pensq-GrgF
Penicillium sp. alpha/beta hydrolase fold protein. Chain-fusing Polyketide Gregatin A GrgF
Comment
The C115S mutant functions as a thioesterase, while losing the ability to perform chain fusion
Relationship
Family : Thiohydrolase
Block : X
Position in NCBI Life Tree : Penicillium sp.
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Aspergillaceae N E > Penicillium N E > unclassified Penicillium N E > Penicillium sp. N EMolecular evidence
Sequence
Peptide
MTASTLPRSD VEFTTLDGLT LRGWLFPASQ RGPALIMSPG FNMPKDAILP DIAKWFQEHG ITCLLYDPRG IGASDGEPRN DIDARQQAEH LHDAVTWFKE NPLVNEKQIA LWGLCFGGNV TLAAAAFDKR VAAAIAVAPL IDSTGNPERR QPILELAMHD RASRLDGEEP MYLPYVNEDG SIPNGLQLAA EMMPALERLG IPVENRISVQ TYYKSLSWNI LNVVQYISPT PAMMVTPELD VSCPTEDQLN CFEHMKEPKE LDILKGKGHL DWVFGDVESI LNRQLDFLKR HMAF
References (1)
| Title : Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A - Wang_2020_J.Am.Chem.Soc_142_8464 |
| Author(s) : Wang WG , Wang H , Du LQ , Li M , Chen L , Yu J , Cheng GG , Zhan MT , Hu QF , Zhang L , Yao M , Matsuda Y |
| Ref : Journal of the American Chemical Society , 142 :8464 , 2020 |
| Abstract : |
| PubMedSearch : Wang_2020_J.Am.Chem.Soc_142_8464 |
| PubMedID: 32275405 |
| Gene_locus related to this paper: pensq-GrgF |