Insect specific protein. Glutactin has a signal peptide and an amino domain of greater than 500 residues that strongly resembles acetylcholine esterases and other serine esterases, but lacks the catalytically critical serine residue. It is located at embryonic basement membranes, particularly to the sequentially invaginated envelope of the central nervous system, muscle apodemes and dorsal median cell processes. Ectopic expression of Glutactin inhibits synapse formation by motor neurons that normally innervate M12 muscle. Only the N-terminal part of Glutactin is a member of the alpha/beta hydrolase family. The C-terminal part is not included in ESTHER
Interpro : IPR002018 Carboxylesterase, type B
PIRSF : PIRSF005676 COesterase
Pdoc : No Pdoc
Pfam : PF00135 COesterase
Prints : No Print
EC Number : No EC Number
No structure scheme yet for this family
Genes Proteins in Glutactin family (49)
Fragments of genes in Glutactin family (7)
No fragment of genesNo substrate
No Inhibitor
Title : Wnt4 is a local repulsive cue that determines synaptic target specificity. - Inaki_2007_Curr.Biol_17_1574 |
Author(s) : Inaki M , Yoshikawa S , Thomas JB , Aburatani H , Nose A |
Ref : Current Biology , 17 :1574 , 2007 |
Abstract : Inaki_2007_Curr.Biol_17_1574 |
ESTHER : Inaki_2007_Curr.Biol_17_1574 |
PubMedSearch : Inaki_2007_Curr.Biol_17_1574 |
PubMedID: 17764943 |
Title : The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties - Darboux_1996_EMBO.J_15_4835 |
Author(s) : Darboux I , Barthalay Y , Piovant M , Hipeau-Jacquotte R |
Ref : EMBO Journal , 15 :4835 , 1996 |
Abstract : Darboux_1996_EMBO.J_15_4835 |
ESTHER : Darboux_1996_EMBO.J_15_4835 |
PubMedSearch : Darboux_1996_EMBO.J_15_4835 |
PubMedID: 8890157 |
Title : Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid - Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647 |
Author(s) : Krejci E , Duval N , Chatonnet A , Vincens P , Massoulie J |
Ref : Proceedings of the National Academy of Sciences of the United States of America , 88 :6647 , 1991 |
Abstract : Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647 |
ESTHER : Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647 |
PubMedSearch : Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647 |
PubMedID: 1862088 |
Title : Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases - Olson_1990_EMBO.J_9_1219 |
Author(s) : Olson PF , Fessler LI , Nelson RE , Sterne RE , Campbell AG , Fessler JH |
Ref : EMBO Journal , 9 :1219 , 1990 |
Abstract : Olson_1990_EMBO.J_9_1219 |
ESTHER : Olson_1990_EMBO.J_9_1219 |
PubMedSearch : Olson_1990_EMBO.J_9_1219 |
PubMedID: 2108864 |
Gene_locus related to this paper: drome-gluta |