FAPI-Gly-Pro-MTX
FAPI-Gly-Pro-MTX integrates a FAPalpha(+) tracer, FAPalpha inhibitor (FAPI), with the traditional drug methotrexate (MTX) via a glycine-proline dipeptide that can be cleaved by the dipeptidyl peptidase activity
General
Type : Peptide
Chemical_Nomenclature :
Canonical SMILES :
InChI :
InChIKey :
Other name(s) : FM
MW :
Formula :
CAS_number :
PubChem :
UniChem :
Target
Families : FAPI-Gly-Pro-MTX ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-FAP
References (3)
| Title : A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPalpha-expressing fibroblasts - Qian_2026_Acta.Pharmacol.Sin__ |
| Author(s) : Qian HY , He Y , Deng CQ , Wang AD , Ma YX , Zhuang HJ , Chen SP , Li Y , Chen SJ , Zhang XW , Jan N , Shi GX , Liu Y |
| Ref : Acta Pharmacol Sin , : , 2026 |
| Abstract : |
| PubMedSearch : Qian_2026_Acta.Pharmacol.Sin__ |
| PubMedID: 41478880 |
| Gene_locus related to this paper: human-FAP |
| Title : A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPalpha-expressing fibroblasts - Qian_2026_Acta.Pharmacol.Sin__ |
| Author(s) : Qian HY , He Y , Deng CQ , Wang AD , Ma YX , Zhuang HJ , Chen SP , Li Y , Chen SJ , Zhang XW , Jan N , Shi GX , Liu Y |
| Ref : Acta Pharmacol Sin , : , 2026 |
| Abstract : |
| PubMedSearch : Qian_2026_Acta.Pharmacol.Sin__ |
| PubMedID: 41478880 |
| Gene_locus related to this paper: human-FAP |
| Title : A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPalpha-expressing fibroblasts - Qian_2026_Acta.Pharmacol.Sin__ |
| Author(s) : Qian HY , He Y , Deng CQ , Wang AD , Ma YX , Zhuang HJ , Chen SP , Li Y , Chen SJ , Zhang XW , Jan N , Shi GX , Liu Y |
| Ref : Acta Pharmacol Sin , : , 2026 |
| Abstract : |
| PubMedSearch : Qian_2026_Acta.Pharmacol.Sin__ |
| PubMedID: 41478880 |
| Gene_locus related to this paper: human-FAP |