Dimethylpiperazinoammonium-benzylidine-dimethoxy-inden-one-cpd5g
IC50 ACHE 0.1 microM; IC50 BCHE 4.00 microM
General
Type : Ammonium, Inden, Piperazine
Chemical_Nomenclature : 2-[4-(N,N-dimethylpiperazinoammonium)benzylidine]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
Canonical SMILES : C12=C(C=C(C(=C1)OC)OC)C(C(C2)=CC3=CC=C(C=C3)N4CC[N+](CC4)(C)C)=O
InChI : InChI=1S\/C24H29N2O3\/c1-26(2)11-9-25(10-12-26)20-7-5-17(6-8-20)13-19-14-18-15-22(28-3)23(29-4)16-21(18)24(19)27\/h5-8,13,15-16H,9-12,14H2,1-4H3\/q+1
InChIKey : VGALIAVOJTTWMJ-UHFFFAOYSA-N
Other name(s) : Compound 5g
Target
Families : Dimethylpiperazinoammonium-benzylidine-dimethoxy-inden-one-cpd5g ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Anti-Alzheimer effects of the newly synthesized cationic compounds as multi-target dual hAChE\/hBuChE inhibitor: An in silico, in vitro, and in vivo approach - Karami_2024_Bioimpacts_15_24196 |
| Author(s) : Karami H , Soltani S , Wolber G , Sadigh-Eteghad S , Nikbakht R , Farrokhi H , Narimani F , Teimuri-Mofrad R , Rashidi MR |
| Ref : Bioimpacts , 15 :24196 , 2024 |
| Abstract : |
| PubMedSearch : Karami_2024_Bioimpacts_15_24196 |
| PubMedID: 40161933 |