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Piperazine

General

Six-membered ring containing two nitrogen atoms at opposite positions in the ring. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
CHEMBL5854413 Monoglyceridelipase_lysophospholip Quinazoline Piperazine Benzoxazol Pyridine
VAV-19 ACHE Monoamine-oxidase-inhibitor Multitarget Quinazoline Piperazine Alkyne
Cyclopentyl-pyridyl-benzoxazol-cyclopropyl-triazol-azaspiro-heptan-methanone-Cpd29 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Triazol Azaspiro Cyclopropyl
Chlorooxazolo-pyridin-piperazin-cyclobutylcyclopropyl-pyridyl-benzoxazol-methanone-Cpd27 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Cyclobutyl Cyclopropyl Organochlorine
Chlorooxazolo-pyridin-piperazin-cyclopentyl-pyridyl-benzoxazol-methanone-Cpd23 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Organochlorine
Chalcone-piperazine-Cpd4g ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Dimethoxyphenyl
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
AKU-010 Plasmodium_subtelomeric_PST-A Monoglyceridelipase_lysophospholip Piperazine Triazol
Terazosin Monoglyceridelipase_lysophospholip Not AlphaBeta Hydrolase target Drug Quinazoline Piperazine Sulfur Compound Adrenergic-Receptor-ligand
LB05 ACHE Piperazine Thiazole Benzothiazol Sulfur Compound Organochlorine
Oxadiazol-one-piperazine-urea-cpd19 Epoxide_hydrolase Oxadiazol Piperazine Urea derivative Organochlorine
CHEMBL3818053 ACHE Pyrimidine Piperazine Inden
Tominostat DPP4N_Peptidase_S9 Indole Isoindole Piperazine
MGL-Inhibitor-candidate1 Monoglyceridelipase_lysophospholip Trifluoro Piperazine
CHEMBL4441719 Monoglyceridelipase_lysophospholip Cyanide Piperazine Carbamate
Benzothiazol-Phenyl-Piperazine-Pyridine-Cpd18 ACHE Benzothiazol Sulfur Compound Piperazine Pyridine Fluorescent Probe
CHEMBL4245414-Cpd2g DPP4N_Peptidase_S9 Quinoline Piperazine Pyrrolidine Organochlorine
SB03178 DPP4N_Peptidase_S9 Pyrrolidine Cyanide PET probe Tetrazacyclododec Piperazine
BDBM243037 ACHE Sulfur Compound Thiazole Piperazine
Benzothiazol-carboxamide-benzyl-piperazine-dimethylamine-cpd4f ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Carboxamide Benzothiazol Thiazole Sulfur Compound
Benzylpiperazinephenyl-phenyl-pyrazol-cpd48 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation Piperazine Pyrazole
Ferulic-Acid-Piperazine-Cpd13a ACHE Multitarget Piperazine Quinoline Feruloyl Metal ion chelator anti-Abeta-aggregation Antioxidant
MGLL-IN-Cpd34 Monoglyceridelipase_lysophospholip Piperazine Naphthalen Naphthylamide
CHEMBL4437989 Monoglyceridelipase_lysophospholip Piperazine Pyrazole Cyanide
CHEMBL4559005 Monoglyceridelipase_lysophospholip Naphthalen Piperazine Pyrazole Cyanide
JNJ-42226314 Monoglyceridelipase_lysophospholip Indole Thiazole Sulfur Compound Azetidin Piperazine
S21-1001 BCHE Piperazine Quinoline
Biphenyl-oxo-triazine-piperazine-cpd6g ACHE Piperazine Multitarget Triazine
X20419 Thioesterase Piperazine Piperidine Pyrimidine Carboxamide Indole
6-(4-4-phenethylpiperazin-1-yl)heptyl-THAI-14d BCHE Indole Azepane Piperazine Multitarget Alkyl linked bis-ligand anti-Abeta-aggregation
ABD-1970 Monoglyceridelipase_lysophospholip Carbamate Trifluoro Piperazine Azabicyclo
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
LE-463 Monoglyceridelipase_lysophospholip Trifluoro Indole Piperazine Triazol Fluorescent Probe
LEI-515 Monoglyceridelipase_lysophospholip Piperazine Sulfur Compound Organochlorine
AKU-005 Monoglyceridelipase_lysophospholip Piperazine Triazol Sulfur Compound
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
SCHEMBL20516363 ABHD6-Lip PAF-Acetylhydrolase Piperazine Imidazole Carbamate Morpholine Organochlorine
MJN193 ABHD6-Lip Piperazine Imidazole Carbamate
JS0-7ZPB BCHE Quinoline Piperazine Multitarget Monoamine-oxidase-inhibitor Alkyne
AI6-7QBR BCHE Quinoline Piperazine tert-Butyl Multitarget Monoamine-oxidase-inhibitor Alkyne
MAGLi-432 Monoglyceridelipase_lysophospholip Piperazine Organochlorine
MAGL-2011 Monoglyceridelipase_lysophospholip Piperazine Azetidin Thiazolidine Sulfur Compound PET probe Biphenyl
FEPAD Monoglyceridelipase_lysophospholip Piperazine Azetidin Trifluoro Thiazolidine Sulfur Compound PET probe Biphenyl
WWL153 PAF-Acetylhydrolase Piperazine Quinoline pNP
JMN4 PAF-Acetylhydrolase Piperazine Quinoline
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 ACHE BCHE Oxadiazol Pyridine Piperazine BACE1-inhibitor
Fragment-927 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperazine
Fragment-277 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperazine Cyanide Organochlorine
YH168 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
T-401 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe Pyridine Thiazole Sulfur Compound
YH149 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
ZYH-deriv-F Monoglyceridelipase_lysophospholip Azetidin Piperazine Carboxamide Pyrimidine PET probe Indole
CHEMBL45663-49N-4Y2Q Epoxide_hydrolase Piperazine Pyridine Trifluoro
CHEMBL48137-49O-4Y2R Epoxide_hydrolase Piperazine Pyridine Cyanide Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand
Fenoverine BCHE Not AlphaBeta Hydrolase target Drug Phenothiazine Sulfur Compound Piperazine Benzodioxo
beta-lactam-A295 DPP4N_Peptidase_S9 Quinoline Piperazine
beta-lactam-A296-1 DPP4N_Peptidase_S9 Piperazine Azetidin beta-Lactam
beta-lactam-B142 DPP4N_Peptidase_S9 Piperazine beta-Lactam Benzoate
beta-lactam-B142-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam Benzoate
4-Oxo-beta-Lactam-A241 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-A241-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-LMC375 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-A272 DPP4N_Peptidase_S9 Piperazine beta-Lactam Naphthalen
4-Oxo-beta-Lactam-A272-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam Naphthalen
4-Oxo-beta-Lactam-B115 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-B115-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-B114 DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
4-Oxo-beta-Lactam-B114-closed DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
beta-lactam-L84 DPP4N_Peptidase_S9 Piperazine beta-Lactam
beta-lactam-L84-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
ABD957 ABHD17-depalmitoylase Trifluoro Sulfur Compound Sulfonamide Piperazine Pyrazole Azabicyclo
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803778 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Sulfur Compound Sulfonamide Pyrazole Organochlorine
ZINC20166201-cpd8 BCHE Piperazine Quinoline
JUB BCHE Piperidine Piperazine NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole Sulfur Compound Sulfonamide Naphthalen Benzylpiperidine Derivative of Donepezil
SR-3133 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran Benzodioxin
SR-3134 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran
SR-4559 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran Benzodioxin
DA-12228 DPP4N_Peptidase_S9 Gliptin Trifluoro Piperazine
KK052 RsbQ-like Urea derivative Triazol Piperazine
(R)-3t Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine
5ZUN-3l Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine Sulfur Compound Organochlorine
FAPI-46 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
FAPI-74 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Cyanide
FAPI-02 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
FAPI-04 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
ML349 LYsophospholipase_carboxylesterase Piperazine Sulfur Compound Chromen
ML348 LYsophospholipase_carboxylesterase Trifluoro Piperazine
Pyrimidinone-inhibitor1 DPP4N_Peptidase_S9 Purine Piperazine Organochlorine
Teneligliptin DPP4N_Peptidase_S9 Drug Piperazine Pyrrolidine Gliptin Thiazolidine Sulfur Compound Pyrazole
BDPX DPP4N_Peptidase_S9 Piperazine Purine
HEPES Hormone-sensitive_lipase_like Buffer Component Piperazine Sulfur Compound
6FSE-15 ACHE Piperidine Piperazine Biphenyl
STK133938 ACHE Piperidine Piperazine
AM9928 Monoglyceridelipase_lysophospholip Piperazine Fluoren Carbamate
AM6580 Monoglyceridelipase_lysophospholip Piperazine Piperidine Fluoren Triazol Urea derivative
MJN110 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Carbamate Piperazine Pyrrolidine Organochlorine
1G244 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro Organochlorine
JZL195 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperazine FAAH inhibitor Multitarget pNP Phenoxyphenyl
DO34 Lipase_3 Trifluoro Piperazine Carbamate tert-Butyloxycarbonyl tert-Butyl
SAR629 Monoglyceridelipase_lysophospholip Piperazine Triazol
ABX-1431 Monoglyceridelipase_lysophospholip Piperazine Carbamate Pyrrolidine Trifluoro
ZYH Monoglyceridelipase_lysophospholip Piperazine Pyrimidine Azetidin Benzoxazol
T-82(2) ACHE Piperazine Phenothiazine Benzoate Sulfur Compound Organochlorine
Diethylcarbamazine ACHE Piperazine Anthelmintic Not AlphaBeta Hydrolase target Carboxamide
Pipecuronium BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Aminosteroid Piperazine Phenanthrene Not AlphaBeta Hydrolase target
A1480LS Lipase_3 Trifluoro Piperazine Indazole Urea derivative
CHEMBL5854413 Monoglyceridelipase_lysophospholip Quinazoline Piperazine Benzoxazol Pyridine
VAV-19 ACHE Monoamine-oxidase-inhibitor Multitarget Quinazoline Piperazine Alkyne
Cyclopentyl-pyridyl-benzoxazol-cyclopropyl-triazol-azaspiro-heptan-methanone-Cpd29 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Triazol Azaspiro Cyclopropyl
Chlorooxazolo-pyridin-piperazin-cyclobutylcyclopropyl-pyridyl-benzoxazol-methanone-Cpd27 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Cyclobutyl Cyclopropyl Organochlorine
Chlorooxazolo-pyridin-piperazin-cyclopentyl-pyridyl-benzoxazol-methanone-Cpd23 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Organochlorine
Chalcone-piperazine-Cpd4g ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Dimethoxyphenyl
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
AKU-010 Plasmodium_subtelomeric_PST-A Monoglyceridelipase_lysophospholip Piperazine Triazol
Terazosin Monoglyceridelipase_lysophospholip Not AlphaBeta Hydrolase target Drug Quinazoline Piperazine Sulfur compound Adrenergic-Receptor-ligand
LB05 ACHE Piperazine Thiazole Benzothiazol Sulfur compound Organochlorine
Oxadiazol-one-piperazine-urea-cpd19 Epoxide_hydrolase Oxadiazol Piperazine Urea derivative Organochlorine
CHEMBL3818053 ACHE Pyrimidine Piperazine Inden
Tominostat DPP4N_Peptidase_S9 Indole Isoindole Piperazine
Dimethylpiperazinoammonium-benzylidine-dimethoxy-inden-one-cpd5g ACHE Ammonium Inden Piperazine
MGL-Inhibitor-candidate1 Monoglyceridelipase_lysophospholip Trifluoro Piperazine
CHEMBL4441719 Monoglyceridelipase_lysophospholip Cyanide Piperazine Carbamate
Benzothiazol-Phenyl-Piperazine-Pyridine-Cpd18 ACHE Benzothiazol Sulfur compound Piperazine Pyridine Fluorescent Probe
CHEMBL4245414-Cpd2g DPP4N_Peptidase_S9 Quinoline Piperazine Pyrrolidine Organochlorine
SB03178 DPP4N_Peptidase_S9 Pyrrolidine Cyanide PET probe Tetrazacyclododec Piperazine
BDBM243037 ACHE Sulfur compound Thiazole Piperazine
Benzothiazol-carboxamide-benzyl-piperazine-dimethylamine-cpd4f ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Carboxamide Benzothiazol Thiazole Sulfur compound
Benzylpiperazinephenyl-phenyl-pyrazol-cpd48 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation Piperazine Pyrazole
Ferulic-Acid-Piperazine-Cpd13a ACHE Multitarget Piperazine Quinoline Feruloyl Metal ion chelator anti-Abeta-aggregation Antioxidant
MGLL-IN-Cpd34 Monoglyceridelipase_lysophospholip Piperazine Naphthalen Naphthylamide
CHEMBL4437989 Monoglyceridelipase_lysophospholip Piperazine Pyrazole Cyanide
CHEMBL4559005 Monoglyceridelipase_lysophospholip Naphthalen Piperazine Pyrazole Cyanide
JNJ-42226314 Monoglyceridelipase_lysophospholip Indole Thiazole Sulfur compound Azetidin Piperazine
S21-1001 BCHE Piperazine Quinoline
Biphenyl-oxo-triazine-piperazine-cpd6g ACHE Piperazine Multitarget Triazine
X20419 Thioesterase Piperazine Piperidine Pyrimidine Carboxamide Indole
6-(4-4-phenethylpiperazin-1-yl)heptyl-THAI-14d BCHE Indole Azepane Piperazine Multitarget Alkyl linked bis-ligand anti-Abeta-aggregation
ABD-1970 Monoglyceridelipase_lysophospholip Carbamate Trifluoro Piperazine Azabicyclo
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
LEI-463 Monoglyceridelipase_lysophospholip Trifluoro Indole Piperazine Triazol Fluorescent Probe
LEI-515 Monoglyceridelipase_lysophospholip Piperazine Sulfur compound Organochlorine
AKU-005 Monoglyceridelipase_lysophospholip Piperazine Triazol Sulfur compound
ZINC22029744 ACHE BCHE Multitarget Sulfur compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
SCHEMBL20516363 ABHD6-Lip PAF-Acetylhydrolase Piperazine Imidazole Carbamate Morpholine Organochlorine
MJN193 ABHD6-Lip Piperazine Imidazole Carbamate
JS0-7ZPB BCHE Quinoline Piperazine Multitarget Monoamine-oxidase-inhibitor Alkyne
AI6-7QBR BCHE Quinoline Piperazine tert-Butyl Multitarget Monoamine-oxidase-inhibitor Alkyne
MAGLi-432 Monoglyceridelipase_lysophospholip Piperazine Organochlorine
MAGL-2011 Monoglyceridelipase_lysophospholip Piperazine Azetidin Thiazolidine Sulfur compound PET probe Biphenyl
FEPAD Monoglyceridelipase_lysophospholip Piperazine Azetidin Trifluoro Thiazolidine Sulfur compound PET probe Biphenyl
WWL153 PAF-Acetylhydrolase Piperazine Quinoline pNP
JMN4 PAF-Acetylhydrolase Piperazine Quinoline
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 ACHE BCHE Oxadiazol Pyridine Piperazine BACE1-inhibitor
Fragment-927 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperazine
Fragment-277 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperazine Cyanide Organochlorine
YH168 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
T-401 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe Pyridine Thiazole Sulfur compound
YH149 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
ZYH-deriv-F Monoglyceridelipase_lysophospholip Azetidin Piperazine Carboxamide Pyrimidine PET probe Indole
CHEMBL45663-49N-4Y2Q Epoxide_hydrolase Piperazine Pyridine Trifluoro
CHEMBL48137-49O-4Y2R Epoxide_hydrolase Piperazine Pyridine Cyanide Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand
Fenoverine BCHE Not AlphaBeta Hydrolase target Drug Phenothiazine Sulfur compound Piperazine Benzodioxo
beta-lactam-A295 DPP4N_Peptidase_S9 Quinoline Piperazine
beta-lactam-A296-1 DPP4N_Peptidase_S9 Piperazine Azetidin beta-Lactam
beta-lactam-B142 DPP4N_Peptidase_S9 Piperazine beta-Lactam Benzoate
beta-lactam-B142-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam Benzoate
4-Oxo-beta-Lactam-A241 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-A241-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-LMC375 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-A272 DPP4N_Peptidase_S9 Piperazine beta-Lactam Naphthalen
4-Oxo-beta-Lactam-A272-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam Naphthalen
4-Oxo-beta-Lactam-B115 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-B115-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-B114 DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
4-Oxo-beta-Lactam-B114-closed DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
beta-lactam-L84 DPP4N_Peptidase_S9 Piperazine beta-Lactam
beta-lactam-L84-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
ABD957 ABHD17-depalmitoylase Trifluoro Sulfur compound Sulfonamide Piperazine Pyrazole Azabicyclo
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803778 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Sulfur compound Sulfonamide Pyrazole Organochlorine
ZINC20166201-cpd8 BCHE Piperazine Quinoline
JUB BCHE Piperidine Piperazine NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole Sulfur compound Sulfonamide Naphthalen Benzylpiperidine Derivative of Donepezil
SR-3133 CGI-58_ABHD5_ABHD4 Piperazine Sulfur compound Sulfonamide Benzofuran Benzodioxin
SR-3134 CGI-58_ABHD5_ABHD4 Piperazine Sulfur compound Sulfonamide Benzofuran
SR-4559 CGI-58_ABHD5_ABHD4 Piperazine Sulfur compound Sulfonamide Benzofuran Benzodioxin
DA-12228 DPP4N_Peptidase_S9 Gliptin Trifluoro Piperazine
KK052 RsbQ-like Urea derivative Triazol Piperazine
(R)-3t Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine
5ZUN-3l Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine Sulfur compound Organochlorine
FAPI-46 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
FAPI-74 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Cyanide
FAPI-02 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
FAPI-04 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
ML349 LYsophospholipase_carboxylesterase Piperazine Sulfur compound Chromen
ML348 LYsophospholipase_carboxylesterase Trifluoro Piperazine
Pyrimidinone-inhibitor1 DPP4N_Peptidase_S9 Purine Piperazine Organochlorine
Teneligliptin DPP4N_Peptidase_S9 Drug Piperazine Pyrrolidine Gliptin Thiazolidine Sulfur compound Pyrazole
BDPX DPP4N_Peptidase_S9 Piperazine Purine
HEPES Hormone-sensitive_lipase_like Buffer Component Piperazine Sulfur compound
6FSE-15 ACHE Piperidine Piperazine Biphenyl
STK133938 ACHE Piperidine Piperazine
AM9928 Monoglyceridelipase_lysophospholip Piperazine Fluoren Carbamate
AM6580 Monoglyceridelipase_lysophospholip Piperazine Piperidine Fluoren Triazol Urea derivative
MJN110 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Carbamate Piperazine Pyrrolidine Organochlorine
1G244 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro Organochlorine
JZL195 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperazine FAAH inhibitor Multitarget pNP Phenoxyphenyl
DO34 Lipase_3 Trifluoro Piperazine Carbamate tert-Butyloxycarbonyl tert-Butyl
SAR629 Monoglyceridelipase_lysophospholip Piperazine Triazol
ABX-1431 Monoglyceridelipase_lysophospholip Piperazine Carbamate Pyrrolidine Trifluoro
ZYH Monoglyceridelipase_lysophospholip Piperazine Pyrimidine Azetidin Benzoxazol
T-82(2) ACHE Piperazine Phenothiazine Benzoate Sulfur compound Organochlorine
Diethylcarbamazine ACHE Piperazine Anthelmintic Not AlphaBeta Hydrolase target Carboxamide
Pipecuronium BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Aminosteroid Piperazine Phenanthrene Not AlphaBeta Hydrolase target
A1480LS Lipase_3 Trifluoro Piperazine Indazole Urea derivative
CHEMBL5854413 Monoglyceridelipase_lysophospholip Quinazoline Piperazine Benzoxazol Pyridine
VAV-19 ACHE Monoamine-oxidase-inhibitor Multitarget Quinazoline Piperazine Alkyne
Cyclopentyl-pyridyl-benzoxazol-cyclopropyl-triazol-azaspiro-heptan-methanone-Cpd29 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Triazol Azaspiro Cyclopropyl
Chlorooxazolo-pyridin-piperazin-cyclobutylcyclopropyl-pyridyl-benzoxazol-methanone-Cpd27 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Cyclobutyl Cyclopropyl Organochlorine
Chlorooxazolo-pyridin-piperazin-cyclopentyl-pyridyl-benzoxazol-methanone-Cpd23 Monoglyceridelipase_lysophospholip Benzoxazol Pyridine Piperazine Organochlorine
Chalcone-piperazine-Cpd4g ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Dimethoxyphenyl
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
AKU-010 Plasmodium_subtelomeric_PST-A Monoglyceridelipase_lysophospholip Piperazine Triazol
Terazosin Monoglyceridelipase_lysophospholip Not AlphaBeta Hydrolase target Drug Quinazoline Piperazine Sulfur compound Adrenergic-Receptor-ligand
LB05 ACHE Piperazine Thiazole Benzothiazol Sulfur compound Organochlorine
Oxadiazol-one-piperazine-urea-cpd19 Epoxide_hydrolase Oxadiazol Piperazine Urea derivative Organochlorine
CHEMBL3818053 ACHE Pyrimidine Piperazine Inden
Tominostat DPP4N_Peptidase_S9 Indole Isoindole Piperazine
Dimethylpiperazinoammonium-benzylidine-dimethoxy-inden-one-cpd5g ACHE Ammonium Inden Piperazine
MGL-Inhibitor-candidate1 Monoglyceridelipase_lysophospholip Trifluoro Piperazine
CHEMBL4441719 Monoglyceridelipase_lysophospholip Cyanide Piperazine Carbamate
Benzothiazol-Phenyl-Piperazine-Pyridine-Cpd18 ACHE Benzothiazol Sulfur compound Piperazine Pyridine Fluorescent Probe
CHEMBL4245414-Cpd2g DPP4N_Peptidase_S9 Quinoline Piperazine Pyrrolidine Organochlorine
SB03178 DPP4N_Peptidase_S9 Pyrrolidine Cyanide PET probe Tetrazacyclododec Piperazine
BDBM243037 ACHE Sulfur compound Thiazole Piperazine
Benzothiazol-carboxamide-benzyl-piperazine-dimethylamine-cpd4f ACHE Monoamine-oxidase-inhibitor Multitarget Piperazine Carboxamide Benzothiazol Thiazole Sulfur compound
Benzylpiperazinephenyl-phenyl-pyrazol-cpd48 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation Piperazine Pyrazole
Ferulic-Acid-Piperazine-Cpd13a ACHE Multitarget Piperazine Quinoline Feruloyl Metal ion chelator anti-Abeta-aggregation Antioxidant
MGLL-IN-Cpd34 Monoglyceridelipase_lysophospholip Piperazine Naphthalen Naphthylamide
CHEMBL4437989 Monoglyceridelipase_lysophospholip Piperazine Pyrazole Cyanide
CHEMBL4559005 Monoglyceridelipase_lysophospholip Naphthalen Piperazine Pyrazole Cyanide
JNJ-42226314 Monoglyceridelipase_lysophospholip Indole Thiazole Sulfur compound Azetidin Piperazine
S21-1001 BCHE Piperazine Quinoline
Biphenyl-oxo-triazine-piperazine-cpd6g ACHE Piperazine Multitarget Triazine
X20419 Thioesterase Piperazine Piperidine Pyrimidine Carboxamide Indole
6-(4-4-phenethylpiperazin-1-yl)heptyl-THAI-14d BCHE Indole Azepane Piperazine Multitarget Alkyl linked bis-ligand anti-Abeta-aggregation
ABD-1970 Monoglyceridelipase_lysophospholip Carbamate Trifluoro Piperazine Azabicyclo
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
LEI-463 Monoglyceridelipase_lysophospholip Trifluoro Indole Piperazine Triazol Fluorescent Probe
LEI-515 Monoglyceridelipase_lysophospholip Piperazine Sulfur compound Organochlorine
AKU-005 Monoglyceridelipase_lysophospholip Piperazine Triazol Sulfur compound
ZINC22029744 ACHE BCHE Multitarget Sulfur compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
SCHEMBL20516363 ABHD6-Lip PAF-Acetylhydrolase Piperazine Imidazole Carbamate Morpholine Organochlorine
MJN193 ABHD6-Lip Piperazine Imidazole Carbamate
JS0-7ZPB BCHE Quinoline Piperazine Multitarget Monoamine-oxidase-inhibitor Alkyne
AI6-7QBR BCHE Quinoline Piperazine tert-Butyl Multitarget Monoamine-oxidase-inhibitor Alkyne
MAGLi-432 Monoglyceridelipase_lysophospholip Piperazine Organochlorine
MAGL-2011 Monoglyceridelipase_lysophospholip Piperazine Azetidin Thiazolidine Sulfur compound PET probe Biphenyl
FEPAD Monoglyceridelipase_lysophospholip Piperazine Azetidin Trifluoro Thiazolidine Sulfur compound PET probe Biphenyl
WWL153 PAF-Acetylhydrolase Piperazine Quinoline pNP
JMN4 PAF-Acetylhydrolase Piperazine Quinoline
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 ACHE BCHE Oxadiazol Pyridine Piperazine BACE1-inhibitor
Fragment-927 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperazine
Fragment-277 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperazine Cyanide Organochlorine
YH168 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
T-401 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe Pyridine Thiazole Sulfur compound
YH149 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
ZYH-deriv-F Monoglyceridelipase_lysophospholip Azetidin Piperazine Carboxamide Pyrimidine PET probe Indole
CHEMBL45663-49N-4Y2Q Epoxide_hydrolase Piperazine Pyridine Trifluoro
CHEMBL48137-49O-4Y2R Epoxide_hydrolase Piperazine Pyridine Cyanide Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand
Fenoverine BCHE Not AlphaBeta Hydrolase target Drug Phenothiazine Sulfur compound Piperazine Benzodioxo
beta-lactam-A295 DPP4N_Peptidase_S9 Quinoline Piperazine
beta-lactam-A296-1 DPP4N_Peptidase_S9 Piperazine Azetidin beta-Lactam
beta-lactam-B142 DPP4N_Peptidase_S9 Piperazine beta-Lactam Benzoate
beta-lactam-B142-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam Benzoate
4-Oxo-beta-Lactam-A241 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-A241-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-LMC375 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-A272 DPP4N_Peptidase_S9 Piperazine beta-Lactam Naphthalen
4-Oxo-beta-Lactam-A272-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam Naphthalen
4-Oxo-beta-Lactam-B115 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-B115-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-B114 DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
4-Oxo-beta-Lactam-B114-closed DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
beta-lactam-L84 DPP4N_Peptidase_S9 Piperazine beta-Lactam
beta-lactam-L84-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
ABD957 ABHD17-depalmitoylase Trifluoro Sulfur compound Sulfonamide Piperazine Pyrazole Azabicyclo
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803778 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Sulfur compound Sulfonamide Pyrazole Organochlorine
ZINC20166201-cpd8 BCHE Piperazine Quinoline
JUB BCHE Piperidine Piperazine NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole Sulfur compound Sulfonamide Naphthalen Benzylpiperidine Derivative of Donepezil
SR-3133 CGI-58_ABHD5_ABHD4 Piperazine Sulfur compound Sulfonamide Benzofuran Benzodioxin
SR-3134 CGI-58_ABHD5_ABHD4 Piperazine Sulfur compound Sulfonamide Benzofuran
SR-4559 CGI-58_ABHD5_ABHD4 Piperazine Sulfur compound Sulfonamide Benzofuran Benzodioxin
DA-12228 DPP4N_Peptidase_S9 Gliptin Trifluoro Piperazine
KK052 RsbQ-like Urea derivative Triazol Piperazine
(R)-3t Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine
5ZUN-3l Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine Sulfur compound Organochlorine
FAPI-46 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
FAPI-74 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Cyanide
FAPI-02 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
FAPI-04 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide Tetrazacyclododec Cyanide
ML349 LYsophospholipase_carboxylesterase Piperazine Sulfur compound Chromen
ML348 LYsophospholipase_carboxylesterase Trifluoro Piperazine
Pyrimidinone-inhibitor1 DPP4N_Peptidase_S9 Purine Piperazine Organochlorine
Teneligliptin DPP4N_Peptidase_S9 Drug Piperazine Pyrrolidine Gliptin Thiazolidine Sulfur compound Pyrazole
BDPX DPP4N_Peptidase_S9 Piperazine Purine
HEPES Hormone-sensitive_lipase_like Buffer Component Piperazine Sulfur compound
6FSE-15 ACHE Piperidine Piperazine Biphenyl
STK133938 ACHE Piperidine Piperazine
AM9928 Monoglyceridelipase_lysophospholip Piperazine Fluoren Carbamate
AM6580 Monoglyceridelipase_lysophospholip Piperazine Piperidine Fluoren Triazol Urea derivative
MJN110 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Carbamate Piperazine Pyrrolidine Organochlorine
1G244 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro Organochlorine
JZL195 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperazine FAAH inhibitor Multitarget pNP Phenoxyphenyl
DO34 Lipase_3 Trifluoro Piperazine Carbamate tert-Butyloxycarbonyl tert-Butyl
SAR629 Monoglyceridelipase_lysophospholip Piperazine Triazol
ABX-1431 Monoglyceridelipase_lysophospholip Piperazine Carbamate Pyrrolidine Trifluoro
ZYH Monoglyceridelipase_lysophospholip Piperazine Pyrimidine Azetidin Benzoxazol
T-82(2) ACHE Piperazine Phenothiazine Benzoate Sulfur compound Organochlorine
Diethylcarbamazine ACHE Piperazine Anthelmintic Not AlphaBeta Hydrolase target Carboxamide
Pipecuronium BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Aminosteroid Piperazine Phenanthrene Not AlphaBeta Hydrolase target