(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Bacteria: NE > Terrabacteria group: NE > Firmicutes: NE > Bacilli: NE > Lactobacillales: NE > Streptococcaceae: NE > Streptococcus: NE > Streptococcus mitis: NE
A85-IroE-IroD-Fes-Yiel : strm6-d3h7r7Streptococcus mitis (strain B6) Esterase of alpha/beta hydrolase superfamily, strm6-d3h9p9Streptococcus mitis (strain B6) Putative uncharacterized protein, strm6-d3h9q0Streptococcus mitis (strain B6) Hydrolase. Asp2 : strmt-a0a081pzg7Streptococcus mitis. Accessory Sec system protein Asp2, strmt-a0a081qbc0Streptococcus mitis. Accessory Sec system protein Asp2, strmt-a0a081qe12Streptococcus mitis. Accessory Sec system protein Asp2, strmt-a0a081qlt1Streptococcus mitis. Accessory Sec system protein Asp2, strmt-a0a081qw56Streptococcus mitis. Accessory Sec system protein Asp2, strmt-a0a0f2e1f7Streptococcus mitis. Accessory Sec system protein Asp2, strmt-a0a0x8uyd4Streptococcus mitis. Accessory Sec system protein Asp2, strmt-a0a133s0y3Streptococcus mitis. Accessory Sec system protein Asp2, strmt-a0a139pqe1Streptococcus mitis. Accessory secretory protein Asp2, strmt-a0a139qce6Streptococcus mitis. Accessory secretory protein Asp2, strm6-d3haj3Streptococcus mitis (strain B6). Uncharacterized protein
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MAVMKIEYYSQVLDMEWGVNVLYPDANRVEEPECKDIPVLYLLHGMSGNH NSWLKRTNVERLLRGTNLIVVMPNTSNGWYTDTQYGFDYYTALAEELPQV LKRFFPNMTSKREKTFIAGLSMGGYGCFKLALATNRFSRAASFSGALSFQ DFSPESQNLGTPAYWRGVFGEIKDWTASSYSLESLAKKSDKKIKLWAWCG EQDFLYKANNLAVNNLKKLGFDVTYSHSAGTHEWYYWEKQLERFLATLPI DFKLEERLT
Streptococcus mitis is the closest relative of the major human pathogen S. pneumoniae. The 2,15 Mb sequence of the Streptococcus mitis B6 chromosome, an unusually high-level beta-lactam resistant and multiple antibiotic resistant strain, has now been determined to encode 2100 genes. The accessory genome is estimated to represent over 40%, including 75 mostly novel transposases and IS, the prophage phiB6 and another seven phage related regions. Tetracycline resistance mediated by Tn5801, and an unusual and large gene cluster containing three aminoglycoside resistance determinants have not been described in other Streptococcus spp. Comparative genomic analyses including hybridization experiments on a S. mitis B6 specific microarray reveal that individual S. mitis strains are almost as distantly related to the B6 strain as S. pneumoniae. Both species share a core of over 900 genes. Most proteins described as pneumococcal virulence factors are present in S. mitis B6, but the three choline binding proteins PcpA, PspA and PspC, and three gene clusters containing the hyaluronidase gene, ply and lytA, and the capsular genes are absent in S. mitis B6 and other S. mitis as well and confirm their importance for the pathogenetic potential of S. pneumoniae. Despite the close relatedness between the two species, the S. mitis B6 genome reveals a striking X-alignment when compared with S. pneumoniae.
