(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Bacteria: NE > FCB group: NE > Bacteroidetes/Chlorobi group: NE > Bacteroidetes: NE > Bacteroidia: NE > Bacteroidales: NE > Bacteroidaceae: NE > Bacteroides: NE > Bacteroides fragilis: NE
No mutation 1 structure: 3NUZ: Crystal structure of a putative acetyl xylan esterase (BF1801) from Bacteroides fragilis NCTC 9343 at 2.30 A resolution No kinetic
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MKNIFLIIGISLFFNGSLYAQSDGWSPKDHNLIKSVREDGRFLSSYGVVH AMLRNTEPRYAFHRDFSPKEFRKWQKGLRHAMEEIMKFPQIKNSPAPVCI KREQREGYRLEKWEFYPLPKCVSTFLVLIPDNINKPVPAILCIPGSGGNK EGLAGEPGIAPKLNDRYKDPKLTQALNFVKEGYIAVAVDNPAAGEASDLE RYTLGSNYDYDVVSRYLLELGWSYLGYASYLDMQVLNWMKTQKHIRKDRI VVSGFSLGTEPMMVLGTLDTSIYAFVYNDFLCQTQERAEVMTMPDKNGRR PFPNSIRHLIPDFWKNFNFPDIVAALAPRPIILTEGGLDRDLDLVRKAYA IVGTPDNVKIYHYKKFSDPDTRKNVEYLPEGLDRNEYFRMVNVDGPNHYF KSELVVPWLRKLLEER
The obligately anaerobic bacterium Bacteroides fragilis, an opportunistic pathogen and inhabitant of the normal human colonic microbiota, exhibits considerable within-strain phase and antigenic variation of surface components. The complete genome sequence has revealed an unusual breadth (in number and in effect) of DNA inversion events that potentially control expression of many different components, including surface and secreted components, regulatory molecules, and restriction-modification proteins. Invertible promoters of two different types (12 group 1 and 11 group 2) were identified. One group has inversion crossover (fix) sites similar to the hix sites of Salmonella typhimurium. There are also four independent intergenic shufflons that potentially alter the expression and function of varied genes. The composition of the 10 different polysaccharide biosynthesis gene clusters identified (7 with associated invertible promoters) suggests a mechanism of synthesis similar to the O-antigen capsules of Escherichia coli.
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) BF1801 putative acetyl xylan esterase
