A85-EsteraseD-FGH

Relationship

Family: A85-EsteraseD-FGH

Block: X

Parent Family: Antigen85c

Comment

This family contains EC 3.1.2.12, human Esterase D and bacterial S-formylglutathione hydrolase. A universal pathway for formaldehyde detoxification. Corresponds to a subset of the Carbohydrate Esterase family CE1 in CAZy - Carbohydrate-Active enZYmes database (CE_1). Arabidopsis thaliana (Mouse-ear cress) serine esterase s-formylglutathione hydrolase SFGH is insensitive to organophosphate. Family TE22 in ThYme database

Database

Interpro : IPR000801 Esterase_put , IPR014186 S-formylglutathione_hydrol

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00756 Esterase

Prints : No Print

EC Number : 3.1.2.12

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (22)

Genes Proteins in A85-EsteraseD-FGH family (596)

Fragments of genes in A85-EsteraseD-FGH family (27)

Structures in A85-EsteraseD-FGH family (22)

Substrates in A85-EsteraseD-FGH family (7)

Inhibitors in A85-EsteraseD-FGH family (7)

References (12)

Title : Thioesterase enzyme families: Functions, structures, and mechanisms - Caswell_2021_Protein.Sci__
Author(s) : Caswell BT , de Carvalho CC , Nguyen H , Roy M , Nguyen T , Cantu DC
Ref : Protein Science , : , 2021
PubMedID: 34921469

Title : Structure and activity of the cold-active and anion-activated carboxyl esterase OLEI01171 from the oil-degrading marine bacterium Oleispira antarctica - Lemak_2012_Biochem.J_445_193
Author(s) : Lemak S , Tchigvintsev A , Petit P , Flick R , Singer AU , Brown G , Evdokimova E , Egorova O , Gonzalez CF , Chernikova TN , Yakimov MM , Kube M , Reinhardt R , Golyshin PN , Savchenko A , Yakunin AF
Ref : Biochemical Journal , 445 :193 , 2012
PubMedID: 22519667
Gene_locus related to this paper: olean-d0vwz4

Title : ThYme: a database for thioester-active enzymes - Cantu_2011_Nucleic.Acids.Res_39_D342
Author(s) : Cantu DC , Chen Y , Lemons ML , Reilly PJ
Ref : Nucleic Acids Research , 39 :D342 , 2011
PubMedID: 21045059

Title : Thioesterases: a new perspective based on their primary and tertiary structures. - Cantu_2010_Protein.Sci_19_1281
Author(s) : Cantu DC , Chen Y , Reilly PJ
Ref : Protein Science , 19 :1281 , 2010
PubMedID: 20506386

Title : Crystal structure of an S-formylglutathione hydrolase from Pseudoalteromonas haloplanktis TAC125 - Alterio_2010_Biopolymers_93_669
Author(s) : Alterio V , Aurilia V , Romanelli A , Parracino A , Saviano M , D'Auria S , De Simone G
Ref : Biopolymers , 93 :669 , 2010
PubMedID: 20209484
Gene_locus related to this paper: pseht-q3il66

Title : Crystal structure of human esterase D: a potential genetic marker of retinoblastoma - Wu_2009_FASEB.J_23_1441
Author(s) : Wu D , Li Y , Song G , Zhang D , Shaw N , Liu ZJ
Ref : FASEB Journal , 23 :1441 , 2009
PubMedID: 19126594
Gene_locus related to this paper: human-ESD

Title : The structure of a putative S-formylglutathione hydrolase from Agrobacterium tumefaciens - van Straaten_2009_Protein.Sci_18_2196
Author(s) : van Straaten KE , Gonzalez CF , Valladares RB , Xu X , Savchenko AV , Sanders DA
Ref : Protein Science , 18 :2196 , 2009
PubMedID: 19653299
Gene_locus related to this paper: agrt5-a9cj11

Title : Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase - Legler_2008_Biochemistry_47_9592
Author(s) : Legler PM , Kumaran D , Swaminathan S , Studier FW , Millard CB
Ref : Biochemistry , 47 :9592 , 2008
PubMedID: 18707125
Gene_locus related to this paper: yeast-yjg8

Title : The crystal structure of the estA protein, a virulence factor from Streptococcus pneumoniae -
Author(s) : Kim MH , Kang BS , Kim S , Kim KJ , Lee CH , Oh BC , Park SC , Oh TK
Ref : Proteins , 70 :578 , 2008
PubMedID: 17932928
Gene_locus related to this paper: strpn-SP0614

Title : Unique regulation of the active site of the serine esterase S-formylglutathione hydrolase - Cummins_2006_J.Mol.Biol_359_422
Author(s) : Cummins I , McAuley K , Fordham-Skelton A , Schwoerer R , Steel PG , Davis BG , Edwards R
Ref : Journal of Molecular Biology , 359 :422 , 2006
PubMedID: 16626737
Gene_locus related to this paper: arath-SFGH

Title : S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification. - Harms_1996_J.Bacteriol_178_6296
Author(s) : Harms N , Ras J , Reijnders WNM , van Spanning RJM , Stouthamer AH
Ref : Journal of Bacteriology , 178 :6296 , 1996
PubMedID: 8892832
Gene_locus related to this paper: parde-FGHA

Title : Molecular analysis of esterase D polymorphism - Tsuchida_1994_Hum.Genet_93_255
Author(s) : Tsuchida S , Fukui E , Ikemoto S
Ref : Hum Genet , 93 :255 , 1994
PubMedID: 7907313
Gene_locus related to this paper: human-ESD