AChE-IN-39
AChE IC50: 0.058 microMM. AChE-IN-39 has DPPH scavenging activity (antioxidant assay is the colorimetric 2,2-diphenyl-1-picrylhydrazyl assay). AChE-IN-39 improves the cognitive impairment in AlCl3-induced amnesia
General
Type : Antioxidant, Benzofuran
Chemical_Nomenclature : (E)-3-(3-acetylanilino)-1-(1-benzofuran-2-yl)prop-2-en-1-one
Canonical SMILES : CC(=O)C1=CC(=CC=C1)NC=CC(=O)C2=CC3=CC=CC=C3O2
InChI : InChI=1S\/C19H15NO3\/c1-13(21)14-6-4-7-16(11-14)20-10-9-17(22)19-12-15-5-2-3-8-18(15)23-19\/h2-12,20H,1H3\/b10-9+
InChIKey : DFVKDAJYKKGIAC-MDZDMXLPSA-N
Other name(s) : HY-149473 || CS-0890696 || Compound 7c
Target
Families : AChE-IN-39 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Discovery of novel benzofuran-based derivatives as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis, biological evaluation, molecular docking and 3D-QSAR investigation - Abd El-Karim_2023_Eur.J.Med.Chem_260_115766 |
| Author(s) : Abd El-Karim SS , Anwar MM , Ahmed NS , Syam YM , Elseginy SA , Aly HF , Younis EA , Khalil WKB , Ahmed KA , Mohammed FF , Rizk M |
| Ref : Eur Journal of Medicinal Chemistry , 260 :115766 , 2023 |
| Abstract : |
| PubMedSearch : Abd El-Karim_2023_Eur.J.Med.Chem_260_115766 |
| PubMedID: 37678141 |