| Title : Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation - McCullough_2024_ACS.Catal_14_12551 |
| Author(s) : McCullough TM , Choudhary V , Akey DL , Skiba MA , Bernard SM , Kittendorf JD , Schmidt JJ , Sherman DH , Smith JL |
| Ref : ACS Catal , 14 :12551 , 2024 |
| Abstract : |
| PubMedSearch : McCullough_2024_ACS.Catal_14_12551 |
| PubMedID: 39927088 |
| Gene_locus related to this paper: 9actn-k4i6l4 , micch-a0a1z1mz81 , strve-PIKAIV |
| Title : Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products - Adrover-Castellano_2021_ChemCatChem_13_2095 |
| Author(s) : Adrover-Castellano ML , Schmidt JJ , Sherman DH |
| Ref : ChemCatChem , 13 :2095 , 2021 |
| Abstract : |
| PubMedSearch : Adrover-Castellano_2021_ChemCatChem_13_2095 |
| PubMedID: 34335987 |
| Title : Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases - Koch_2020_Angew.Chem.Int.Ed.Engl_59_13575 |
| Author(s) : Koch AA , Schmidt JJ , Lowell AN , Hansen DA , Coburn KM , Chemler JA , Sherman DH |
| Ref : Angew Chem Int Ed Engl , 59 :13575 , 2020 |
| Abstract : |
| PubMedSearch : Koch_2020_Angew.Chem.Int.Ed.Engl_59_13575 |
| PubMedID: 32357274 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Stereoselective Synthesis of Baulamycin A - Thielman_2020_J.Org.Chem_85_3812 |
| Author(s) : Thielman JR , Sherman DH , Williams RM |
| Ref : J Org Chem , 85 :3812 , 2020 |
| Abstract : |
| PubMedSearch : Thielman_2020_J.Org.Chem_85_3812 |
| PubMedID: 31970985 |
| Title : Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides - Hansen_2017_J.Am.Chem.Soc_139_13450 |
| Author(s) : Hansen DA , Koch AA , Sherman DH |
| Ref : Journal of the American Chemical Society , 139 :13450 , 2017 |
| Abstract : |
| PubMedSearch : Hansen_2017_J.Am.Chem.Soc_139_13450 |
| PubMedID: 28836772 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst - Koch_2017_J.Am.Chem.Soc_139_13456 |
| Author(s) : Koch AA , Hansen DA , Shende VV , Furan LR , Houk KN , Jimenez-Oses G , Sherman DH |
| Ref : Journal of the American Chemical Society , 139 :13456 , 2017 |
| Abstract : |
| PubMedSearch : Koch_2017_J.Am.Chem.Soc_139_13456 |
| PubMedID: 28836768 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412 - Tripathi_2016_J.Ind.Microbiol.Biotechnol_43_1189 |
| Author(s) : Tripathi A , Choi SS , Sherman DH , Kim ES |
| Ref : J Ind Microbiol Biotechnol , 43 :1189 , 2016 |
| Abstract : |
| PubMedSearch : Tripathi_2016_J.Ind.Microbiol.Biotechnol_43_1189 |
| PubMedID: 27277081 |
| Title : Architecture of the polyketide synthase module: surprises from electron cryo-microscopy - Smith_2015_Curr.Opin.Struct.Biol_31_9 |
| Author(s) : Smith JL , Skiniotis G , Sherman DH |
| Ref : Current Opinion in Structural Biology , 31 :9 , 2015 |
| Abstract : |
| PubMedSearch : Smith_2015_Curr.Opin.Struct.Biol_31_9 |
| PubMedID: 25791608 |
| Title : Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination - Chemler_2015_J.Am.Chem.Soc_137_10603 |
| Author(s) : Chemler JA , Tripathi A , Hansen DA , O'Neil-Johnson M , Williams RB , Starks C , Park SR , Sherman DH |
| Ref : Journal of the American Chemical Society , 137 :10603 , 2015 |
| Abstract : |
| PubMedSearch : Chemler_2015_J.Am.Chem.Soc_137_10603 |
| PubMedID: 26230368 |
| Title : Structural rearrangements of a polyketide synthase module during its catalytic cycle - Whicher_2014_Nature_510_560 |
| Author(s) : Whicher JR , Dutta S , Hansen DA , Hale WA , Chemler JA , Dosey AM , Narayan AR , Hakansson K , Sherman DH , Smith JL , Skiniotis G |
| Ref : Nature , 510 :560 , 2014 |
| Abstract : |
| PubMedSearch : Whicher_2014_Nature_510_560 |
| PubMedID: 24965656 |
| Title : Structure of a modular polyketide synthase - Dutta_2014_Nature_510_512 |
| Author(s) : Dutta S , Whicher JR , Hansen DA , Hale WA , Chemler JA , Congdon GR , Narayan AR , Hakansson K , Sherman DH , Smith JL , Skiniotis G |
| Ref : Nature , 510 :512 , 2014 |
| Abstract : |
| PubMedSearch : Dutta_2014_Nature_510_512 |
| PubMedID: 24965652 |
| Title : Structure and activity of DmmA, a marine haloalkane dehalogenase - Gehret_2012_Protein.Sci_21_239 |
| Author(s) : Gehret JJ , Gu L , Geders TW , Brown WC , Gerwick L , Gerwick WH , Sherman DH , Smith JL |
| Ref : Protein Science , 21 :239 , 2012 |
| Abstract : |
| PubMedSearch : Gehret_2012_Protein.Sci_21_239 |
| PubMedID: 22124946 |
| Gene_locus related to this paper: 9cyan-q6dnd9 |
| Title : Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase - Gehret_2011_J.Biol.Chem_286_14445 |
| Author(s) : Gehret JJ , Gu L , Gerwick WH , Wipf P , Sherman DH , Smith JL |
| Ref : Journal of Biological Chemistry , 286 :14445 , 2011 |
| Abstract : |
| PubMedSearch : Gehret_2011_J.Biol.Chem_286_14445 |
| PubMedID: 21357626 |
| Gene_locus related to this paper: 9cyan-d0e8e2 |
| Title : Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9 - Carlson_2010_Chembiochem_11_564 |
| Author(s) : Carlson JC , Fortman JL , Anzai Y , Li S , Burr DA , Sherman DH |
| Ref : Chembiochem , 11 :564 , 2010 |
| Abstract : |
| PubMedSearch : Carlson_2010_Chembiochem_11_564 |
| PubMedID: 20127927 |
| Gene_locus related to this paper: 9actn-f1di35 |
| Title : Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase - |
| Author(s) : Scaglione JB , Akey DL , Sullivan R , Kittendorf JD , Rath CM , Kim ES , Smith JL , Sherman DH |
| Ref : Angew Chem Int Ed Engl , 49 :5726 , 2010 |
| PubMedID: 20623733 |
| Gene_locus related to this paper: 9acto-C6ZCS0 |
| Title : Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis - Gu_2009_J.Am.Chem.Soc_131_16033 |
| Author(s) : Gu L , Wang B , Kulkarni A , Gehret JJ , Lloyd KR , Gerwick L , Gerwick WH , Wipf P , Hakansson K , Smith JL , Sherman DH |
| Ref : Journal of the American Chemical Society , 131 :16033 , 2009 |
| Abstract : |
| PubMedSearch : Gu_2009_J.Am.Chem.Soc_131_16033 |
| PubMedID: 19835378 |
| Gene_locus related to this paper: 9cyan-d0e8e2 |
| Title : Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains - Buchholz_2009_ACS.Chem.Biol_4_41 |
| Author(s) : Buchholz TJ , Geders TW , Bartley FE, 3rd , Reynolds KA , Smith JL , Sherman DH |
| Ref : ACS Chemical Biology , 4 :41 , 2009 |
| Abstract : |
| PubMedSearch : Buchholz_2009_ACS.Chem.Biol_4_41 |
| PubMedID: 19146481 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : The methymycin\/pikromycin pathway: a model for metabolic diversity in natural product biosynthesis - Kittendorf_2009_Bioorg.Med.Chem_17_2137 |
| Author(s) : Kittendorf JD , Sherman DH |
| Ref : Bioorganic & Medicinal Chemistry , 17 :2137 , 2009 |
| Abstract : |
| PubMedSearch : Kittendorf_2009_Bioorg.Med.Chem_17_2137 |
| PubMedID: 19027305 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : An enzyme assembly line - |
| Author(s) : Smith JL , Sherman DH |
| Ref : Science , 321 :1304 , 2008 |
| PubMedID: 18772425 |
| Title : Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412 - Choi_2007_Microbiology_153_1095 |
| Author(s) : Choi SS , Hur YA , Sherman DH , Kim ES |
| Ref : Microbiology , 153 :1095 , 2007 |
| Abstract : |
| PubMedSearch : Choi_2007_Microbiology_153_1095 |
| PubMedID: 17379718 |
| Gene_locus related to this paper: 9acto-a4kcf7 |
| Title : Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase - Kittendorf_2007_Chem.Biol_14_944 |
| Author(s) : Kittendorf JD , Beck BJ , Buchholz TJ , Seufert W , Sherman DH |
| Ref : Chemical Biology , 14 :944 , 2007 |
| Abstract : |
| PubMedSearch : Kittendorf_2007_Chem.Biol_14_944 |
| PubMedID: 17719493 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels - Giraldes_2006_Nat.Chem.Biol_2_531 |
| Author(s) : Giraldes JW , Akey DL , Kittendorf JD , Sherman DH , Smith JL , Fecik RA |
| Ref : Nat Chemical Biology , 2 :531 , 2006 |
| Abstract : |
| PubMedSearch : Giraldes_2006_Nat.Chem.Biol_2_531 |
| PubMedID: 16969373 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Structural basis for macrolactonization by the pikromycin thioesterase - Akey_2006_Nat.Chem.Biol_2_537 |
| Author(s) : Akey DL , Kittendorf JD , Giraldes JW , Fecik RA , Sherman DH , Smith JL |
| Ref : Nat Chemical Biology , 2 :537 , 2006 |
| Abstract : |
| PubMedSearch : Akey_2006_Nat.Chem.Biol_2_537 |
| PubMedID: 16969372 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Developing tools for engineering hybrid polyketide synthetic pathways - Kittendorf_2006_Curr.Opin.Biotechnol_17_597 |
| Author(s) : Kittendorf JD , Sherman DH |
| Ref : Curr Opin Biotechnol , 17 :597 , 2006 |
| Abstract : |
| PubMedSearch : Kittendorf_2006_Curr.Opin.Biotechnol_17_597 |
| PubMedID: 17046237 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae - Lee_2006_J.Nat.Prod_69_847 |
| Author(s) : Lee SK , Park JW , Kim JW , Jung WS , Park SR , Choi CY , Kim ES , Kim BS , Ahn JS , Sherman DH , Yoon YJ |
| Ref : Journal of Natural Products , 69 :847 , 2006 |
| Abstract : |
| PubMedSearch : Lee_2006_J.Nat.Prod_69_847 |
| PubMedID: 16724858 |
| Gene_locus related to this paper: strve-PIKAIV |
| Title : Development of an internally quenched fluorogenic substrate for kinetic analysis of thioesterases - |
| Author(s) : Beck ZQ , Sherman DH |
| Ref : Analytical Biochemistry , 349 :309 , 2006 |
| PubMedID: 16360105 |
| Title : Formal total synthesis of the polyketide macrolactone narbonolide - Venkatraman_2005_J.Org.Chem_70_7267 |
| Author(s) : Venkatraman L , Aldrich CC , Sherman DH , Fecik RA |
| Ref : J Org Chem , 70 :7267 , 2005 |
| Abstract : |
| PubMedSearch : Venkatraman_2005_J.Org.Chem_70_7267 |
| PubMedID: 16122247 |
| Title : Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide - Aldrich_2005_J.Am.Chem.Soc_127_8910 |
| Author(s) : Aldrich CC , Venkatraman L , Sherman DH , Fecik RA |
| Ref : Journal of the American Chemical Society , 127 :8910 , 2005 |
| Abstract : |
| PubMedSearch : Aldrich_2005_J.Am.Chem.Soc_127_8910 |
| PubMedID: 15969542 |
| Title : Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula - Chang_2004_J.Nat.Prod_67_1356 |
| Author(s) : Chang Z , Sitachitta N , Rossi JV , Roberts MA , Flatt PM , Jia J , Sherman DH , Gerwick WH |
| Ref : Journal of Natural Products , 67 :1356 , 2004 |
| Abstract : |
| PubMedSearch : Chang_2004_J.Nat.Prod_67_1356 |
| PubMedID: 15332855 |
| Gene_locus related to this paper: 9cyan-d0e8e2 , 9cyan-q6dnd9 |
| Title : The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit - Chang_2002_Gene_296_235 |
| Author(s) : Chang Z , Flatt P , Gerwick WH , Nguyen VA , Willis CL , Sherman DH |
| Ref : Gene , 296 :235 , 2002 |
| Abstract : |
| PubMedSearch : Chang_2002_Gene_296_235 |
| PubMedID: 12383521 |
| Gene_locus related to this paper: lynma-BARC , lynma-BARG |
| Title : Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae - Xue_2001_Metab.Eng_3_15 |
| Author(s) : Xue Y , Sherman DH |
| Ref : Metab Eng , 3 :15 , 2001 |
| Abstract : |
| PubMedSearch : Xue_2001_Metab.Eng_3_15 |
| PubMedID: 11162229 |
| Title : Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides - Xue_2000_Gene_245_203 |
| Author(s) : Xue Y , Wilson D , Sherman DH |
| Ref : Gene , 245 :203 , 2000 |
| Abstract : |
| PubMedSearch : Xue_2000_Gene_245_203 |
| PubMedID: 10713461 |
| Gene_locus related to this paper: strve-PIKAV |
| Title : A gene cluster for macrolide antibiotic biosynthesis in streptomyces venezuelae: architecture of metabolic diversity. - |
| Author(s) : Xue Y , Zhao L , Liu Hw , Sherman DH |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 95 :12111 , 1998 |
| PubMedID: 9770448 |
| Gene_locus related to this paper: strve-PIKAIV , strve-PIKAV |