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Peptide

General

Some naturel toxins or poisons are peptides inhibitors of alpha/beta hydrolases (esterases lipases or peptidases). Some derivatives of amino-acids chains have been developped as inhibitors of the petidases belonging to the family
Inhibitor Main targeted enzyme families Type Structure
Fasciculin2 ACHE Fasciculin2 variant Natural_modified Natural Peptide Sulfur Compound
ARI-4175 DPP4N_Peptidase_S9 Boron compound Peptide Pyrrolidine
FAP-2286 DPP4N_Peptidase_S9 Peptide PET probe Tetrazacyclododec
FphB-OX-5 Hormone-sensitive_lipase_like 6_AlphaBeta_hydrolase Peptide Sulfur Compound Oxadiazolone Oxadiazol
FphB-OX-14 Hormone-sensitive_lipase_like 6_AlphaBeta_hydrolase Peptide Sulfur Compound Oxadiazolone Oxadiazol
Fmoc-prolyl-pyrrolidine-2-nitrile S9N_PPCE_Peptidase_S9 Peptide Fluoren Pyrrolidine Cyanide
11tA-WWRGAWKGCIS-NH2 ACHE Peptide
VAMP DPP4N_Peptidase_S9 Peptide
Cyclo(L-leu-L-pro) RsbQ-like Peptide
Acetylleucine-chloromethyl-ketone ACPH_Peptidase_S9 Peptide
PNT6555 DPP4N_Peptidase_S9 PET probe Boron compound Peptide Tetrazacyclododec
ILAPPER DPP4N_Peptidase_S9 Natural Peptide
H-Lys(4-nitro-Z)-pyrrolidide DPP4N_Peptidase_S9 Pyrrolidine Carbamate pNP Peptide
Lys-phospho-isoindoline DPP4N_Peptidase_S9 Acetanilide Peptide Indole Organophosphate
Phenylalanine Hydrolase_RBBP9_YdeN Product-like inhibitor Peptide
FphF16 A85-EsteraseD-FGH Peptide
Presegetalin-B1 S9N_PPCE_Peptidase_S9 Peptide
Presegetalin-A1 S9N_PPCE_Peptidase_S9 Peptide
Presegetalin-F1 S9N_PPCE_Peptidase_S9 Peptide
Follower-Peptide-Presegetalin-A1 S9N_PPCE_Peptidase_S9 Peptide
Tosyl-L-lysine-chloromethyl-ketone Carb_B_Bacteria BCHE S9N_PREPL_Peptidase_S9 Ketone Peptide Sulfur Compound Sulfonamide Benzenesulfonamide
Histidine Hydroxynitrile_lyase Peptide Imidazole
Ile-Pro DPP4N_Peptidase_S9 Peptide
Lys-Pro DPP4N_Peptidase_S9 Peptide Product-like inhibitor
Z-Gly-Pro-CHN2 S9N_PREPL_Peptidase_S9 Peptide Benzyloxycarbonyl
Z-Pro-Prolinal-IC1 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide tert-Butyl
Z-Pro-Prolinal-IC2 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide Carboxamide
Z-Pro-Prolinal-IC3 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide Cyanide
Z-Pro-Prolinal-IC4 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide Carboxamide Urea derivative
Z-Pro-Prolinal-derived S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Piperidine Peptide Pyrrolidine Carboxamide Carbamate
Alanyl-Isoleucyl-pyrrolidin-boronic-acid DPP4N_Peptidase_S9 Pyrrolidine Peptide Boron compound
Gly-Phe-OH ACPH_Peptidase_S9 Product-like inhibitor Peptide
Ac-Phe-OH ACPH_Peptidase_S9 Product-like inhibitor Peptide
6Z8 DPP4N_Peptidase_S9 Purine Piperidine Gliptin Peptide
tBu-GPI DPP4N_Peptidase_S9 Peptide Pyrrolidine tert-Butyl
Pro-boropro DPP4N_Peptidase_S9 Peptide Pyrrolidine Boron compound
Z-Ala_prolinal S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Peptide Pyrrolidine
SLRFLYEG DPP4N_Peptidase_S9 Peptide
SUMO1-EIL DPP4N_Peptidase_S9 Peptide
Talabostat DPP4N_Peptidase_S9 Peptide Pyrrolidine Boron compound
Leupeptin S9N_PREPL_Peptidase_S9 Peptide Natural
Ala-Tboda Proline_iminopeptidase Peptide Oxadiazol tert-Butyl
Sar-Tboda Proline_iminopeptidase Peptide Oxadiazol tert-Butyl
Pro-Tboda Proline_iminopeptidase Peptide Pyrrolidine Oxadiazol tert-Butyl
Z-Gly-Gly-Phe-chloromethyl-ketone ACPH_Peptidase_S9 Benzyloxycarbonyl Carbamate Peptide Ketone Carboxamide
Chymostatin Carboxypeptidase_S10 Peptide
Antipain S9N_PREPL_Peptidase_S9 Carboxypeptidase_S10 Peptide
Didemnin-B Palmitoyl-protein_thioesterase Natural Peptide Pyrrolidine Carboxamide
PHK Proline_iminopeptidase Peptide Halo ketone
p-Iodo-Phe-Pyr-CN DPP4N_Peptidase_S9 Peptide Pyrrolidine Cyanide
Trp2-Tat-(1-9) DPP4N_Peptidase_S9 Peptide Sulfur Compound
Tat-(1-9) DPP4N_Peptidase_S9 Peptide Pyrrolidine Sulfur Compound
Ala(1-naph)-Pro-CN Hydrolase_RBBP9_YdeN DPP4N_Peptidase_S9 Peptide Pyrrolidine Naphthalen Cyanide
CHEMBL1086968 S9N_PPCE_Peptidase_S9 Peptide Thiazolidine Cyclopropyl Indole Sulfur Compound
Sin-Gly-Pro S9N_PPCE_Peptidase_S9 Peptide Pyrrolidine
Diprotin-A DPP4N_Peptidase_S9 Peptide Pyrrolidine
Diprotin-B DPP4N_Peptidase_S9 Peptide Pyrrolidine
1-valylpyrrolidine DPP4N_Peptidase_S9 Peptide Pyrrolidine
Z-Pro-Prolinal S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Peptide Pyrrolidine Carbamate
Z-Gly-Pro S9N_PPCE_Peptidase_S9 Peptide Pyrrolidine Benzyloxycarbonyl
OP5 ACHE Peptide
Fasciculin1 ACHE Natural Peptide
K32G-fasciculin2 ACHE Fasciculin2 variant Peptide Natural_modified
K25L-fasciculin2 ACHE Fasciculin2 variant Peptide Natural_modified
V34A,L35A-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
R28D-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
R27W-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
P31R-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
K51S-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
R11Q-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
H29D-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
P30del-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
R24T-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
D45K-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
T8A,T9A-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
M33A-fasciculin2 ACHE Fasciculin2 variant Natural_modified Peptide
Fasciculin3 ACHE Peptide Natural