A85-Mycolyl-transferase

Relationship

Family: A85-Mycolyl-transferase

Block: X

Parent Family: Antigen85c

Comment

This family contains Antigen85 responsible for high affinity of mycobacteria for fibronectin. Proteins of the antigen 85 possess a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity. Mycobacterium tuberculosis MPT51 (FbpC1) is a non-catalytic alpha/beta hydrolases member of this family. This family corresponds to a subset of the the Carbohydrate Esterase family CE1 in CAZy - Carbohydrate-Active enZYmes database (CE_1)

Database

Interpro : IPR000801 Esterase_put

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00756 Esterase

Prints : No Print

EC Number : 2.3.1.20 || 2.3.1.122

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (26)

Genes Proteins in A85-Mycolyl-transferase family (194)

Fragments of genes in A85-Mycolyl-transferase family (8)

Structures in A85-Mycolyl-transferase family (26)

Substrates in A85-Mycolyl-transferase family (4)

Inhibitors in A85-Mycolyl-transferase family (19)

References (5)

Title : Mycoloyltransferases: A large and major family of enzymes shaping the cell envelope of Corynebacteriales - Dautin_2017_Biochim.Biophys.Acta_1861_3581
Author(s) : Dautin N , de Sousa-D'Auria C , Constantinesco-Becker F , Labarre C , Oberto J , de la Sierra-Gallay IL , Dietrich C , Issa H , Houssin C , Bayan N
Ref : Biochimica & Biophysica Acta , 1861 :3581 , 2017
PubMedID: 27345499

Title : Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity - Ronning_2004_J.Biol.Chem_279_36771
Author(s) : Ronning DR , Vissa V , Besra GS , Belisle JT , Sacchettini JC
Ref : Journal of Biological Chemistry , 279 :36771 , 2004
PubMedID: 15192106
Gene_locus related to this paper: myctu-a85a , myctu-a85c

Title : The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha\/beta hydrolases - Wilson_2004_J.Mol.Biol_335_519
Author(s) : Wilson RA , Maughan WN , Kremer L , Besra GS , Futterer K
Ref : Journal of Molecular Biology , 335 :519 , 2004
PubMedID: 14672660
Gene_locus related to this paper: myctu-mpt51

Title : An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase. - Anderson_2001_J.Mol.Biol_307_671
Author(s) : Anderson DH , Harth G , Horwitz MA , Eisenberg D
Ref : Journal of Molecular Biology , 307 :671\ , 2001
PubMedID: 11254389
Gene_locus related to this paper: myctu-a85b

Title : Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines - Ronning_2000_Nat.Struct.Biol_7_141
Author(s) : Ronning DR , Klabunde T , Besra GS , Vissa VD , Belisle JT , Sacchettini JC
Ref : Nat Struct Biol , 7 :141 , 2000
PubMedID: 10655617
Gene_locus related to this paper: myctu-a85c