Pancreatic, hepatic and gastric/lingual lipase are closely related to each other and to lipoprotein lipase (EC: 3.1.1.34), which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL). Familial human hepatic lipase deficiency is a rare recessive disorder Two variants (S267F and T383M) are rare mutations found to date only in HL deficient subjects and their relatives. Of the six HL variants described to date, only S267F and T383M are associated with hyperlipidemia. human-LIPC. The disease is characterised by premature atherosclerosis and abnormal circulating lipoproteins
Interpro : IPR000734 Lipase , IPR002333 Hepatic lipase , IPR016272 Lipase, LIPH-type , IPR013818 Lipase
PIRSF : No PIRSF
Pdoc : PDOC00110
Pfam : PF00151 Lipase
Prints : PR00821 , PR00824
EC Number : 3.1.1.3
No structure scheme yet for this family
Genes Proteins in Hepatic_Lipase family (116)
Fragments of genes in Hepatic_Lipase family (68)
No fragment of genesSubstrates in Hepatic_Lipase family (8)
Inhibitors in Hepatic_Lipase family (1)
Title : Vertebrate hepatic lipase genes and proteins: a review supported by bioinformatic studies - Holmes_2011_Open.Access.Bioinformatics_2011_85 |
Author(s) : Holmes RS , Vandeberg JL , Cox LA |
Ref : Open Access Bioinformatics , 2011 :85 , 2011 |
Abstract : Holmes_2011_Open.Access.Bioinformatics_2011_85 |
ESTHER : Holmes_2011_Open.Access.Bioinformatics_2011_85 |
PubMedSearch : Holmes_2011_Open.Access.Bioinformatics_2011_85 |
PubMedID: 22408368 |
Title : Human hepatic lipase mutations and polymorphisms - Hegele_1992_Hum.Mutat_1_320 |
Author(s) : Hegele RA , Tu L , Connelly PW |
Ref : Hum Mutat , 1 :320 , 1992 |
Abstract : Hegele_1992_Hum.Mutat_1_320 |
ESTHER : Hegele_1992_Hum.Mutat_1_320 |
PubMedSearch : Hegele_1992_Hum.Mutat_1_320 |
PubMedID: 1301939 |