catro-TS
Catharanthus roseus (Madagascar periwinkle) hydrolase 2, Tabersonine Synthase TS
Comment
Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of a derivative of O-acetylstemmadenine (OAS) ie dehydrosecodine to tabersonine, a precursor of vindoline (which results in vinblastine: connection of vindoline and catharanthine.
Relationship
Family : Plant_carboxylesterase
Block : H
Position in NCBI Life Tree : Catharanthus roseus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Viridiplantae N E > Streptophyta N E > Streptophytina N E > Embryophyta N E > Tracheophyta N E > Euphyllophyta N E > Spermatophyta N E > Magnoliophyta N E > Mesangiospermae N E > eudicotyledons N E > Gunneridae N E > Pentapetalae N E > asterids N E > lamiids N E > Gentianales N E > Apocynaceae N E > Rauvolfioideae N E > Vinceae N E > Catharanthinae N E > Catharanthus N E > Catharanthus roseus N EMolecular evidence
Sequence
Peptide
MGSSDETIFD LPPYIKVFKD GRVERLHSSP YVPPSLNDPE TGGVSWKDVP ISSVVSARIY LPKINNHDEK LPIIVYFHGA GFCLESAFKS FFHTYVKHFV AEAKAIAVSV EFRLAPENHL PAAYEDCWEA LQWVASHVGL DISSLKTCID KDPWIINYAD FDRLYLWGDS TGANIVHNTL IRSGKEKLNG GKVKILGAIL YYPYFLIRTS SKQSDYMENE YRSYWKLAYP DAPGGNDNPM INPTAENAPD LAGYGCSRLL ISMVADEARD ITLLYIDALE KSGWKGELDV ADFDKQYFEL FEMETEVAKN MLRRLASFIK
References (4)
| Title : Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis - DeMars_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2318586121 |
| Author(s) : DeMars MD, 2nd , O'Connor SE |
| Ref : Proc Natl Acad Sci U S A , 121 :e2318586121 , 2024 |
| Abstract : |
| PubMedSearch : DeMars_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2318586121 |
| PubMedID: 38319969 |
| Gene_locus related to this paper: catro-CS , catro-TS , tabib-a0a5b8x6s2 , tabib-CorS |
| Title : Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids - Caputi_2020_Nat.Chem.Biol_16_383 |
| Author(s) : Caputi L , Franke J , Bussey K , Farrow SC , Vieira IJC , Stevenson CEM , Lawson DM , O'Connor SE |
| Ref : Nat Chemical Biology , 16 :383 , 2020 |
| Abstract : |
| PubMedSearch : Caputi_2020_Nat.Chem.Biol_16_383 |
| PubMedID: 32066966 |
| Gene_locus related to this paper: catro-CS , catro-TS , tabib-a0a5b8x6s2 , tabib-CorS |
| Title : Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle - Caputi_2018_Science_360_1235 |
| Author(s) : Caputi L , Franke J , Farrow SC , Chung K , Payne RME , Nguyen TD , Dang TT , Soares Teto Carqueijeiro I , Koudounas K , Duge de Bernonville T , Ameyaw B , Jones DM , Vieira IJC , Courdavault V , O'Connor SE |
| Ref : Science , 360 :1235 , 2018 |
| Abstract : |
| PubMedSearch : Caputi_2018_Science_360_1235 |
| PubMedID: 29724909 |
| Gene_locus related to this paper: catro-CS , catro-TS |
| Title : Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine - Qu_2018_Proc.Natl.Acad.Sci.U.S.A_115_3180 |
| Author(s) : Qu Y , Easson M , Simionescu R , Hajicek J , Thamm AMK , Salim V , De Luca V |
| Ref : Proc Natl Acad Sci U S A , 115 :3180 , 2018 |
| Abstract : |
| PubMedSearch : Qu_2018_Proc.Natl.Acad.Sci.U.S.A_115_3180 |
| PubMedID: 29511102 |
| Gene_locus related to this paper: catro-CS , catro-TS , catro-hl3 , catro-hl4 |