Enterococcus faecium (Streptococcus faecium) alpha/beta hydrolase fold AhyD aminoacylphosphatidylglycerol hydrolase
A conserved hydrolase responsible for the cleavage of aminoacylphosphatidylglycerol (aa-PG hydrolase) in the membrane of Enterococcus faecium. ahyD is located upstream and adjacent to Aminoacylphosphatidylglycerol synthase (rakPGS) in E. faecium (aa-PGs provide bacteria with resistance to a range of antimicrobial compounds and stress conditions). AhyD hydrolyzes Ala-PG and Lys-PG. AhyD act in concert with RakPGS to maintain optimal levels of aa-PG.. Deletion of ahyD or rakPGS resulted in increased susceptibility to bacitracin || Other strains: Enterococcus faecium DO\; CRL1879\; TX0133a01\; ERV168\; 1,231,501\; SD3B-2
MTDIIVILYT VGDYVKKEKK YAKMPDGSEI YYEKSGQGFP LFLLHGNDGS GRFFSEQVPV LERYYTVYLV DSRGHGRSTN EASMLNFQLM AEDLNTIMLL EKIDQADFLG FSDGANLALV FASSFPKKVH RLILNSGNTL VKGVRFSARV ISNIHYAWVW LLSLFRPSLR KNLLVIKLLL HDIGLTENDL KKINSPTLII VGKKDVIKLK HSLYIAKTIP KASFVLVKEQ GHELARKDPE RFNREVLQFL SET
Title : A conserved hydrolase responsible for the cleavage of aminoacylphosphatidylglycerol in the membrane of Enterococcus faecium - Smith_2013_J.Biol.Chem_288_22768 |
Author(s) : Smith AM , Harrison JS , Sprague KM , Roy H |
Ref : Journal of Biological Chemistry , 288 :22768 , 2013 |
Abstract : Smith_2013_J.Biol.Chem_288_22768 |
ESTHER : Smith_2013_J.Biol.Chem_288_22768 |
PubMedSearch : Smith_2013_J.Biol.Chem_288_22768 |
PubMedID: 23793054 |
Gene_locus related to this paper: entfc-q3xx25 |