Azo-9
Derivative of S11-1014. Azo-9 exhibits dynamic cis/trans conformational shifts, enabling dynamic modulation of its BChE-binding efficacy
General
Type : Photoswitch, Benzamide
Chemical_Nomenclature : (E)-N-(2-((Diethylamino)methyl)benzyl)-3-(4-((4-isopropylphenyl)diazinyl)benzamido)benzamide
Canonical SMILES : C1(=CC=CC(=C1)C(NCC2=CC=CC=C2CN(CC)CC)=O)NC(C3=CC=C(C=C3)N=NC4=CC=C(C=C4)C(C)C)=O
InChI : InChI=1S\/C35H39N5O2\/c1-5-40(6-2)24-30-11-8-7-10-29(30)23-36-34(41)28-12-9-13-33(22-28)37-35(42)27-16-20-32(21-17-27)39-38-31-18-14-26(15-19-31)25(3)4\/h7-22,25H,5-6,23-24H2,1-4H3,(H,36,41)(H,37,42)
InChIKey : DTKPZIJYSBZJSV-UHFFFAOYSA-N
Other name(s) :
Target
Families : Azo-9 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Optical control of butyrylcholinesterase (BChE) activity via photoswitchable azobenzene for potential treatment of Alzheimer's disease - Wang_2024_Bioorg.Chem_153_107845 |
| Author(s) : Wang L , Gao Z , Sun T , Chen C , Zhu J , Wang S , Chen Y , Sun H |
| Ref : Bioorg Chem , 153 :107845 , 2024 |
| Abstract : |
| PubMedSearch : Wang_2024_Bioorg.Chem_153_107845 |
| PubMedID: 39348751 |