Gliotactin

Relationship

Family: Gliotactin

Block: C

Parent Family: Non-catalytic_C

Comment

Gliotactin, a transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila. It is a marker of tricellular junctions, is necessary for septate junction development in Drosophila. Gliotactin and Discs large form a protein complex at the tricellular junction of polarized epithelial cells in Drosophila. The intracellular domain of gliotactin, is natively unfolded. Control of Gliotactin localization and levels by tyrosine phosphorylation and endocytosis is necessary for survival of polarized epithelia

Database

Interpro : IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : No Pdoc

Pfam : PF00135 COesterase

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in Gliotactin family (108)

Fragments of genes in Gliotactin family (32)

No fragment of genes

No substrate

No Inhibitor

References (11)

Title : The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila - Wittek_2020_Curr.Biol_30_4254
Author(s) : Wittek A , Hollmann M , Schleutker R , Luschnig S
Ref : Current Biology , 30 :4254 , 2020
PubMedID: 32857972

Title : Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium - Esmangart_2020_Curr.Biol_30_4245
Author(s) : Esmangart de Bournonville T , Le Borgne R
Ref : Current Biology , 30 :4245 , 2020
PubMedID: 32857971

Title : Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment - Offenburger_2018_PLoS.Genet_14_e1007106
Author(s) : Offenburger SL , Jongsma E , Gartner A
Ref : PLoS Genet , 14 :e1007106 , 2018
PubMedID: 29346364
Gene_locus related to this paper: caeel-f55d10.3

Title : C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src - Samarasekera_2018_Mol.Biol.Cell_29_123
Author(s) : Samarasekera G , Auld VJ
Ref : Mol Biology of the cell , 29 :123 , 2018
PubMedID: 29167383

Title : The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184 - Sharifkhodaei_2016_J.Cell.Sci_129_1477
Author(s) : Sharifkhodaei Z , Padash-Barmchi M , Gilbert MM , Samarasekera G , Fulga TA , Van Vactor D , Auld VJ
Ref : Journal of Cell Science , 129 :1477 , 2016
PubMedID: 26906422
Gene_locus related to this paper: drome-glita

Title : Control of Gliotactin localization and levels by tyrosine phosphorylation and endocytosis is necessary for survival of polarized epithelia - Padash-Barmchi_2010_J.Cell.Sci_123_4052
Author(s) : Padash-Barmchi M , Browne K , Sturgeon K , Jusiak B , Auld VJ
Ref : Journal of Cell Science , 123 :4052 , 2010
PubMedID: 21045109

Title : Gliotactin and Discs large form a protein complex at the tricellular junction of polarized epithelial cells in Drosophila - Schulte_2006_J.Cell.Sci_119_4391
Author(s) : Schulte J , Charish K , Que J , Ravn S , MacKinnon C , Auld VJ
Ref : Journal of Cell Science , 119 :4391 , 2006
PubMedID: 17032735

Title : Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila - Schulte_2003_J.Cell.Biol_161_991
Author(s) : Schulte J , Tepass U , Auld VJ
Ref : Journal of Cell Biology , 161 :991 , 2003
PubMedID: 12782681

Title : The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded - Zeev-Ben-Mordehai_2003_Proteins_53_758
Author(s) : Zeev-Ben-Mordehai T , Rydberg EH , Solomon A , Toker L , Auld VJ , Silman I , Botti SA , Sussman JL
Ref : Proteins , 53 :758 , 2003
PubMedID: 14579366

Title : Neuroglian, Gliotactin, and the Na+\/K+ ATPase are essential for septate junction function in Drosophila - Genova_2003_J.Cell.Biol_161_979
Author(s) : Genova JL , Fehon RG
Ref : Journal of Cell Biology , 161 :979 , 2003
PubMedID: 12782686

Title : Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila - Auld_1995_Cell_81_757
Author(s) : Auld VJ , Fetter RD , Broadie K , Goodman CS
Ref : Cell , 81 :757 , 1995
PubMedID: 7539719
Gene_locus related to this paper: drome-glita