Catharanthus roseus (Madagascar periwinkle) (Vinca rosea). Hydrolase 3
Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. vincadifformine) biosynthesis pathway. Catalyzes the conversion of O-acetylstemmadenine (OAS) to vincadifformine. May also trigger the formation of additional unknown MIAs.
MASSDETIFD LPPYIRVFKD GRVERLHSSP YVPPSLNDPE TGVSWKDVPI SSKVSARIYL PKISDQQENE EKLPIFVYFH GAGFCLESAF RSFFHTFIKH FVSEAKAIGV SVEYRLAPEH PLPAAYEDCW EALQWVASHV RLDNSSLKRS MDKDPWIINY GDFDRLYLGG DSPGGNIVHN VLLRAGKEKL NGGVKILGAI QYYPYFLIRT SSKQSDYMEN DYRCYWKLAY PNAPGGTDNP MINPTVENAP DLAGYGCSRL LISMVADETR DITLLFIEAL KKSGWKGQLD VADFEAEFFD LFQTQTEVGK NMIRRLTSFI K
| Title : Completion of the canonical pathway for assembly of anticancer drugs vincristine\/vinblastine in Catharanthus roseus - Qu_2019_Plant.J_97_257 |
| Author(s) : Qu Y , Safonova O , De Luca V |
| Ref : Plant J , 97 :257 , 2019 |
| Abstract : Qu_2019_Plant.J_97_257 |
| ESTHER : Qu_2019_Plant.J_97_257 |
| PubMedSearch : Qu_2019_Plant.J_97_257 |
| PubMedID: 30256480 |
| Gene_locus related to this paper: catro-hl3 , catro-hl4 |
| Title : Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine - Qu_2018_Proc.Natl.Acad.Sci.U.S.A_115_3180 |
| Author(s) : Qu Y , Easson M , Simionescu R , Hajicek J , Thamm AMK , Salim V , De Luca V |
| Ref : Proc Natl Acad Sci U S A , 115 :3180 , 2018 |
| Abstract : Qu_2018_Proc.Natl.Acad.Sci.U.S.A_115_3180 |
| ESTHER : Qu_2018_Proc.Natl.Acad.Sci.U.S.A_115_3180 |
| PubMedSearch : Qu_2018_Proc.Natl.Acad.Sci.U.S.A_115_3180 |
| PubMedID: 29511102 |
| Gene_locus related to this paper: catro-CS , catro-TS , catro-hl3 , catro-hl4 |