(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Bacteria: NE > Terrabacteria group: NE > Actinobacteria [phylum]: NE > Actinobacteria [class]: NE > Corynebacteriales: NE > Mycobacteriaceae: NE > Mycobacterium: NE > Mycobacterium avium complex (MAC): NE > Mycobacterium avium: NE > Mycobacterium avium subsp. paratuberculosis: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Mycobacterium avium subsp. paratuberculosis K-10: N, E.
Mycobacterium avium subsp. paratuberculosis: N, E.
Mycobacterium avium subsp. paratuberculosis S397: N, E.
Mycobacterium avium subsp. paratuberculosis MAP4: N, E.
Mycobacterium avium subsp. paratuberculosis S5: N, E.
Mycobacterium avium subsp. paratuberculosis 10-4404: N, E.
Mycobacterium avium subsp. paratuberculosis 10-8425: N, E.
Mycobacterium avium subsp. paratuberculosis 08-8281: N, E.
Mycobacterium avium subsp. paratuberculosis 10-5975: N, E.
Mycobacterium avium subsp. paratuberculosis 10-5864: N, E.
Mycobacterium avium subsp. paratuberculosis 11-1786: N, E.
Mycobacterium avium: N, E.
Mycobacterium avium subsp. hominissuis TH135: N, E.
Mycobacterium avium MAV_120709_2344: N, E.
Mycobacterium avium 10-5581: N, E.
Mycobacterium avium 104: N, E.
Mycobacterium avium subsp. hominissuis: N, E.
Mycobacterium avium subsp. silvaticum: N, E.
Mycobacterium avium subsp. avium: N, E.
Mycobacterium avium MAV_061107_1842: N, E.
Mycobacterium avium subsp. hominissuis 10-5606: N, E.
Mycobacterium avium MAV_120809_2495: N, E.
Mycobacterium avium 09-5983: N, E.
Mycobacterium avium 2285 (R): N, E.
Mycobacterium tuberculosis XTB13-223: N, E.
Mycobacterium avium 05-4293: N, E.
Mycobacterium avium subsp. hominissuis 101: N, E.
Mycobacterium avium XTB13-223: N, E.
Mycobacterium avium subsp. silvaticum ATCC 49884: N, E.
Mycobacterium avium subsp. avium 10-9275: N, E.
Mycobacterium avium subsp. avium 11-4751: N, E.
Mycobacterium avium 11-0986: N, E.
Mycobacterium avium subsp. hominissuis 10-4249: N, E.
Mycobacterium avium subsp. avium 2285 (S): N, E.
Mycobacterium avium subsp. hominissuis A5: N, E.
Mycobacterium avium subsp. hominissuis 3388: N, E.
Mycobacterium avium subsp. hominissuis 100: N, E.
Mycobacterium avium subsp. avium 2285 (R): N, E.
Mycobacterium avium 10-5560: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MTDLSEKVRAWGRRLLVGAAAAVTLPGLIGLAGGAATANAFSRPGLPVEY LQVPSAGMGRDIKVQFQSGGNGSPAVYLLDGLRAQDDYNGWDINTPAFEW YYQSGLSVIMPVGGQSSFYADWYQPACGKAGCSTYKWETFLTSELPSYLA SNKGVKRTGNAAVGISMSGSSAMILAVNHPDQFIYAGSLSALLDPSQGMG PSLIGLAMGDAGGYKADAMWGPSSDPAWQRNDPSLHIPELVGHNTRLWLY CGNGTPSELGGANMPAEFLENFVRSSNLKFQDAYNGAGGHNAVFNFNANG THSWEYWGAQLNAMKPDLQGTLGASPGGGG
The complete nucleotide sequence of alpha antigen secreted from Mycobacterium avium (A-alpha) was determined. The gene encodes 330 amino acids, including 40 amino acids for the signal peptide, followed by 290 amino acids for the mature protein with a molecular mass of 30,811 Da. This is the first sequence of A-alpha. Comparisons between A-alpha and alpha antigens of Mycobacterium leprae, Mycobacterium bovis BCG, and Mycobacterium kansasii showed highly homologous regions which suggested a conserved functional domain and two less-homologous regions. Serological analysis of recombinant A-alpha, expressed by a series of deletion constructs, indicated the possibility that A-alpha carries at least six B-cell epitopes. The three antigenic determinants were common to Mycobacterium tuberculosis, M. kansasii, and M. avium. The results also suggested the possibility that there are three species-specific epitopes.
