Glutactin
Relationship
Comment
Insect specific protein. Glutactin has a signal peptide and an amino domain of greater than 500 residues that strongly resembles acetylcholine esterases and other serine esterases, but lacks the catalytically critical serine residue. It is located at embryonic basement membranes, particularly to the sequentially invaginated envelope of the central nervous system, muscle apodemes and dorsal median cell processes. Ectopic expression of Glutactin inhibits synapse formation by motor neurons that normally innervate M12 muscle. Only the N-terminal part of Glutactin is a member of the alpha/beta hydrolase family. The C-terminal part is not included in ESTHER
Database
Interpro : IPR002018 Carboxylesterase, type B
PIRSF : PIRSF005676 COesterase
Pdoc : No Pdoc
Pfam : PF00135 COesterase
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| baccu-a0a0a1x3h2 | Bactrocera cucurbitae (Melon fruit fly) (Dacus cucurbitae). Glutactin | Bactrocera cucurbitae |
| baccu-a0a0a1xlb3 | Bactrocera cucurbitae (Melon fruit fly) (Dacus cucurbitae). Glutactin | Bactrocera cucurbitae |
| bacdo-a0a034vqe3 | Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis). Glutactin | Bactrocera dorsalis |
| bacdo-a0a034w869 | Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis). Glutactin | Bactrocera dorsalis |
| bacdo-a0a034wjs7 | Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis). Glutactin | Bactrocera dorsalis |
| calsg-a0a068f5u5 | Calliphora stygia (Common brown blowfly). Esterase | Calliphora stygia |
| cerca-w8b8t7 | Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata). Glutactin | Ceratitis capitata |
| droan-b3mly4 | Drosophila ananassae (Fruit fly) GF15538 | Drosophila ananassae |
| droan-b3mly5 | Drosophila ananassae (Fruit fly) GF14362 | Drosophila ananassae |
| droan-b3mly6 | Drosophila ananassae (Fruit fly) GF14361 | Drosophila ananassae |
| drobs-a0a0m3qti9 | Drosophila busckii Uncharacterized protein | Drosophila busckii |
| drobs-a0a0m4edd9 | Drosophila busckii Uncharacterized protein | Drosophila busckii |
| drobs-a0a0m4erk6 | Drosophila busckii Uncharacterized protein | Drosophila busckii |
| droer-b3n7d2 | Drosophila erecta (Fruit fly) GG25298 | Drosophila erecta |
| droer-b3n7d3 | Drosophila erecta (Fruit fly) GG24059 | Drosophila erecta |
| droer-b3n7d4 | Drosophila erecta (Fruit fly) GG24058 | Drosophila erecta |
| drogr-b4jdz1 | Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) GH11275 | Drosophila grimshawi |
| drogr-b4jdz2 | Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) GH11276 | Drosophila grimshawi |
| drogr-b4jdz4 | Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) GH10463 | Drosophila grimshawi |
| drome-CG9287 | Drosophila melanogaster (Fruit fly) CG9287 homologous to glutactin gene | Drosophila melanogaster |
| drome-CG9289 | Drosophila melanogaster (Fruit fly) CG9289 homologous to glutactin gene MIP25834p | Drosophila melanogaster |
| drome-gluta | Drosophila melanogaster (Fruit fly) glutactin GLT | Drosophila melanogaster |
| dromo-b4kg04 | Drosophila mojavensis (Fruit fly) GI18058 | Drosophila mojavensis |
| dromo-b4kg05 | Drosophila mojavensis (Fruit fly) GI21473 | Drosophila mojavensis |
| dromo-b4kg06 | Drosophila mojavensis (Fruit fly) GI21463 | Drosophila mojavensis |
| drope-b4gj62 | Drosophila persimilis (Fruit fly) GL26221 | Drosophila persimilis |
| drope-b4gj64 | Drosophila persimilis (Fruit fly) GL25558 | Drosophila persimilis |
| drops-b5dk96 | Drosophila pseudoobscura pseudoobscura (Fruit fly) GA28035 | Drosophila pseudoobscura pseudoobscura |
| drops-q29jt5 | Drosophila pseudoobscura (Fruit fly) ga21671-pa (fragment) | Drosophila pseudoobscura |
| drops-q29jt6 | Drosophila pseudoobscura (Fruit fly) ga21673-pa (fragment) | Drosophila pseudoobscura |
| drose-b4hyp8 | Drosophila sechellia (Fruit fly) GM17098 | Drosophila sechellia |
| drose-b4hyp9 | Drosophila sechellia (Fruit fly) GM12802 | Drosophila sechellia |
| drose-b4hyq0 | Drosophila sechellia (Fruit fly) GM12791 | Drosophila sechellia |
| drosi-a0a0j9qye3 | Drosophila simulans (Fruit fly). Uncharacterized protein | Drosophila simulans |
| drosi-b4q782 | Drosophila simulans (Fruit fly) GD23558 | Drosophila simulans |
| drosi-b4q783 | Drosophila simulans (Fruit fly) GD22390 | Drosophila simulans |
| drovi-b4lse7 | Drosophila virilis (Fruit fly) GJ16436 | Drosophila virilis |
| drovi-b4lse9 | Drosophila virilis (Fruit fly) GJ11290 | Drosophila virilis |
| drovi-b4lsf0 | Drosophila virilis (Fruit fly) GJ11279 | Drosophila virilis |
| drowi-b4n7s6 | Drosophila willistoni (Fruit fly) GK18752 | Drosophila willistoni |
| drowi-b4n7s7 | Drosophila willistoni (Fruit fly) GK18669 | Drosophila willistoni |
| drowi-b4n7s8 | Drosophila willistoni (Fruit fly) GK18668 | Drosophila willistoni |
| droya-b4nxg5 | Drosophila yakuba (Fruit fly) GE18789 | Drosophila yakuba |
| droya-b4nxg6 | Drosophila yakuba (Fruit fly) GE10861 | Drosophila yakuba |
| droya-b4nxg8 | Drosophila yakuba (Fruit fly) GE10839 | Drosophila yakuba |
| luccu-a0a0l0cd96.1 | Lucilia cuprina (Green bottle fly) (Australian sheep blowfly) Uncharacterized protein | Lucilia cuprina |
| luccu-a0a0l0cd96.2 | Lucilia cuprina (Green bottle fly) (Australian sheep blowfly) Uncharacterized protein | Lucilia cuprina |
| luccu-a0a0l0cdc1 | Lucilia cuprina (Green bottle fly) (Australian sheep blowfly) Uncharacterized protein | Lucilia cuprina |
| musdo-t1png3 | Musca domestica (House fly) Carboxylesterase | Musca domestica |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| calsg-a0a068f7w0 | Calliphora stygia (Common brown blowfly). Esterase | Calliphora stygia |
| calsg-a0a068fbu6 | Calliphora stygia (Common brown blowfly). Esterase | Calliphora stygia |
| calsg-a0a068fbv6 | Calliphora stygia (Common brown blowfly). Esterase | Calliphora stygia |
| drope-b4gj63 | Drosophila persimilis (Fruit fly) GL26222 | Drosophila persimilis |
| drose-b4hyq1 | Drosophila sechellia (Fruit fly) GM12781 | Drosophila sechellia |
| drosi-b4q784 | Drosophila simulans (Fruit fly) GD22389 | Drosophila simulans |
| megsc-t1h4i1 | Megaselia scalaris (Humpbacked fly) (Phora scalaris) Uncharacterized protein | Megaselia scalaris |
References (4)
| Title : Wnt4 is a local repulsive cue that determines synaptic target specificity. - Inaki_2007_Curr.Biol_17_1574 |
| Author(s) : Inaki M , Yoshikawa S , Thomas JB , Aburatani H , Nose A |
| Ref : Current Biology , 17 :1574 , 2007 |
| Abstract : |
| PubMedSearch : Inaki_2007_Curr.Biol_17_1574 |
| PubMedID: 17764943 |
| Title : The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties - Darboux_1996_EMBO.J_15_4835 |
| Author(s) : Darboux I , Barthalay Y , Piovant M , Hipeau-Jacquotte R |
| Ref : EMBO Journal , 15 :4835 , 1996 |
| Abstract : |
| PubMedSearch : Darboux_1996_EMBO.J_15_4835 |
| PubMedID: 8890157 |
| Title : Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid - Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647 |
| Author(s) : Krejci E , Duval N , Chatonnet A , Vincens P , Massoulie J |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 88 :6647 , 1991 |
| Abstract : |
| PubMedSearch : Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647 |
| PubMedID: 1862088 |
| Title : Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases - Olson_1990_EMBO.J_9_1219 |
| Author(s) : Olson PF , Fessler LI , Nelson RE , Sterne RE , Campbell AG , Fessler JH |
| Ref : EMBO Journal , 9 :1219 , 1990 |
| Abstract : |
| PubMedSearch : Olson_1990_EMBO.J_9_1219 |
| PubMedID: 2108864 |
| Gene_locus related to this paper: drome-gluta |