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Gene_locus Report for: funhe-a0a147ar95

Fundulus heteroclitus (Killifish) (Mummichog). Hepatic triacylglycerol lipase

Relationship
Family|Hepatic_Lipase
Block| L
Position in NCBI Life Tree|Fundulus heteroclitus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Actinopterygii: N E > Actinopteri: N E > Neopterygii: N E > Teleostei: N E > Osteoglossocephalai: N E > Clupeocephala: N E > Euteleosteomorpha: N E > Neoteleostei: N E > Eurypterygia: N E > Ctenosquamata: N E > Acanthomorphata: N E > Euacanthomorphacea: N E > Percomorphaceae: N E > Ovalentaria: N E > Atherinomorphae: N E > Cyprinodontiformes: N E > Cyprinodontoidei: N E > Fundulidae: N E > Fundulus: N E > Fundulus heteroclitus: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
Sequence
Graphical view for this peptide sequence: funhe-a0a147ar95
Colored MSA for Hepatic_Lipase (raw)
MSFSDRASSPKGAHLQNPSAPELKPPRFRGTNQKRPSGAMSVLKILCCLL
IACYLGEGKKIRGSRASVTHTEEGGVLRMKEPYVSSSVFRLFLGGEDTCT
LDPLQLHTLTSCGFNSSNPLIIITHGWSVDGMMESWVLRMATTLKSNLVD
VNVVMTDWLSLAHQHYPLAVQSTRTVGKDIAHLLQSLQREYRYPVRKAHL
IGYSLGAHISGFAGSFLQGSDKIGRITGLDPAGPLFEGMSPTDRLSPDDA
EFVDAIHTFTHERLGLSVGIKQAVAHYDFYPNGGDFQPGCDFHNIYDHIS
EYGILGFEQTVKCAHERSVHLFMDSLLNKDKQSMAYRCSDNSAFVRGICL
DCRKNRCNTLGYDIRKVRTARSKKLYLKTRSRMPYKLYHYQFRIQFVNQT
ERITPSLIFSLQGTEEESGDLFITIDEGIHGNTTFSFLITLDKDLGELMM
LKLSWETSDLWRNVWTRMQSILPWGGQRSKPQMMVGKISVKAGETQDRTS
FCAMNNDGPHIEVGEDKVFVRCKEDKPTLRRRKHSRPLKMNTSVQQTKY
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MSFSDRASSPKGAHLQNPSAPELKPPRFRGTNQKRPSGAMSVLKILCCLL
IACYLGEGKKIRGSRASVTHTEEGGVLRMKEPYVSSSVFRLFLGGEDTCT
LDPLQLHTLTSCGFNSSNPLIIITHGWSVDGMMESWVLRMATTLKSNLVD
VNVVMTDWLSLAHQHYPLAVQSTRTVGKDIAHLLQSLQREYRYPVRKAHL
IGYSLGAHISGFAGSFLQGSDKIGRITGLDPAGPLFEGMSPTDRLSPDDA
EFVDAIHTFTHERLGLSVGIKQAVAHYDFYPNGGDFQPGCDFHNIYDHIS
EYGILGFEQTVKCAHERSVHLFMDSLLNKDKQSMAYRCSDNSAFVRGICL
DCRKNRCNTLGYDIRKVRTARSKKLYLKTRSRMPYKLYHYQFRIQFVNQT
ERITPSLIFSLQGTEEESGDLFITIDEGIHGNTTFSFLITLDKDLGELMM
LKLSWETSDLWRNVWTRMQSILPWGGQRSKPQMMVGKISVKAGETQDRTS
FCAMNNDGPHIEVGEDKVFVRCKEDKPTLRRRKHSRPLKMNTSVQQTKY


Reference
    Title: The effects of 17-alpha-ethinylestradiol (EE2) on molecular signaling cascades in mummichog (Fundulus heteroclitus)
    Doyle MA, Bosker T, Martyniuk CJ, Maclatchy DL, Munkittrick KR
    Ref: Aquat Toxicol, 134-135:34, 2013 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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