Lipase_3

Relationship

Family: Lipase_3

Block: L

Parent Family: No family

Comment

Triglyceride lipases are lipases that hydrolyse ester linkages of triglycerides. These lipases are widely distributed in animals, plants and prokaryotes. This family was also called class 3 lipases as they are only distantly related to other lipase families. In some fungi DDHD domain Pfam PF02862 180 residues long containing four conserved residues that may form a metal binding site is associated with the Lipase_3. Bacterial enzymes (LipG Lee et al. 2006) belong to family XI of the classification of Arpigny and Jaeger 1999. The (phospho)lipase of F.solani has the highest microbial activity on galactolipids Jallouli et al. Feruloyl esterases are enzymes produced by micro-organisms to deconstruct plant cell walls by hydrolyzing phenolic groups involved in the cross-linking of arabinoxylan to other polymeric structures. The non-modular type-A feruloyl esterase from Aspergillus niger AnFaeA is similar to fungal lipases and different from other feruloyl esterases. Feruloyl esterases are distributed in different sub-classes type-A B C,D and E and fall respectively in the following families. Type-A in Lipase_3, Type-B in Esterase_phb (PHB depolymerase), Type-C in Tannase, Type-D in FaeC, Type-E in A85-Feruloyl-Esterase, Type-F in BD-FAE. (cd00741: Lipase)

Database

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (62)

Genes Proteins in Lipase_3 family (407)

Fragments of genes in Lipase_3 family (39)

Structures in Lipase_3 family (62)

Substrates in Lipase_3 family (41)

Inhibitors in Lipase_3 family (29)

References (17)

Title : Diacylglycerol Lipase-beta Knockout Mice Display a Sex-Dependent Attenuation of Traumatic Brain Injury-Induced Mortality with No Impact on Memory or Other Functional Consequences - O'Brien_2021_Cannabis.Cannabinoid.Res__
Author(s) : O'Brien LD , Smith TL , Donvito G , Cravatt BF , Newton J , Spiegel S , Reeves TM , Phillips LL , Lichtman AH
Ref : Cannabis Cannabinoid Res , : , 2021
PubMedID: 34142866
Gene_locus related to this paper: human-DAGLB , mouse-DGLB

Title : A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography - de Wijn_2019_IUCrJ_6_454
Author(s) : de Wijn R , Hennig O , Roche J , Engilberge S , Rollet K , Fernandez-Millan P , Brillet K , Betat H , Morl M , Roussel A , Girard E , Mueller-Dieckmann C , Fox GC , Olieric V , Gavira JA , Lorber B , Sauter C
Ref : IUCrJ , 6 :454 , 2019
PubMedID: 31098026
Gene_locus related to this paper: humla-1lipa

Title : Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition - Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26
Author(s) : Ogasawara D , Deng H , Viader A , Baggelaar MP , Breman A , den Dulk H , van den Nieuwendijk AM , Soethoudt M , van der Wel T , Zhou J , Overkleeft HS , Sanchez-Alavez M , Mori S , Nguyen W , Conti B , Liu X , Chen Y , Liu QS , Cravatt BF , van der Stelt M
Ref : Proc Natl Acad Sci U S A , 113 :26 , 2016
PubMedID: 26668358
Gene_locus related to this paper: human-DAGLA , human-DAGLB

Title : The galactolipase activity of Fusarium solani (phospho)lipase - Jallouli_2015_Biochim.Biophys.Acta_1851_282
Author(s) : Jallouli R , Othman H , Amara S , Parsiegla G , Carriere F , Srairi-Abid N , Gargouri Y , Bezzine S
Ref : Biochimica & Biophysica Acta , 1851 :282 , 2015
PubMedID: 25529980
Gene_locus related to this paper: nech7-c7yuz1

Title : Crystal structure of a secreted lipase from Gibberella zeae reveals a novel double-lock mechanism - Lou_2010_Protein.Cell_1_760
Author(s) : Lou Z , Li M , Sun Y , Liu Y , Liu Z , Wu W , Rao Z
Ref : Protein Cell , 1 :760 , 2010
PubMedID: 21203917
Gene_locus related to this paper: gibze-q6wer3

Title : Structural redesign of lipase B from Candida antarctica by circular permutation and incremental truncation - Qian_2009_J.Mol.Biol_393_191
Author(s) : Qian Z , Horton JR , Cheng X , Lutz S
Ref : Journal of Molecular Biology , 393 :191 , 2009
PubMedID: 19683009
Gene_locus related to this paper: canar-LipB

Title : Structural basis for the cold adaptation of psychrophilic M37 lipase from Photobacterium lipolyticum - Jung_2008_Proteins_71_476
Author(s) : Jung SK , Jeong DG , Lee MS , Lee JK , Kim HK , Ryu SE , Park BC , Kim JH , Kim SJ
Ref : Proteins , 71 :476 , 2008
PubMedID: 18186467
Gene_locus related to this paper: 9gamm-q5drn8

Title : Isolation and characterization of a novel lipase from a metagenomic library of tidal flat sediments: evidence for a new family of bacterial lipases - Lee_2006_Appl.Environ.Microbiol_72_7406
Author(s) : Lee MH , Lee CH , Oh TK , Song JK , Yoon JH
Ref : Applied Environmental Microbiology , 72 :7406 , 2006
PubMedID: 16950897
Gene_locus related to this paper: 9bact-q1paf1

Title : Feruloyl esterase: a key enzyme in biomass degradation - Wong_2006_Appl.Biochem.Biotechnol_133_87
Author(s) : Wong DWS
Ref : Appl Biochem Biotechnol , 133 :87 , 2006
PubMedID: 16702605

Title : The crystal structure of feruloyl esterase A from Aspergillus niger suggests evolutive functional convergence in feruloyl esterase family - Hermoso_2004_J.Mol.Biol_338_495
Author(s) : Hermoso JA , Sanz-Aparicio J , Molina R , Juge N , Gonzalez R , Faulds CB
Ref : Journal of Molecular Biology , 338 :495 , 2004
PubMedID: 15081808
Gene_locus related to this paper: aspni-FAEA

Title : Structure of a feruloyl esterase from Aspergillus niger - McAuley_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_878
Author(s) : McAuley KE , Svendsen A , Patkar SA , Wilson KS
Ref : Acta Crystallographica D Biol Crystallogr , 60 :878 , 2004
PubMedID: 15103133
Gene_locus related to this paper: aspni-FAEA

Title : The faeA genes from Aspergillus niger and Aspergillus tubingensis encode ferulic acid esterases involved in degradation of complex cell wall polysaccharides - de Vries_1997_Appl.Environ.Microbiol_63_4638
Author(s) : de Vries RP , Michelsen B , Poulsen CH , Kroon PA , van den Heuvel RH , Faulds CB , Williamson G , van den Hombergh JP , Visser J
Ref : Applied Environmental Microbiology , 63 :4638 , 1997
PubMedID: 9406381
Gene_locus related to this paper: aspni-FAEA , asptu-FAEA

Title : The sequence, crystal structure determination and refinement of two crystal forms of lipase B from Candida antarctica - Uppenberg_1994_Structure_2_293
Author(s) : Uppenberg J , Hansen MT , Patkar S , Jones TA
Ref : Structure , 2 :293 , 1994
PubMedID: 8087556
Gene_locus related to this paper: canar-LipB

Title : Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar - Derewenda_1994_J.Lipid.Res_35_524
Author(s) : Derewenda U , Swenson L , Wei Y , Green R , Kobos PM , Joerger R , Haas MJ , Derewenda ZS
Ref : J Lipid Res , 35 :524 , 1994
PubMedID: 8014587
Gene_locus related to this paper: humla-1lipa , rhidl-lipas

Title : An unusual buried polar cluster in a family of fungal lipases - Derewenda_1994_Nat.Struct.Biol_1_36
Author(s) : Derewenda U , Swenson L , Green R , Wei Y , Dodson GG , Yamaguchi S , Haas MJ , Derewenda ZS
Ref : Nat Struct Biol , 1 :36 , 1994
PubMedID: 7656005
Gene_locus related to this paper: humla-1lipa , penca-mdgli , rhidl-lipas

Title : Current progress in crystallographic studies of new lipases from filamentous fungi - Derewenda_1994_Protein.Eng_7_551
Author(s) : Derewenda U , Swenson L , Green R , Wei Y , Yamaguchi S , Joerger R , Haas MJ , Derewenda ZS
Ref : Protein Engineering , 7 :551 , 1994
PubMedID: 8029211
Gene_locus related to this paper: humla-1lipa , penca-mdgli , rhidl-lipas

Title : A serine protease triad forms the catalytic centre of a triacylglycerol lipase - Brady_1990_Nature_343_767
Author(s) : Brady L , Brzozowski AM , Derewenda ZS , Dodson E , Dodson G , Tolley S , Turkenburg JP , Christiansen L , Huge-Jensen B , Norskov L , Thim L , Menge U
Ref : Nature , 343 :767 , 1990
PubMedID: 2304552
Gene_locus related to this paper: rhimi-lipas