9cyan-d0e8e2

Lyngbya majuscula 19L Polyketide synthase

Comment

only a little C-terminal 1979-2036 part homologous to ab-hydrolases. || In Gu et al. the sequence is corrected because Q6DNE0 may have been partially replaced with exogenous DNA during construction of the genomic library

Relationship

Family : 6_AlphaBeta_hydrolase

Block : X

Position in NCBI Life Tree : Lyngbya majuscula 19L

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Cyanobacteria\/Melainabacteria group N E > Cyanobacteria N E > Oscillatoriophycideae N E > Oscillatoriales N E > Oscillatoriaceae N E > Moorea N E > Moorea producens N E > Moorea producens 19L N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MEEKFLEFGG NQICLCSWGS PEHPVVLCIH GILEQGLAWQ EVALPLAAQG YRVVAPDLFG HGRSSHLEMV TSYSSLTFLA QIDRVIQELP DQPLLLVGHS MGAMLATAIA SVRPKKIKEL ILVELPLPAE ESKKESAVNQ LTTCLDYLSS TPQHPIFPDV ATAASRLRQA IPSLSEEFSY ILAQRITQPN QGGVRWSWDA IIRTRSILGL NNLPGGRSQY LEMLKSIQVP TTLVYGDSSK LNRPEDLQQQ KMTMTQAKRV FLSGGHNLHI DAAAALASLI LTS

References (3)

Title : Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase - Gehret_2011_J.Biol.Chem_286_14445
Author(s) : Gehret JJ , Gu L , Gerwick WH , Wipf P , Sherman DH , Smith JL
Ref : Journal of Biological Chemistry , 286 :14445 , 2011
PubMedID: 21357626
Gene_locus related to this paper: 9cyan-d0e8e2

Title : Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis - Gu_2009_J.Am.Chem.Soc_131_16033
Author(s) : Gu L , Wang B , Kulkarni A , Gehret JJ , Lloyd KR , Gerwick L , Gerwick WH , Wipf P , Hakansson K , Smith JL , Sherman DH
Ref : Journal of the American Chemical Society , 131 :16033 , 2009
PubMedID: 19835378
Gene_locus related to this paper: 9cyan-d0e8e2

Title : Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula - Chang_2004_J.Nat.Prod_67_1356
Author(s) : Chang Z , Sitachitta N , Rossi JV , Roberts MA , Flatt PM , Jia J , Sherman DH , Gerwick WH
Ref : Journal of Natural Products , 67 :1356 , 2004
PubMedID: 15332855
Gene_locus related to this paper: 9cyan-d0e8e2 , 9cyan-q6dnd9