MenH_SHCHC

Relationship

Family: MenH_SHCHC

Block: X

Parent Family: Abhydrolase_6

Comment

In the menaquinone biosynthesis pathway, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase: MenH SHCHC catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro

Database

Interpro : IPR022485 SHCHC_synthase_MenH 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF12697 Abhydrolase_6

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (8)

Genes Proteins in MenH_SHCHC family (296)

Fragments of genes in MenH_SHCHC family (3)

Structures in MenH_SHCHC family (8)

Substrates in MenH_SHCHC family (2)

Inhibitors in MenH_SHCHC family (1)

References (4)

Title : Molecular Basis of the General Base Catalysis of an alpha\/beta-Hydrolase Catalytic Triad - Sun_2014_J.Biol.Chem_289_15867
Author(s) : Sun Y , Yin S , Feng Y , Li J , Zhou J , Liu C , Zhu G , Guo Z
Ref : Journal of Biological Chemistry , 289 :15867 , 2014
PubMedID: 24737327
Gene_locus related to this paper: ecoli-YFBB

Title : Crystal Structures of E. coli Native MenH and Two Active Site Mutants. - Johnston_2013_Plos.One_8_e61325
Author(s) : Johnston JM , Jiang M , Guo Z , Baker EN
Ref : PLoS ONE , 8 :e61325 , 2013
PubMedID: 23637813
Gene_locus related to this paper: ecoli-YFBB

Title : Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity - Dawson_2011_BMC.Struct.Biol_11_19
Author(s) : Dawson A , Fyfe PK , Gillet F , Hunter WN
Ref : BMC Struct Biol , 11 :19 , 2011
PubMedID: 21513522
Gene_locus related to this paper: staau-SA0897

Title : Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli - Jiang_2008_Biochemistry_47_3426
Author(s) : Jiang M , Chen X , Guo ZF , Cao Y , Chen M , Guo Z
Ref : Biochemistry , 47 :3426 , 2008
PubMedID: 18284213
Gene_locus related to this paper: ecoli-YFBB