1. Home
  2. Type Inhibitor
  3. Pyrrolidine

Pyrrolidine

General

Pyrrolidine (tetrahydropyrrole), is an organic compound with the molecular formula (CH2)4NH. Cyclic amine with five atoms. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
DPP4-inhibitor-Cpd46 DPP4N_Peptidase_S9 Sulfur Compound Pyrazole Pyrimidine Pyrrolidine
HY-155961 DPP4N_Peptidase_S9 Thiazolidine Sulfur Compound Pyrazole Pyrrolidine
N-(3,3-diphenylpropyl)pyrrolidine-1-carboxamide Epoxide_hydrolase Pyrrolidine Carboxamide
VN-19 ACHE Monoamine-oxidase-inhibitor Multitarget Pyrrolidine Chromen
5ISM-6DG DPP4N_Peptidase_S9 Pyrimidine Pyrrolidine Pyrazole
Tacrine-Sibiriline-Cpd7 BCHE ACHE Multitarget Acridine Derivative of Tacrine Alkyl linked bis-ligand Pyridine Carbamate Pyrrolidine Antioxidant
BR102910 DPP4N_Peptidase_S9 Quinoline Carboxamide Pyrrolidine Cyanide Sulfur Compound
UAMC-1110 DPP4N_Peptidase_S9 Quinoline Carboxamide Pyrrolidine Cyanide
IOCB22-AP446 DPP4N_Peptidase_S9 Pyrrolidine Quinoline Carboxamide
spiro-b-lactam-pyrroloquinoline-6b S9N_PPCE_Peptidase_S9 Azaspiro beta-Lactam Pyrrolidine Quinoline
Meropenem ACPH_Peptidase_S9 Antibiotic Pyrrolidine Carbamate Sulfur Compound
H-Lys(4-nitro-Z)-pyrrolidide DPP4N_Peptidase_S9 Pyrrolidine Carbamate pNP Peptide
ICeD-1 DPP4N_Peptidase_S9 Cyanide Pyrrolidine
ICeD-2 DPP4N_Peptidase_S9 Pyrrolidine Indole
Cpd17-Pyrrolidine-THL-derivative Cutinase Oxooxetan Lipase inhibitor Pyrrolidine
7BP-5LZ8 PAF-Acetylhydrolase Pyrrolidine Cyanide tert-Butyl
CHEMBL3924430 PAF-Acetylhydrolase Pyrrolidine Cyanide
CHEMBL3983270 PAF-Acetylhydrolase Pyrrolidine Cyanide
CHEMBL3975283 PAF-Acetylhydrolase Pyrrolidine Cyanide
AA39-2 PAF-Acetylhydrolase Triazol Pyrrolidine
AA74-1 ACPH_Peptidase_S9 Triazol Pyrrolidine
ML225 PAF-Acetylhydrolase Triazol Urea derivative Pyrrolidine
6M08-BWL PAF-Acetylhydrolase Trifluoro Pyrrolidine
6M07-BWO PAF-Acetylhydrolase Trifluoro Pyrrolidine
6M06-BWF PAF-Acetylhydrolase Pyrrolidine
Prusogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Cyanide Pyrrolidine
Fragment-722 Pectinacetylesterase-Notum Fragment inhibitor of Notum Pyrrolidine
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not AlphaBeta Hydrolase target
Bepridil Pectinacetylesterase-Notum Pyrrolidine Not AlphaBeta Hydrolase target Drug Calcium Channel Antagonist
YH168 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
YH149 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
XP7-7L4U Monoglyceridelipase_lysophospholip Piperidine Pyrrolidine
6E6T-HVV Dieckmann_Cyclase Pyrrolidine
Pyrrole-5-6YUY Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Trifluoro
Pyrrole-6-6YV4 Pectinacetylesterase-Notum Cyclopropyl Pyrrole_Pyrrolidine-derivative
Pyrrole-7-6YUW Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Cyclopropyl
Pyrrolidine-8-6YV2 Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative
Pyrrolidine-10-6YV0 Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative
Pyrrole-20i-6YXI Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative
Pyrrole-26-6YSK Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Trifluoro
T-401 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe Sulfur Compound
BYYT-25 ACHE BCHE Cholinesterase Derivative of Donepezil Inden Pyrrolidine
Debromoflustramine-B BCHE Natural Pyrrolidine Indole Derivative of physostigmine-eserine
ZINC12863377 Monoglyceridelipase_lysophospholip Pyrrolidine Indole Carboxamide
ZINC24092691 Monoglyceridelipase_lysophospholip Pyrrolidine Benzothiazol Sulfur Compound Triazol
(R)-3t Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine
5ZUN-3l Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine Sulfur Compound
5YP2-8YC DPP4N_Peptidase_S9 Pyrrolidine Cyanide
TAM3 Thioesterase Pyrrolidine Benzofuran
D3C DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Carboxamide
Anagliptin DPP4N_Peptidase_S9 Drug Cyanide Pyrrolidine Gliptin Pyrimidine Carboxamide Pyrazole
BMS-744891 DPP4N_Peptidase_S9 Pyrrolidine Pyridine
3-Bromo-5-pyrrolidinophenylboronic-acid Carb_B_Arthropoda Boron compound Pyrrolidine
N-acyl-prolylpyrrolidine-inhibitor-1 S9N_PPCE_Peptidase_S9 Pyrrolidine Azido
N-acyl-prolylpyrrolidine-inhibitor-2 S9N_PPCE_Peptidase_S9 Pyrrolidine Triazol Carbamate tert-Butyloxycarbonyl tert-Butyl
N-acyl-prolylpyrrolidine-inhibitor-3 S9N_PPCE_Peptidase_S9 Pyrrolidine Triazol
CHEMBL1951424 DPP4N_Peptidase_S9 Piperidine Cyanide Quinoline Pyrrolidine
CHEMBL2147710 DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Thiazolidine Sulfur Compound Pyrazole
CHEMBL2058971 DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Quinoline Thiazolidine Sulfur Compound
CHEMBL2441952 DPP4N_Peptidase_S9 Pyrrolidine Pyridine
CHEMBL1910114 DPP4N_Peptidase_S9 Pyrrolidine Pyridine
CHEMBL1909991 DPP4N_Peptidase_S9 Pyrrolidine Pyridine
SCHEMBL13923509 DPP4N_Peptidase_S9 Pyrrolidine Piperidine
CHEMBL1910111 DPP4N_Peptidase_S9 Pyrrolidine Pyridine Pyrimidine
Z-Pro-Prolinal-IC1 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide tert-Butyl
Z-Pro-Prolinal-IC2 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide Carboxamide
Z-Pro-Prolinal-IC3 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide Cyanide
Z-Pro-Prolinal-IC4 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide Carboxamide Urea derivative
Z-Pro-Prolinal-derived S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Piperidine Peptide Pyrrolidine Carboxamide Carbamate
Carmegliptin DPP4N_Peptidase_S9 Drug Pyrrolidine Gliptin Quinolizine
JNH DPP4N_Peptidase_S9 Biphenyl Pyrrolidine
FPB-derived-7k DPP4N_Peptidase_S9 Pyrrolidine Sulfur Compound
Dutogliptin DPP4N_Peptidase_S9 Drug Pyrrolidine Gliptin Boron compound
Teneligliptin DPP4N_Peptidase_S9 Drug Piperazine Pyrrolidine Gliptin Thiazolidine Sulfur Compound Pyrazole
R-Pro-(decarboxy-Pro)-X99 S9N_PPCE_Peptidase_S9 Pyrrolidine Isoindole Indole
R-Pro-(decarboxy-Pro)-X98 S9N_PPCE_Peptidase_S9 Pyrrolidine Quinoxaline
R-Pro-(decarboxy-Pro)-X97 S9N_PPCE_Peptidase_S9 Pyrrolidine Imidazole
CHEMBL4576969 S9N_PPCE_Peptidase_S9 Pyrrolidine Boron compound
CHEMBL4559324 S9N_PPCE_Peptidase_S9 Pyrrolidine Boron compound
DB07148 S9N_PPCE_Peptidase_S9 Pyrrolidine
Flouroolefin-1 DPP4N_Peptidase_S9 Sulfur Compound Pyrrolidine Cyclopropyl Oxadiazol
cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl-34Q DPP4N_Peptidase_S9 Pyrrolidine Quinoxaline
4-aryl-cyclohexylalanine-inhibitor-1 DPP4N_Peptidase_S9 Triazol Pyrrolidine
4-aryl-cyclohexylalanine-inhibitor-2 DPP4N_Peptidase_S9 Triazol Pyrrolidine
3-amino-4-phenyl-pyrrolidine-15B DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Pyridine Pyrimidine
1,3,4-oxadiazolyl-ketone-18h DPP4N_Peptidase_S9 Pyrrolidine Ketone Oxadiazol tert-Butyl
Alanyl-Isoleucyl-pyrrolidin-boronic-acid DPP4N_Peptidase_S9 Pyrrolidine Peptide Boron compound
4-aminocyclohexylalanine-derivative-25 DPP4N_Peptidase_S9 Pyrrolidine
AIL DPP4N_Peptidase_S9 Pyrrolidine Sulfur Compound Thiazolidine Carboxamide
DLI DPP4N_Peptidase_S9 Trifluoro Sulfur Compound Pyrrolidine Pyrimidine
ABT-279 DPP4N_Peptidase_S9 Pyrrolidine Cyanide
3TP DPP4N_Peptidase_S9 Pyrrolidine Sulfur Compound Oxadiazol Sulfonyl
Alkynyl-cyanopyrrolidine-1 DPP4N_Peptidase_S9 Pyrrolidine Cyanide
Alkynyl-cyanopyrrolidine-2 DPP4N_Peptidase_S9 Pyrrolidine Cyanide
AAF DPP4N_Peptidase_S9 Pyrrolidine Benzoate Urea derivative
ACF DPP4N_Peptidase_S9 Pyrrolidine
ADF DPP4N_Peptidase_S9 Pyrrolidine
MK0626 DPP4N_Peptidase_S9 Pyridine Pyrrolidine Triazol
tBu-GPI DPP4N_Peptidase_S9 Peptide Pyrrolidine tert-Butyl
Pro-boropro DPP4N_Peptidase_S9 Peptide Pyrrolidine Boron compound
FPB DPP4N_Peptidase_S9 Pyrrolidine
Z-Ala_prolinal S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Peptide Pyrrolidine
Talabostat DPP4N_Peptidase_S9 Peptide Pyrrolidine Boron compound
Pro-Tboda Proline_iminopeptidase Peptide Pyrrolidine Oxadiazol tert-Butyl
Didemnin-B Palmitoyl-protein_thioesterase Natural Peptide Pyrrolidine Carboxamide
MJN110 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Carbamate Piperazine Pyrrolidine
p-Iodo-Phe-Pyr-CN DPP4N_Peptidase_S9 Peptide Pyrrolidine Cyanide
Tat-(1-9) DPP4N_Peptidase_S9 Peptide Pyrrolidine Sulfur Compound
Ala(1-naph)-Pro-CN Hydrolase_RBBP9_YdeN DPP4N_Peptidase_S9 Peptide Pyrrolidine Naphthalen Cyanide
ARI-3531 S9N_PPCE_Peptidase_S9 Pyridine Pyrrolidine Boron compound
CHEMBL1684295 Prolylcarboxypeptidase Pyrrolidine Imidazole Pyridine Oxadiazol Piperidine Benzimidazole
UCI-80224067 Prolylcarboxypeptidase Pyrrolidine Imidazole Benzimidazole
5LZ9-7BR PAF-Acetylhydrolase Pyrrolidine Cyanide Sulfur Compound
Saxagliptin DPP4N_Peptidase_S9 Adamantyl Drug Cyanide Pyrrolidine Gliptin Azabicyclo
VildaSaxagliptin-analogue DPP4N_Peptidase_S9 Pyrrolidine Gliptin Adamantyl Azabicyclo
NVP-DPP728 DPP4N_Peptidase_S9 Cyanide Pyrrolidine Pyridine
Vildagliptin DPP4N_Peptidase_S9 Drug Pyrrolidine Gliptin Adamantyl Cyanide
ARI-3099 DPP4N_Peptidase_S9 ACPH_Peptidase_S9 Pyridine Pyrrolidine Boron compound
Sin-Gly-Pro S9N_PPCE_Peptidase_S9 Peptide Pyrrolidine
Diprotin-A DPP4N_Peptidase_S9 Peptide Pyrrolidine
Diprotin-B DPP4N_Peptidase_S9 Peptide Pyrrolidine
1-valylpyrrolidine DPP4N_Peptidase_S9 Peptide Pyrrolidine
Z-Pro-Prolinal S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Peptide Pyrrolidine Carbamate
Z-Gly-Pro S9N_PPCE_Peptidase_S9 Peptide Pyrrolidine Benzyloxycarbonyl
ABX-1431 Monoglyceridelipase_lysophospholip Piperazine Carbamate Pyrrolidine Trifluoro
C5685 ACHE Benzamide Pyrrolidine
Duador BCHE Pyrrolidine Neuromuscular Nondepolarizing Agents Quinoline Not AlphaBeta Hydrolase target
CHEMBL4793341 ACHE BCHE Trifluoro Pyrrolidine Multitarget BACE1-inhibitor
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Nicotinic agonist Natural Alkaloid Drug Not AlphaBeta Hydrolase target