Full name : Silman Israel
First name : Israel
Mail : Department of Neurobiology\; Weizmann Institute of Science\; Rehovot 76100
Zip Code : 76100
City : Rehovot
Country : Israel
Email :
Phone :
Fax :
Website : \/\/www.weizmann.ac.il\/neurobiology\/labs\/silman\/silman.html
Directory :
Comment
Israel Silman was one of the most prominent scientist in the cholinesterase and neurobiology fields. He did his Ph.D. thesis under the supervision of Prof. E. Katzir at The Weizmann Institute. He returned there in 1968 after postdoctoral studies in the U.S, and joined the newly founded department of Neurobiology in 1975. He was lately Head of the Nella and Leon Benoziyo Center for the Neurosciences. With Mike Ferguson and Steve Homans, he determined the structure of the anchoring domain of the dimeric form of AChE from the electric organ of Torpedo californica. This form is anchored to the outer face of the plasma membrane by a phosphatidylinositol (PI), covalently attached, via an oligoglycan (G) extension. With Joel Sussman and Michal Harel he obtained AChE crystals and revealed the first 3D structure of a cholinesterase. This lead to the definition of the alpha/beta hydrolase fold. He was part of the team of leaders who created the cholinesterase meeting series
| Title : Why is binding of a divalent metal cation to a structural motif containing four carboxylate residues not accompanied by a conformational change? - Lushchekina_2024_Protein.Sci_33_e5206 |
| Author(s) : Lushchekina S , Weiner L , Ashani Y , Emrizal R , Firdaus-Raih M , Silman I , Sussman JL |
| Ref : Protein Science , 33 :e5206 , 2024 |
| Abstract : |
| PubMedSearch : Lushchekina_2024_Protein.Sci_33_e5206 |
| PubMedID: 39548604 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Do 'Newly Born' orphan proteins resemble 'Never Born' proteins? A study using three deep learning algorithms - Liu_2023_Proteins__ |
| Author(s) : Liu J , Yuan R , Shao W , Wang J , Silman I , Sussman JL |
| Ref : Proteins , : , 2023 |
| Abstract : |
| PubMedSearch : Liu_2023_Proteins__ |
| PubMedID: 37092778 |
| Title : Preface: Cholinergic mechanisms: This is the Preface for the special issue Cholinergic Mechanisms - Anglister_2021_J.Neurochem__ |
| Author(s) : Anglister L , Silman I , Soreq H |
| Ref : Journal of Neurochemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Anglister_2021_J.Neurochem__ |
| PubMedID: 34458988 |
| Title : Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif - Silman_2021_Protein.Sci_30_966 |
| Author(s) : Silman I , Shnyrov VL , Ashani Y , Roth E , Nicolas A , Sussman JL , Weiner L |
| Ref : Protein Science , 30 :966 , 2021 |
| Abstract : |
| PubMedSearch : Silman_2021_Protein.Sci_30_966 |
| PubMedID: 33686648 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812 |
| Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 64 :812 , 2021 |
| Abstract : |
| PubMedSearch : Viayna_2021_J.Med.Chem_64_812 |
| PubMedID: 33356266 |
| Gene_locus related to this paper: human-ACHE |
| Title : The multiple biological roles of the cholinesterases - Silman_2021_Prog.Biophys.Mol.Biol_162_41 |
| Author(s) : Silman I |
| Ref : Prog Biophys Mol Biol , 162 :41 , 2021 |
| Abstract : |
| PubMedSearch : Silman_2021_Prog.Biophys.Mol.Biol_162_41 |
| PubMedID: 33307019 |
| Title : Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers - Toker_2020_Chem.Biol.Interact__109007 |
| Author(s) : Toker L , Silman I , Zeev-Ben-Mordehai T , Sussman JL , Schopfer LM , Lockridge O |
| Ref : Chemico-Biological Interactions , :109007 , 2020 |
| Abstract : |
| PubMedSearch : Toker_2020_Chem.Biol.Interact__109007 |
| PubMedID: 32087110 |
| Title : Computational studies on cholinesterases: Strengthening our understanding of the integration of structure, dynamics and function - Sussman_2020_Neuropharmacol__108265 |
| Author(s) : Sussman JL , Silman I |
| Ref : Neuropharmacology , :108265 , 2020 |
| Abstract : |
| PubMedSearch : Sussman_2020_Neuropharmacol__108265 |
| PubMedID: 32795461 |
| Title : Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor - Catto_2020_ACS.Med.Chem.Lett_11_869 |
| Author(s) : Catto M , Pisani L , De la Mora E , Belviso BD , Mangiatordi GF , Pinto A , Palma A , Denora N , Caliandro R , Colletier JP , Silman I , Nicolotti O , Altomare CD |
| Ref : ACS Med Chem Lett , 11 :869 , 2020 |
| Abstract : |
| PubMedSearch : Catto_2020_ACS.Med.Chem.Lett_11_869 |
| PubMedID: 32435398 |
| Title : A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides - Nachon_2020_Molecules_25_1198 |
| Author(s) : Nachon F , Rosenberry TL , Silman I , Sussman JL |
| Ref : Molecules , 25 :1198 , 2020 |
| Abstract : |
| PubMedSearch : Nachon_2020_Molecules_25_1198 |
| PubMedID: 32155891 |
| Gene_locus related to this paper: drome-ACHE |
| Title : Molecular dynamics simulations of the interaction of Mouse and Torpedo acetylcholinesterase with covalent inhibitors explain their differential reactivity: Implications for drug design - Chandar_2019_Chem.Biol.Interact_13ChEPon_310_108715 |
| Author(s) : Chandar NB , Efremenko I , Silman I , Martin JML , Sussman JL |
| Ref : Chemico-Biological Interactions , 310 :108715 , 2019 |
| Abstract : |
| PubMedSearch : Chandar_2019_Chem.Biol.Interact_13ChEPon_310_108715 |
| PubMedID: 31226285 |
| Title : Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase - Lalut_2019_Eur.J.Med.Chem_162_234 |
| Author(s) : Lalut J , Santoni G , Karila D , Lecoutey C , Davis A , Nachon F , Silman I , Sussman JL , Weik M , Maurice T , Dallemagne P , Rochais C |
| Ref : Eur Journal of Medicinal Chemistry , 162 :234 , 2019 |
| Abstract : |
| PubMedSearch : Lalut_2019_Eur.J.Med.Chem_162_234 |
| PubMedID: 30447434 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model. - Dighe_2019_Commun.Chem_2_35 |
| Author(s) : Dighe SN , De la Mora E , Chan S , Kantham S , McColl G , Miles JA , Veliyath SK , Sreenivas BY , Nassar ZD , Silman I , Sussman JL , Weik M , McGeary RP , Parat MO , Brazzolotto X , Ross BP |
| Ref : Communications chemistry , 2 :35 , 2019 |
| Abstract : |
| PubMedSearch : Dighe_2019_Commun.Chem_2_35 |
| PubMedID: |
| Gene_locus related to this paper: human-BCHE , torca-ACHE |
| Title : Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 - Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| Author(s) : Oukoloff K , Coquelle N , Bartolini M , Naldi M , Le Guevel R , Bach S , Josselin B , Ruchaud S , Catto M , Pisani L , Denora N , Iacobazzi RM , Silman I , Sussman JL , Buron F , Colletier JP , Jean L , Routier S , Renard PY |
| Ref : Eur Journal of Medicinal Chemistry , 168 :58 , 2019 |
| Abstract : |
| PubMedSearch : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| PubMedID: 30798053 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability - Novichkova_2019_Chem.Biol.Interact_13ChEPon_309_108699 |
| Author(s) : Novichkova DA , Lushchekina SV , Dym O , Masson P , Silman I , Sussman JL |
| Ref : Chemico-Biological Interactions , 309 :108699 , 2019 |
| Abstract : |
| PubMedSearch : Novichkova_2019_Chem.Biol.Interact_13ChEPon_309_108699 |
| PubMedID: 31202688 |
| Title : Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis - Galdeano_2018_Molecules_23_ |
| Author(s) : Galdeano C , Coquelle N , Cieslikiewicz-Bouet M , Bartolini M , Perez B , Clos MV , Silman I , Jean L , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Galdeano_2018_Molecules_23_ |
| PubMedID: 29534488 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents - Santoni_2018_J.Med.Chem_61_7630 |
| Author(s) : Santoni G , de Sousa J , De la Mora E , Dias J , Jean L , Sussman JL , Silman I , Renard PY , Brown RCD , Weik M , Baati R , Nachon F |
| Ref : Journal of Medicinal Chemistry , 61 :7630 , 2018 |
| Abstract : |
| PubMedSearch : Santoni_2018_J.Med.Chem_61_7630 |
| PubMedID: 30125110 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration - Zorbaz_2018_Chemistry_24_9675 |
| Author(s) : Zorbaz T , Braiki A , Marakovic N , Renou J , De la Mora E , Macek Hrvat N , Katalinic M , Silman I , Sussman JL , Mercey G , Gomez C , Mougeot R , Perez B , Baati R , Nachon F , Weik M , Jean L , Kovarik Z , Renard PY |
| Ref : Chemistry , 24 :9675 , 2018 |
| Abstract : |
| PubMedSearch : Zorbaz_2018_Chemistry_24_9675 |
| PubMedID: 29672968 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly - Leung_2018_Proc.Natl.Acad.Sci.U.S.A_115_13270 |
| Author(s) : Leung MR , van Bezouwen LS , Schopfer LM , Sussman JL , Silman I , Lockridge O , Zeev-Ben-Mordehai T |
| Ref : Proc Natl Acad Sci U S A , 115 :13270 , 2018 |
| Abstract : |
| PubMedSearch : Leung_2018_Proc.Natl.Acad.Sci.U.S.A_115_13270 |
| PubMedID: 30538207 |
| Gene_locus related to this paper: human-BCHE |
| Title : Generation of Reactive Oxygen Species by Photosensitizers and their Modes of Action on Proteins - Bilkis_2018_Curr.Med.Chem_25_5528 |
| Author(s) : Bilkis I , Silman I , Weiner L |
| Ref : Curr Med Chem , 25 :5528 , 2018 |
| Abstract : |
| PubMedSearch : Bilkis_2018_Curr.Med.Chem_25_5528 |
| PubMedID: 29303072 |
| Title : Computational Studies on Acetylcholinesterases - Xu_2017_Molecules_22_ |
| Author(s) : Xu Y , Cheng S , Sussman JL , Silman I , Jiang H |
| Ref : Molecules , 22 : , 2017 |
| Abstract : |
| PubMedSearch : Xu_2017_Molecules_22_ |
| PubMedID: 28796192 |
| Title : Alexander George Karczmar (1917-2017) - Soreq_2017_J.Neurochem_143_609 |
| Author(s) : Soreq H , Silman I |
| Ref : Journal of Neurochemistry , 143 :609 , 2017 |
| Abstract : |
| PubMedSearch : Soreq_2017_J.Neurochem_143_609 |
| PubMedID: 29027666 |
| Title : Preface: Cholinergic Mechanisms - Prado_2017_J.Neurochem_142 Suppl 2_3 |
| Author(s) : Prado MAM , Marchot P , Silman I |
| Ref : Journal of Neurochemistry , 142 Suppl 2 :3 , 2017 |
| Abstract : |
| PubMedSearch : Prado_2017_J.Neurochem_142 Suppl 2_3 |
| PubMedID: 28791707 |
| Title : Recent developments in structural studies on acetylcholinesterase - Silman_2017_J.Neurochem_142 Suppl 2_19 |
| Author(s) : Silman I , Sussman JL |
| Ref : Journal of Neurochemistry , 142 Suppl 2 :19 , 2017 |
| Abstract : |
| PubMedSearch : Silman_2017_J.Neurochem_142 Suppl 2_19 |
| PubMedID: 28503857 |
| Title : Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse - Haronen_2017_Hum.Mol.Genet_26_2076 |
| Author(s) : Haronen H , Zainul Z , Tu H , Naumenko N , Sormunen R , Miinalainen I , Shakirzyanova A , Oikarainen T , Abdullin A , Martin P , Santoleri S , Koistinaho J , Silman I , Giniatullin R , Fox MA , Heikkinen A , Pihlajaniemi T |
| Ref : Hum Mol Genet , 26 :2076 , 2017 |
| Abstract : |
| PubMedSearch : Haronen_2017_Hum.Mol.Genet_26_2076 |
| PubMedID: 28369367 |
| Title : The Impact of Crystallization Conditions on Structure-Based Drug Design: A Case Study on the Methylene Blue\/Acetylcholinesterase Complex - Dym_2016_Protein.Sci_25_1096 |
| Author(s) : Dym O , Song W , Felder CE , Roth E , Shnyrov V , Ashani Y , Xu Y , Joosten RP , Weiner L , Sussman JL , Silman I |
| Ref : Protein Science , 25 :1096 , 2016 |
| Abstract : |
| PubMedSearch : Dym_2016_Protein.Sci_25_1096 |
| PubMedID: 26990888 |
| Gene_locus related to this paper: torca-ACHE |
| Title : In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications - Ashani_2016_Chem.Biol.Interact_259_252 |
| Author(s) : Ashani Y , Leader H , Aggarwal N , Silman I , Worek F , Sussman JL , Goldsmith M |
| Ref : Chemico-Biological Interactions , 259 :252 , 2016 |
| Abstract : |
| PubMedSearch : Ashani_2016_Chem.Biol.Interact_259_252 |
| PubMedID: 27163850 |
| Title : Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability - Goldenzweig_2016_Mol.Cell_63_337 |
| Author(s) : Goldenzweig A , Goldsmith M , Hill SE , Gertman O , Laurino P , Ashani Y , Dym O , Unger T , Albeck S , Prilusky J , Lieberman RL , Aharoni A , Silman I , Sussman JL , Tawfik DS , Fleishman SJ |
| Ref : Mol Cell , 63 :337 , 2016 |
| Abstract : |
| PubMedSearch : Goldenzweig_2016_Mol.Cell_63_337 |
| PubMedID: 27425410 |
| Gene_locus related to this paper: human-ACHE |
| Title : Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme - Ben-David_2013_J.Mol.Biol_425_1028 |
| Author(s) : Ben-David M , Wieczorek G , Elias M , Silman I , Sussman JL , Tawfik DS |
| Ref : Journal of Molecular Biology , 425 :1028 , 2013 |
| Abstract : |
| PubMedSearch : Ben-David_2013_J.Mol.Biol_425_1028 |
| PubMedID: 23318950 |
| Title : The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy - Silman_2013_Chem.Biol.Interact_203_63 |
| Author(s) : Silman I , Roth E , Paz A , Triquigneaux MM , Ehrenshaft M , Xu Y , Shnyrov VL , Sussman JL , Deterding LJ , Ashani Y , Mason RP , Weiner L |
| Ref : Chemico-Biological Interactions , 203 :63 , 2013 |
| Abstract : |
| PubMedSearch : Silman_2013_Chem.Biol.Interact_203_63 |
| PubMedID: 23159732 |
| Title : Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1 - Ben-David_2012_J.Mol.Biol_418_181 |
| Author(s) : Ben-David M , Elias M , Filippi JJ , Dunach E , Silman I , Sussman JL , Tawfik DS |
| Ref : Journal of Molecular Biology , 418 :181 , 2012 |
| Abstract : |
| PubMedSearch : Ben-David_2012_J.Mol.Biol_418_181 |
| PubMedID: 22387469 |
| Title : Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer Methylene Blue - Triquigneaux_2012_Biochem.J_448_83 |
| Author(s) : Triquigneaux MM , Ehrenshaft M , Roth E , Silman I , Ashani Y , Mason RP , Weiner L , Deterding LJ |
| Ref : Biochemical Journal , 448 :83 , 2012 |
| Abstract : |
| PubMedSearch : Triquigneaux_2012_Biochem.J_448_83 |
| PubMedID: 22888904 |
| Title : Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase - Paz_2012_Protein.Sci_21_1138 |
| Author(s) : Paz A , Roth E , Ashani Y , Xu Y , Shnyrov VL , Sussman JL , Silman I , Weiner L |
| Ref : Protein Science , 21 :1138 , 2012 |
| Abstract : |
| PubMedSearch : Paz_2012_Protein.Sci_21_1138 |
| PubMedID: 22674800 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification - Goldsmith_2012_Chem.Biol_19_456 |
| Author(s) : Goldsmith M , Ashani Y , Simo Y , Ben-David M , Leader H , Silman I , Sussman JL , Tawfik DS |
| Ref : Chemical Biology , 19 :456 , 2012 |
| Abstract : |
| PubMedSearch : Goldsmith_2012_Chem.Biol_19_456 |
| PubMedID: 22520752 |
| Title : Backbone and side chain NMR assignments for the intrinsically disordered cytoplasmic domain of human neuroligin-3 - Wood_2012_Biomol.NMR.Assign_6_15 |
| Author(s) : Wood K , Paz A , Dijkstra K , Scheek RM , Otten R , Silman I , Sussman JL , Mulder FA |
| Ref : Biomol NMR Assign , 6 :15 , 2012 |
| Abstract : |
| PubMedSearch : Wood_2012_Biomol.NMR.Assign_6_15 |
| PubMedID: 21647611 |
| Title : Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis - Khare_2012_Nat.Chem.Biol_8_294 |
| Author(s) : Khare SD , Kipnis Y , Greisen P, Jr. , Takeuchi R , Ashani Y , Goldsmith M , Song Y , Gallaher JL , Silman I , Leader H , Sussman JL , Stoddard BL , Tawfik DS , Baker D |
| Ref : Nat Chemical Biology , 8 :294 , 2012 |
| Abstract : |
| PubMedSearch : Khare_2012_Nat.Chem.Biol_8_294 |
| PubMedID: 22306579 |
| Title : Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen - Weiner_2011_Photochem.Photobiol_87_308 |
| Author(s) : Weiner L , Roth E , Silman I |
| Ref : Photochem Photobiol , 87 :308 , 2011 |
| Abstract : |
| PubMedSearch : Weiner_2011_Photochem.Photobiol_87_308 |
| PubMedID: 21155827 |
| Title : In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases - Ashani_2011_Toxicol.Lett_206_24 |
| Author(s) : Ashani Y , Goldsmith M , Leader H , Silman I , Sussman JL , Tawfik DS |
| Ref : Toxicol Lett , 206 :24 , 2011 |
| Abstract : |
| PubMedSearch : Ashani_2011_Toxicol.Lett_206_24 |
| PubMedID: 21807078 |
| Title : Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations - Sanson_2011_Protein.Sci_20_1114 |
| Author(s) : Sanson B , Colletier JP , Xu Y , Lang PT , Jiang H , Silman I , Sussman JL , Weik M |
| Ref : Protein Science , 20 :1114 , 2011 |
| Abstract : |
| PubMedSearch : Sanson_2011_Protein.Sci_20_1114 |
| PubMedID: 21594947 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Directed evolution of hydrolases for prevention of G-type nerve agent intoxication - Gupta_2011_Nat.Chem.Biol_7_120 |
| Author(s) : Gupta RD , Goldsmith M , Ashani Y , Simo Y , Mullokandov G , Bar H , Ben-David M , Leader H , Margalit R , Silman I , Sussman JL , Tawfik DS |
| Ref : Nat Chemical Biology , 7 :120 , 2011 |
| Abstract : |
| PubMedSearch : Gupta_2011_Nat.Chem.Biol_7_120 |
| PubMedID: 21217689 |
| Title : Acetylcholinesterase: from 3D structure to function - Dvir_2010_Chem.Biol.Interact_187_10 |
| Author(s) : Dvir H , Silman I , Harel M , Rosenberry TL , Sussman JL |
| Ref : Chemico-Biological Interactions , 187 :10 , 2010 |
| Abstract : |
| PubMedSearch : Dvir_2010_Chem.Biol.Interact_187_10 |
| PubMedID: 20138030 |
| Gene_locus related to this paper: human-ACHE |
| Title : Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers - Ashani_2010_Chem.Biol.Interact_187_362 |
| Author(s) : Ashani Y , Gupta RD , Goldsmith M , Silman I , Sussman JL , Tawfik DS , Leader H |
| Ref : Chemico-Biological Interactions , 187 :362 , 2010 |
| Abstract : |
| PubMedSearch : Ashani_2010_Chem.Biol.Interact_187_362 |
| PubMedID: 20303930 |
| Title : Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase - Xu_2010_Biophys.J_99_4003 |
| Author(s) : Xu Y , Colletier JP , Weik M , Qin G , Jiang H , Silman I , Sussman JL |
| Ref : Biophysical Journal , 99 :4003 , 2010 |
| Abstract : |
| PubMedSearch : Xu_2010_Biophys.J_99_4003 |
| PubMedID: 21156143 |
| Title : Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime - Sanson_2009_J.Med.Chem_52_7593 |
| Author(s) : Sanson B , Nachon F , Colletier JP , Froment MT , Toker L , Greenblatt HM , Sussman JL , Ashani Y , Masson P , Silman I , Weik M |
| Ref : Journal of Medicinal Chemistry , 52 :7593 , 2009 |
| Abstract : |
| PubMedSearch : Sanson_2009_J.Med.Chem_52_7593 |
| PubMedID: 19642642 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties - Zeev-Ben-Mordehai_2009_Biophys.J_97_2316 |
| Author(s) : Zeev-Ben-Mordehai T , Mylonas E , Paz A , Peleg Y , Toker L , Silman I , Svergun DI , Sussman JL |
| Ref : Biophysical Journal , 97 :2316 , 2009 |
| Abstract : |
| PubMedSearch : Zeev-Ben-Mordehai_2009_Biophys.J_97_2316 |
| PubMedID: 19843464 |
| Title : Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors - Weiner_2009_Biochemistry_48_563 |
| Author(s) : Weiner L , Shnyrov VL , Konstantinovskii L , Roth E , Ashani Y , Silman I |
| Ref : Biochemistry , 48 :563 , 2009 |
| Abstract : |
| PubMedSearch : Weiner_2009_Biochemistry_48_563 |
| PubMedID: 19115961 |
| Title : Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor\/consensus mutagenesis, and its biochemical characterization - Khersonsky_2009_Biochemistry_48_6644 |
| Author(s) : Khersonsky O , Rosenblat M , Toker L , Yacobson S , Hugenmatter A , Silman I , Sussman JL , Aviram M , Tawfik DS |
| Ref : Biochemistry , 48 :6644 , 2009 |
| Abstract : |
| PubMedSearch : Khersonsky_2009_Biochemistry_48_6644 |
| PubMedID: 19492856 |
| Title : Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its aged soman conjugate - Gabel_2009_Biophys.J_96_1489 |
| Author(s) : Gabel F , Masson P , Froment MT , Doctor BP , Saxena A , Silman I , Zaccai G , Weik M |
| Ref : Biophysical Journal , 96 :1489 , 2009 |
| Abstract : |
| PubMedSearch : Gabel_2009_Biophys.J_96_1489 |
| PubMedID: 19217865 |
| Title : Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization - Zeev-Ben-Mordehai_2009_Protein.Expr.Purif_63_147 |
| Author(s) : Zeev-Ben-Mordehai T , Paz A , Peleg Y , Toker L , Wolf SG , Rydberg EH , Sussman JL , Silman I |
| Ref : Protein Expr Purif , 63 :147 , 2009 |
| Abstract : |
| PubMedSearch : Zeev-Ben-Mordehai_2009_Protein.Expr.Purif_63_147 |
| PubMedID: 18938249 |
| Title : The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad - Paz_2009_J.Med.Chem_52_2543 |
| Author(s) : Paz A , Xie Q , Greenblatt HM , Fu W , Tang Y , Silman I , Qiu Z , Sussman JL |
| Ref : Journal of Medicinal Chemistry , 52 :2543 , 2009 |
| Abstract : |
| PubMedSearch : Paz_2009_J.Med.Chem_52_2543 |
| PubMedID: 19326912 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography - Colletier_2008_Proc.Natl.Acad.Sci.U.S.A_105_11742 |
| Author(s) : Colletier JP , Bourgeois D , Sanson B , Fournier D , Sussman JL , Silman I , Weik M |
| Ref : Proc Natl Acad Sci U S A , 105 :11742 , 2008 |
| Abstract : |
| PubMedSearch : Colletier_2008_Proc.Natl.Acad.Sci.U.S.A_105_11742 |
| PubMedID: 18701720 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Acetylcholinesterase: how is structure related to function? - Silman_2008_Chem.Biol.Interact_175_3 |
| Author(s) : Silman I , Sussman JL |
| Ref : Chemico-Biological Interactions , 175 :3 , 2008 |
| Abstract : |
| PubMedSearch : Silman_2008_Chem.Biol.Interact_175_3 |
| PubMedID: 18586019 |
| Title : Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3 - Paz_2008_Biophys.J_95_1928 |
| Author(s) : Paz A , Zeev-Ben-Mordehai T , Lundqvist M , Sherman E , Mylonas E , Weiner L , Haran G , Svergun DI , Mulder FA , Sussman JL , Silman I |
| Ref : Biophysical Journal , 95 :1928 , 2008 |
| Abstract : |
| PubMedSearch : Paz_2008_Biophys.J_95_1928 |
| PubMedID: 18456828 |
| Title : Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics - Xu_2008_Biophys.J_95_2500 |
| Author(s) : Xu Y , Colletier JP , Weik M , Jiang H , Moult J , Silman I , Sussman JL |
| Ref : Biophysical Journal , 95 :2500 , 2008 |
| Abstract : |
| PubMedSearch : Xu_2008_Biophys.J_95_2500 |
| PubMedID: 18502801 |
| Title : Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design - Xu_2008_Protein.Sci_17_601 |
| Author(s) : Xu Y , Colletier JP , Jiang H , Silman I , Sussman JL , Weik M |
| Ref : Protein Science , 17 :601 , 2008 |
| Abstract : |
| PubMedSearch : Xu_2008_Protein.Sci_17_601 |
| PubMedID: 18359854 |
| Title : Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site - Harel_2008_J.Am.Chem.Soc_130_7856 |
| Author(s) : Harel M , Sonoda LK , Silman I , Sussman JL , Rosenberry TL |
| Ref : Journal of the American Chemical Society , 130 :7856 , 2008 |
| Abstract : |
| PubMedSearch : Harel_2008_J.Am.Chem.Soc_130_7856 |
| PubMedID: 18512913 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography - Colletier_2007_Acta.Crystallogr.D.Biol.Crystallogr_63_1115 |
| Author(s) : Colletier JP , Royant A , Specht A , Sanson B , Nachon F , Masson P , Zaccai G , Sussman JL , Goeldner M , Silman I , Bourgeois D , Weik M |
| Ref : Acta Crystallographica D Biol Crystallogr , 63 :1115 , 2007 |
| Abstract : |
| PubMedSearch : Colletier_2007_Acta.Crystallogr.D.Biol.Crystallogr_63_1115 |
| PubMedID: 18007027 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors - Haviv_2007_Curr.Top.Med.Chem_7_375 |
| Author(s) : Haviv H , Wong DM , Silman I , Sussman JL |
| Ref : Curr Top Med Chem , 7 :375 , 2007 |
| Abstract : |
| PubMedSearch : Haviv_2007_Curr.Top.Med.Chem_7_375 |
| PubMedID: 17305579 |
| Title : Structural insights into substrate traffic and inhibition in acetylcholinesterase - Colletier_2006_EMBO.J_25_2746 |
| Author(s) : Colletier JP , Fournier D , Greenblatt HM , Stojan J , Sussman JL , Zaccai G , Silman I , Weik M |
| Ref : EMBO Journal , 25 :2746 , 2006 |
| Abstract : |
| PubMedSearch : Colletier_2006_EMBO.J_25_2746 |
| PubMedID: 16763558 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge - Rydberg_2006_J.Med.Chem_49_5491 |
| Author(s) : Rydberg EH , Brumshtein B , Greenblatt HM , Wong DM , Shaya D , Williams LD , Carlier PR , Pang YP , Silman I , Sussman JL |
| Ref : Journal of Medicinal Chemistry , 49 :5491 , 2006 |
| Abstract : |
| PubMedSearch : Rydberg_2006_J.Med.Chem_49_5491 |
| PubMedID: 16942022 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology - Silman_2005_Curr.Opin.Pharmacol_5_293 |
| Author(s) : Silman I , Sussman JL |
| Ref : Curr Opin Pharmacol , 5 :293 , 2005 |
| Abstract : |
| PubMedSearch : Silman_2005_Curr.Opin.Pharmacol_5_293 |
| PubMedID: 15907917 |
| Title : Depolarization initiates phasic acetylcholine release by relief of a tonic block imposed by presynaptic M2 muscarinic receptors - Parnas_2005_J.Neurophysiol_93_3257 |
| Author(s) : Parnas H , Slutsky I , Rashkovan G , Silman I , Wess J , Parnas I |
| Ref : Journal of Neurophysiology , 93 :3257 , 2005 |
| Abstract : |
| PubMedSearch : Parnas_2005_J.Neurophysiol_93_3257 |
| PubMedID: 15703226 |
| Title : Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11 - Hyatt_2005_Chem.Biol.Interact_157-158_247 |
| Author(s) : Hyatt JL , Tsurkan L , Morton CL , Yoon KJ , Harel M , Brumshtein B , Silman I , Sussman JL , Wadkins RM , Potter PM |
| Ref : Chemico-Biological Interactions , 157-158 :247 , 2005 |
| Abstract : |
| PubMedSearch : Hyatt_2005_Chem.Biol.Interact_157-158_247 |
| PubMedID: 16257398 |
| Title : Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study - Gabel_2005_Biophys.J_89_3303 |
| Author(s) : Gabel F , Weik M , Masson P , Renault F , Fournier D , Brochier L , Doctor BP , Saxena A , Silman I , Zaccai G |
| Ref : Biophysical Journal , 89 :3303 , 2005 |
| Abstract : |
| PubMedSearch : Gabel_2005_Biophys.J_89_3303 |
| PubMedID: 16100272 |
| Title : Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation - Niu_2005_J.Phys.Chem.B_109_23730 |
| Author(s) : Niu C , Xu Y , Luo X , Duan W , Silman I , Sussman JL , Zhu W , Chen K , Shen J , Jiang H |
| Ref : J Phys Chem B , 109 :23730 , 2005 |
| Abstract : |
| PubMedSearch : Niu_2005_J.Phys.Chem.B_109_23730 |
| PubMedID: 16375354 |
| Title : Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations - Hasin_2005_Curr.Alzheimer.Res_2_207 |
| Author(s) : Hasin Y , Avidan N , Bercovich D , Korczyn AD , Silman I , Beckmann JS , Sussman JL |
| Ref : Curr Alzheimer Res , 2 :207 , 2005 |
| Abstract : |
| PubMedSearch : Hasin_2005_Curr.Alzheimer.Res_2_207 |
| PubMedID: 15974920 |
| Title : The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase - Harel_2005_Chem.Biol.Interact_157-158_153 |
| Author(s) : Harel M , Hyatt JL , Brumshtein B , Morton CL , Wadkins RM , Silman I , Sussman JL , Potter PM |
| Ref : Chemico-Biological Interactions , 157-158 :153 , 2005 |
| Abstract : |
| PubMedSearch : Harel_2005_Chem.Biol.Interact_157-158_153 |
| PubMedID: 16289500 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action - Harel_2005_Mol.Pharmacol_67_1874 |
| Author(s) : Harel M , Hyatt JL , Brumshtein B , Morton CL , Yoon KJ , Wadkins RM , Silman I , Sussman JL , Potter PM |
| Ref : Molecular Pharmacology , 67 :1874 , 2005 |
| Abstract : |
| PubMedSearch : Harel_2005_Mol.Pharmacol_67_1874 |
| PubMedID: 15772291 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase - Haviv_2005_J.Am.Chem.Soc_127_11029 |
| Author(s) : Haviv H , Wong DM , Greenblatt HM , Carlier PR , Pang YP , Silman I , Sussman JL |
| Ref : Journal of the American Chemical Society , 127 :11029 , 2005 |
| Abstract : |
| PubMedSearch : Haviv_2005_J.Am.Chem.Soc_127_11029 |
| PubMedID: 16076210 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes - Harel_2004_Nat.Struct.Mol.Biol_11_412 |
| Author(s) : Harel M , Aharoni A , Gaidukov L , Brumshtein B , Khersonsky O , Meged R , Dvir H , Ravelli RB , McCarthy A , Toker L , Silman I , Sussman JL , Tawfik DS |
| Ref : Nat Struct Mol Biol , 11 :412 , 2004 |
| Abstract : |
| PubMedSearch : Harel_2004_Nat.Struct.Mol.Biol_11_412 |
| PubMedID: 15098021 |
| Title : The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study - Gabel_2004_Biophys.J_86_3152 |
| Author(s) : Gabel F , Weik M , Doctor BP , Saxena A , Fournier D , Brochier L , Renault F , Masson P , Silman I , Zaccai G |
| Ref : Biophysical Journal , 86 :3152 , 2004 |
| Abstract : |
| PubMedSearch : Gabel_2004_Biophys.J_86_3152 |
| PubMedID: 15111428 |
| Title : Poster (47) Conformational plasticity of acetylcholinesterase - |
| Author(s) : Silman I , Greenblatt HM , Zeev-Ben-Mordehai T , Sussman JL |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :346 , 2004 |
| PubMedID: |
| Title : Poster (48) Crystal structure of the tetramerization domain of acetylcholinesterase reveals a model of the AChE tetramer - |
| Author(s) : Harel M , Dvir H , Bon S , Liu WQ , Garbay C , Sussman JL , Massoulie J , Silman I |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :347 , 2004 |
| PubMedID: |
| Title : A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene - Hasin_2004_Hum.Mutat_24_408 |
| Author(s) : Hasin Y , Avidan N , Bercovich D , Korczyn A , Silman I , Beckmann JS , Sussman JL |
| Ref : Hum Mutat , 24 :408 , 2004 |
| Abstract : |
| PubMedSearch : Hasin_2004_Hum.Mutat_24_408 |
| PubMedID: 15459952 |
| Title : Overexpression of the extracellular and cytoplasmic domains of the Drosophila adhesion protein, gliotactin. - |
| Author(s) : Rydberg EH , Macion R , Zeev-Ben-Mordehai T , Solomon A , Rees DM , Toker L , Botti SA , Auld VJ , Silman I , Sussman JL |
| Ref : Cholinergic Mechanisms, CRC Press :687 , 2004 |
| PubMedID: |
| Title : Poster (74) Structural studies on torpedo californica acetylcholinesterase in complex with a substrate analogue - |
| Author(s) : Colletier JP , Fournier D , Greenblatt HM , Sussman JL , Zaccai G , Silman I , Weik M |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :359 , 2004 |
| PubMedID: |
| Title : Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization - Aharoni_2004_Proc.Natl.Acad.Sci.U.S.A_101_482 |
| Author(s) : Aharoni A , Gaidukov L , Yagur S , Toker L , Silman I , Tawfik DS |
| Ref : Proc Natl Acad Sci U S A , 101 :482 , 2004 |
| Abstract : |
| PubMedSearch : Aharoni_2004_Proc.Natl.Acad.Sci.U.S.A_101_482 |
| PubMedID: 14695884 |
| Title : Poster (79) X-ray structures of TcAChE complexed with (+)-huperzine a and (-)-huperzine b: structural evidence for an active-site rearrangement - |
| Author(s) : Dvir H , Jiang H , Wong DM , Harel M , Chetrit M , He XC , Jin GY , Yu GL , Tang XC , Silman I , Bai DL , Sussman JL |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :362 , 2004 |
| PubMedID: |
| Title : Use of the morphing graphics technique to visualize conformational differences between acetylcholinesterases from different species and inhibitor-induced conformational changes. - |
| Author(s) : Zeev-Ben-Mordehai T , Silman I , Sussman JL |
| Ref : Cholinergic Mechanisms, CRC Press :747 , 2004 |
| PubMedID: |
| Title : The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix - Dvir_2004_EMBO.J_23_4394 |
| Author(s) : Dvir H , Harel M , Bon S , Liu WQ , Vidal M , Garbay C , Sussman JL , Massoulie J , Silman I |
| Ref : EMBO Journal , 23 :4394 , 2004 |
| Abstract : |
| PubMedSearch : Dvir_2004_EMBO.J_23_4394 |
| PubMedID: 15526038 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Crystal structure of the tetramerization domain of acetylcholinesterase at 2. - |
| Author(s) : Harel M , Dvir H , Bon S , Liu WQ , Garbay C , Sussman JL , Massoulie J , Silman I |
| Ref : Cholinergic Mechanisms, CRC Press :183 , 2004 |
| PubMedID: |
| Title : Poster (104) Biophysical and bioinformatic analysis of the cytoplasmic portion of gliotactin - |
| Author(s) : Zeev-Ben-Mordehai T , Rydberg EH , Solomon A , Toker L , Silman I , Sussman JL |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :375 , 2004 |
| PubMedID: |
| Title : The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design - Greenblatt_2004_J.Am.Chem.Soc_126_15405 |
| Author(s) : Greenblatt HM , Guillou C , Guenard D , Argaman A , Botti SA , Badet B , Thal C , Silman I , Sussman JL |
| Ref : Journal of the American Chemical Society , 126 :15405 , 2004 |
| Abstract : |
| PubMedSearch : Greenblatt_2004_J.Am.Chem.Soc_126_15405 |
| PubMedID: 15563167 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Poster (24) New biosensors for improved detection of environmental contamination by anticholinesterase pesticides - |
| Author(s) : Toutant JP , Massoulie J , Fournier D , Schmid RD , Pfeiffer D , Selkirk ME , Sussman JL , Silman I , Talesa V , Wodak SJ |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :333 , 2004 |
| PubMedID: |
| Title : New biosensors for improved detection of environmental and food contamination by anticholinesterase pesticides - |
| Author(s) : Toutant JP , Massoulie J , Fournier D , Marty JL , Schmid RD , Pfeiffer D , Selkirk ME , Sussman JL , Silman I , Talesa V , Wodak SJ , Stojan J , Magearu V |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :233 , 2004 |
| PubMedID: |
| Title : Poster (31) Natively unstructured proteins: a case study of cholinesterase-like adhesion molecules (clams) - |
| Author(s) : Sussman JL , Zeev-Ben-Mordehai T , Rydberg EH , Solomon A , Toker L , Botti SA , Auld VJ , Silman I |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :337 , 2004 |
| PubMedID: |
| Title : Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity - Wong_2003_J.Am.Chem.Soc_125_363 |
| Author(s) : Wong DM , Greenblatt HM , Dvir H , Carlier PR , Han YF , Pang YP , Silman I , Sussman JL |
| Ref : J Am Chem Soc , 125 :363 , 2003 |
| Abstract : |
| PubMedSearch : Wong_2003_J.Am.Chem.Soc_125_363 |
| PubMedID: 12517147 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones - Millard_2003_Protein.Sci_12_2337 |
| Author(s) : Millard CB , Shnyrov VL , Newstead S , Shin I , Roth E , Silman I , Weiner L |
| Ref : Protein Science , 12 :2337 , 2003 |
| Abstract : |
| PubMedSearch : Millard_2003_Protein.Sci_12_2337 |
| PubMedID: 14500892 |
| Title : Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease - Greenblatt_2003_J.Mol.Neurosci_20_369 |
| Author(s) : Greenblatt HM , Dvir H , Silman I , Sussman JL |
| Ref : Journal of Molecular Neuroscience , 20 :369 , 2003 |
| Abstract : |
| PubMedSearch : Greenblatt_2003_J.Mol.Neurosci_20_369 |
| PubMedID: 14501022 |
| Title : How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations - Xu_2003_J.Am.Chem.Soc_125_11340 |
| Author(s) : Xu Y , Shen J , Luo X , Silman I , Sussman JL , Chen K , Jiang H |
| Ref : Journal of the American Chemical Society , 125 :11340 , 2003 |
| Abstract : |
| PubMedSearch : Xu_2003_J.Am.Chem.Soc_125_11340 |
| PubMedID: 16220957 |
| Title : Acetylcholinesterase in motion: visualizing conformational changes in crystal structures by a morphing procedure - Zeev-Ben-Mordehai_2003_Biopolymers_68_395 |
| Author(s) : Zeev-Ben-Mordehai T , Silman I , Sussman JL |
| Ref : Biopolymers , 68 :395 , 2003 |
| Abstract : |
| PubMedSearch : Zeev-Ben-Mordehai_2003_Biopolymers_68_395 |
| PubMedID: 12601798 |
| Title : The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded - Zeev-Ben-Mordehai_2003_Proteins_53_758 |
| Author(s) : Zeev-Ben-Mordehai T , Rydberg EH , Solomon A , Toker L , Auld VJ , Silman I , Botti SA , Sussman JL |
| Ref : Proteins , 53 :758 , 2003 |
| Abstract : |
| PubMedSearch : Zeev-Ben-Mordehai_2003_Proteins_53_758 |
| PubMedID: 14579366 |
| Title : Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation - Weik_2002_J.Synchrotron.Radiat_9_342 |
| Author(s) : Weik M , Berges J , Raves ML , Gros P , McSweeney S , Silman I , Sussman JL , Houee-Levin C , Ravelli RB |
| Ref : J Synchrotron Radiat , 9 :342 , 2002 |
| Abstract : |
| PubMedSearch : Weik_2002_J.Synchrotron.Radiat_9_342 |
| PubMedID: 12409620 |
| Title : Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine - Bar-On_2002_Biochemistry_41_3555 |
| Author(s) : Bar-On P , Millard CB , Harel M , Dvir H , Enz A , Sussman JL , Silman I |
| Ref : Biochemistry , 41 :3555 , 2002 |
| Abstract : |
| PubMedSearch : Bar-On_2002_Biochemistry_41_3555 |
| PubMedID: 11888271 |
| Gene_locus related to this paper: torca-ACHE |
| Title : 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates - Dvir_2002_Biochemistry_41_2970 |
| Author(s) : Dvir H , Wong DM , Harel M , Barril X , Orozco M , Luque FJ , Munoz-Torrero D , Camps P , Rosenberry TL , Silman I , Sussman JL |
| Ref : Biochemistry , 41 :2970 , 2002 |
| Abstract : |
| PubMedSearch : Dvir_2002_Biochemistry_41_2970 |
| PubMedID: 11863435 |
| Gene_locus related to this paper: torca-ACHE |
| Title : X-ray Structures of Torpedo californica Acetylcholinesterase Complexed with (+)-Huperzine A and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement - Dvir_2002_Biochemistry_41_10810 |
| Author(s) : Dvir H , Jiang H , Wong DM , Harel M , Chetrit M , He XC , Jin GY , Yu GL , Tang XC , Silman I , Bai DL , Sussman JL |
| Ref : Biochemistry , 41 :10810 , 2002 |
| Abstract : |
| PubMedSearch : Dvir_2002_Biochemistry_41_10810 |
| PubMedID: 12196020 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase - Felder_2002_Acta.Crystallogr.D.Biol.Crystallogr_58_1765 |
| Author(s) : Felder CE , Harel M , Silman I , Sussman JL |
| Ref : Acta Crystallographica D Biol Crystallogr , 58 :1765 , 2002 |
| Abstract : |
| PubMedSearch : Felder_2002_Acta.Crystallogr.D.Biol.Crystallogr_58_1765 |
| PubMedID: 12351819 |
| Gene_locus related to this paper: torca-ACHE |
| Title : A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica - Koellner_2002_J.Mol.Biol_320_721 |
| Author(s) : Koellner G , Steiner T , Millard CB , Silman I , Sussman JL |
| Ref : Journal of Molecular Biology , 320 :721 , 2002 |
| Abstract : |
| PubMedSearch : Koellner_2002_J.Mol.Biol_320_721 |
| PubMedID: 12095250 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding? - Shin_2002_Protein.Sci_11_2022 |
| Author(s) : Shin I , Wachtel E , Roth E , Bon C , Silman I , Weiner L |
| Ref : Protein Science , 11 :2022 , 2002 |
| Abstract : |
| PubMedSearch : Shin_2002_Protein.Sci_11_2022 |
| PubMedID: 12142456 |
| Title : A structure-based design approach to the development of novel, reversible AChE inhibitors - Doucet-Personeni_2001_J.Med.Chem_44_3203 |
| Author(s) : Doucet-Personeni C , Bentley PD , Fletcher RJ , Kinkaid A , Kryger G , Pirard B , Taylor A , Taylor R , Taylor J , Viner R , Silman I , Sussman JL , Greenblatt HM , Lewis T |
| Ref : Journal of Medicinal Chemistry , 44 :3203 , 2001 |
| Abstract : |
| PubMedSearch : Doucet-Personeni_2001_J.Med.Chem_44_3203 |
| PubMedID: 11563919 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes - Weik_2001_Protein.Sci_10_1953 |
| Author(s) : Weik M , Ravelli RB , Silman I , Sussman JL , Gros P , Kroon J |
| Ref : Protein Science , 10 :1953 , 2001 |
| Abstract : |
| PubMedSearch : Weik_2001_Protein.Sci_10_1953 |
| PubMedID: 11567086 |
| Title : Presynaptic M(2) muscarinic receptors are involved in controlling the kinetics of ACh release at the frog neuromuscular junction - Slutsky_2001_J.Physiol_536_717 |
| Author(s) : Slutsky I , Silman I , Parnas I , Parnas H |
| Ref : The Journal of Physiology , 536 :717 , 2001 |
| Abstract : |
| PubMedSearch : Slutsky_2001_J.Physiol_536_717 |
| PubMedID: 11691867 |
| Title : A Structural Motif of Acetylcholinesterase That Promotes Amyloid beta-Peptide Fibril Formation - De Ferrari_2001_Biochemistry_40_10447 |
| Author(s) : De Ferrari GV , Canales MA , Shin I , Weiner L , Silman I , Inestrosa NC |
| Ref : Biochemistry , 40 :10447 , 2001 |
| Abstract : |
| PubMedSearch : De Ferrari_2001_Biochemistry_40_10447 |
| PubMedID: 11523986 |
| Title : Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase - Nicolas_2001_Acta.Crystallogr.D.Biol.Crystallogr_57_1348 |
| Author(s) : Nicolas A , Ferron F , Toker L , Sussman JL , Silman I |
| Ref : Acta Crystallographica D Biol Crystallogr , 57 :1348 , 2001 |
| Abstract : |
| PubMedSearch : Nicolas_2001_Acta.Crystallogr.D.Biol.Crystallogr_57_1348 |
| PubMedID: 11526341 |
| Title : Specific chemical and structural damage to proteins produced by synchrotron radiation - Weik_2000_Proc.Natl.Acad.Sci.U.S.A_97_623 |
| Author(s) : Weik M , Ravelli RB , Kryger G , McSweeney S , Raves ML , Harel M , Gros P , Silman I , Kroon J , Sussman JL |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 97 :623 , 2000 |
| Abstract : |
| PubMedSearch : Weik_2000_Proc.Natl.Acad.Sci.U.S.A_97_623 |
| PubMedID: 10639129 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica - Koellner_2000_J.Mol.Biol_296_713 |
| Author(s) : Koellner G , Kryger G , Millard CB , Silman I , Sussman JL , Steiner T |
| Ref : Journal of Molecular Biology , 296 :713 , 2000 |
| Abstract : |
| PubMedSearch : Koellner_2000_J.Mol.Biol_296_713 |
| PubMedID: 10669619 |
| Title : Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride - Kraut_2000_Mol.Pharmacol_57_1243 |
| Author(s) : Kraut D , Goff H , Pai RK , Hosea NA , Silman I , Sussman JL , Taylor P , Voet JG |
| Ref : Molecular Pharmacology , 57 :1243 , 2000 |
| Abstract : |
| PubMedSearch : Kraut_2000_Mol.Pharmacol_57_1243 |
| PubMedID: 10825396 |
| Title : Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II - Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385 |
| Author(s) : Kryger G , Harel M , Giles K , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL |
| Ref : Acta Crystallographica D Biol Crystallogr , 56 :1385 , 2000 |
| Abstract : |
| PubMedSearch : Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385 |
| PubMedID: 11053835 |
| Gene_locus related to this paper: human-ACHE |
| Title : Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors - Harel_2000_Protein.Sci_9_1063 |
| Author(s) : Harel M , Kryger G , Rosenberry TL , Mallender WD , Lewis T , Fletcher RJ , Guss JM , Silman I , Sussman JL |
| Ref : Protein Science , 9 :1063 , 2000 |
| Abstract : |
| PubMedSearch : Harel_2000_Protein.Sci_9_1063 |
| PubMedID: 10892800 |
| Gene_locus related to this paper: drome-ACHE |
| Title : Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthday - Arnon_1999_Protein.Sci_8_2553 |
| Author(s) : Arnon R , Silman I , Tarrab-Hazdai R |
| Ref : Protein Science , 8 :2553 , 1999 |
| Abstract : |
| PubMedSearch : Arnon_1999_Protein.Sci_8_2553 |
| PubMedID: 10631970 |
| Title : Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin - Weiner_1999_Biochemistry_38_11401 |
| Author(s) : Weiner L , Roth E , Mazur Y , Silman I |
| Ref : Biochemistry , 38 :11401 , 1999 |
| Abstract : |
| PubMedSearch : Weiner_1999_Biochemistry_38_11401 |
| PubMedID: 10471290 |
| Title : Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase - Morel_1999_Mol.Pharmacol_55_982 |
| Author(s) : Morel N , Bon S , Greenblatt HM , Van Belle D , Wodak SJ , Sussman JL , Massoulie J , Silman I |
| Ref : Molecular Pharmacology , 55 :982 , 1999 |
| Abstract : |
| PubMedSearch : Morel_1999_Mol.Pharmacol_55_982 |
| PubMedID: 10347238 |
| Title : Acetylcholinesterase from Schistosoma mansoni: interaction of globular species with heparin - Tarrab-Hazdai_1999_Biochem.J_344 Pt 3_945 |
| Author(s) : Tarrab-Hazdai R , Toker L , Silman I , Arnon R |
| Ref : Biochemical Journal , 344 Pt 3 :945 , 1999 |
| Abstract : |
| PubMedSearch : Tarrab-Hazdai_1999_Biochem.J_344 Pt 3_945 |
| PubMedID: 10585885 |
| Title : A modular treatment of molecular traffic through the active site of cholinesterase - Botti_1999_Biophys.J_77_2430 |
| Author(s) : Botti SA , Felder CE , Lifson S , Sussman JL , Silman I |
| Ref : Biophysical Journal , 77 :2430 , 1999 |
| Abstract : |
| PubMedSearch : Botti_1999_Biophys.J_77_2430 |
| PubMedID: 10545346 |
| Title : Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution - Greenblatt_1999_FEBS.Lett_463_321 |
| Author(s) : Greenblatt HM , Kryger G , Lewis T , Silman I , Sussman JL |
| Ref : FEBS Letters , 463 :321 , 1999 |
| Abstract : |
| PubMedSearch : Greenblatt_1999_FEBS.Lett_463_321 |
| PubMedID: 10606746 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs - Kryger_1999_Structure_7_297 |
| Author(s) : Kryger G , Silman I , Sussman JL |
| Ref : Structure , 7 :297 , 1999 |
| Abstract : |
| PubMedSearch : Kryger_1999_Structure_7_297 |
| PubMedID: 10368299 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level - Millard_1999_Biochemistry_38_7032 |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Greenblatt HM , Harel M , Raves ML , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : Biochemistry , 38 :7032 , 1999 |
| Abstract : |
| PubMedSearch : Millard_1999_Biochemistry_38_7032 |
| PubMedID: 10353814 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Reaction Products of Acetylcholinesterase and Vx Reveal a Mobile Histidine in the Catalytic Triad - Millard_1999_J.Am.Chem.Soc_121_9883 |
| Author(s) : Millard CB , Koellner G , Ordentlich A , Shafferman A , Silman I , Sussman JL |
| Ref : Journal of the American Chemical Society , 121 :9883 , 1999 |
| Abstract : |
| PubMedSearch : Millard_1999_J.Am.Chem.Soc_121_9883 |
| PubMedID: |
| Gene_locus related to this paper: torca-ACHE |
| Title : A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase - Silman_1999_Chem.Biol.Interact_119-120_43 |
| Author(s) : Silman I , Millard CB , Ordentlich A , Greenblatt HM , Harel M , Barak D , Shafferman A , Sussman JL |
| Ref : Chemico-Biological Interactions , 119-120 :43 , 1999 |
| Abstract : |
| PubMedSearch : Silman_1999_Chem.Biol.Interact_119-120_43 |
| PubMedID: 10421437 |
| Gene_locus related to this paper: torca-ACHE |
| Title : 3D Structure at 2.7 Resolution of Native and E202Q Mutant Human Acetylcholinesterase Complexed with Fasciculin-II - |
| Author(s) : Kryger G , Giles K , Harel M , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :323 , 1998 |
| PubMedID: |
| Title : Irwin B. Wilson Plenary Lecture Structural and Functional Studies on Acetylcholinesterase - |
| Author(s) : Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :25 , 1998 |
| PubMedID: |
| Title : 3D Structure of a Complex of Human Acetylcholinesterase with Fasciculin-II at 2.7 Resolution - |
| Author(s) : Kryger G , Giles K , Harel M , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :370 , 1998 |
| PubMedID: |
| Title : Crystal Structures of Complexes of E2020-Related Compounds with Torpedo Californica Acetylcholinesterase - |
| Author(s) : Greenblatt HM , Kryger G , Harel M , Lewis T , Taylor J , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :371-371 , 1998 |
| PubMedID: |
| Title : Alternative Crystal Forms of Torpedo Californica Acetylcholinesterase - |
| Author(s) : Raves ML , Greenblatt HM , Kryger G , Nicolas A , Ravelli RB , Harel M , Kroon J , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :372 , 1998 |
| PubMedID: |
| Title : Kinetic and X-Ray Crystallographic Studies of the Binding of ENA-713 to Torpedo Californica Acetylcholinesterase - |
| Author(s) : Bar-On P , Harel M , Millard CB , Enz A , Sussman JL , Silman I |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :373 , 1998 |
| PubMedID: |
| Title : Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase - |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :425 , 1998 |
| PubMedID: |
| Title : Surface Residues Near the Peripheral Site Affect the Stability of Torpedo Acetylcholinesterase - |
| Author(s) : Morel N , Bon S , Sussman JL , Massoulie J , Silman I |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :435 , 1998 |
| PubMedID: |
| Title : Membrane-Promoted Unfolding of Torpedo Californica and Bungarus Fasciatus Acetylcholinesterase - |
| Author(s) : Shin I , Silman I , Bon C , Weiner L |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :438 , 1998 |
| PubMedID: |
| Title : Assembly of Acetylcholinesterase Subunits in vitro - |
| Author(s) : Giles K , Ben-Yohanan R , Velan B , Shafferman A , Sussman JL , Silman I |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :442 , 1998 |
| PubMedID: |
| Title : The Conjunction of a Conserved Electrostatic Motif and a Common Cholinesterase Fold Defines a Class of Adhesion Proteins - |
| Author(s) : Botti SA , Felder CE , Sussman JL , Silman I |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :448 , 1998 |
| PubMedID: |
| Title : Quaternary Structure of Tetrameric Acetylcholinesterase - |
| Author(s) : Raves ML , Giles K , Schrag JD , Schmid MF , Phillips JN, Jr. , Chiu W , Howard AJ , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :351 , 1998 |
| PubMedID: |
| Gene_locus related to this paper: eleel-ACHE |
| Title : Expression and Tissue Distribution of Cholinesterases Via EST Analysis - |
| Author(s) : Giles K , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :450 , 1998 |
| PubMedID: |
| Title : Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase - |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :454 , 1998 |
| PubMedID: |
| Title : Kinetic and structural studies on the interaction of the anti-Alzheimer drug, ENA-713, with Torpedo californica acetylcholinesterase - |
| Author(s) : Bar-On P , Harel M , Millard CB , Enz A , Sussman JL , Silman I |
| Ref : Journal de Physiologie (Paris) , 92 :406 , 1998 |
| PubMedID: |
| Title : 3D Structure of a Complex of the Anti-Alzheimer Drug, E2020, with Acetylcholinesterase at 2.5 Resolution - |
| Author(s) : Kryger G , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :469 , 1998 |
| PubMedID: |
| Title : Electrotactins: a class of adhesion proteins with conserved electrostatic and structural motifs - Botti_1998_Protein.Eng_11_415 |
| Author(s) : Botti SA , Felder CE , Sussman JL , Silman I |
| Ref : Protein Engineering , 11 :415 , 1998 |
| Abstract : |
| PubMedSearch : Botti_1998_Protein.Eng_11_415 |
| PubMedID: 9725619 |
| Title : Acetylcholinesterase of S. mansoni (Trematode). Interaction of globular species with glycosaminoglycans - |
| Author(s) : Tarrab-Hazdai R , Silman I , Toker L , Schechtman D , Arnon R |
| Ref : Journal de Physiologie (Paris) , 92 :501 , 1998 |
| PubMedID: |
| Title : Electrostatic homology modelling of a set of ChE-like neural adhesion proteins identifies a shared annular motif with ChEs. Structural implications for a cell-recognition role of ChEs - |
| Author(s) : Botti SA , Felder CE , Sussman JL , Silman I |
| Ref : Journal de Physiologie (Paris) , 92 :414 , 1998 |
| PubMedID: |
| Title : An Integrated Model for the Molecular Traffic through the Active Site of Cholinesterases - |
| Author(s) : Botti SA , Felder CE , Lifson S , Sussman JL , Silman I |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :227 , 1998 |
| PubMedID: |
| Title : Activity of Torpedo Californica Acetylcholinesterase in the Crystalline State - |
| Author(s) : Nicolas A , Millard CB , Raves ML , Ravelli RB , Kroon J , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :230 , 1998 |
| PubMedID: |
| Title : Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica - Kryger_1998_J.Physiol.Paris_92_191 |
| Author(s) : Kryger G , Silman I , Sussman JL |
| Ref : Journal de Physiologie Paris , 92 :191 , 1998 |
| Abstract : |
| PubMedSearch : Kryger_1998_J.Physiol.Paris_92_191 |
| PubMedID: 9789806 |
| Title : Crystal structure of Aged phosphorylated and phosphonylated Torpedo Californica Acetylcholinesterase - |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
| Ref : In Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :425 , 1998 |
| PubMedID: |
| Gene_locus related to this paper: torca-ACHE |
| Title : Static laue diffraction studies on acetylcholinesterase - Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359 |
| Author(s) : Ravelli RB , Raves ML , Ren Z , Bourgeois D , Roth M , Kroon J , Silman I , Sussman JL |
| Ref : Acta Crystallographica D Biol Crystallogr , 54 :1359 , 1998 |
| Abstract : |
| PubMedSearch : Ravelli_1998_Acta.Crystallogr.D.Biol.Crystallogr_54_1359 |
| PubMedID: 10089512 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Liposome-catalyzed unfolding of acetylcholinesterase from Bungarus fasciatus - Shin_1998_Biochemistry_37_4310 |
| Author(s) : Shin I , Silman I , Bon C , Weiner L |
| Ref : Biochemistry , 37 :4310 , 1998 |
| Abstract : |
| PubMedSearch : Shin_1998_Biochemistry_37_4310 |
| PubMedID: 9556345 |
| Title : Membrane-promoted unfolding of acetylcholinesterase: a possible mechanism for insertion into the lipid bilayer - Shin_1997_Proc.Natl.Acad.Sci.U.S.A_94_2848 |
| Author(s) : Shin I , Kreimer DI , Silman I , Weiner L |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 94 :2848 , 1997 |
| Abstract : |
| PubMedSearch : Shin_1997_Proc.Natl.Acad.Sci.U.S.A_94_2848 |
| PubMedID: 9096309 |
| Title : Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A - Raves_1997_Nat.Struct.Biol_4_57 |
| Author(s) : Raves ML , Harel M , Pang YP , Silman I , Kozikowski AP , Sussman JL |
| Ref : Nat Struct Biol , 4 :57 , 1997 |
| Abstract : |
| PubMedSearch : Raves_1997_Nat.Struct.Biol_4_57 |
| PubMedID: 8989325 |
| Gene_locus related to this paper: torca-ACHE |
| Title : External and internal electrostatic potentials of cholinesterase models - Felder_1997_J.Mol.Graph.Model_15_318 |
| Author(s) : Felder CE , Botti SA , Lifson S , Silman I , Sussman JL |
| Ref : J Mol Graph Model , 15 :318 , 1997 |
| Abstract : |
| PubMedSearch : Felder_1997_J.Mol.Graph.Model_15_318 |
| PubMedID: 9640563 |
| Title : Two partially unfolded states of Torpedo californica acetylcholinesterase - Kreimer_1996_Protein.Sci_5_1852 |
| Author(s) : Kreimer DI , Shin I , Shnyrov VL , Villar E , Silman I , Weiner L |
| Ref : Protein Science , 5 :1852 , 1996 |
| Abstract : |
| PubMedSearch : Kreimer_1996_Protein.Sci_5_1852 |
| PubMedID: 8880909 |
| Title : Biochemical evaluation of photolabile precursors of choline and of carbamylcholine for potential time-resolved crystallographic studies on cholinesterases - Peng_1996_Biochemistry_35_10854 |
| Author(s) : Peng L , Silman I , Sussman JL , Goeldner M |
| Ref : Biochemistry , 35 :10854 , 1996 |
| Abstract : |
| PubMedSearch : Peng_1996_Biochemistry_35_10854 |
| PubMedID: 8718877 |
| Title : The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase. - |
| Author(s) : Harel M , Quinn DM , Nair HK , Silman I , Sussman JL |
| Ref : Journal of the American Chemical Society , 118 :2340 , 1996 |
| PubMedID: |
| Gene_locus related to this paper: torca-ACHE |
| Title : Interaction of partially unfolded forms of Torpedo acetylcholinesterase with liposomes - Shin_1996_Prot.Sci_5_42 |
| Author(s) : Shin I , Silman I , Weiner L |
| Ref : Protein Science , 5 :42 , 1996 |
| Abstract : |
| PubMedSearch : Shin_1996_Prot.Sci_5_42 |
| PubMedID: 8771195 |
| Title : Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function - Faerman_1996_FEBS.Lett_386_65 |
| Author(s) : Faerman C , Ripoll D , Bon S , Le Feuvre Y , Morel N , Massoulie J , Sussman JL , Silman I |
| Ref : FEBS Letters , 386 :65 , 1996 |
| Abstract : |
| PubMedSearch : Faerman_1996_FEBS.Lett_386_65 |
| PubMedID: 8635606 |
| Title : Electrooptical measurements demonstrate a large permanent dipole moment associated with acetylcholinesterase - Porschke_1996_Biophys.J_70_1603 |
| Author(s) : Porschke D , Creminon C , Cousin X , Bon C , Sussman JL , Silman I |
| Ref : Biophysical Journal , 70 :1603 , 1996 |
| Abstract : |
| PubMedSearch : Porschke_1996_Biophys.J_70_1603 |
| PubMedID: 8785319 |
| Title : Irreversible thermal denaturation of Torpedo californica acetylcholinesterase - Kreimer_1995_Prot.Sci_4_2349 |
| Author(s) : Kreimer DI , Shnyrov VL , Villar E , Silman I , Weiner L |
| Ref : Protein Science , 4 :2349 , 1995 |
| Abstract : |
| PubMedSearch : Kreimer_1995_Prot.Sci_4_2349 |
| PubMedID: 8563632 |
| Title : Structures of Complexes of Acetylcholinesterase with Covalently and Non-Covalently Bound Inhibitors - |
| Author(s) : Sussman JL , Harel M , Raves ML , Quinn DM , Nair HK , Silman I |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :59 , 1995 |
| PubMedID: |
| Title : Electrostatic Properties of Human Acetylcholinesterase - |
| Author(s) : Ripoll DR , Faerman CH , Gillilan R , Silman I , Sussman JL |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :67 , 1995 |
| PubMedID: |
| Title : Studies on Partially Unfolded States of Torpedo californica Acetylcholinesterase - |
| Author(s) : Silman I , Kreimer DI , Shin I , Dolginova EA , Roth E , Goldfarb D , Szosenfogel R , Raves ML , Sussman JL , Borochov N , Weiner L |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :77 , 1995 |
| PubMedID: |
| Title : The activity of an endoplasmic reticulum-localized pool of acetylcholinesterase is modulated by heat shock - Eichler_1995_J.Biol.Chem_270_4466 |
| Author(s) : Eichler J , Silman I |
| Ref : Journal of Biological Chemistry , 270 :4466 , 1995 |
| Abstract : |
| PubMedSearch : Eichler_1995_J.Biol.Chem_270_4466 |
| PubMedID: 7876213 |
| Title : Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target - Harel_1995_Structure_3_1355 |
| Author(s) : Harel M , Kleywegt GJ , Ravelli RB , Silman I , Sussman JL |
| Ref : Structure , 3 :1355 , 1995 |
| Abstract : |
| PubMedSearch : Harel_1995_Structure_3_1355 |
| PubMedID: 8747462 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Oxidative stress transforms acetylcholinesterase to a molten-globule-like state - Weiner_1994_Biochem.Biophys.Res.Commun_198_915 |
| Author(s) : Weiner L , Kreimer D , Roth E , Silman I |
| Ref : Biochemical & Biophysical Research Communications , 198 :915 , 1994 |
| Abstract : |
| PubMedSearch : Weiner_1994_Biochem.Biophys.Res.Commun_198_915 |
| PubMedID: 8117296 |
| Title : Novel GPI structures of the membrane anchor of acetylcholinesterase from the electric organ of Torpedo californica - Mehlert_1994_Brazilian.J.Med.Biol.Res_27_243 |
| Author(s) : Mehlert A , Varon L , Silman I , Homans SW , Ferguson MA |
| Ref : Brazilian Journal of Medical & Biological Research , 27 :243 , 1994 |
| Abstract : |
| PubMedSearch : Mehlert_1994_Brazilian.J.Med.Biol.Res_27_243 |
| PubMedID: 8081237 |
| Title : Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography - Axelsen_1994_Prot.Sci_3_188 |
| Author(s) : Axelsen PH , Harel M , Silman I , Sussman JL |
| Ref : Protein Science , 3 :188 , 1994 |
| Abstract : |
| PubMedSearch : Axelsen_1994_Prot.Sci_3_188 |
| PubMedID: 8003956 |
| Title : Open back door in a molecular dynamics simulation of acetylcholinesterase - Gilson_1994_Science_263_1276 |
| Author(s) : Gilson MK , Straatsma TP , McCammon JA , Ripoll DR , Faerman CH , Axelsen PH , Silman I , Sussman JL |
| Ref : Science , 263 :1276 , 1994 |
| Abstract : |
| PubMedSearch : Gilson_1994_Science_263_1276 |
| PubMedID: 8122110 |
| Title : Three-dimensional structures of acetylcholinesterase and of its complexes with anticholinesterase agents - |
| Author(s) : Silman I , Harel M , Axelsen PH , Raves ML , Sussman JL |
| Ref : Biochemical Society Transactions , 22 :745 , 1994 |
| PubMedID: 7821677 |
| Title : A molten globule of Torpedo acetylcholinesterase undergoes thiol-disulfide exchange - Eichler_1994_J.Biol.Chem_269_30093 |
| Author(s) : Eichler J , Kreimer DI , Varon L , Silman I , Weiner L |
| Ref : Journal of Biological Chemistry , 269 :30093 , 1994 |
| Abstract : |
| PubMedSearch : Eichler_1994_J.Biol.Chem_269_30093 |
| PubMedID: 7982909 |
| Title : Two-state transition between molten globule and unfolded states of acetylcholinesterase as monitored by electron paramagnetic resonance spectroscopy - Kreimer_1994_Proc.Natl.Acad.Sci.U.S.A_91_12145 |
| Author(s) : Kreimer DI , Szosenfogel R , Goldfarb D , Silman I , Weiner L |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :12145 , 1994 |
| Abstract : |
| PubMedSearch : Kreimer_1994_Proc.Natl.Acad.Sci.U.S.A_91_12145 |
| PubMedID: 7991597 |
| Title : Differential effects of peripheral site ligands on Torpedo and chicken acetylcholinesterase - Eichler_1994_Mol.Pharmacol_45_335 |
| Author(s) : Eichler J , Anselmet A , Sussman JL , Massoulie J , Silman I |
| Ref : Molecular Pharmacology , 45 :335 , 1994 |
| Abstract : |
| PubMedSearch : Eichler_1994_Mol.Pharmacol_45_335 |
| PubMedID: 8114681 |
| Title : A metastable state of Torpedo californica acetylcholinesterase generated by modification with organomercurials - Kreimer_1994_Biochemistry_33_14407 |
| Author(s) : Kreimer DI , Dolginova EA , Raves ML , Sussman JL , Silman I , Weiner L |
| Ref : Biochemistry , 33 :14407 , 1994 |
| Abstract : |
| PubMedSearch : Kreimer_1994_Biochemistry_33_14407 |
| PubMedID: 7981200 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica - Mehlert_1993_Biochem.J_296_473 |
| Author(s) : Mehlert A , Varon L , Silman I , Homans SW , Ferguson MA |
| Ref : Biochemical Journal , 296 :473 , 1993 |
| Abstract : |
| PubMedSearch : Mehlert_1993_Biochem.J_296_473 |
| PubMedID: 8257440 |
| Title : Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins - Cygler_1993_Protein.Sci_2_366 |
| Author(s) : Cygler M , Schrag JD , Sussman JL , Harel M , Silman I , Gentry MK , Doctor BP |
| Ref : Protein Science , 2 :366 , 1993 |
| Abstract : |
| PubMedSearch : Cygler_1993_Protein.Sci_2_366 |
| PubMedID: 8453375 |
| Title : Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs - Sussman_1993_Chem.Biol.Interact_87_187 |
| Author(s) : Sussman JL , Harel M , Silman I |
| Ref : Chemico-Biological Interactions , 87 :187 , 1993 |
| Abstract : |
| PubMedSearch : Sussman_1993_Chem.Biol.Interact_87_187 |
| PubMedID: 8343975 |
| Title : Structure and functions of acetylcholinesterase and butyrylcholinesterase - |
| Author(s) : Massoulie J , Sussman JL , Bon S , Silman I |
| Ref : Prog Brain Res , 98 :139 , 1993 |
| PubMedID: 8248501 |
| Title : Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase - Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 |
| Author(s) : Harel M , Schalk I , Ehret-Sabatier L , Bouet F , Goeldner M , Hirth C , Axelsen PH , Silman I , Sussman JL |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 90 :9031 , 1993 |
| Abstract : |
| PubMedSearch : Harel_1993_Proc.Natl.Acad.Sci.U.S.A_90_9031 |
| PubMedID: 8415649 |
| Gene_locus related to this paper: torca-ACHE |
| Title : An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase - Ripoll_1993_Proc.Natl.Acad.Sci.U.S.A_90_5128 |
| Author(s) : Ripoll DR , Faerman CH , Axelsen PH , Silman I , Sussman JL |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 90 :5128 , 1993 |
| Abstract : |
| PubMedSearch : Ripoll_1993_Proc.Natl.Acad.Sci.U.S.A_90_5128 |
| PubMedID: 8506359 |
| Title : The structure of the glycosylphosphatidylinositol anchor from Torpedo californica acetylcholinesterase - |
| Author(s) : Mehlert A , Silman I , Homans SW , Ferguson MA |
| Ref : Biochemical Society Transactions , 21 , 1993 |
| PubMedID: 8449327 |
| Title : Site-directed mutagenesis of active-site-related residues in Torpedo acetylcholinesterase. Presence of a glutamic acid in the catalytic triad - Duval_1992_FEBS.Lett_309_421 |
| Author(s) : Duval N , Bon S , Silman I , Sussman JL , Massoulie J |
| Ref : FEBS Letters , 309 :421 , 1992 |
| Abstract : |
| PubMedSearch : Duval_1992_FEBS.Lett_309_421 |
| PubMedID: 1355448 |
| Title : Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis - Harel_1992_Proc.Natl.Acad.Sci.U.S.A_89_10827 |
| Author(s) : Harel M , Sussman JL , Krejci E , Bon S , Chanal P , Massoulie J , Silman I |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 89 :10827 , 1992 |
| Abstract : |
| PubMedSearch : Harel_1992_Proc.Natl.Acad.Sci.U.S.A_89_10827 |
| PubMedID: 1438284 |
| Title : The alpha\/beta hydrolase fold - Ollis_1992_Prot.Engin_5_197 |
| Author(s) : Ollis DL , Cheah E , Cygler M , Dijkstra B , Frolow F , Franken SM , Harel M , Remington SJ , Silman I , Schrag JD , Sussman JL , Verschueren KHG , Goldman A |
| Ref : Protein Engineering , 5 :197 , 1992 |
| Abstract : |
| PubMedSearch : Ollis_1992_Prot.Engin_5_197 |
| PubMedID: 1409539 |
| Title : G2-acetylcholinesterase is presynaptically localized in Torpedo electric organ - Eichler_1992_J.Neurocytol_21_707 |
| Author(s) : Eichler J , Silman I , Anglister L |
| Ref : Journal of Neurocytology , 21 :707 , 1992 |
| Abstract : |
| PubMedSearch : Eichler_1992_J.Neurocytol_21_707 |
| PubMedID: 1331340 |
| Title : Chemical modification of Torpedo acetylcholinesterase by disulfides: appearance of a molten globule state - Dolginova_1992_Biochemistry_31_12248 |
| Author(s) : Dolginova EA , Roth E , Silman I , Weiner L |
| Ref : Biochemistry , 31 :12248 , 1992 |
| Abstract : |
| PubMedSearch : Dolginova_1992_Biochemistry_31_12248 |
| PubMedID: 1333796 |
| Title : Site-Directed Mutagenesis of Functional Residues in Torpedo Acetylcholinesterase - |
| Author(s) : Silman I , Krejci E , Duval N |
| Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :177 , 1992 |
| PubMedID: |
| Title : Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding - Shafferman_1992_J.Biol.Chem_267_17640 |
| Author(s) : Shafferman A , Kronman C , Flashner Y , Leitner M , Grosfeld H , Ordentlich A , Gozes Y , Cohen S , Ariel N , Barak D , Harel M , Silman I , Sussman JL , Velan B |
| Ref : Journal of Biological Chemistry , 267 :17640 , 1992 |
| Abstract : |
| PubMedSearch : Shafferman_1992_J.Biol.Chem_267_17640 |
| PubMedID: 1517212 |
| Title : Three Dimensional Structure of Acetylcholinesterase - |
| Author(s) : Sussman JL , Harel M , Silman I |
| Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :95 , 1992 |
| PubMedID: |
| Title : A Model of Butyrylcholinesterase Based on the X-Ray Structure of Acetylcholinesterase Indicates Differences in Specificity - |
| Author(s) : Harel M , Silman I , Sussman JL |
| Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :189 , 1992 |
| PubMedID: |
| Title : Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein - Sussman_1991_Science_253_872 |
| Author(s) : Sussman JL , Harel M , Frolow F , Oefner C , Goldman A , Toker L , Silman I |
| Ref : Science , 253 :872 , 1991 |
| Abstract : |
| PubMedSearch : Sussman_1991_Science_253_872 |
| PubMedID: 1678899 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Poster: Physicochemical and crystallographic studies on the stability and structure of aged and nonaged organophosphoryl conjugates of chymotrypsin - |
| Author(s) : Su CT , Steinberg N , Silman I , Harel M , Sussman JL , Grunwald J , Ashani Y |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :274 , 1991 |
| PubMedID: |
| Title : Refined crystal structures of aged and non-aged organophosphoryl conjugates of gamma-chymotrypsin - Harel_1991_J.Mol.Biol_221_909 |
| Author(s) : Harel M , Su CT , Frolow F , Ashani Y , Silman I , Sussman JL |
| Ref : Journal of Molecular Biology , 221 :909 , 1991 |
| Abstract : |
| PubMedSearch : Harel_1991_J.Mol.Biol_221_909 |
| PubMedID: 1942036 |
| Title : Phosphatidylinositol-specific phospholipase C induces biosynthesis of acetylcholinesterase via diacylglycerol in Schistosoma mansoni - Espinoza_1991_Eur.J.Biochem_195_863 |
| Author(s) : Espinoza B , Silman I , Arnon R , Tarrab-Hazdai R |
| Ref : European Journal of Biochemistry , 195 :863 , 1991 |
| Abstract : |
| PubMedSearch : Espinoza_1991_Eur.J.Biochem_195_863 |
| PubMedID: 1847873 |
| Title : Poster: Effects of exposure to PIPL-C on AChE activity of Schistosoma mansoni - |
| Author(s) : Espinoza B , Silman I , Arnon R , Tarrab-Hazdai R |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :50 , 1991 |
| PubMedID: |
| Title : Effect of heat shock on acetylcholinesterase activity in chick muscle cultures - Eichler_1991_FEBS.Lett_293_16 |
| Author(s) : Eichler J , Toker L , Silman I |
| Ref : FEBS Letters , 293 :16 , 1991 |
| Abstract : |
| PubMedSearch : Eichler_1991_FEBS.Lett_293_16 |
| PubMedID: 1959652 |
| Title : Poster: Immunocytochemical localization of phosphatidylinositol-anchored acetylcholinesterase in excitable membranes of Torpedo ocellata - |
| Author(s) : Eichler J , Silman I , Gentry MK , Anglister L |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :49 , 1991 |
| PubMedID: |
| Title : Structural Studies on Acetylcholinesterase from Torpedo californica - |
| Author(s) : Sussman JL , Harel M , Frolow F , Oefner C , Toker L , Silman I |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :7 , 1991 |
| PubMedID: |
| Title : Immunocytochemical localization of phosphatidylinositol-anchored acetylcholinesterase in excitable membranes of Torpedo ocellata - Eichler_1990_Brain.Res.Molecular.Brain.Research_8_213 |
| Author(s) : Eichler J , Silman I , Gentry MK , Anglister L |
| Ref : Brain Research Mol Brain Res , 8 :213 , 1990 |
| Abstract : |
| PubMedSearch : Eichler_1990_Brain.Res.Molecular.Brain.Research_8_213 |
| PubMedID: 2170799 |
| Title : Torpedo acetylcholinesterase is inactivated by thiol reagents - Steinberg_1990_Biochem.Int_21_1043 |
| Author(s) : Steinberg N , Roth E , Silman I |
| Ref : Biochemistry International , 21 :1043 , 1990 |
| Abstract : |
| PubMedSearch : Steinberg_1990_Biochem.Int_21_1043 |
| PubMedID: 1964378 |
| Title : Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin - |
| Author(s) : Steinberg N , Grunwald J , Roth E , August R , Haas E , Ashani Y , Silman I |
| Ref : Prog Clin Biol Res , 289 :293 , 1989 |
| PubMedID: 2726802 |
| Title : Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy - Steinberg_1989_Biochemistry_28_1248 |
| Author(s) : Steinberg N , van der Drift AC , Grunwald J , Segall Y , Shirin E , Haas E , Ashani Y , Silman I |
| Ref : Biochemistry , 28 :1248 , 1989 |
| Abstract : |
| PubMedSearch : Steinberg_1989_Biochemistry_28_1248 |
| PubMedID: 2713362 |
| Title : Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C - Sussman_1988_J.Mol.Biol_203_821 |
| Author(s) : Sussman JL , Harel M , Frolow F , Varon L , Toker L , Futerman AH , Silman I |
| Ref : Journal of Molecular Biology , 203 :821 , 1988 |
| Abstract : |
| PubMedSearch : Sussman_1988_J.Mol.Biol_203_821 |
| PubMedID: 2850366 |
| Title : Visualization of collagenase-sensitive acetylcholinesterase in isolated cardiomyocytes and in heart tissue - Eghbali_1988_Cell.Tiss.Res_253_281 |
| Author(s) : Eghbali M , Silman I , Robinson TF , Seifter S |
| Ref : Cell & Tissue Research , 253 :281 , 1988 |
| Abstract : |
| PubMedSearch : Eghbali_1988_Cell.Tiss.Res_253_281 |
| PubMedID: 2842053 |
| Title : Acetylcholinesterase in Schistosoma mansoni is anchored to the membrane via covalently attached phosphatidylinositol - Espinoza_1988_Mol.Biochem.Parasitol_29_171 |
| Author(s) : Espinoza B , Tarrab-Hazdai R , Silman I , Arnon R |
| Ref : Molecular & Biochemical Parasitology , 29 :171 , 1988 |
| Abstract : |
| PubMedSearch : Espinoza_1988_Mol.Biochem.Parasitol_29_171 |
| PubMedID: 3137466 |
| Title : A membrane-associated dimer of acetylcholinesterase from Xenopus skeletal muscle is solubilized by phosphatidylinositol-specific phospholipase C - Inestrosa_1988_Neurosci.Lett_90_186 |
| Author(s) : Inestrosa NC , Fuentes ME , Anglister L , Futerman AH , Silman I |
| Ref : Neuroscience Letters , 90 :186 , 1988 |
| Abstract : |
| PubMedSearch : Inestrosa_1988_Neurosci.Lett_90_186 |
| PubMedID: 3412641 |
| Title : Posttranslational modification as a means of anchoring acetylcholinesterase to the cell surface - |
| Author(s) : Silman I , Futerman AH |
| Ref : Biopolymers , 26 :S241 , 1987 |
| PubMedID: 3555636 |
| Title : Removal of covalently bound inositol from Torpedo acetylcholinesterase and mammalian alkaline phosphatases by deamination with nitrous acid. Evidence for a common membrane-anchoring structure - Low_1987_Biochem.J_241_615 |
| Author(s) : Low MG , Futerman AH , Ackermann KE , Sherman WR , Silman I |
| Ref : Biochemical Journal , 241 :615 , 1987 |
| Abstract : |
| PubMedSearch : Low_1987_Biochem.J_241_615 |
| PubMedID: 3593210 |
| Title : Differential susceptibility to phosphatidylinositol-specific phospholipase C of acetylcholinesterase in excitable tissues of embryonic and adult Torpedo ocellata - Futerman_1987_Brain.Res_388_105 |
| Author(s) : Futerman AH , Raviv D , Michaelson DM , Silman I |
| Ref : Brain Research , 388 :105 , 1987 |
| Abstract : |
| PubMedSearch : Futerman_1987_Brain.Res_388_105 |
| PubMedID: 3040164 |
| Title : Modes of attachment of acetylcholinesterase to the surface membrane. - Silman_1987_Eur.J.Biochem_170_11 |
| Author(s) : Silman I , Futerman AH |
| Ref : European Journal of Biochemistry , 170 :11 , 1987 |
| Abstract : |
| PubMedSearch : Silman_1987_Eur.J.Biochem_170_11 |
| PubMedID: 3319614 |
| Title : Microtiter assay for acetylcholinesterase - Doctor_1987_Anal.Biochem_166_399 |
| Author(s) : Doctor BP , Toker L , Roth E , Silman I |
| Ref : Analytical Biochemistry , 166 :399 , 1987 |
| Abstract : |
| PubMedSearch : Doctor_1987_Anal.Biochem_166_399 |
| PubMedID: 3434781 |
| Title : Acetylcholinesterase of Schistosoma mansoni: purification and characterization - Goldlust_1986_J.Neurosci.Res_15_569 |
| Author(s) : Goldlust A , Arnon R , Silman I , Tarrab-Hazdai R |
| Ref : Journal of Neuroscience Research , 15 :569 , 1986 |
| Abstract : |
| PubMedSearch : Goldlust_1986_J.Neurosci.Res_15_569 |
| PubMedID: 3723610 |
| Title : Physicochemical behaviour and structural characteristics of membrane-bound acetylcholinesterase from Torpedo electric organ. Effect of phosphatidylinositol-specific phospholipase C - Futerman_1985_Biochem.J_226_369 |
| Author(s) : Futerman AH , Fiorini RM , Roth E , Low MG , Silman I |
| Ref : Biochemical Journal , 226 :369 , 1985 |
| Abstract : |
| PubMedSearch : Futerman_1985_Biochem.J_226_369 |
| PubMedID: 2986594 |
| Title : Identification of covalently bound inositol in the hydrophobic membrane-anchoring domain of Torpedo acetylcholinesterase - Futerman_1985_Biochem.Biophys.Res.Commun_129_312 |
| Author(s) : Futerman AH , Low MG , Ackermann KE , Sherman WR , Silman I |
| Ref : Biochemical & Biophysical Research Communications , 129 :312 , 1985 |
| Abstract : |
| PubMedSearch : Futerman_1985_Biochem.Biophys.Res.Commun_129_312 |
| PubMedID: 4004881 |
| Title : Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C - Futerman_1985_J.Neurochem_45_1487 |
| Author(s) : Futerman AH , Low MG , Michaelson DM , Silman I |
| Ref : Journal of Neurochemistry , 45 :1487 , 1985 |
| Abstract : |
| PubMedSearch : Futerman_1985_J.Neurochem_45_1487 |
| PubMedID: 4045459 |
| Title : Arrhenius plots of acetylcholinesterase activity in mammalian erythrocytes and in Torpedo electric organ. Effect of solubilization by proteinases and by a phosphatidylinositol-specific phospholipase C - Barton_1985_Biochem.J_231_237 |
| Author(s) : Barton PL , Futerman AH , Silman I |
| Ref : Biochemical Journal , 231 :237 , 1985 |
| Abstract : |
| PubMedSearch : Barton_1985_Biochem.J_231_237 |
| PubMedID: 3904734 |
| Title : Butyrylcholinesterase: inhibition by arsenite, fluoride, and other ligands, cooperativity in binding - Page_1985_Mol.Pharmacol_27_437 |
| Author(s) : Page JD , Wilson IB , Silman I |
| Ref : Molecular Pharmacology , 27 :437 , 1985 |
| Abstract : |
| PubMedSearch : Page_1985_Mol.Pharmacol_27_437 |
| PubMedID: 3982389 |
| Title : Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C: enzymatic and physicochemical studies - |
| Author(s) : Futerman AH , Fiorini RM , Roth E , Michaelson DM , Low MG , Silman I |
| Ref : In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases , (Brzin M, Barnard EA, Sket D, Eds) De Gruyter :99 , 1984 |
| PubMedID: |
| Title : Ontogenic and agranulation-induced alterations in cholinesterases and in cholinesterase mRNA in the rodent cerebellum - |
| Author(s) : Parvari R , Silman I , Soreq H |
| Ref : In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases , (Brzin M, Barnard EA, Sket D, Eds) De Gruyter :219 , 1984 |
| PubMedID: |
| Title : Poster 9. Solubilisation of acetylchoinesterase from Torpedo electric organ by a phosphatidylinositol-specific phospholipase C - |
| Author(s) : Futerman AH , Low MG , Silman I |
| Ref : In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases , (Brzin M, Barnard EA, Sket D, Eds) De Gruyter , 1984 |
| PubMedID: |
| Title : Poster 19. Molecular forms of the cholinesterases Inside and outside endplates in. slow-tonic chicken muscle fibers - |
| Author(s) : Jedrzejczyk J , Silman I , Barnard EA |
| Ref : In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases , (Brzin M, Barnard EA, Sket D, Eds) De Gruyter , 1984 |
| PubMedID: |
| Title : Characterization of activities and forms of cholinesterases in human primary brain tumors - Razon_1984_Exp.Neurol_84_681 |
| Author(s) : Razon N , Soreq H , Roth E , Bartal A , Silman I |
| Ref : Experimental Neurology , 84 :681 , 1984 |
| Abstract : |
| PubMedSearch : Razon_1984_Exp.Neurol_84_681 |
| PubMedID: 6723888 |
| Title : Molecular forms of acetylcholinesterase in synaptic and extrasynaptic regions of avian tonic muscle - Jedrzejczyk_1984_Neurosci.Lett_46_283 |
| Author(s) : Jedrzejczyk J , Silman I , Lai J , Barnard EA |
| Ref : Neuroscience Letters , 46 :283 , 1984 |
| Abstract : |
| PubMedSearch : Jedrzejczyk_1984_Neurosci.Lett_46_283 |
| PubMedID: 6738921 |
| Title : A hydrophobic dimer of acetylcholinesterase from Torpedo californica electric organ is solubilized by phosphatidylinositol-specific phospholipase C - Futerman_1983_Neurosci.Lett_40_85 |
| Author(s) : Futerman AH , Low MG , Silman I |
| Ref : Neuroscience Letters , 40 :85 , 1983 |
| Abstract : |
| PubMedSearch : Futerman_1983_Neurosci.Lett_40_85 |
| PubMedID: 6633970 |
| Title : Molecular forms of acetylcholinesterase and pseudocholinesterase in chicken skeletal muscles: their distribution and change with muscular dystrophy - Barnard_1982_Rep.Nutr.Dev_22_261 |
| Author(s) : Barnard EA , Lyles JM , Silman I , Jedrzejczyk J , Barnard PJ |
| Ref : Reproduction, Nutrition, Developpement , 22 :261 , 1982 |
| Abstract : |
| PubMedSearch : Barnard_1982_Rep.Nutr.Dev_22_261 |
| PubMedID: 7156481 |
| Title : Comparison of the molecular forms of the cholinesterases in tissues of normal and dystrophic chickens - Lyles_1982_J.Neurochem_38_1007 |
| Author(s) : Lyles JM , Silman I , Di Giamberardino L , Couraud JY , Barnard EA |
| Ref : Journal of Neurochemistry , 38 :1007 , 1982 |
| Abstract : |
| PubMedSearch : Lyles_1982_J.Neurochem_38_1007 |
| PubMedID: 7062026 |
| Title : Biosynthesis and secretion of catalytically active acetylcholinesterase in Xenopus oocytes microinjected with mRNA from rat brain and from Torpedo electric organ - Soreq_1982_Proc.Natl.Acad.Sci.U.S.A_79_830 |
| Author(s) : Soreq H , Parvari R , Silman I |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 79 :830 , 1982 |
| Abstract : |
| PubMedSearch : Soreq_1982_Proc.Natl.Acad.Sci.U.S.A_79_830 |
| PubMedID: 6950429 |
| Title : In vivo modulation of the number of muscarinic receptors in rat brain by cholinergic ligands - Ben-Barak_1981_Eur.J.Pharmacol_74_73 |
| Author(s) : Ben-Barak J , Gazit H , Silman I , Dudai Y |
| Ref : European Journal of Pharmacology , 74 :73 , 1981 |
| Abstract : |
| PubMedSearch : Ben-Barak_1981_Eur.J.Pharmacol_74_73 |
| PubMedID: 7318895 |
| Title : Molecular forms of the cholinesterases inside and outside muscle endplates - Jedrzejczyk_1981_Biosci.Rep_1_45 |
| Author(s) : Jedrzejczyk J , Silman I , Lyles JM , Barnard EA |
| Ref : Bioscience Reports , 1 :45 , 1981 |
| Abstract : |
| PubMedSearch : Jedrzejczyk_1981_Biosci.Rep_1_45 |
| PubMedID: 7284574 |
| Title : New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase - Amitai_1980_Neurochem.Int_2C_199 |
| Author(s) : Amitai G , Ashani Y , Gafni A , Silman I |
| Ref : Neurochem Int , 2C :199 , 1980 |
| Abstract : |
| PubMedSearch : Amitai_1980_Neurochem.Int_2C_199 |
| PubMedID: 20487784 |
| Title : Changes in the levels and forms of cholinesterases in the blood plasma of normal and dystrophic chickens - |
| Author(s) : Lyles JM , Barnard EA , Silman I |
| Ref : Journal of Neurochemistry , 34 :978 , 1980 |
| PubMedID: 7359144 |
| Title : Electric eel acetylcholinesterase: a multisubunit enzyme containing a collagen tail - Silman_1980_Monogr.Neural.Sci_7_55 |
| Author(s) : Silman I , Anglister L |
| Ref : Monographs in Neural Sciences , 7 :55 , 1980 |
| Abstract : |
| PubMedSearch : Silman_1980_Monogr.Neural.Sci_7_55 |
| PubMedID: 6262636 |
| Title : Fluorescent organophosphates: novel probes for studying aging-induced conformational changes in inhibited acetylcholinesterase and for localization of cholinesterase in nervous tissue - Amitai_1980_Monogr.Neural.Sci_7_70 |
| Author(s) : Amitai G , Ashani Y , Shahar A , Gafni A , Silman I |
| Ref : Monographs in Neural Sciences , 7 :70 , 1980 |
| Abstract : |
| PubMedSearch : Amitai_1980_Monogr.Neural.Sci_7_70 |
| PubMedID: 7015117 |
| Title : The induction of ion channels through excitable membranes by acetylcholinesterase - |
| Author(s) : Kaufmann K , Silman I |
| Ref : Naturwissenschaften , 67 :608 , 1980 |
| PubMedID: 6262662 |
| Title : Developmental changes in levels and forms of cholinesterases in muscles of normal and dystrophic chickens - |
| Author(s) : Lyles JM , Silman I , Barnard EA |
| Ref : Journal of Neurochemistry , 33 :727 , 1979 |
| PubMedID: 479887 |
| Title : Parallel regulation of acetylcholinesterase and pseudocholinesterase in normal, denervated and dystrophic chicken skeletal muscle - |
| Author(s) : Silman I , Di Giamberardino L , Lyles L , Couraud JY , Barnard EA |
| Ref : Nature , 280 :160 , 1979 |
| PubMedID: 552605 |
| Title : Immunological cross-reactivity between electric-eel acetylcholinesterase and rat-tail-tendon collagen - Anglister_1979_Eur.J.Biochem_94_25 |
| Author(s) : Anglister L , Tarrab-Hazdai R , Fuchs S , Silman I |
| Ref : European Journal of Biochemistry , 94 :25 , 1979 |
| Abstract : |
| PubMedSearch : Anglister_1979_Eur.J.Biochem_94_25 |
| PubMedID: 436842 |
| Title : Inactivation of electric eel acetylcholinesterase by acylation with N-hydroxysuccinimide esters of amino acid derivatives - |
| Author(s) : Blumberg S , Silman I |
| Ref : Biochemistry , 17 :1125 , 1978 |
| PubMedID: 629951 |
| Title : Intrinsic forms of acetylcholinesterase in skeletal muscle - |
| Author(s) : Silman I , Lyles JM , Barnard EA |
| Ref : FEBS Letters , 94 :166 , 1978 |
| PubMedID: 700129 |
| Title : Molecular structure of elongated forms of electric eel acetylcholinesterase - |
| Author(s) : Anglister L , Silman I |
| Ref : Journal of Molecular Biology , 125 :293 , 1978 |
| PubMedID: 215774 |
| Title : Effects of quaternary ligands on the inhibition of acetylcholinesterase by arsenite - Wilson_1977_Biochemistry_16_2701 |
| Author(s) : Wilson IB , Silman I |
| Ref : Biochemistry , 16 :2701 , 1977 |
| Abstract : |
| PubMedSearch : Wilson_1977_Biochemistry_16_2701 |
| PubMedID: 19036 |
| Title : Characterization of membranes obtained from electric organ of the electric eel by sucrose gradient fractionation and by microdissection - |
| Author(s) : Rosenberg P , Silman I , Ben-David E , De Vries A , Condrea E |
| Ref : Journal of Neurochemistry , 29 :561 , 1977 |
| PubMedID: 142822 |
| Title : Detection of hydroxyproline in preparations of acetylcholinesterase from the electric organ of the electric eel - |
| Author(s) : Anglister L , Rogozinski S , Silman I |
| Ref : FEBS Letters , 69 :129 , 1976 |
| PubMedID: 992021 |
| Title : Appearance and disappearance of acetycholine receptor during differentiation of chick skeletal muscle in vitro - Prives_1976_Cell_7_543 |
| Author(s) : Prives J , Silman I , Amsterdam A |
| Ref : Cell , 7 :543 , 1976 |
| Abstract : |
| PubMedSearch : Prives_1976_Cell_7_543 |
| PubMedID: 954086 |
| Title : Proceedings: Thymus, acetylcholine receptor and myasthenia gravis - |
| Author(s) : Aharonov A , Tarrab-Hazdai R , Abramsky O , Silman I , Fuchs S |
| Ref : Isr J Med Sci , 11 :1390 , 1975 |
| PubMedID: 1218989 |
| Title : Proceedings: A water-soluble acetylcholine receptor fraction from electric organ tissue of the electric eel Electrophorus electricus - |
| Author(s) : Kalderon N , Silman I |
| Ref : Isr J Med Sci , 11 :1192 , 1975 |
| PubMedID: 1205776 |
| Title : Proceedings: Appearance and disappearance of acetylcholine receptor during differentiation of embryonic chick skeletal muscle in vitro - |
| Author(s) : Prives J , Silman I , Amsterdam A |
| Ref : Isr J Med Sci , 11 :1192 , 1975 |
| PubMedID: 1205775 |
| Title : General discussion on models for the ligand binding sites of cholinesterase - |
| Author(s) : Reiner E , Aldridge WN , Hopff WH , Taylor P , Krupka RM , Rosenberry TL , Augustinsson KB , Mooser G , O'Brien RD , Brodbeck U , Massoulie J , Maricic S , Eldefrawi ME , Silman I |
| Ref : Croatica Chemica Acta , 47 :499 , 1975 |
| PubMedID: |
| Title : Proceedings: Animal model for myasthenia gravis: acetylcholine receptor-induced myasthenia in rabbits, guinea pigs and monkeys - |
| Author(s) : Tarrab-Hazdai R , Aharonov A , Abramsky O , Silman I , Fuchs S |
| Ref : Isr J Med Sci , 11 :1390 , 1975 |
| PubMedID: 815200 |
| Title : Effect of cholinesterase inhibitors on active potassium influx in monkey erythrocytes - |
| Author(s) : Giberman E , Silman I , Edery H |
| Ref : Biochemical Pharmacology , 22 :271 , 1973 |
| PubMedID: 4202811 |
| Title : Spectral evidence for the presence of tryptophan in the binding site of acetylcholinesterase - |
| Author(s) : Shinitzky M , Dudai Y , Silman I |
| Ref : FEBS Letters , 30 :125 , 1973 |
| PubMedID: 11947075 |
| Title : Molecular structures of acetylcholinesterase from electric organ tissue of the electric eel - Dudai_1973_Proc.Natl.Acad.Sci.U.S.A_70_2473 |
| Author(s) : Dudai Y , Herzberg M , Silman I |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 70 :2473 , 1973 |
| Abstract : |
| PubMedSearch : Dudai_1973_Proc.Natl.Acad.Sci.U.S.A_70_2473 |
| PubMedID: 4517659 |
| Title : Purification by affinity chromatography of acetylcholinesterase from electric organ tissue of the electric eel subsequent to tryptic treatment - |
| Author(s) : Dudai Y , Silman I , Kalderon N , Blumberg S |
| Ref : Biochimica & Biophysica Acta , 268 :138 , 1972 |
| PubMedID: 5018273 |
| Title : Purification by affinity chromatography of the molecular forms of acetylcholinesterase present in fresh electric-organ tissue of electric eel - Dudai_1972_Proc.Natl.Acad.Sci.U.S.A_69_2400 |
| Author(s) : Dudai Y , Silman I , Shinitzky M , Blumberg S |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 69 :2400 , 1972 |
| Abstract : |
| PubMedSearch : Dudai_1972_Proc.Natl.Acad.Sci.U.S.A_69_2400 |
| PubMedID: 4506759 |
| Title : A method for the purification of acetylcholinesterase by affinity chromatography - |
| Author(s) : Kalderon N , Silman I , Blumberg S , Dudai Y |
| Ref : Biochimica & Biophysica Acta , 207 :560 , 1970 |
| PubMedID: 5452681 |
| Title : Acetylcholine receptor: covalent attachment of depolarizing groups at the active site - Silman_1969_Science_164_1420 |
| Author(s) : Silman I , Karlin A |
| Ref : Science , 164 :1420 , 1969 |
| Abstract : |
| PubMedSearch : Silman_1969_Science_164_1420 |
| PubMedID: 5783718 |
| Title : Water-insoluble derivatives of enzymes, antigens, and antibodies - |
| Author(s) : Silman I , Katchalski E |
| Ref : Annual Review of Biochemistry , 35 :873 , 1966 |
| PubMedID: 5329475 |
| Title : Some water-insoluble papain derivatives - |
| Author(s) : Silman I , Albu-Weissenberg M , Katchalski E |
| Ref : Biopolymers , 4 :441 , 1966 |
| PubMedID: 5948638 |