pseae-T6SSTseL

Pseudomonas aeruginosa T6SS Effector TseL lipase family protein

Comment

Here a T6SS Effector TseL. The type VI lipase effectors Tle1-Tle5 secreted by the bacterial type VI secretion system (T6SS) have recently been identified as antibacterial effectors that hydrolyze membrane phospholipids. The Tle1-4 display phospholipase A1 and A2 (PLA1) (PLA2) activities. Tle1 belongs to Duf_2235(T6SS-TLE1) family, TLE2 to Lipase_3, TLE3 to alpha\/ beta hydrolase and Tle4 belongs to PGAP1

Relationship

Family : Lipase_3

Block : L

Position in NCBI Life Tree : Pseudomonas aeruginosa

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Pseudomonadales N E > Pseudomonadaceae N E > Pseudomonas N E > Pseudomonas aeruginosa group N E > Pseudomonas aeruginosa N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

No Interpro

No Pfam

No UniProt

No PIRSF

No SUPERFAM

Sequence

Peptide

MILGPMEEWE KPFFSERIHA CPRRTHSTSF QLVDERGDGR PYAGLAYEVS DSEEVVYLGV LDETGTGRIN RHYCGSVVLK LAQAYQGSEK SYTFLQKRPH YPLPITELQV RAEKTRFVNP DGARTRSNPA QGQADSFCQV EVSELVEHRA HLPPLALRYF PPRHQVHALM RRPLAAMAEL GFAPRPPRVR GIALLPNRHH VLEVRPLRAL SPLLSTGEAF CYLNLYQLAL MSTLSYSPFG QEPDTQPVET DSVSFPAQPS VGNWFGDALA RSDELWQVDA TQAGGKAYYP LYEDVAYSRR LEVIPFDPEL YPEVNSPELG VDQEHPARLH YLDDAKKRGG TDTQAYITHN DELILLVVRG TASMADVLRD VDAAQTPFEE TSGKVHNGFY ESAKVAIKFF TTYLDKFYSG QKLVITGHSL GGAVALLIAE MLRHRSGFTY DIVLYTYGSP RVGDKTFVEN ARPLVHHRMV NQNDPVPSVP AAWMKTSWRM SGAGVLLMLF NPAIGGAVVL LSPVNIVGEP YTHHGKLRHF MPVSFADGHK SAILWTPGCE SITERGGAAV CAKALAARNG LPERGGLLRQ MLDNADHKMV ASYIPHCWAS LRRAQEALEE GRTVVTPTEY ERVGEALQDF KAQLREKEAA AYGSAREQQI MGPLRAEIGR LQQTAVRLKA LSVERVSEAK VYGRVAERPE ALAVSLERWL AHSFNRSHEQ LAMAPPDADS NERAIATLVG GHAPGAVFDL DIDTLG

References (1)

Title : Acquisition of T6SS Effector TseL Contributes to the Emerging of Novel Epidemic Strains of Pseudomonas aeruginosa - Ren_2022_Microbiol.Spectr__e0330822
Author(s) : Ren A , Jia M , Liu J , Zhou T , Wu L , Dong T , Cai Z , Qu J , Liu Y , Yang L , Zhang Y
Ref : Microbiol Spectr , :e0330822 , 2022
Abstract :
PubMedSearch : Ren_2022_Microbiol.Spectr__e0330822
PubMedID: 36546869
Gene_locus related to this paper: pseae-T6SSTseL