Dimethylphenyl-naphthalen-4-phenyl-triazol-thio-acetamide-cpd8a
AChE IC50 0.697 +/- 0.43 microM
General
Type : Naphthalen, Triazol
Chemical_Nomenclature : N-(2,4-Dimethylphenyl)-2-((5-((naphthalen-2-yloxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide
Canonical SMILES : C1=CC=CC2=C1C=C(C=C2)OCC3=NN=C([N]3C4=CC=CC=C4)SCC(=O)NC5=CC=C(C=C5C)C
InChI : InChI=1S\/C29H26N4O2S\/c1-20-12-15-26(21(2)16-20)30-28(34)19-36-29-32-31-27(33(29)24-10-4-3-5-11-24)18-35-25-14-13-22-8-6-7-9-23(22)17-25\/h3-17H,18-19H2,1-2H3,(H,30,34)
InChIKey : MTIRJTGUNISSFT-UHFFFAOYSA-N
Other name(s) : Compound 8a
Target
Families : Dimethylphenyl-naphthalen-4-phenyl-triazol-thio-acetamide-cpd8a ligand of proteins in family
ACHE
References (1)
| Title : Design, Synthesis, and Computational Studies of Novel N-(Substituted phenyl)-3-(5-((naphthalen-2-yloxy)methyl)-4-phenyl4H1,2,4-triazol-3-ylthio)acetamides as Potent Acetylcholinesterase Inhibitors - Ayub_2025_ACS.Omega_10_45191 |
| Author(s) : Ayub M , Siddiqui SZ , Rehman AU , Abbasi MA , Parveen R , Ali Shah SA , Mushtaq A , Iqbal J , Khalid H , Imran S , Abbas G |
| Ref : ACS Omega , 10 :45191 , 2025 |
| Abstract : |
| PubMedSearch : Ayub_2025_ACS.Omega_10_45191 |
| PubMedID: 41078825 |