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A85-Mycolyl-transferase

Relationship

Family: A85-Mycolyl-transferase

Block: X

Parent Family: Antigen85c

Comment

This family contains Antigen85 responsible for high affinity of mycobacteria for fibronectin. Proteins of the antigen 85 possess a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity. Mycobacterium tuberculosis MPT51 (FbpC1) is a non-catalytic alpha/beta hydrolases member of this family. This family corresponds to a subset of the the Carbohydrate Esterase family CE1 in CAZy - Carbohydrate-Active enZYmes database (CE_1)

Database

Interpro : IPR000801 Esterase_put

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00756 Esterase

Prints : No Print

EC Number : 2.3.1.20 || 2.3.1.122

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
1F0N Mycobacterium tuberculosis Antigen 85B myctu-a85b
1F0P Mycobacterium tuberculosis Antigen 85B with trehalose myctu-a85b
1DQZ Mycobacterium tuberculosis Antigen85c myctu-a85c
1DQY Mycobacterium tuberculosis Antigen85c with diethyl phosphate inhibitor myctu-a85c
6SX4 Structure of C. glutamicum mycoloyltransferase A corgl-csp1
4H18 Three dimensional structure of corynomycoloyl transferase C corgl-CGL0343
7MYG Crystal structure of Ag85C modified by THL-10d myctu-a85c
5OCJ Crystal structure of Ag85C bound to cyclophostin 8beta inhibitor myctu-a85c
5VNS M.tb Ag85C covalently modified by tetrahydrolipstatin (THL, Orlistat) myctu-a85c
5KWI M.tb Ag85C modified at C209 by adamantyl-ebselen myctu-a85c
5KWJ M.tb Ag85C modified at C209 by amino-ebselen myctu-a85c
4QDO Crystal structure of Ag85C co-crystallized with p-chloromercuribenzoic acid myctu-a85c
4QDT Crystal structure of Antigen 85C co-crystallized with iodoacetamide myctu-a85c
4QDU Crystal structure of Antigen 85C co-crystallized with ebselen myctu-a85c
4QDX Crystal structure of Antigen 85C-C209G mutant myctu-a85c
4QDZ Crystal structure of Antigen 85C-E228Q mutant myctu-a85c
4QE3 Crystal structure of Antigen 85C-H260Q mutant myctu-a85c
4QEK Crystal structure of Antigen 85C-S124A mutant myctu-a85c
3HRH Crystal Structure of Antigen 85C and Glycerol myctu-a85c
4MQM Crystal structure of Antigen 85C in presence of Ebselen myctu-a85c
4MQL Crystal structure of Antigen 85C-C209S mutant myctu-a85c
5TS1 Crystal structure of MHC-I H2-KD complexed with peptides of Mycobacterial tuberculosis: (YYQSGLSIV) a fragment of Mycobacterium Tuberculosis Antigen 85B myctu-a85b
5TRZ Crystal structure of MHC-I H2-KD complexed with peptides of Mycobacterial tuberculosis: (YQSGLSIVM) a fragment of Mycobacterium Tuberculosis Antigen 85B myctu-a85b
1R88 Structure of Mycobacterium tuberculosis MPT51 (FbpC1) myctu-mpt51
1SFR Mycobacterium Tuberculosis Antigen 85A myctu-a85a
1VA5 Mycobacterium Tuberculosis Antigen 85C with octylthioglucoside in active site myctu-a85c

Gene_locus Name Species
9acto-c0jrv0 Streptomyces sioyaensis Sio2 Streptomyces sioyaensis
9acto-d3cyj3 Frankia sp. EUN1f Putative esterase Frankia sp. EUN1f
9cory-c0dzu7 Corynebacterium matruchotii ATCC 33806 Putative uncharacterized protein Corynebacterium matruchotii ATCC 33806
9cory-c0e0l1 Corynebacterium matruchotii ATCC 33806 Putative uncharacterized protein Corynebacterium matruchotii ATCC 33806
9cory-c0e5x9 Corynebacterium matruchotii ATCC 33806 Putative uncharacterized protein Corynebacterium matruchotii ATCC 33806
9cory-c0e5y0 Corynebacterium matruchotii ATCC 33806 Putative uncharacterized protein Corynebacterium matruchotii ATCC 33806
9cory-c0e429 Corynebacterium matruchotii ATCC 33806 Putative uncharacterized protein Corynebacterium matruchotii ATCC 33806
9cory-c0e430 Corynebacterium matruchotii Putative uncharacterized protein Corynebacterium matruchotii ATCC 33806
9cory-c0e434 Corynebacterium matruchotii ATCC 33806 Putative uncharacterized protein Corynebacterium matruchotii ATCC 33806
9cory-c0e717 Corynebacterium matruchotii ATCC 33806 Putative uncharacterized protein Corynebacterium matruchotii ATCC 33806
9cory-c0vrd2 Corynebacterium glucuronolyticum ATCC 51867 Antigen 85 protein Corynebacterium glucuronolyticum ATCC 51867
9cory-c0vwv6 Corynebacterium glucuronolyticum (strains ATCC 51867\; ATCC 51866) Secreted antigen Corynebacterium glucuronolyticum
9cory-c0wgb2 Corynebacterium accolens ATCC 49725 Secreted antigen Corynebacterium accolens ATCC 49725
9cory-c0wgb3 Corynebacterium accolens ATCC 49725 Trehalose corynomycolyl transferase C Corynebacterium accolens ATCC 49725
9cory-c0wi14 Corynebacterium accolens ATCC 49725 Antigenic 85 complex protein Corynebacterium accolens ATCC 49725
9cory-c0xnr5 Corynebacterium lipophiloflavum DSM 44291 Secreted antigen Corynebacterium lipophiloflavum DSM 44291
9cory-c0xnr8 Corynebacterium lipophiloflavum DSM 44291 Trehalose corynomycolyl transferase C Corynebacterium lipophiloflavum DSM 44291
9cory-c0xpm2 Corynebacterium lipophiloflavum DSM 44291 A85 antigen family 85 complex protein Corynebacterium lipophiloflavum DSM 44291
9cory-c0xpm4 Corynebacterium lipophiloflavum DSM 44291 A85 antigen family 85 complex protein Corynebacterium lipophiloflavum DSM 44291
9cory-c0xrb3 Corynebacterium lipophiloflavum DSM 44291 Antigen 85-A Corynebacterium lipophiloflavum DSM 44291
9cory-c0xub1 Corynebacterium lipophiloflavum DSM 44291 Antigenic 85 complex protein Corynebacterium lipophiloflavum DSM 44291
9cory-c2gdp1 Corynebacterium glucuronolyticum (strains ATCC 51866 ATCC 51867) Trehalose corynomycolyl transferase C Corynebacterium glucuronolyticum
9cory-c2gg83 Corynebacterium glucuronolyticum ATCC 51866 Antigen Corynebacterium glucuronolyticum ATCC 51866
9cory-c6r7h6 Corynebacterium tuberculostearicum SK141 Antigen 85-C Corynebacterium tuberculostearicum SK141
9cory-c6r7h9 Corynebacterium tuberculostearicum SK141 PS1 protein Corynebacterium tuberculostearicum SK141
9cory-c6r7q5 Corynebacterium tuberculostearicum SK141 Cell surface protein A Corynebacterium tuberculostearicum SK141
9cory-c6r7q6 Corynebacterium tuberculostearicum SK141 Cell surface protein A Corynebacterium tuberculostearicum SK141
9noca-q06gc0 Rhodococcus sp. NS1 Putative esterase Rhodococcus sp. NS1
actmd-c6waq3 Actinosynnema mirum (strain ATCC 29888 \/ DSM 43827 \/ NBRC 14064 \/ IMR3971) Putative esterase Actinosynnema mirum
actmd-c6wnr8 Actinosynnema mirum (strain ATCC 29888 \/ DSM 43827 \/ NBRC 14064 \/ IMR3971) Putative esterase Actinosynnema mirum
cora7-c3peg4 Corynebacterium aurimucosum (strain ATCC 700975 \/ DSM 44827 \/ CN-1 (Corynebacterium nigricans)) Putative esterase Corynebacterium aurimucosum
cora7-c3phx8 Corynebacterium aurimucosum (strain ATCC 700975 \/ DSM 44827 \/ CN-1 (Corynebacterium nigricans)) Putative esterase Corynebacterium aurimucosum
cora7-c3piw1 Corynebacterium aurimucosum (strain ATCC 700975 \/ DSM 44827 \/ CN-1 (Corynebacterium nigricans)) Putative esterase Corynebacterium aurimucosum
cora7-c3pjx9 Corynebacterium aurimucosum (strain ATCC 700975 \/ DSM 44827 \/ CN-1 (Corynebacterium nigricans)) Trehalose corynomycolyl transferase A Corynebacterium aurimucosum
cora7-c3pjy0 Corynebacterium aurimucosum (strain ATCC 700975 \/ DSM 44827 \/ CN-1 (Corynebacterium nigricans)) Corynomycolyl transferase Corynebacterium aurimucosum
cora7-c3pk62 Corynebacterium aurimucosum (strain ATCC 700975 \/ DSM 44827 \/ CN-1) (Corynebacterium nigricans)Trehalose corynomycolyl transferase C Corynebacterium aurimucosum
cora7-c3pk63 Corynebacterium aurimucosum (strain ATCC 700975 \/ DSM 44827 \/ CN-1) (Corynebacterium nigricans)Trehalose corynomycolyl transferase B Corynebacterium aurimucosum
coram-SLPA Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) surface layer protein a Corynebacterium ammoniagenes
cordi-q6ned6 Corynebacterium diphtheriae putative major secreted protein Corynebacterium diphtheriae
cordi-q6nes3 Corynebacterium diphtheriae putative secreted antigen Corynebacterium diphtheriae
cordi-q6nes4 Corynebacterium diphtheriae putative secreted antigen Corynebacterium diphtheriae
cordi-q6njn3 Corynebacterium diphtheriae surface layer protein a Corynebacterium diphtheriae
coref-CE0356 Corynebacterium efficiens (and strain YS-314) conserved hypothetical protein Corynebacterium efficiens
coref-CE0984 Corynebacterium efficiens (and strain YS-314) putative surface layer protein Corynebacterium efficiens
coref-CE1488 Corynebacterium efficiens putative (and strain YS-314) ps1 protein Corynebacterium efficiens
coref-CE2710 Corynebacterium efficiens (and strain YS-314) putative ps1 protein Corynebacterium efficiens
coref-CSPA Corynebacterium efficiens (and strain YS-314) ps1 protein Corynebacterium efficiens
corgb-a4qhr7 Corynebacterium glutamicum (strain R) Putative uncharacterized protein Corynebacterium glutamicum
corgl-CGL0343 Corynebacterium glutamicum (Brevibacterium flavum), hypothetical protein cgl0343 Corynebacterium glutamicum
corgl-CGL0922 Corynebacterium glutamicum (Brevibacterium flavum) hypothetical protein cgl0922 Corynebacterium glutamicum
corgl-CGL1031 Corynebacterium glutamicum (Brevibacterium flavum) (and ATCC 13032\; R) hypothetical protein cgl1031 Corynebacterium glutamicum
corgl-CGL2181 Corynebacterium glutamicum (Brevibacterium flavum) (and strains ATCC 13032\; R) hypothetical protein cgl2181 Corynebacterium glutamicum
corgl-CGL2878 Corynebacterium glutamicum (Brevibacterium flavum) (and strains ATCC 13032\; R) predicted esterase Corynebacterium glutamicum
corgl-CMT3 Corynebacterium glutamicum (Brevibacterium flavum) corynomycolyl transferase (EC 2.3.1.122) cmt3 Corynebacterium glutamicum
corgl-csp1 Corynebacterium glutamicum (Brevibacterium flavum)\; Corynebacterium melassecola mycoloyltransferase ps1 protein precursor CSP1 COP1 MytA NCgl2777 CGL2875 Corynebacterium glutamicum
corjk-q4jst9 Corynebacterium jeikeium (strains K411\; ATCC 43734) trehalose corynomycolyl transferase a precursor (EC 2.3.1.122) Corynebacterium jeikeium
corjk-q4jy21 Corynebacterium jeikeium (strain K411\; ATCC 43734) trehalose corynomycolyl transferase c precursor (EC 2.3.1.122) Corynebacterium jeikeium
corjk-q4jy22 Corynebacterium jeikeium (strains K411\; ATCC 43734) trehalose corynomycolyl transferase b precursor (EC 2.3.1.122) Corynebacterium jeikeium
cork4-c4lgs3 Corynebacterium kroppenstedtii (strain DSM 44385 \/ CCUG 35717) Trehalose corynomycolyl transferase Corynebacterium kroppenstedtii
cork4-c4lgs4 Corynebacterium kroppenstedtii (strain DSM 44385 \/ CCUG 35717) Trehalose corynomycolyl transferase Corynebacterium kroppenstedtii
cork4-c4lic3 Corynebacterium kroppenstedtii (strain DSM 44385 \/ CCUG 35717) Trehalose corynomycolyl transferase Corynebacterium kroppenstedtii
corst-c2cr50 Corynebacterium striatum ATCC 6940 A85 antigen family 85 complex protein Corynebacterium striatum ATCC 6940
corst-c2cr69 Corynebacterium striatum ATCC 6940 Antigen 85 protein Corynebacterium striatum ATCC 6940
corst-c2crh2 Corynebacterium striatum ATCC 6940 Secreted antigen Corynebacterium striatum ATCC 6940
corst-c2crh3 Corynebacterium striatum ATCC 6940 Trehalose corynomycolyl transferase C Corynebacterium striatum ATCC 6940
coru7-b1vec6 Corynebacterium urealyticum (strain ATCC 43042 \/ DSM 7109) Trehalose corynomycolyl transferase B Corynebacterium urealyticum
coru7-b1vec7 Corynebacterium urealyticum (strain ATCC 43042 \/ DSM 7109) Trehalose corynomycolyl transferase C Corynebacterium urealyticum
coru7-b1vi01 Corynebacterium urealyticum (strain ATCC 43042 \/ DSM 7109) Trehalose corynomycolyl transferase A Corynebacterium urealyticum
fraaa-q0rev2 Frankia alni (strain ACN14a) Putative uncharacterized protein Frankia alni
fraaa-q0rkm8 Frankia alni (strain ACN14a) Putative uncharacterized protein Frankia alni
gorb4-d0l2k2 Gordonia bronchialis (strain ATCC 25592 \/ DSM 43247 \/ JCM 3198 \/ NCT 10667) (Rhodococcus bronchialis) Putative esterase Gordonia bronchialis
gorb4-d0l3j0 Gordonia bronchialis (strain ATCC 25592 \/ DSM 43247 \/ JCM 3198 \/ NCT10667) (Rhodococcus bronchialis) Putative esterase Gordonia bronchialis
gorb4-d0l7a2 Gordonia bronchialis (strain ATCC 25592 \/ DSM 43247 \/ JCM 3198 \/ NCT10667) (Rhodococcus bronchialis) Putative esterase Gordonia bronchialis
gorb4-d0l349 Gordonia bronchialis (strain ATCC 25592 \/ DSM 43247 \/ JCM 3198 \/ NCT10667) (Rhodococcus bronchialis) Putative esterase Gordonia bronchialis
gorb4-d0l786 Gordonia bronchialis (strain ATCC 25592 \/ DSM 43247 \/ JCM 3198 \/ NCT 10667) (Rhodococcus bronchialis) Putative esterase Gordonia bronchialis
gorb4-d0lbc5 Gordonia bronchialis (strain ATCC 25592 \/ DSM 43247 \/ JCM 3198 \/ NCT10667) (Rhodococcus bronchialis) Putative esterase Gordonia bronchialis
gorb4-d0lbc6 Gordonia bronchialis (strain ATCC 25592 \/ DSM 43247 \/ JCM 3198 \/ NCT10667) (Rhodococcus bronchialis) Putative esterase Gordonia bronchialis
gorb4-d0lcb9 Gordonia bronchialis (strain ATCC 25592 \/ DSM 43247 \/ JCM 3198 \/ NCT 10667) (Rhodococcus bronchialis) Putative esterase Gordonia bronchialis
kocrd-b2gh24 Kocuria rhizophila (strain ATCC 9341 \/ DSM 348 \/ NBRC 103217\/ DC2201) Putative esterase family protein Kocuria rhizophila
myca1-a0q9c0 Mycobacterium avium (strain 104)Mycobacterium avium subsp. avium Mycobacterium indicus pranii Antigen 85-A Mycobacterium avium
myca9-b1mel1 Mycobacterium abscessus (strain ATCC 19977 \/ DSM 44196) Antigen 85-C Mycobacterium abscessus
myca9-b1mel2 Mycobacterium abscessus (strain ATCC 19977 \/ DSM 44196) Antigen 85-A Mycobacterium abscessus
myca9-b1mel3 Mycobacterium abscessus (strain ATCC 19977 \/ DSM 44196) Antigen 85-A\/B\/C Mycobacterium abscessus
myca9-b1mm89 Mycobacterium abscessus (strain ATCC 19977 \/ DSM 44196) Putative uncharacterized protein Mycobacterium abscessus
myca9-b1mmv2 Mycobacterium abscessus (strain ATCC 19977 \/ DSM 44196) Antigen 85-B Mycobacterium abscessus
mycav-a85a Mycobacterium avium and Mycobacterium paratuberculosis ag85A fibronectin-binding protein A antigen 85-a (mycolyl transferase) (EC 2.3.1.122) (fragment) Mycobacterium paratuberculosis
mycav-a85b Mycobacterium avium (strain 104) complex B ag85B and Mycobacterium paratuberculosis fbpb fibronectin-binding protein B Mycobacterium paratuberculosis
mycav-a85c Mycobacterium avium (and strain 104), Mycobacterium paratuberculosis fbpc2 antigen 85c complex Mycobacterium avium
mycgi-a4t1j0 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) Putative esterase Mycobacterium gilvum
mycgi-a4t6e3 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) Putative esterase Mycobacterium gilvum
mycgi-a4t6e4 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) Putative esterase Mycobacterium gilvum
mycgi-a4taf0 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) Putative esterase Mycobacterium gilvum
mycgi-a4tap7 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) Putative esterase Mycobacterium gilvum
mycgi-a4tdd9 Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 \/ PYR-GCK)) Putative esterase Mycobacterium gilvum
mycgo-a85a Mycobacterium gordonae ag85A fibronectin-binding protein A Mycobacterium gordonae
mycit-a85b Mycobacterium intracellulare complex B ag85B fibronectin-binding protein B Mycobacterium intracellulare
mycka-a85b Mycobacterium kansasii complex B ag85B fibronectin-binding protein B Mycobacterium kansasii
mycle-a85a Mycobacterium leprae (and strain Br4923) Antigen 85A, mycolytransferase Mycobacterium leprae
mycle-a85b Mycobacterium leprae (strain Br4923\; complex B) ag85B fibronectin-binding protein B Mycobacterium leprae
mycle-a85c Mycobacterium leprae (and strain Br4923) binding protein C ag85C Mycobacterium leprae
mycle-mpt5 Mycobacterium leprae (and strain Br4923) mpt51 antigen precursor Mycobacterium leprae
mycmm-b2hed7 Mycobacterium marinum (strain ATCC BAA-535 \/ M) Secreted antigen 85-C FbpC_2 Mycobacterium marinum
mycpa-Q8KY59 Mycobacterium paratuberculosis antigen 85a complex Mycobacterium paratuberculosis
mycpa-Q8L371 Mycobacterium paratuberculosis 85b protein Mycobacterium paratuberculosis
mycpa-q745l2 Mycobacterium paratuberculosis Mycobacterium avium (strain 104) fbpc1 Mycobacterium paratuberculosis
mycs2-a0qu51 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Antigen 85-C Mycobacterium smegmatis
mycs2-a0qxv3 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Putative esterase family protein Mycobacterium smegmatis
mycs2-a0qy95 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Antigen 85-C Mycobacterium smegmatis
mycs2-a0r6k6 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Antigen 85-C Mycobacterium smegmatis
mycs2-a0r621 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Antigen 85-C Mycobacterium smegmatis
mycs2-a0r623 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Antigen 85-A Mycobacterium smegmatis
mycs2-a0r624 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) Antigen 85-C Mycobacterium smegmatis
mycsc-a85b Mycobacterium scrofulaceum complex B ag85B fibronectin-binding protein B Mycobacterium scrofulaceum
mycsj-a3pxh7 Mycobacterium sp. (strains JLS\; MCS\; KMS) Putative esterase Mycobacterium sp.
mycsj-a3q4u8 Mycobacterium sp. (strains JLS\; MCS\; KMS) Putative esterase Mycobacterium sp.
mycsj-a3q7n1 Mycobacterium sp. (strains JLS\; MCS\; KMS) Putative esterase Mycobacterium sp.
mycsj-a3q553 Mycobacterium sp. (strain JLS) Putative esterase Mycobacterium sp.
mycsk-a1ugq3 Mycobacterium sp. (strains KMS\; MCS\; JLS) Putative esterase Mycobacterium sp.
mycss-q1b1w5 Mycobacterium sp. (strains MCS\; JLS\; KMS) Putative esterase Mycobacterium sp.
mycss-q1bbm7 Mycobacterium sp. (strains MCS\; KMS\; JLS) Putative esterase Mycobacterium sp.
myctu-a85a Mycobacterium tuberculosis, Mycobacterium bovis, fibronectin-binding protein A FbpA Rv3804c Mycobacterium tuberculosis
myctu-a85b Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium microti, fibronectin-binding protein Bcomplex Bag85B fbpB Rv1886c Mycobacterium tuberculosis
myctu-a85c Mycobacterium tuberculosis, Mycobacterium bovis Antigen85c H37Rv FBPC fbpC or MPT45 or RV0129C or MTCI5.03C Mycobacterium tuberculosis
myctu-mpt51 Mycobacterium tuberculosis, Mycobacterium bovis, Secreted fibronectin-binding protein antigen protein fbpD MPT51\/MPB51 antigen RV3803C MT3910 MB3833C Mycobacterium tuberculosis
myctu-yc88 Mycobacterium tuberculosis, Mycobacterium bovis, hypothetical 49.6 kda protein rv1288 Mycobacterium tuberculosis
mycua-a0psb1 Mycobacterium ulcerans (strain Agy99) Mycobacterium marinum (strain ATCC BAA-535 \/ M) Secreted antigen 85-B FbpB Mycobacterium ulcerans
mycua-a0pwi8 Mycobacterium ulcerans (strain Agy99) Mycobacterium marinum (strain ATCC BAA-535 \/ M) Secreted antigen 85-C FbpC Mycobacterium ulcerans
mycua-a0pwz5 Mycobacterium ulcerans (strain Agy99) Mycobacterium marinum (strain ATCC BAA-535 \/ M) Secreted Mpt51\/Mpb51 antigen protein FbpD Mycobacterium ulcerans
mycul-a85a Mycobacterium ulcerans and (strain Agy99) Mycobacterium marinum (strains ATCCBAA-535\/M Secreted antigen 85a (EC 2.3.1.-) (fibronectin-binding protein a) Mycobacterium ulcerans
mycvp-a1t4c5 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) Putative esterase Mycobacterium vanbaalenii
mycvp-a1t6c2 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) Putative esterase Mycobacterium vanbaalenii
mycvp-a1t9b0 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) Putative esterase Mycobacterium vanbaalenii
mycvp-a1t9l3 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) Putative esterase Mycobacterium vanbaalenii
mycvp-a1tgm5 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) Putative esterase Mycobacterium vanbaalenii
mycvp-a1tgv9 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) Putative esterase Mycobacterium vanbaalenii
mycvp-a1tgw0 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) Putative esterase Mycobacterium vanbaalenii
mycvp-a1thj5 Mycobacterium vanbaalenii (strain DSM 7251 \/ PYR-1) Putative esterase Mycobacterium vanbaalenii
myxxd-q1d2n2 Myxococcus xanthus (strain DK 1622) Putative esterase Myxococcus xanthus
nocfa-q5yqy4 Nocardia farcinica putative esterase Nocardia farcinica
nocfa-q5yrg2 Nocardia farcinica putative esterase Nocardia farcinica
nocfa-q5yt17 Nocardia farcinica putative esterase Nocardia farcinica
nocfa-q5yuq2 Nocardia farcinica putative esterase Nocardia farcinica
nocfa-q5yvb8 Nocardia farcinica putative esterase Nocardia farcinica
nocfa-q5ywt3 Nocardia farcinica putative esterase Nocardia farcinica
nocfa-q5yx67 Nocardia farcinica putative esterase Nocardia farcinica
nocfa-q5z0s0 Nocardia farcinica hypothetical protein Nocardia farcinica
nocfa-q5z1x5 Nocardia farcinica putative esterase Nocardia farcinica
nocfa-q5z2d5 Nocardia farcinica putative esterase Nocardia farcinica
nocfa-q5z3g5 Nocardia farcinica putative esterase Nocardia farcinica
nocfa-q5z3g6 Nocardia farcinica putative mycolyltransferase Nocardia farcinica
nocfa-q5z3g7 Nocardia farcinica putative mycolyltransferase Nocardia farcinica
nocfa-q5z3g8 Nocardia farcinica putative mycolyltransferase Nocardia farcinica
rhoe4-c0zm41 Rhodococcus erythropolis (strains PR4 \/ NBRC 100887\; SK121) Putative mycolyltransferase Rhodococcus erythropolis
rhoe4-c0zw14 Rhodococcus erythropolis (strain PR4 \/ NBRC 100887) Putative mycolyltransferase Rhodococcus erythropolis
rhoer-c3jdh1 Rhodococcus erythropolis (strains PR4 \/ NBRC 100887\; SK121) Antigen 85-C Rhodococcus erythropolis
rhoer-c3jg26 Rhodococcus erythropolis (strain PR4 \/ NBRC 100887\; SK121) Putative antigen 85-A Rhodococcus erythropolis
rhoer-c3jh41 Rhodococcus erythropolis SK121 Cell surface protein A Rhodococcus erythropolis SK121
rhoer-c3jh61 Rhodococcus erythropolis SK121 Antigen 85-C Rhodococcus erythropolis SK121
rhoer-c3jif5 Rhodococcus erythropolis (strains PR4 \/ NBRC 100887\; SK121) Trehalose corynomycolyl transferase A Rhodococcus erythropolis
rhoer-c3jif6 Rhodococcus erythropolis (strains PR4 \/ NBRC 100887\; SK121) Cell surface protein A Rhodococcus erythropolis SK121
rhoer-c3jiw5 Rhodococcus erythropolis (strains PR4 \/ NBRC 100887\; SK121) Antigen 85-C Rhodococcus erythropolis
rhoer-c3jqd8 Rhodococcus erythropolis (strains SK121\; PR4\/NBRC100887) Trehalose corynomycolyl transferase C Rhodococcus erythropolis
rhoer-c3jqd9 Rhodococcus erythropolis (strains PR4 \/ NBRC 100887\; SK121) Antigen 85-C Rhodococcus erythropolis SK121
rhoer-c3jqg3 Rhodococcus erythropolis (strains PR4 \/ NBRC 100887\; SK121) Corynomycolyl transferase Rhodococcus erythropolis
rhoer-c3jrb8 Rhodococcus erythropolis (strains PR4 \/ NBRC 100887\; SK121) Surface layer protein A Rhodococcus erythropolis
rhoer-c3jt01 Rhodococcus erythropolis (strains PR4 \/ NBRC 100887\; SK121) Putative antigen 85 protein Rhodococcus erythropolis
rhoer-c3jtx3 Rhodococcus erythropolis (strain PR4 \/ NBRC 100887\; SK121) Antigen 85-A Rhodococcus erythropolis
rhoer-c3jtx4 Rhodococcus erythropolis (strains PR4 \/ NBRC 100887\; SK121) Antigen 85-A Rhodococcus erythropolis SK121
rhoob-c1atk8 Rhodococcus opacus (strain B4)Rhodococcus sp. (strain RHA1) Mycolyltransferase Rhodococcus opacus
rhoob-c1atq0 Rhodococcus opacus (strain B4) Rhodococcus sp. (strain RHA1) Putative mycolyltransferase Rhodococcus opacus
rhoob-c1av24 Rhodococcus opacus (strain B4)Rhodococcus sp. (strain RHA1) Putative mycolyltransferase Rhodococcus opacus
rhoob-c1awr1 Rhodococcus opacus (strain B4) Rhodococcus sp. (strain RHA1) Putative mycolyltransferase Rhodococcus opacus
rhoob-c1b0a8 Rhodococcus opacus (strain B4) Rhodococcus sp. (strain RHA1) Putative mycolyltransferase Rhodococcus opacus
rhoob-c1b0g7 Rhodococcus opacus (strain B4)Rhodococcus sp. (strain RHA1) Putative mycolyltransferase Rhodococcus opacus
rhoob-c1b7b4 Rhodococcus opacus (strain B4) Putative mycolyltransferase Rhodococcus opacus
rhoob-c1b9l2 Rhodococcus opacus (strain B4) Rhodococcus sp. (strain RHA1) Putative mycolyltransferase Rhodococcus opacus
rhoob-c1b930 Rhodococcus opacus (strain B4) Rhodococcus sp. (strain RHA1) Mycolyltransferase Rhodococcus opacus
rhoob-c1b931 Rhodococcus opacus (strain B4)Rhodococcus sp. (strain RHA1) Mycolyltransferase Rhodococcus opacus
rhoob-c1b932 Rhodococcus opacus (strain B4) Rhodococcus sp. (strain RHA1) Probable antigen 85 complex Mycolyltransferase Rhodococcus opacus
rhoob-c1b996 Rhodococcus opacus (strain B4) Rhodococcus sp. (strain RHA1) Putative mycolyltransferase Rhodococcus opacus
rhosr-q0s5h5 Rhodococcus sp. (strain RHA1) Possible antigenic 85 complex protein Rhodococcus sp.
sacvd-c7mvm9 Saccharomonospora viridis (strain ATCC 15386 \/ DSM 43017 \/ JCM 3036 NBRC 12207 \/ P101) Predicted esterase Saccharomonospora viridis
salai-a8m383 Salinispora arenicola (strain CNS-205) Putative esterase Salinispora arenicola
salai-a8m385 Salinispora arenicola (strain CNS-205) Putative esterase Salinispora arenicola
strco-SC1F2.06 Streptomyces coelicolor putative secreted protein Streptomyces coelicolor
strrd-d2ayq3 Streptosporangium roseum (strain ATCC 12428 \/ DSM 43021 \/ JCM 3005\/NI 9100) Putative esterase Streptosporangium roseum
strrd-d2b5z6 Streptosporangium roseum (strain ATCC 12428 \/ DSM 43021 \/ JCM 3005\/NI 9100) Esterase-like protein Streptosporangium roseum
strrd-d2bdh0 Streptosporangium roseum (strain ATCC 12428 \/ DSM 43021 \/ JCM 3005 \/NI 9100) Esterase-like protein Streptosporangium roseum
strsw-c9yxp5 Streptomyces scabies (strain 87.22) (Streptomyces scabiei) Putative secreted esterase Streptomyces scabies
strsw-c9zcs0 Streptomyces scabies (strain 87.22) (Streptomyces scabiei) Putative sugar\/fatty acid transferase Streptomyces scabies
thecd-d1a7b6 Thermomonospora curvata (strain ATCC 19995 \/ DSM 43183 \/ JCM 3096\/NCIMB 10081) Putative esterase Thermomonospora curvata
thecd-d1a9a3 Thermomonospora curvata (strain ATCC 19995 \/ DSM 43183 \/ JCM 3096 \/NCIMB 10081) Putative esterase Thermomonospora curvata
thecd-d1a838 Thermomonospora curvata (strain ATCC 19995 \/ DSM 43183 \/ JCM 3096\/NCIMB 10081) Putative esterase Thermomonospora curvata
thecd-d1acs0 Thermomonospora curvata (strain ATCC 19995 \/ DSM 43183 \/ JCM 3096 \/ NCIMB 10081) Putative esterase Thermomonospora curvata

Gene_locus_frgt Name Species
mycas-P71483 Mycobacterium asiaticum 32-kda protein (fragment) Mycobacterium asiaticum
mycav-mp51 Mycobacterium avium mpt51 antigen precursor (fragment) Mycobacterium avium
mycfl-P71519 Mycobacterium flavescens 32-kda protein (fragment) Mycobacterium flavescens
mycin-FBPA Mycobacterium intracellulare ag85a (fragment) Mycobacterium intracellulare
mycsm-P71531 Mycobacterium smegmatis 32-kda protein (fragment) Mycobacterium smegmatis
myctr-P71536 Mycobacterium triviale 32-kda protein (fragment) Mycobacterium triviale
mycva-P72063 Mycobacterium vaccae 32-kda protein (fragment) Mycobacterium vaccae
sacen-a4fc64 Saccharopolyspora erythraea (strain NRRL 23338) Trehalose corynomycolyl transferase C Saccharopolyspora erythraea

Substrate Chemical Nomenclature Proteins
alpha,alpha'-trehalose-6-mycolate [(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methyl (E)-3-hydroxy-2-tetradecyloctadec-11-enoate myctu-a85c    myctu-a85a    myctu-a85b
Resorufin-butyrate (7-oxophenoxazin-3-yl) butanoate human-MGLL
Homatropine (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate human-CES1
Octylthioglucoside (2R,3S,5R,6S)-2-(hydroxymethyl)-6-octylsulfanyloxane-3,4,5-triol myctu-a85c

Inhibitor Chemical Nomenclature Proteins
iBpPPOX 5-(2-methylpropoxy)-3-(3-phenoxyphenyl)-1,3,4-oxadiazol-2-one mycle-a85c
EZ120P myctu-a85a    myctu-a85b    myctu-a85c
EZ120 4-(dimethylamino)-N-[5-[(2R,3R)-3-non-8-enyl-4-oxooxetan-2-yl]pentyl]benzamide myctu-a85a    myctu-a85b    myctu-a85c
p-chloromercuribenzoic-acid (4-carboxyphenyl)-chloromercury myctu-a85c
Iodoacetamide 2-iodoacetamide myctu-a85c
Hexaethylene-glycol 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol mouse-ACHE    human-EPHX2    myctu-a85c
Amino-ebselen N-(4-aminophenyl)-2-$l^{1}-selanylbenzamide myctu-a85c
Adamantyl-ebselen N-(1-adamantyl)-2-$l^{1}-selanylbenzamide myctu-a85c
Ebselen 2-phenyl-1,2-benzoselenazol-3-one myctu-a85c
I3-AG85 2-amino-6-propyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile myctu-a85c
CyC-17 myctu-a85c    ratno-hslip    myctu-cutas1    myctu-Rv3569c    myctu-a85a    myctu-yt28
CyC-17-open hexadecyl dihydrogen phosphate myctu-a85c
CyC-7beta methyl (2R,5R)-5-decyl-2-methoxy-7-methyl-2-oxo-4,5-dihydro-3H-1,2$l^{5}-oxaphosphepine-6-carboxylate myctu-a85c
CyC-7beta-open methoxy-[(~{E},3~{R})-3-[(2~{R})-1-methoxy-1,3-bis(oxidanylidene)butan-2-yl]tridec-11-enyl]phosphinic acid myctu-a85c
CyC-8beta methyl (2R,5R)-5-dodecyl-2-methoxy-7-methyl-2-oxo-4,5-dihydro-3H-1,2$l^{5}-oxaphosphepine-6-carboxylate myctu-a85c
CyC-8beta-open methoxy-[(3~{R})-3-[(2~{R})-1-methoxy-1,3-bis(oxidanylidene)butan-2-yl]pentadecyl]phosphinic acid myctu-a85c
Paraoxon diethyl (4-nitrophenyl) phosphate human-PLA2G7    human-PNLIPRP2    humin-cut    human-ACHE    promi-c2lfd0    yeast-yjg8    bacpu-AXE    sulto-ST0071    aspor-cutas    pig-1plip    fusso-cutas    lacrh-B2CZF3    thema-TM0033    colgl-cutas    psesp-Q9RBY1    actde-CXE1    myctu-a85c    thema-TM0077    rhimi-lipas    bacpu-w8fke7    9bact-KP212148
THL-10d (2S)-1-((2S)-3-isopropyl-4-oxooxetan-2-yl)tridecan-2-yl ((benzyloxy)carbonyl)-L-leucinate myctu-a85c
Orlistat [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate human-DAGLA    human-DAGLB    human-PNLIP    human-FASN    mycs2-a0r619    human-PNLIPRP2    human-ABHD16A    myctu-a85c    myctu-Rv3822    plafa-PF10.0379    staau-lipas    human-CES2

References (5)

Title : Mycoloyltransferases: A large and major family of enzymes shaping the cell envelope of Corynebacteriales - Dautin_2017_Biochim.Biophys.Acta_1861_3581
Author(s) : Dautin N , de Sousa-D'Auria C , Constantinesco-Becker F , Labarre C , Oberto J , de la Sierra-Gallay IL , Dietrich C , Issa H , Houssin C , Bayan N
Ref : Biochimica & Biophysica Acta , 1861 :3581 , 2017
Abstract :
PubMedSearch : Dautin_2017_Biochim.Biophys.Acta_1861_3581
PubMedID: 27345499

Title : The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha\/beta hydrolases - Wilson_2004_J.Mol.Biol_335_519
Author(s) : Wilson RA , Maughan WN , Kremer L , Besra GS , Futterer K
Ref : Journal of Molecular Biology , 335 :519 , 2004
Abstract :
PubMedSearch : Wilson_2004_J.Mol.Biol_335_519
PubMedID: 14672660
Gene_locus related to this paper: myctu-mpt51

Title : Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity - Ronning_2004_J.Biol.Chem_279_36771
Author(s) : Ronning DR , Vissa V , Besra GS , Belisle JT , Sacchettini JC
Ref : Journal of Biological Chemistry , 279 :36771 , 2004
Abstract :
PubMedSearch : Ronning_2004_J.Biol.Chem_279_36771
PubMedID: 15192106
Gene_locus related to this paper: myctu-a85a , myctu-a85c

Title : An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase. - Anderson_2001_J.Mol.Biol_307_671
Author(s) : Anderson DH , Harth G , Horwitz MA , Eisenberg D
Ref : Journal of Molecular Biology , 307 :671\ , 2001
Abstract :
PubMedSearch : Anderson_2001_J.Mol.Biol_307_671
PubMedID: 11254389
Gene_locus related to this paper: myctu-a85b

Title : Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines - Ronning_2000_Nat.Struct.Biol_7_141
Author(s) : Ronning DR , Klabunde T , Besra GS , Vissa VD , Belisle JT , Sacchettini JC
Ref : Nat Struct Biol , 7 :141 , 2000
Abstract :
PubMedSearch : Ronning_2000_Nat.Struct.Biol_7_141
PubMedID: 10655617
Gene_locus related to this paper: myctu-a85c