Diphenyl-chlorophosphate
Acetylcholinesterase is readily inhibited by 10-5 M diphenylphosphorochloridate even though the inhibitor hydrolyzes in a few seconds. Diphenyl phosphoryl enzyme spontaneously recovers only about 50% of its activity with a half time of about 17 min at pH 7.0 and 6 min at pH 8.0. The fact that only 50% of the original activity returns is due to aging.
General
Type : Organophosphate
Chemical_Nomenclature : [chloro(phenoxy)phosphoryl]oxybenzene
Canonical SMILES : C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl
InChI : InChI=1S\/C12H10ClO3P\/c13-17(14,15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12\/h1-10H
InChIKey : BHIIGRBMZRSDRI-UHFFFAOYSA-N
Other name(s) : Diphenyl chlorophosphate, Diphenyl phosphorochloridate, Diphenylchlorophosphate, Chlorodiphenyl Phosphate, Chlorodiphenoxyphosphine oxide
MW : 268.63
Formula : C12H10ClO3P
CAS_number : 2524-64-3
PubChem : 75654
UniChem : BHIIGRBMZRSDRI-UHFFFAOYSA-N
Target
Families : Diphenyl-chlorophosphate ligand of proteins in family
ACHE
References (1)
| Title : Reactivation and aging of diphenyl phosphoryl acetylcholinesterase - Maglothin_1975_Biochim.Biophys.Acta_403_370 |
| Author(s) : Maglothin JA , Wins P , Wilson IB |
| Ref : Biochimica & Biophysica Acta , 403 :370 , 1975 |
| PubMedID: 241402 |