CHEMBL4241199-like-phenylphenyl-Cpd7q
IC50 DPP4 0.66 microM
General
Type : Pyrrolidine, Triazol
Chemical_Nomenclature : (3,3-difluoropyrrolidin-1-yl)-[(2S,4S)-4-[4-(4-phenylphenyl)triazol-1-yl]pyrrolidin-2-yl]methanone
Canonical SMILES : C1CN(CC1(F)F)C(=O)[C@@H]2C[C@@H](CN2)N3C=C(N=N3)C4=CC=C(C=C4)C5=CC=CC=C5
InChI : InChI=1S\/C23H23F2N5O\/c24-23(25)10-11-29(15-23)22(31)20-12-19(13-26-20)30-14-21(27-28-30)18-8-6-17(7-9-18)16-4-2-1-3-5-16\/h1-9,14,19-20,26H,10-13,15H2\/t19-,20-\/m0\/s1
InChIKey : KBUXRFIMNCOMSO-PMACEKPBSA-N
Other name(s) : Compound 7q
MW : 423.5
Formula : C23H23F2N5O
CAS_number :
PubChem : 71520161
UniChem : KBUXRFIMNCOMSO-PMACEKPBSA-N
Target
Families : CHEMBL4241199-like-phenylphenyl-Cpd7q ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-DPP4
References (1)
| Title : Design, synthesis, structure-activity relationships, and docking studies of 1-(gamma-1,2,3-triazol substituted prolyl)-(S)-3,3-difluoropyrrolidines as a novel series of potent and selective dipeptidyl peptidase-4 inhibitors - Zhang_2013_Chem.Biol.Drug.Des_81_198 |
| Author(s) : Zhang L , Su M , Li J , Ji X , Wang J , Li Z , Liu H |
| Ref : Chemical Biology Drug Des , 81 :198 , 2013 |
| Abstract : |
| PubMedSearch : Zhang_2013_Chem.Biol.Drug.Des_81_198 |
| PubMedID: 22994702 |