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Family Report for: MenH_SHCHC

MenH_SHCHC



Relationship
Family MenH_SHCHC
Block X
Parent Family : Abhydrolase_6

Comment
In the menaquinone biosynthesis pathway, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase: MenH SHCHC catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro

Database
Sequences
Interpro
|
IPR022485 (SHCHC_synthase_MenH)
PIRSF
|
Pdoc
|
PFam
|
PF12697 (Abhydrolase_6)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
1 more
    Title: Molecular Basis of the General Base Catalysis of an alpha/beta-Hydrolase Catalytic Triad
    Sun Y, Yin S, Feng Y, Li J, Zhou J, Liu C, Zhu G, Guo Z
    Ref: Journal of Biological Chemistry, 289:15867, 2014 : PubMed

            

    Title: Crystal Structures of E. coli Native MenH and Two Active Site Mutants.
    Johnston JM, Jiang M, Guo Z, Baker EN
    Ref: PLoS ONE, 8:e61325, 2013 : PubMed

            

    Title: Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity
    Dawson A, Fyfe PK, Gillet F, Hunter WN
    Ref: BMC Struct Biol, 11:19, 2011 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in MenH_SHCHC family (8)

Genes Proteins in MenH_SHCHC family (295)

Fragments of genes in MenH_SHCHC family (3)

Substrates of some enzymes in the MenH_SHCHC family (2)

Inhibitors of some enzymes in the MenH_SHCHC family (1)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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