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Piperazine

General

Six-membered ring containing two nitrogen atoms at opposite positions in the ring. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme familyes Type Structure
S21-1001 Piperazine Quinoline
Biphenyl-oxo-triazine-piperazine-cpd6g Piperazine Multitarget Triazine
X20419 Thioesterase Piperazine Piperidine Pyrimidine Carboxamide Indole
6-(4-4-phenethylpiperazin-1-yl)heptyl-THAI-14d Indole Azepine Piperazine Multitarget Alkyl linked bis-ligand
ABD-1970 Monoglyceridelipase_lysophospholip Carbamate Trifluoro Piperazine Azabicyclo
LEI-515 Monoglyceridelipase_lysophospholip Piperazine Sulfur Compound
AKU-005 Monoglyceridelipase_lysophospholip Piperazine Triazol
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
SCHEMBL20516363 ABHD6-Lip PAF-Acetylhydrolase Piperazine Imidazole Carbamate Morpholine
MJN193 ABHD6-Lip Piperazine Imidazole Carbamate
JS0-7ZPB BCHE Quinoline Piperazine Multitarget Monoamine-oxidase-inhibitor
AI6-7QBR BCHE Quinoline Piperazine tert-Butyl Multitarget Monoamine-oxidase-inhibitor
MAGLi-432 Monoglyceridelipase_lysophospholip Piperazine
FEPAD Monoglyceridelipase_lysophospholip Piperazine Azetidin Trifluoro Thiazolidine Sulfur Compound PET probe
WWL153 PAF-Acetylhydrolase Piperazine Quinoline pNP
JMN4 PAF-Acetylhydrolase Piperazine Quinoline
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 ACHE BCHE Oxadiazol Pyridine Piperazine
Fragment-927 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperazine
Fragment-277 Pectinacetylesterase-Notum Fragment inhibitor of Notum Piperazine Cyanide
YH149 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
ZYH-deriv-F Monoglyceridelipase_lysophospholip Azetidin Piperazine Carboxamide Pyrimidine PET probe Indole
CHEMBL45663-49N-4Y2Q Epoxide_hydrolase Piperazine Pyridine Trifluoro
CHEMBL48137-49O-4Y2R Epoxide_hydrolase Piperazine Pyridine Cyanide Not A\/B H target Adrenergic-Receptor-ligand
Fenoverine BCHE Not A\/B H target Drug Phenothiazine Sulfur Compound Piperazine Benzodioxo
beta-lactam-A295 DPP4N_Peptidase_S9 Quinoline Piperazine
beta-lactam-A296-1 DPP4N_Peptidase_S9 Piperazine Azetidin beta-Lactam
beta-lactam-B142 DPP4N_Peptidase_S9 Piperazine beta-Lactam Benzoate
beta-lactam-B142-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam Benzoate
4-Oxo-beta-Lactam-A241 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-A241-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-LMC375 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-A272 DPP4N_Peptidase_S9 Piperazine beta-Lactam Naphthalen
4-Oxo-beta-Lactam-A272-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam Naphthalen
4-Oxo-beta-Lactam-B115 DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-B115-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
4-Oxo-beta-Lactam-B114 DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
4-Oxo-beta-Lactam-B114-closed DPP4N_Peptidase_S9 Piperazine Carboxamide beta-Lactam
beta-lactam-L84 DPP4N_Peptidase_S9 Piperazine beta-Lactam
beta-lactam-L84-closed DPP4N_Peptidase_S9 Piperazine beta-Lactam
ABD957 ABHD17-depalmitoylase Trifluoro Sulfur Compound Sulfonamide Piperazine Pyrazole Azabicyclo
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803778 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Sulfur Compound Sulfonamide Pyrazole
ZINC20166201-cpd8 BCHE Piperazine Quinoline
JUB BCHE Piperidine Piperazine NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole Sulfur Compound Sulfonamide Naphthalen
SR-3133 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran
SR-3134 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran
SR-4559 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran
T-401 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe Sulfur Compound
DA-12228 DPP4N_Peptidase_S9 Gliptin Trifluoro Piperazine
KK052 RsbQ-like Urea derivative Triazol Piperazine
(R)-3t Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine
5ZUN-3l Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine Sulfur Compound
FAPI-04 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide tert-Butyl tert-Butyloxycarbonyl
ML349 LYsophospholipase_carboxylesterase Piperazine Sulfur Compound Chromen
ML348 LYsophospholipase_carboxylesterase Trifluoro Piperazine
Pyrimidinone-inhibitor1 DPP4N_Peptidase_S9 Purine Piperazine
Teneligliptin DPP4N_Peptidase_S9 Drug Piperazine Pyrrolidine Gliptin Thiazolidine Sulfur Compound Pyrazole
BDPX DPP4N_Peptidase_S9 Piperazine Purine
HEPES Hormone-sensitive_lipase_like Buffer Component Piperazine Sulfur Compound
STK133938 ACHE Piperidine Piperazine
AM9928 Monoglyceridelipase_lysophospholip Piperazine Fluoren Carbamate
AM6580 Monoglyceridelipase_lysophospholip Piperazine Piperidine Fluoren Triazol Urea derivative
MJN110 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Carbamate Piperazine Pyrrolidine
isoquinolinederivative18 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
1G244 DPP4N_Peptidase_S9 Piperazine Isoindole Indole
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro
JZL195 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperazine FAAH inhibitor Multitarget pNP Phenoxyphenyl
DO34 Lipase_3 Trifluoro Piperazine Carbamate tert-Butyloxycarbonyl tert-Butyl
F4P Monoglyceridelipase_lysophospholip Piperazine Triazol
ABX-1431 Monoglyceridelipase_lysophospholip Piperazine Carbamate Pyrrolidine Trifluoro
ZYH Monoglyceridelipase_lysophospholip Piperazine Pyrimidine Azetidin Benzoxazol
T-82(2) ACHE Piperazine Phenothiazine Benzoate Sulfur Compound
Diethylcarbamazine ACHE Piperazine Anthelmintic Not A\/B H target Carboxamide
Pipecuronium BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Aminosteroid Piperazine Phenanthrene Not A\/B H target