripennis (Asian longhorn beetle) (Anoplophora nobilis) Phenmedipham hydrolase Anoplophora glabripennis
bacdo-a0a034vpx8 Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis). Neuroligin-3 Bactrocera dorsalis
necam-w2sff4 Necator americanus (Human hookworm). Ribosomal protein L23 Necator americanus
bacdo-a0a034vlg9 Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis). Neuroligin-1 Bactrocera dorsalis
9bila-a0a0c2bv93 Ancylostoma duodenale. Uncharacterized protein Ancylostoma duodenale
9arac-a0a087u3g5 Stegodyphus mimosarum Uncharacterized protein Stegodyphus mimosarum
lepsm-a0a0k2tpj2 Lepeophtheirus salmonis (Salmon louse) Uncharacterized protein Lepeophtheirus salmonis
lyghe-a0a0k8sb85 Lygus hesperus (Western plant bug) Uncharacterized protein Lygus hesperus
octbm-a0a0l8i3t8 Octopus bimaculoides (California two-spotted octopus) Uncharacterized protein Octopus bimaculoides
9bila-a0a0n5avs4 Syphacia muris (rat pinworm) Uncharacterized protein Syphacia muris
9bila-a0a0r3qxe2 Brugia timori. Uncharacterized protein Brugia timori
9bila-a0a0r3rbi5 Brugia timori. Uncharacterized protein Brugia timori
9scar-a0a0t6atm1 Oryctes borbonicus. Esterase Oryctes borbonicus
9scar-a0a0t6bau0 Oryctes borbonicus. Hydrolase Oryctes borbonicus
spoli-a0a0u2kap7 Spodoptera littoralis (Egyptian cotton leafworm). Gliotactin Spodoptera littoralis
9metz-a0a177arw3 Intoshia linei. Uncharacterized protein Intoshia linei
9metz-a0a177ayc2 Intoshia linei. Uncharacterized protein Intoshia linei
9metz-a0a177b5f4 Intoshia linei. Uncharacterized protein Intoshia linei

References (11)

Title : The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila - Wittek_2020_Curr.Biol_30_4254
Author(s) : Wittek A , Hollmann M , Schleutker R , Luschnig S
Ref : Current Biology , 30 :4254 , 2020
Abstract :
PubMedSearch : Wittek_2020_Curr.Biol_30_4254
PubMedID: 32857972

Title : Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium - Esmangart_2020_Curr.Biol_30_4245
Author(s) : Esmangart de Bournonville T , Le Borgne R
Ref : Current Biology , 30 :4245 , 2020
Abstract :
PubMedSearch : Esmangart_2020_Curr.Biol_30_4245
PubMedID: 32857971

Title : C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src - Samarasekera_2018_Mol.Biol.Cell_29_123
Author(s) : Samarasekera G , Auld VJ
Ref : Mol Biology of the cell , 29 :123 , 2018
Abstract :
PubMedSearch : Samarasekera_2018_Mol.Biol.Cell_29_123
PubMedID: 29167383

Title : Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment - Offenburger_2018_PLoS.Genet_14_e1007106
Author(s) : Offenburger SL , Jongsma E , Gartner A
Ref : PLoS Genet , 14 :e1007106 , 2018
Abstract :
PubMedSearch : Offenburger_2018_PLoS.Genet_14_e1007106
PubMedID: 29346364
Gene_locus related to this paper: caeel-f55d10.3

Title : The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184 - Sharifkhodaei_2016_J.Cell.Sci_129_1477
Author(s) : Sharifkhodaei Z , Padash-Barmchi M , Gilbert MM , Samarasekera G , Fulga TA , Van Vactor D , Auld VJ
Ref : Journal of Cell Science , 129 :1477 , 2016
Abstract :
PubMedSearch : Sharifkhodaei_2016_J.Cell.Sci_129_1477
PubMedID: 26906422
Gene_locus related to this paper: drome-glita

Title : Control of Gliotactin localization and levels by tyrosine phosphorylation and endocytosis is necessary for survival of polarized epithelia - Padash-Barmchi_2010_J.Cell.Sci_123_4052
Author(s) : Padash-Barmchi M , Browne K , Sturgeon K , Jusiak B , Auld VJ
Ref : Journal of Cell Science , 123 :4052 , 2010
Abstract :
PubMedSearch : Padash-Barmchi_2010_J.Cell.Sci_123_4052
PubMedID: 21045109

Title : Gliotactin and Discs large form a protein complex at the tricellular junction of polarized epithelial cells in Drosophila - Schulte_2006_J.Cell.Sci_119_4391
Author(s) : Schulte J , Charish K , Que J , Ravn S , MacKinnon C , Auld VJ
Ref : Journal of Cell Science , 119 :4391 , 2006
Abstract :
PubMedSearch : Schulte_2006_J.Cell.Sci_119_4391
PubMedID: 17032735

Title : Neuroglian, Gliotactin, and the Na+\/K+ ATPase are essential for septate junction function in Drosophila - Genova_2003_J.Cell.Biol_161_979
Author(s) : Genova JL , Fehon RG
Ref : Journal of Cell Biology , 161 :979 , 2003
Abstract :
PubMedSearch : Genova_2003_J.Cell.Biol_161_979
PubMedID: 12782686

Title : The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded - Zeev-Ben-Mordehai_2003_Proteins_53_758
Author(s) : Zeev-Ben-Mordehai T , Rydberg EH , Solomon A , Toker L , Auld VJ , Silman I , Botti SA , Sussman JL
Ref : Proteins , 53 :758 , 2003
Abstract :
PubMedSearch : Zeev-Ben-Mordehai_2003_Proteins_53_758
PubMedID: 14579366

Title : Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila - Schulte_2003_J.Cell.Biol_161_991
Author(s) : Schulte J , Tepass U , Auld VJ
Ref : Journal of Cell Biology , 161 :991 , 2003
Abstract :
PubMedSearch : Schulte_2003_J.Cell.Biol_161_991
PubMedID: 12782681

Title : Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila - Auld_1995_Cell_81_757
Author(s) : Auld VJ , Fetter RD , Broadie K , Goodman CS
Ref : Cell , 81 :757 , 1995
Abstract :
PubMedSearch : Auld_1995_Cell_81_757
PubMedID: 7539719
Gene_locus related to this paper: drome-glita