1. Home
  2. Gene Locus
  3. caeel-K02F2.1

caeel-K02F2.1

Caenorhabditis elegans CEL DPF-3 N-terminal processing of Argonaute (Ago) proteins

Comment

DPF-3 dipeptidase orthologous to mammalian dipeptidyl peptidase (DPP) 8\/9, processes the unusually proline-rich N termini of WAGO-1 and WAGO-3 Argonaute (Ago) proteins Without DPF-3 activity, these WAGO proteins lose their proper complement of 22G RNAs. Desilencing of repeat-containing and transposon-derived transcripts, DNA damage, and acute sterility ensue (Gudipati et al.2021)

Relationship

Family : DPP4N_Peptidase_S9

Block : X

Position in NCBI Life Tree : Caenorhabditis elegans

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Protostomia N E > Ecdysozoa N E > Nematoda N E > Chromadorea N E > Rhabditida N E > Rhabditoidea N E > Rhabditidae N E > Peloderinae N E > Caenorhabditis N E > Caenorhabditis elegans N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MMFNFYQFLY NLQNVSPFID FSVLKQLTHT KMRENEPARF ETRSFSQLID HARSWKTEVR GMTTQGFTKI SLMRAEKDRL NMYAISSVPG TNTQSIFSVT IPLELVEKAQ VADRKFELKL KSGYNVDSYI RMSCRKTPPS AEFTLQCERQ RSQVVTGISD YEIRNGKMIL MAGDQLFRYN PLNEALAAIP IAVPDDQSST EPMDISEGSI TSGTKGCSNE APQSSTVPPV TRIPIKKPTT STEKPATAPP TNNFVSSAKV CPADSSLLAY VLNKQVYIEK NGKIIHRTSS NSKHITNGVP SYIVQEELER FEGIWWSESK TRLLYEHVNE EKVAESQFGV NGDPPVAPMK YPRAGTKNAY STLRMVILEN GKAYDVPLKD EVIYKHCPFY EYITRAGFFS DGTTVWVQVM SRDQAQCSLL LIPYTDFLLP EELGGSIKED NLQLSTDLNM GVWDDKSHEE TMEKPPRGKL RGTVQIHKAR NDYWINTHNA IYPLKITDEE HPMYEFIYCL EKPNGSCLAL ISAELDQNGY CRHTEEKLLM AENFSINKSM GIVVDEVREL VYYVANESHP TEWNICVSHY RTGQHAQLTE SGICFKSERA NGKLALDLDH GFACYMTSVG SPAECRFYSF RWKENEVLPS TVYAANITVS GHPGQPDLHF DSPEMIEFQS KKTGLMHYAM ILRPSNFDPY KKYPVFHYVY GGPGIQIVHN DFSWIQYIRF CRLGYVVVFI DNRGSAHRGI EFERHIHKKM GTVEVEDQVE GLQMLAERTG GFMDMSRVVV HGWSYGGYMA LQMIAKHPNI YRAAIAGGAV SDWRLYDTAY TERYMGYPLE EHVYGASSIT GLVEKLPDEP NRLMLVHGLM DENVHFAHLT HLVDECIKKG KWHELVIFPN ERHGVRNNDA SIYLDARMMY FAQQAIQGFG PTTAAPRQGP L

References (5)

Title : Dipeptidyl peptidase DPF-3 is a gatekeeper of microRNA Argonaute compensation in animals - Harvey_2025_Nat.Commun_16_2738
Author(s) : Harvey LM , Frederick PM , Gudipati RK , Michaud P , Houle F , Young D , Desbiens C , Ladouceur S , Dufour A , Grosshans H , Simard MJ
Ref : Nat Commun , 16 :2738 , 2025
Abstract :
PubMedSearch : Harvey_2025_Nat.Commun_16_2738
PubMedID: 40108168
Gene_locus related to this paper: caeel-K02F2.1

Title : Deep quantification of substrate turnover defines protease subsite cooperativity - Gudipati_2024_Mol.Syst.Biol__
Author(s) : Gudipati RK , Gaidatzis D , Seebacher J , Muehlhaeusser S , Kempf G , Cavadini S , Hess D , Soneson C , Grosshans H
Ref : Mol Syst Biol , : , 2024
Abstract :
PubMedSearch : Gudipati_2024_Mol.Syst.Biol__
PubMedID: 39468329
Gene_locus related to this paper: caeel-K02F2.1 , human-DPP4

Title : Protease-mediated processing of Argonaute proteins controls small RNA association - Gudipati_2021_Mol.Cell_81_2388
Author(s) : Gudipati RK , Braun K , Gypas F , Hess D , Schreier J , Carl SH , Ketting RF , Grosshans H
Ref : Mol Cell , 81 :2388 , 2021
Abstract :
PubMedSearch : Gudipati_2021_Mol.Cell_81_2388
PubMedID: 33852894
Gene_locus related to this paper: caeel-K02F2.1

Title : Genome sequence of the nematode C. elegans: a platform for investigating biology. The C. elegans Sequencing Consortium - CEGSC_1998_Science_282_2012
Author(s) : CEGSC
Ref : Science , 282 :2012 , 1998
Abstract :
PubMedSearch : CEGSC_1998_Science_282_2012
PubMedID: 9851916
Gene_locus related to this paper: caeel-1llip , caeel-ACHE1 , caeel-ACHE2 , caeel-ACHE3 , caeel-ACHE4 , caeel-b0238.1 , caeel-b0238.2 , caeel-b0238.7 , caeel-c01b10.4 , caeel-c01b10.10 , caeel-C04B4.3 , caeel-c08h9.1 , caeel-C09D4.4 , caeel-C09E8.2 , caeel-c17h12.4 , caeel-c23h4.2 , caeel-c23h4.3 , caeel-c23h4.7 , caeel-C25A1.12 , caeel-C25G4.2 , caeel-C26B9.5 , caeel-C27C12.7 , caeel-C31H5.1 , caeel-C31H5.6 , caeel-C37H5.2 , caeel-C37H5.3 , caeel-C39B5.5 , caeel-C40H1.7 , caeel-C41A3.1 , caeel-c42d4.2 , caeel-C45B11.6 , caeel-C46C11.1 , caeel-C50B6.9 , caeel-C52A10.1 , caeel-C54G4.7 , caeel-D1022.3 , caeel-D1022.4 , caeel-D2024.2 , caeel-E01G6.3 , caeel-ester , caeel-F01D5.7 , caeel-F01D5.8 , caeel-F01F1.5 , caeel-F01G10.7 , caeel-F10D2.10 , caeel-F10F2.3 , caeel-F11C1.4 , caeel-f13d12.6 , caeel-F14E5.5 , caeel-f15a8.6 , caeel-f16f9.4 , caeel-F19C7.2 , caeel-F19C7.4 , caeel-O02252.1 , caeel-O02252.2 , caeel-G5EFJ8.1 , caeel-G5EFJ8.2 , caeel-F25A2.1 , caeel-F26A3.1 , caeel-f27c8.6 , caeel-F28H7.3 , caeel-F31F6.7 , caeel-f32a5.3 , caeel-F32B4.6 , caeel-F32H2.5 , caeel-F35H12.5 , caeel-f41c3.5 , caeel-F42G9.6 , caeel-f44b9.1 , caeel-F44C4.5 , caeel-F45E6.4 , caeel-F46B6.8 , caeel-F46G10.4 , caeel-F54F3.3 , caeel-f55d10.3 , caeel-f55f3.c , caeel-f56c11.6 , caeel-F58G1.5 , caeel-ges1e , caeel-H41C03.2 , caeel-K01A2.5 , caeel-K02F2.1 , caeel-K02F3.6 , caeel-K03H6.2 , caeel-K04A8.5 , caeel-K04G2.2 , caeel-K04G2.5 , caeel-K05B2.4 , caeel-K07C5.5 , caeel-k07c11.4 , caeel-K08B12.1 , caeel-K08D9.4 , caeel-k10b2.2 , caeel-K10C2.1.1 , caeel-K10C2.1.2 , caeel-K10C2.1.3 , caeel-K10C2.1.4 , caeel-k11g9.1 , caeel-k11g9.2 , caeel-K12B6.3 , caeel-M05B5.4 , caeel-pafa , caeel-PCP5 , caeel-ppme1 , caeel-q4r165 , caeel-q5fc17 , caeel-q7m3k8 , caeel-q7yx60 , caeel-q7yx61 , caeel-q9tzh8 , caeel-q9tzh9 , caeel-q336k8 , caeel-q17846 , caeel-q22750 , caeel-q22992 , caeel-R05D7.4 , caeel-R11E3.8 , caeel-R11G11.14 , caeel-T01C3.4 , caeel-t02b5.1 , caeel-t02b5.3 , caeel-T05E7.1 , caeel-T07H6.1 , caeel-T08B1.4 , caeel-t09b9.1 , caeel-T10B5.7 , caeel-T12A7.4 , caeel-T19B10.8 , caeel-T21H3.1 , caeel-t22d1.11 , caeel-T23F1.7 , caeel-T23F4.3 , caeel-t28c12.4 , caeel-tmco4 , caeel-W01A11.1 , caeel-W03D8.8 , caeel-W03G9.6 , caeel-NLGN1 , caeel-Y16B4A.2 , caeel-Y32F6A.5 , caeel-Y38E10A.7 , caeel-Y40D12A.2 , caeel-Y43F8A.3 , caeel-Y46H3A.4 , caeel-Y48G10A.1 , caeel-Y48G10A.3 , caeel-Y49E10.16 , caeel-Y49E10.18 , caeel-Y49E10.25 , caeel-Y50E8A.7 , caeel-Y51H4A.5 , caeel-Y55F3AM.10 , caeel-Y57E12B.3 , caeel-Y60A3A.7 , caeel-Y71G12A.4 , caeel-Y71H2AM.K , caeel-Y73C8B.1 , caeel-Y73C8B.2 , caeel-Y73C8B.3 , caeel-Y75b8.3 , caeel-Y97E10AL.2 , caeel-Y110A7A.7 , caeel-q9grv9.1 , caeel-q9grv9.2 , caeel-ydj1 , caeel-ym9i , caeel-ym67 , caeel-yog1 , caeel-ypt1 , caeel-yyc5 , caeel-zc376.1 , caeel-zc376.2 , caeel-zc376.3 , caeel-ZK262.2 , caeel-ZK262.3 , caeel-ZK617.2 , caeel-f172a

Title : 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans - Wilson_1994_Nature_368_32
Author(s) : Wilson R , Ainscough R , Anderson K , Baynes C , Berks M , Bonfield J , Burton J , Connell M , Copsey T , Cooper J , et al.
Ref : Nature , 368 :32 , 1994
Abstract :
PubMedSearch : Wilson_1994_Nature_368_32
PubMedID: 7906398
Gene_locus related to this paper: caeel-1llip , caeel-c01b10.4 , caeel-C04B4.3 , caeel-c08h9.1 , caeel-C09E8.2 , caeel-c17h12.4 , caeel-c23h4.2 , caeel-c23h4.3 , caeel-c23h4.4 , caeel-c23h4.7 , caeel-C26B9.5 , caeel-C27C12.7 , caeel-C31H5.1 , caeel-C31H5.6 , caeel-C37H5.2 , caeel-C37H5.3 , caeel-c42d4.2 , caeel-D1022.3 , caeel-D1022.4 , caeel-F01D5.7 , caeel-F01D5.8 , caeel-F01F1.5 , caeel-F01G10.7 , caeel-F10F2.3 , caeel-f13d12.6 , caeel-F14E5.5 , caeel-f15a8.6 , caeel-f16f9.4 , caeel-F19C7.2 , caeel-F19C7.4 , caeel-O02252.1 , caeel-O02252.2 , caeel-G5EFJ8.1 , caeel-G5EFJ8.2 , caeel-F25A2.1 , caeel-f27c8.6 , caeel-F28H7.3 , caeel-F31F6.7 , caeel-f32a5.3 , caeel-F32B4.6 , caeel-f41c3.5 , caeel-F44C4.5 , caeel-F45E6.4 , caeel-F46B6.8 , caeel-F54F3.3 , caeel-f56c11.6 , caeel-F58G1.5 , caeel-K01A2.5 , caeel-K02F2.1 , caeel-K03H6.2 , caeel-K04A8.5 , caeel-k07c11.4 , caeel-K08B12.1 , caeel-k10b2.2 , caeel-k11g9.1 , caeel-k11g9.2 , caeel-K12B6.3 , caeel-PCP5 , caeel-ppme1 , caeel-q336k8 , caeel-R05D7.4 , caeel-R11G11.14 , caeel-T01C3.4 , caeel-t02b5.1 , caeel-t02b5.3 , caeel-T05E7.1 , caeel-T07H6.1 , caeel-T08B1.4 , caeel-T12A7.4 , caeel-T19B10.8 , caeel-T21H3.1 , caeel-t22d1.11 , caeel-T23F4.3 , caeel-t28c12.4 , caeel-W01A11.1 , caeel-Y32F6A.5 , caeel-Y40D12A.2 , caeel-Y49E10.16 , caeel-Y49E10.18 , caeel-ym67 , caeel-yog1 , caeel-ZK262.2 , caeel-ZK262.3 , caeel-ZK617.2