(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Bacteria: NE > Terrabacteria group: NE > Actinobacteria [phylum]: NE > Actinobacteria [class]: NE > Corynebacteriales: NE > Mycobacteriaceae: NE > Mycobacterium: NE > Mycobacterium avium complex (MAC): NE > Mycobacterium avium: NE > Mycobacterium avium subsp. paratuberculosis: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Mycobacterium avium subsp. paratuberculosis K-10: N, E.
Mycobacterium avium subsp. paratuberculosis: N, E.
Mycobacterium avium subsp. paratuberculosis S397: N, E.
Mycobacterium avium subsp. paratuberculosis MAP4: N, E.
Mycobacterium avium subsp. paratuberculosis S5: N, E.
Mycobacterium avium subsp. paratuberculosis 10-4404: N, E.
Mycobacterium avium subsp. paratuberculosis 10-8425: N, E.
Mycobacterium avium subsp. paratuberculosis 08-8281: N, E.
Mycobacterium avium subsp. paratuberculosis 10-5975: N, E.
Mycobacterium avium subsp. paratuberculosis 10-5864: N, E.
Mycobacterium avium subsp. paratuberculosis 11-1786: N, E.
Mycobacterium avium 104: N, E.
Mycobacterium tuberculosis XTB13-223: N, E.
Mycobacterium avium XTB13-223: N, E.
Mycobacterium avium subsp. hominissuis A5: N, E.
Mycobacterium avium subsp. hominissuis 101: N, E.
Mycobacterium avium subsp. hominissuis 100: N, E.
Mycobacterium avium subsp. hominissuis TH135: N, E.
Mycobacterium avium subsp. hominissuis: N, E.
Mycobacterium avium subsp. hominissuis 10-5606: N, E.
Mycobacterium avium subsp. hominissuis 10-4249: N, E.
Mycobacterium avium subsp. hominissuis 3388: N, E.
Mycobacterium avium 05-4293: N, E.
Mycobacterium avium 10-5581: N, E.
Mycobacterium avium subsp. silvaticum ATCC 49884: N, E.
Mycobacterium avium subsp. avium 10-9275: N, E.
Mycobacterium avium subsp. avium 11-4751: N, E.
Mycobacterium avium 10-5560: N, E.
Mycobacterium avium MAV_120709_2344: N, E.
Mycobacterium sp. MAC_080597_8934: N, E.
Mycobacterium avium 2285 (R): N, E.
Mycobacterium avium subsp. avium 2285 (R): N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MSEPGSATDTDTGDEPAQQQTAPDGTRTGAQTAVAEHPAPKAPAPGTQQP EKPWWVRHYTFTGTTVGLVFIWFSLTPSLLPRGAIFQGLVSGISGAIGYG LGVFAVWLYRYLWAKPSSPPPPRWAWKILIPVGAVGMVLMAIWFHVWQDK VRDLMGVAHLKWYDYPVAGVLSLVVLFTCVEIGQFTRWLVSFLVGRLDRI APFRLSATIVVALLVVLTITLLNGVVLKFAMRTMNNTFASANNEMSPDTA PPKTPLRSGGPESLVSWESLGHQGRVFIEGGPRVEQLTAFNGAPATEPIR AYAGLNSADGITATAELATRELQRTGGLRRAVVAVATTTGTGWINEAEAT ALEYMYNGNTAIVSMQYSFLPSWLSFLVDKENARHAGQALFEAVDRLVRQ LPEAQRPKLVVFGESLGSFGGEAPFMSLNNVLARTDGALFSGPTFNNTIW TDLTSTRDAGSPEWLPIYNDGRNVRFVARAANLARPKDPWDHPRVVYLQH ASDPIAWWTTDLLFARPDWLKERRGYDVLPETTWIPVVTFLQVSADMAVA QNVPDGHGHHYVADVADAWASVLSPPGWTPDKTDRLRPLLHANG
We describe here the complete genome sequence of a common clone of Mycobacterium avium subspecies paratuberculosis (Map) strain K-10, the causative agent of Johne's disease in cattle and other ruminants. The K-10 genome is a single circular chromosome of 4,829,781 base pairs and encodes 4,350 predicted ORFs, 45 tRNAs, and one rRNA operon. In silico analysis identified >3,000 genes with homologs to the human pathogen, M. tuberculosis (Mtb), and 161 unique genomic regions that encode 39 previously unknown Map genes. Analysis of nucleotide substitution rates with Mtb homologs suggest overall strong selection for a vast majority of these shared mycobacterial genes, with only 68 ORFs with a synonymous to nonsynonymous substitution ratio of >2. Comparative sequence analysis reveals several noteworthy features of the K-10 genome including: a relative paucity of the PE/PPE family of sequences that are implicated as virulence factors and known to be immunostimulatory during Mtb infection; truncation in the EntE domain of a salicyl-AMP ligase (MbtA), the first gene in the mycobactin biosynthesis gene cluster, providing a possible explanation for mycobactin dependence of Map; and Map-specific sequences that are likely to serve as potential targets for sensitive and specific molecular and immunologic diagnostic tests. Taken together, the availability of the complete genome sequence offers a foundation for the study of the genetic basis for virulence and physiology in Map and enables the development of new generations of diagnostic tests for bovine Johne's disease.
