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Piperazine

General

Six-membered ring containing two nitrogen atoms at opposite positions in the ring. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
Benzyl-piperazinyl-propylamino-nitrophenyl-phenyl-triazole-Cpd11n ACHE Nitrobenzyl Piperazine Triazol
Fluoro-methylpiperazin-phenyl-oxo-chromene-carboxamide-CpdE12 ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Carboxamide Chromen anti-Abeta-aggregation anti-tau-aggregation
A1480LS Lipase_3 Trifluoro Piperazine Indazole Urea derivative
CHEMBL5854413 Monoglyceridelipase_lysophospholip Quinazoline Piperazine Benzoxazol Pyridine
VAV-19 ACHE Monoamine-oxidase-inhibitor Multitarget Quinazoline Piperazine Alkyne
Cyclopentyl-pyridyl-benzoxazol-cyclopropyl-triazol-azaspiro-heptan-methanone-Cpd29 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Triazol Azaspiro Cyclopropyl
Chlorooxazolo-pyridin-piperazin-cyclobutylcyclopropyl-pyridyl-benzoxazol-methanone-Cpd27 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Cyclobutyl Cyclopropyl Organochlorine
Chlorooxazolo-pyridin-piperazin-cyclopentyl-pyridyl-benzoxazol-methanone-Cpd23 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Organochlorine
Chalcone-piperazine-Cpd4g ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Dimethoxyphenyl
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
AKU-010 Plasmodium_subtelomeric_PST-A Monoglyceridelipase_lysophospholip Piperazine Triazol
Terazosin Monoglyceridelipase_lysophospholip Not AlphaBeta Hydrolase target Drug Quinazoline Piperazine Sulfur Compound Adrenergic-Receptor-ligand
LB05 ACHE Piperazine Thiazole Benzothiazol Sulfur Compound Organochlorine
Oxadiazol-one-piperazine-urea-cpd19 Epoxide_hydrolase Oxadiazol Piperazine Urea derivative Organochlorine
CHEMBL3818053 ACHE Pyrimidine Piperazine Inden
Tominostat DPP4N_Peptidase_S9 Indole Isoindole Piperazine
Dimethylpiperazinoammonium-benzylidine-dimethoxy-inden-one-cpd5g ACHE Ammonium Inden Piperazine
MGL-Inhibitor-candidate1 Monoglyceridelipase_lysophospholip Trifluoro Piperazine
CHEMBL4441719 Monoglyceridelipase_lysophospholip Cyanide Piperazine Carbamate
Benzothiazol-Phenyl-Piperazine-Pyridine-Cpd18 ACHE Benzothiazol Sulfur Compound Piperazine Pyridine Fluorescent Probe
CHEMBL4245414-Cpd2g DPP4N_Peptidase_S9 Quinoline Piperazine Pyrrolidine Organochlorine
SB03178 DPP4N_Peptidase_S9 Pyrrolidine Cyanide PET probe Tetrazacyclododec Piperazine
BDBM243037 ACHE Sulfur Compound Thiazole Piperazine
Benzothiazol-carboxamide-benzyl-piperazine-dimethylamine-cpd4f ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Carboxamide Benzothiazol Thiazole Sulfur Compound
Benzylpiperazinephenyl-phenyl-pyrazol-cpd48 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation Piperazine Pyrazole
Ferulic-Acid-Piperazine-Cpd13a ACHE Multitarget Piperazine Quinoline Feruloyl Metal ion chelator anti-Abeta-aggregation Antioxidant
MGLL-IN-Cpd34 Monoglyceridelipase_lysophospholip Piperazine Naphthalen Naphthylamide
CHEMBL4437989 Monoglyceridelipase_lysophospholip Piperazine Pyrazole Cyanide
CHEMBL4559005 Monoglyceridelipase_lysophospholip Naphthalen Piperazine Pyrazole Cyanide
JNJ-42226314 Monoglyceridelipase_lysophospholip Indole Thiazole Sulfur Compound Azetidin Piperazine
S21-1001 BCHE Piperazine Quinoline
Biphenyl-oxo-triazine-piperazine-cpd6g ACHE Piperazine Multitarget Triazine
X20419 Thioesterase Piperazine Piperidine Pyrimidine Carboxamide Indole
6-(4-4-phenethylpiperazin-1-yl)heptyl-THAI-14d BCHE Indole Azepane Piperazine Multitarget Alkyl linked bis-ligand anti-Abeta-aggregation
ABD-1970 Monoglyceridelipase_lysophospholip Carbamate Trifluoro Piperazine Azabicyclo
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
LEI-463 Monoglyceridelipase_lysophospholip Trifluoro Indole Piperazine Triazol Fluorescent Probe
LEI-515 Monoglyceridelipase_lysophospholip Piperazine Sulfur Compound Organochlorine
AKU-005 Monoglyceridelipase_lysophospholip Piperazine Triazol Sulfur Compound
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
SCHEMBL20516363 ABHD6-Lip PAF-Acetylhydrolase Piperazine Imidazole Carbamate Morpholine Organochlorine
MJN193 ABHD6-Lip Piperazine Imidazole Carbamate
JS0-7ZPB BCHE Quinoline Piperazine Multitarget Monoamine-oxidase-inhibitor Alkyne
AI6-7QBR BCHE Quinoline Piperazine tert-Butyl Multitarget Monoamine-oxidase-inhibitor Alkyne
MAGLi-432 Monoglyceridelipase_lysophospholip Piperazine Organochlorine
MAGL-2011 Monoglyceridelipase_lysophospholip Piperazine Azetidin Thiazolidine Sulfur Compound PET probe Biphenyl
FEPAD Monoglyceridelipase_lysophospholip Piperazine Azetidin Trifluoro Thiazolidine Sulfur Compound PET probe Biphenyl
WWL153 PAF-Acetylhydrolase Piperazine Quinoline pNP
JMN4 PAF-Acetylhydrolase Piperazine Quinoline
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 ACHE BCHE Oxadiazol Pyridine Piperazine BACE1-inhibitor
Fragment-927 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperazine
Fragment-277 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperazine Cyanide Organochlorine
YH168 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
T-401 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe Pyridine Thiazole Sulfur Compound
YH149 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
ZYH-deriv-F Monoglyceridelipase_lysophospholip Azetidin Piperazine Carboxamide Pyrimidine PET probe Indole
CHEMBL45663-49N-4Y2Q Epoxide_hydrolase Piperazine Pyridine Trifluoro
CHEMBL48137-49O-4Y2R Epoxide_hydrolase Piperazine Pyridine Cyanide Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand
Fenoverine BCHE Not AlphaBeta Hydrolase target Drug Phenothiazine Sulfur Compound Piperazine Benzodioxo
beta-lactam-A295 DPP4N_Peptidase_S9 Quinoline Piperazine
beta-lactam-A296-1 DPP4N_Peptidase_S9 Piperazine Azetidin beta-Lactam
beta-lactam-B142 DPP4N_Peptidase_S9 Piperazine beta-Lactam Benzoate
beta-lactam-B142-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam Benzoate
4-Oxo-beta-Lactam-A241 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-A241-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-LMC375 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-A272 DPP4N_Peptidase_S9 Piperazine beta-Lactam Naphthalen
4-Oxo-beta-Lactam-A272-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam Naphthalen
4-Oxo-beta-Lactam-B115 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-B115-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-B114 DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
4-Oxo-beta-Lactam-B114-closed DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
beta-lactam-L84 DPP4N_Peptidase_S9 Piperazine beta-Lactam
beta-lactam-L84-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
ABD957 ABHD17-depalmitoylase Trifluoro Sulfur Compound Sulfonamide Piperazine Pyrazole Azabicyclo
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803778 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Sulfur Compound Sulfonamide Pyrazole Organochlorine
ZINC20166201-cpd8 BCHE Piperazine Quinoline
JUB BCHE Piperidine Piperazine NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole Sulfur Compound Sulfonamide Naphthalen Benzylpiperidine Derivative of Donepezil
SR-3133 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran Benzodioxin
SR-3134 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran
SR-4559 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran Benzodioxin
DA-12228 DPP4N_Peptidase_S9 Gliptin Trifluoro Piperazine
KK052 RsbQ-like Urea derivative Triazol Piperazine
(R)-3t Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine
5ZUN-3l Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine Sulfur Compound Organochlorine
FAPI-46 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
FAPI-74 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Cyanide
FAPI-02 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
FAPI-04 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
ML349 LYsophospholipase_carboxylesterase Piperazine Sulfur Compound Chromen
ML348 LYsophospholipase_carboxylesterase Trifluoro Piperazine
Pyrimidinone-inhibitor1 DPP4N_Peptidase_S9 Purine Piperazine Organochlorine
Teneligliptin DPP4N_Peptidase_S9 Drug Piperazine Pyrrolidine Gliptin Thiazolidine Sulfur Compound Pyrazole
BDPX DPP4N_Peptidase_S9 Piperazine Purine
HEPES Hormone-sensitive_lipase_like Buffer Component Piperazine Sulfur Compound
6FSE-15 ACHE Piperidine Piperazine Biphenyl
STK133938 ACHE Piperidine Piperazine
AM9928 Monoglyceridelipase_lysophospholip Piperazine Pyridine Fluoren Carboxylate Cyanide
AM6580 Monoglyceridelipase_lysophospholip Piperazine Piperidine Fluoren Triazol Urea derivative
MJN110 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Carbamate Piperazine Pyrrolidine Organochlorine
1G244 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro Organochlorine
JZL195 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperazine FAAH inhibitor Multitarget pNP Phenoxyphenyl
DO34 Lipase_3 Trifluoro Piperazine Carbamate tert-Butyloxycarbonyl tert-Butyl
SAR629 Monoglyceridelipase_lysophospholip Piperazine Triazol
ABX-1431 Monoglyceridelipase_lysophospholip Piperazine Carbamate Pyrrolidine Trifluoro
ZYH Monoglyceridelipase_lysophospholip Piperazine Pyrimidine Azetidin Benzoxazol
T-82(2) ACHE Piperazine Phenothiazine Benzoate Sulfur Compound Organochlorine
Diethylcarbamazine ACHE Piperazine Anthelmintic Not AlphaBeta Hydrolase target Carboxamide
Pipecuronium BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Aminosteroid Piperazine Phenanthrene Not AlphaBeta Hydrolase target