human-FAP
Homo sapiens (Human) fibroblast activation protein alpha FAPalpha, integral membrane serine protease seprase FAPA, FAP, SEPR
Comment
Fibroblast activation protein (FAP). However, FAP is not expressed in normal fibroblasts, normal or malignant epithelial cells, or the stroma of benign epithelial tumors. FAP is a cell membrane-bound serine peptidase overexpressed on the surface of cancer-associated fibroblasts. Serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala\/Ser-Gly-Pro-Ser\/Asn\/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein. FAP can hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY cleavage product proangiogenic FAP enhances tumor growth progression), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB). Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner. FAP inhibitors (FAPis) have recently been developed for PET imaging and radioligand therapy
Relationship
Family : DPP4N_Peptidase_S9
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
No mutation
No kinetic
No disease
Sequence
Peptide
MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP FQITFNGREN KIFNGIPDWV YEEEMLPTKY ALWWSPNGKF LAYAEFNDKD IPVIAYSYYG DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSRPVFSYD AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD
References (101)
| Title : Macrocyclic phage display for identification of selective protease substrates - Faucher_2025_bioRxiv__ |
| Author(s) : Faucher FF , Lovell S , Bertolini M , Blazkova K , Cosco ED , Bogyo M , Barniol-Xicota M |
| Ref : Biorxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Faucher_2025_bioRxiv__ |
| PubMedID: 40161698 |
| Gene_locus related to this paper: human-DPP4 , human-FAP |
| Title : 4-1BB agonist targeted to fibroblast activation protein alpha synergizes with radiotherapy to treat murine breast tumor models - Garate-Soraluze_2025_J.Immunother.Cancer_13_e009852 |
| Author(s) : Garate-Soraluze E , Serrano-Mendioroz I , Fernandez-Rubio L , De Andrea CE , Barrio-Alonso C , Herrero CDP , Teijeira A , Luri-Rey C , Claus C , Tanos T , Klein C , Umana P , Rullan A , Simon JA , Collantes M , Sanchez-Mateos P , Melero I , Rodriguez-Ruiz ME |
| Ref : J Immunother Cancer , 13 : , 2025 |
| Abstract : |
| PubMedSearch : Garate-Soraluze_2025_J.Immunother.Cancer_13_e009852 |
| PubMedID: 39933836 |
| Gene_locus related to this paper: human-FAP |
| Title : Aged-Related Fibroblast Activation Protein Expression in Skeletal Muscles Evaluated by PET Imaging - Suh_2025_J.Cachexia.Sarcopenia.Muscle_16_e13730 |
| Author(s) : Suh M , Gil J , Kang YK , Choi H , Cheon GJ |
| Ref : J Cachexia Sarcopenia Muscle , 16 :e13730 , 2025 |
| Abstract : |
| PubMedSearch : Suh_2025_J.Cachexia.Sarcopenia.Muscle_16_e13730 |
| PubMedID: 39956945 |
| Gene_locus related to this paper: human-FAP |
| Title : Expression of fibroblast activation protein-alpha in human deep vein thrombosis - Oguri_2024_Thromb.Res_241_109075 |
| Author(s) : Oguri N , Gi T , Nakamura E , Furukoji E , Goto H , Maekawa K , Tsuji AB , Nishii R , Aman M , Moriguchi-Goto S , Sakae T , Azuma M , Yamashita A |
| Ref : Thromb Res , 241 :109075 , 2024 |
| Abstract : |
| PubMedSearch : Oguri_2024_Thromb.Res_241_109075 |
| PubMedID: 38955058 |
| Gene_locus related to this paper: human-FAP |
| Title : Expression of FAP in Oral Leukoplakia and Oral Squamous Cell Carcinoma - Li_2024_Int.Dent.J_74_581 |
| Author(s) : Li R , Zhang R , Shi X , Jiao X , Li Y , Zhao Y , Liu T , Zhang C |
| Ref : Int Dent J , 74 :581 , 2024 |
| Abstract : |
| PubMedSearch : Li_2024_Int.Dent.J_74_581 |
| PubMedID: 38278714 |
| Gene_locus related to this paper: human-FAP |
| Title : Beyond Small Molecules: Antibodies and Peptides for Fibroblast Activation Protein Targeting Radiopharmaceuticals - Sun_2024_Pharmaceutics_16_ |
| Author(s) : Sun X , Wu Y , Wang X , Gao X , Zhang S , Sun Z , Liu R , Hu K |
| Ref : Pharmaceutics , 16 : , 2024 |
| Abstract : |
| PubMedSearch : Sun_2024_Pharmaceutics_16_ |
| PubMedID: 38543239 |
| Gene_locus related to this paper: human-FAP |
| Title : Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-alpha-targeted radiotheranostic for cancer imaging and therapy - Bendre_2024_Eur.J.Med.Chem_268_116238 |
| Author(s) : Bendre S , Merkens H , Kuo HT , Ng P , Wong A , Lau WS , Zhang Z , Kurkowska S , Chen CC , Uribe C , Benard F , Lin KS |
| Ref : Eur Journal of Medicinal Chemistry , 268 :116238 , 2024 |
| Abstract : |
| PubMedSearch : Bendre_2024_Eur.J.Med.Chem_268_116238 |
| PubMedID: 38367492 |
| Gene_locus related to this paper: human-FAP |
| Title : Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds - Cermakova_2024_Eur.J.Med.Chem_280_116948 |
| Author(s) : Cermakova K , Simkova A , Wichterle F , Krystufek R , Stanurova J , Vanickova Z , Busek P , Konvalinka J , Sacha P |
| Ref : Eur Journal of Medicinal Chemistry , 280 :116948 , 2024 |
| Abstract : |
| PubMedSearch : Cermakova_2024_Eur.J.Med.Chem_280_116948 |
| PubMedID: 39437576 |
| Gene_locus related to this paper: human-FAP |
| Title : Recent Clinical Implications of FAPI: Imaging and Therapy - Kiani_2024_Clin.Nucl.Med_49_e538 |
| Author(s) : Kiani M , Jokar S , Hassanzadeh L , Behnammanesh H , Bavi O , Beiki D , Assadi M |
| Ref : Clin Nucl Med , 49 :e538 , 2024 |
| Abstract : |
| PubMedSearch : Kiani_2024_Clin.Nucl.Med_49_e538 |
| PubMedID: 39025634 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast Activation Protein-Targeted Radioligand Therapy for Treatment of Solid Tumors - Lindeman_2023_J.Nucl.Med_64_759 |
| Author(s) : Lindeman SD , Mukkamala R , Horner A , Tudi P , Booth OC , Huff R , Hinsey J , Hovstadius A , Martone P , Zhang F , Srinivasarao M , Cox A , Low PS |
| Ref : J Nucl Med , 64 :759 , 2023 |
| Abstract : |
| PubMedSearch : Lindeman_2023_J.Nucl.Med_64_759 |
| PubMedID: 37116911 |
| Gene_locus related to this paper: human-FAP |
| Title : Synthesis and Evaluation of (99m)Tc-Labeled FAP Inhibitors with Different Linkers for Imaging of Fibroblast Activation Proteins in Tumors - Ruan_2023_J.Med.Chem_66_4952 |
| Author(s) : Ruan Q , Wang Q , Jiang Y , Feng J , Yin G , Zhang J |
| Ref : Journal of Medicinal Chemistry , 66 :4952 , 2023 |
| Abstract : |
| PubMedSearch : Ruan_2023_J.Med.Chem_66_4952 |
| PubMedID: 36972467 |
| Gene_locus related to this paper: human-FAP |
| Title : Selection and Identification of an ssDNA Aptamer for Fibroblast Activation Protein - Zhang_2023_Molecules_28_ |
| Author(s) : Zhang X , Yang G , Zhao Y , Dai X , Liu W , Qu F , Huang Y |
| Ref : Molecules , 28 : , 2023 |
| Abstract : |
| PubMedSearch : Zhang_2023_Molecules_28_ |
| PubMedID: 36838669 |
| Gene_locus related to this paper: human-FAP |
| Title : FAP expression in adipose tissue macrophages promotes obesity and metabolic inflammation - Wu_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2303075120 |
| Author(s) : Wu Y , Wu C , Shi T , Cai Q , Wang T , Xiong Y , Zhang Y , Jiang W , Lu M , Chen Z , Chen J , Wang J , He R |
| Ref : Proc Natl Acad Sci U S A , 120 :e2303075120 , 2023 |
| Abstract : |
| PubMedSearch : Wu_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2303075120 |
| PubMedID: 38100414 |
| Gene_locus related to this paper: human-FAP |
| Title : Identifying the oncogenic roles of FAP in human cancers based on systematic analysis - Ma_2023_Aging.(Albany.NY)_15_7056 |
| Author(s) : Ma C , Xi S , Sun H , Zhang M , Pei Y |
| Ref : Aging (Albany NY) , 15 :7056 , 2023 |
| Abstract : |
| PubMedSearch : Ma_2023_Aging.(Albany.NY)_15_7056 |
| PubMedID: 37490719 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein (FAP)-targeted radionuclide therapy: which ligand is the best? - |
| Author(s) : Chakravarty R , Song W , Chakraborty S , Cai W |
| Ref : Eur J Nucl Med Mol Imaging , 50 :2935 , 2023 |
| PubMedID: 37452872 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast Activation Protein-alpha (FAP) Identifies Stromal Invasion in Colorectal Neoplasia - Tarin-Nieto_2023_Am.J.Surg.Pathol_47_1027 |
| Author(s) : Tarin-Nieto A , Solano-Iturri JD , Arrieta-Aguirre I , Valdivia A , Etxezarraga MC , Loizate A , Lopez JI , Larrinaga G |
| Ref : American Journal of Surgery Pathol , 47 :1027 , 2023 |
| Abstract : |
| PubMedSearch : Tarin-Nieto_2023_Am.J.Surg.Pathol_47_1027 |
| PubMedID: 37366169 |
| Gene_locus related to this paper: human-FAP |
| Title : Comprehensive analysis of the oncogenic and immunological role of FAP and identification of the ceRNA network in human cancers - Mai_2023_Aging.(Albany.NY)_15_3738 |
| Author(s) : Mai W , Liu Q , Li J , Zheng M , Yan F , Liu H , Lei Y , Xu J |
| Ref : Aging (Albany NY) , 15 :3738 , 2023 |
| Abstract : |
| PubMedSearch : Mai_2023_Aging.(Albany.NY)_15_3738 |
| PubMedID: 37166418 |
| Gene_locus related to this paper: human-FAP |
| Title : FAP expression in alpha cells of Langherhans insulae-implications for FAPI radiopharmaceuticals' use - Kirienko_2023_Eur.J.Nucl.Med.Mol.Imaging_50_3042 |
| Author(s) : Kirienko M , Centonze G , Sabella G , Sollai M , Sollini M , Lan X , Chen H , Terracciano L , Seregni E , Milione M |
| Ref : Eur J Nucl Med Mol Imaging , 50 :3042 , 2023 |
| Abstract : |
| PubMedSearch : Kirienko_2023_Eur.J.Nucl.Med.Mol.Imaging_50_3042 |
| PubMedID: 37140668 |
| Gene_locus related to this paper: human-FAP |
| Title : Joint analysis identified FAP as a prognostic and diagnostic biomarker correlated immune infiltration in gastric cancer - Zhang_2023_Pathol.Res.Pract_245_154462 |
| Author(s) : Zhang K , Yue B , Duan X , Chen W , Dai X , Chen Y , Li X , Lu J |
| Ref : Pathol Res Pract , 245 :154462 , 2023 |
| Abstract : |
| PubMedSearch : Zhang_2023_Pathol.Res.Pract_245_154462 |
| PubMedID: 37068372 |
| Gene_locus related to this paper: human-FAP |
| Title : FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer - Liu_2023_J.Transl.Med_21_255 |
| Author(s) : Liu Y , Sun Y , Wang P , Li S , Dong Y , Zhou M , Shi B , Jiang H , Sun R , Li Z |
| Ref : J Transl Med , 21 :255 , 2023 |
| Abstract : |
| PubMedSearch : Liu_2023_J.Transl.Med_21_255 |
| PubMedID: 37046312 |
| Gene_locus related to this paper: human-FAP |
| Title : Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP - Sun_2023_Circ.Res_132_586 |
| Author(s) : Sun Y , Ma M , Cao D , Zheng A , Zhang Y , Su Y , Wang J , Xu Y , Zhou M , Tang Y , Liu Y , Ma T , Fan A , Zhang X , Zhu Q , Qin J , Mo C , Zhang L , Xu D , Yue R |
| Ref : Circulation Research , 132 :586 , 2023 |
| Abstract : |
| PubMedSearch : Sun_2023_Circ.Res_132_586 |
| PubMedID: 36756875 |
| Gene_locus related to this paper: human-FAP |
| Title : FAP is critical for ovarian cancer cell survival by sustaining NF-B activation through recruitment of PRKDC in lipid rafts - Li_2023_Cancer.Gene.Ther_30_608 |
| Author(s) : Li B , Ding Z , Calbay O , Li Y , Li T , Jin L , Huang S |
| Ref : Cancer Gene Therapy , 30 :608 , 2023 |
| Abstract : |
| PubMedSearch : Li_2023_Cancer.Gene.Ther_30_608 |
| PubMedID: 36494579 |
| Gene_locus related to this paper: human-FAP |
| Title : Comprehensive Analysis of Fibroblast Activation Protein Expression in Interstitial Lung Diseases - Yang_2023_Am.J.Respir.Crit.Care.Med_207_160 |
| Author(s) : Yang P , Luo Q , Wang X , Fang Q , Fu Z , Li J , Lai Y , Chen X , Xu X , Peng X , Hu K , Nie X , Liu S , Zhang J , Shen C , Gu Y , Liu J , Chen J , Zhong N , Su J |
| Ref : American Journal of Respiratory & Critical Care Medicine , 207 :160 , 2023 |
| Abstract : |
| PubMedSearch : Yang_2023_Am.J.Respir.Crit.Care.Med_207_160 |
| PubMedID: 35984444 |
| Gene_locus related to this paper: human-FAP |
| Title : Cell-specific expression of the FAP gene is regulated by enhancer elements - Antonova_2023_Front.Mol.Biosci_10_1111511 |
| Author(s) : Antonova DV , Gnatenko DA , Kotova ES , Pleshkan VV , Kuzmich AI , Didych DA , Sverdlov ED , Alekseenko IV |
| Ref : Front Mol Biosci , 10 :1111511 , 2023 |
| Abstract : |
| PubMedSearch : Antonova_2023_Front.Mol.Biosci_10_1111511 |
| PubMedID: 36825204 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast Activation Protein Inhibitor Theranostics: Preclinical Considerations - Kaneda-Nakashima_2023_PET.Clin_18_397 |
| Author(s) : Kaneda-Nakashima K , Shirakami Y , Kadonaga Y , Watabe T |
| Ref : PET Clin , 18 :397 , 2023 |
| Abstract : |
| PubMedSearch : Kaneda-Nakashima_2023_PET.Clin_18_397 |
| PubMedID: 36997365 |
| Gene_locus related to this paper: human-FAP |
| Title : Synthesis and Preclinical Evaluation of Novel (68)Ga-Labeled (R)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging - Bendre_2023_Pharmaceuticals.(Basel)_16_798 |
| Author(s) : Bendre S , Kuo HT , Merkens H , Zhang Z , Wong A , Benard F , Lin KS |
| Ref : Pharmaceuticals (Basel) , 16 :798 , 2023 |
| Abstract : |
| PubMedSearch : Bendre_2023_Pharmaceuticals.(Basel)_16_798 |
| PubMedID: 37375746 |
| Gene_locus related to this paper: human-FAP |
| Title : Radiosynthesis, preclinical evaluation and pilot clinical PET imaging study of a (18)F-labeled tracer targeting fibroblast activation protein - Fu_2023_Bioorg.Chem_141_106878 |
| Author(s) : Fu L , Huang J , Liu Q , Xie F , Han Y , Sun P , Cao M , Huang Y , Hu K , Tang G |
| Ref : Bioorg Chem , 141 :106878 , 2023 |
| Abstract : |
| PubMedSearch : Fu_2023_Bioorg.Chem_141_106878 |
| PubMedID: 37774434 |
| Gene_locus related to this paper: human-FAP |
| Title : Design and characterization of fibroblast activation protein targeted pan-cancer imaging agent for fluorescence-guided surgery of solid tumors - Mukkamala_2022_J.Mater.Chem.B_10_2038 |
| Author(s) : Mukkamala R , Lindeman SD , Kragness KA , Shahriar I , Srinivasarao M , Low PS |
| Ref : J Mater Chem B , 10 :2038 , 2022 |
| Abstract : |
| PubMedSearch : Mukkamala_2022_J.Mater.Chem.B_10_2038 |
| PubMedID: 35255116 |
| Gene_locus related to this paper: human-FAP |
| Title : [(68)Ga]\/[(90)Y]FAPI-46: Automated production and analytical validation of a theranostic pair - Nader_2022_Nucl.Med.Biol_110-111_37 |
| Author(s) : Nader M , Valla DF , Vriamont C , Masset J , Pacelli A , Herrmann K , Zarrad F |
| Ref : Nucl Med Biol , 110-111 :37 , 2022 |
| Abstract : |
| PubMedSearch : Nader_2022_Nucl.Med.Biol_110-111_37 |
| PubMedID: 35533534 |
| Gene_locus related to this paper: human-FAP |
| Title : Preparation and Bioevaluation of (99m)Tc-Labeled FAP Inhibitors as Tumor Radiotracers to Target the Fibroblast Activation Protein - Ruan_2022_Mol.Pharm_19_160 |
| Author(s) : Ruan Q , Feng J , Jiang Y , Zhang X , Duan X , Wang Q , Yin G , Xiao D , Zhang J |
| Ref : Mol Pharm , 19 :160 , 2022 |
| Abstract : |
| PubMedSearch : Ruan_2022_Mol.Pharm_19_160 |
| PubMedID: 34904839 |
| Gene_locus related to this paper: human-FAP |
| Title : Stromal FAP Expression is Associated with MRI Visibility and Patient Survival in Prostate Cancer - Pellinen_2022_Cancer.Res.Commun_2_172 |
| Author(s) : Pellinen T , Sandeman K , Blom S , Turkki R , Hemmes A , Valimaki K , Eineluoto J , Kenttamies A , Nordling S , Kallioniemi O , Rannikko A , Mirtti T |
| Ref : Cancer Research Commun , 2 :172 , 2022 |
| Abstract : |
| PubMedSearch : Pellinen_2022_Cancer.Res.Commun_2_172 |
| PubMedID: 36874403 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein-alpha knockdown suppresses prostate cancer cell invasion and proliferation - An_2022_Histol.Histopathol_37_597 |
| Author(s) : An J , Hou D , Wang L , Yang Y , Wang H |
| Ref : Histol Histopathol , 37 :597 , 2022 |
| Abstract : |
| PubMedSearch : An_2022_Histol.Histopathol_37_597 |
| PubMedID: 35129203 |
| Gene_locus related to this paper: human-FAP |
| Title : Expression of Fibroblast Activation Protein Is Enriched in Neuroendocrine Prostate Cancer and Predicts Worse Survival - Vlachostergios_2022_Genes.(Basel)_13_135 |
| Author(s) : Vlachostergios PJ , Karathanasis A , Tzortzis V |
| Ref : Genes (Basel) , 13 :135 , 2022 |
| Abstract : |
| PubMedSearch : Vlachostergios_2022_Genes.(Basel)_13_135 |
| PubMedID: 35052475 |
| Gene_locus related to this paper: human-FAP |
| Title : Design, Synthesis and Preclinical Assessment of (99m)Tc-iFAP for In Vivo Fibroblast Activation Protein (FAP) Imaging - Trujillo-Benitez_2022_Molecules_27_264 |
| Author(s) : Trujillo-Benitez D , Luna-Gutierrez M , Ferro-Flores G , Ocampo-Garcia B , Santos-Cuevas C , Bravo-Villegas G , Morales-Avila E , Cruz-Nova P , Diaz-Nieto L , Garcia-Quiroz J , Azorin-Vega E , Rosato A , Melendez-Alafort L |
| Ref : Molecules , 27 :264 , 2022 |
| Abstract : |
| PubMedSearch : Trujillo-Benitez_2022_Molecules_27_264 |
| PubMedID: 35011496 |
| Gene_locus related to this paper: human-FAP |
| Title : Increased Expression of Fibroblast Activation Protein is Associated with Autophagy Dysregulation and Oxidative Stress in Obese Women with Uterine Fibroids - Maghraby_2022_Reprod.Sci_29_448 |
| Author(s) : Maghraby N , El Noweihi AM , El-Melegy NT , Mostafa NAM , Abbas AM , El-Deek HEM , Radwan E |
| Ref : Reprod Sci , 29 :448 , 2022 |
| Abstract : |
| PubMedSearch : Maghraby_2022_Reprod.Sci_29_448 |
| PubMedID: 34845667 |
| Gene_locus related to this paper: human-FAP |
| Title : Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-alpha for different indications - Plescia_2022_Eur.J.Med.Chem_240_114543 |
| Author(s) : Plescia J , Hedou D , Pousse ME , Labarre A , Dufresne C , Mittermaier A , Moitessier N |
| Ref : Eur Journal of Medicinal Chemistry , 240 :114543 , 2022 |
| Abstract : |
| PubMedSearch : Plescia_2022_Eur.J.Med.Chem_240_114543 |
| PubMedID: 35797897 |
| Gene_locus related to this paper: human-FAP , human-PREP |
| Title : Fibroblast activation protein alpha: Comprehensive detection methods for drug target and tumor marker - Song_2022_Chem.Biol.Interact__109830 |
| Author(s) : Song P , Pan Q , Sun Z , Zou L , Yang L |
| Ref : Chemico-Biological Interactions , :109830 , 2022 |
| Abstract : |
| PubMedSearch : Song_2022_Chem.Biol.Interact__109830 |
| PubMedID: 35104486 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein-based theranostics in pancreatic cancer - Cheng_2022_Front.Oncol_12_969731 |
| Author(s) : Cheng CS , Yang PW , Sun Y , Song SL , Chen Z |
| Ref : Front Oncol , 12 :969731 , 2022 |
| Abstract : |
| PubMedSearch : Cheng_2022_Front.Oncol_12_969731 |
| PubMedID: 36263225 |
| Gene_locus related to this paper: human-FAP |
| Title : Dynamic PET\/CT Imaging of (68)Ga-FAPI-04 in Chinese Subjects - Wang_2021_Front.Oncol_11_651005 |
| Author(s) : Wang S , Zhou X , Xu X , Ding J , Liu T , Jiang J , Li N , Zhu H , Yang Z |
| Ref : Front Oncol , 11 :651005 , 2021 |
| Abstract : |
| PubMedSearch : Wang_2021_Front.Oncol_11_651005 |
| PubMedID: 33777814 |
| Gene_locus related to this paper: human-FAP |
| Title : Long-Lasting Bioluminescence Imaging of the Fibroblast Activation Protein by an Amphiphilic Block Copolymer-Based Probe - Zhou_2021_Anal.Chem_93_3726 |
| Author(s) : Zhou Y , Yin K , Dong H , Yang S , Li J , Luo J , Li Y , Yang R |
| Ref : Analytical Chemistry , 93 :3726 , 2021 |
| Abstract : |
| PubMedSearch : Zhou_2021_Anal.Chem_93_3726 |
| PubMedID: 33601885 |
| Gene_locus related to this paper: human-FAP |
| Title : Molecular imaging of fibroblast activation protein after myocardial infarction using the novel radiotracer [(68)Ga]MHLL1 - Langer_2021_Theranostics_11_7755 |
| Author(s) : Langer LBN , Hess A , Korkmaz Z , Tillmanns J , Reffert LM , Bankstahl JP , Bengel FM , Thackeray JT , Ross TL |
| Ref : Theranostics , 11 :7755 , 2021 |
| Abstract : |
| PubMedSearch : Langer_2021_Theranostics_11_7755 |
| PubMedID: 34335962 |
| Gene_locus related to this paper: human-FAP |
| Title : In Vitro Evaluation of the Squaramide-Conjugated Fibroblast Activation Protein Inhibitor-Based Agents AAZTA(5).SA.FAPi and DOTA.SA.FAPi - Moon_2021_Molecules_26_3482 |
| Author(s) : Moon ES , Van Rymenant Y , Battan S , De Loose J , Bracke A , Van der Veken P , De Meester I , Rosch F |
| Ref : Molecules , 26 :3482 , 2021 |
| Abstract : |
| PubMedSearch : Moon_2021_Molecules_26_3482 |
| PubMedID: 34201111 |
| Gene_locus related to this paper: human-FAP |
| Title : Role of Fibroblast Activation Protein Alpha in Fibroblast-like Synoviocytes of Rheumatoid Arthritis - Mousavi_2021_Iran.J.Allergy.Asthma.Immunol_20_338 |
| Author(s) : Mousavi MJ , Farhadi E , Vodjgani M , Karami J , Tahmasebi MN , Sharafat Vaziri A , Asgari M , Rezaei N , Mostafaei S , Jamshidi A , Mahmoudi M |
| Ref : Iran J Allergy Asthma Immunol , 20 :338 , 2021 |
| Abstract : |
| PubMedSearch : Mousavi_2021_Iran.J.Allergy.Asthma.Immunol_20_338 |
| PubMedID: 34134455 |
| Gene_locus related to this paper: human-FAP |
| Title : Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-?B pathway to promote metastasis - Yuan_2021_Cell.Death.Dis_12_543 |
| Author(s) : Yuan Z , Hu H , Zhu Y , Zhang W , Fang Q , Qiao T , Ma T , Wang M , Huang R , Tang Q , Gao F , Zou C , Gao X , Wang G , Wang X |
| Ref : Cell Death Dis , 12 :543 , 2021 |
| Abstract : |
| PubMedSearch : Yuan_2021_Cell.Death.Dis_12_543 |
| PubMedID: 34035230 |
| Gene_locus related to this paper: human-FAP |
| Title : A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein - Schnapp_2021_ChemMedChem_16_630 |
| Author(s) : Schnapp G , Hoevels Y , Bakker RA , Schreiner P , Klein T , Nar H |
| Ref : ChemMedChem , 16 :630 , 2021 |
| Abstract : |
| PubMedSearch : Schnapp_2021_ChemMedChem_16_630 |
| PubMedID: 33030297 |
| Gene_locus related to this paper: human-FAP |
| Title : Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation - Moreno-Ruiz_2021_Lung.Cancer_155_10 |
| Author(s) : Moreno-Ruiz P , Corvigno S , Te Grootenhuis NC , La Fleur L , Backman M , Strell C , Mezheyeuski A , Hoelzlwimmer G , Klein C , Botling J , Micke P , Ostman A |
| Ref : Lung Cancer , 155 :10 , 2021 |
| Abstract : |
| PubMedSearch : Moreno-Ruiz_2021_Lung.Cancer_155_10 |
| PubMedID: 33706022 |
| Gene_locus related to this paper: human-FAP |
| Title : Targeting FAPalpha-expressing tumor-associated mesenchymal stromal cells inhibits triple-negative breast cancer pulmonary metastasis - Li_2021_Cancer.Lett_503_32 |
| Author(s) : Li X , Chen M , Lu W , Tang J , Deng L , Wen Q , Huang M , Deng R , Ye G , Ye W , Zhang D |
| Ref : Cancer Letters , 503 :32 , 2021 |
| Abstract : |
| PubMedSearch : Li_2021_Cancer.Lett_503_32 |
| PubMedID: 33482262 |
| Gene_locus related to this paper: human-FAP |
| Title : Expression and role of fibroblast activation protein alpha in acute myeloid leukemia - Mei_2021_Oncol.Rep_45_641 |
| Author(s) : Mei S , Zhang Y , Yu L , Chen G , Zi F |
| Ref : Oncol Rep , 45 :641 , 2021 |
| Abstract : |
| PubMedSearch : Mei_2021_Oncol.Rep_45_641 |
| PubMedID: 33416165 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast Activation Protein Inhibitor PET\/CT: A Promising Molecular Imaging Tool - Sharma_2021_Clin.Nucl.Med_48_4396 |
| Author(s) : Sharma P , Singh SS , Gayana S |
| Ref : Clin Nucl Med , 48 :4396 , 2021 |
| Abstract : |
| PubMedSearch : Sharma_2021_Clin.Nucl.Med_48_4396 |
| PubMedID: 33351507 |
| Gene_locus related to this paper: human-FAP |
| Title : Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with alpha-ketoamide warheads - Simkova_2021_Eur.J.Med.Chem_224_113717 |
| Author(s) : Simkova A , Ormsby T , Sidej N , Slavetinska LP , Brynda J , Beranova J , Sacha P , Majer P , Konvalinka J |
| Ref : Eur Journal of Medicinal Chemistry , 224 :113717 , 2021 |
| Abstract : |
| PubMedSearch : Simkova_2021_Eur.J.Med.Chem_224_113717 |
| PubMedID: 34371463 |
| Gene_locus related to this paper: human-FAP |
| Title : FAPI PET\/CT: Will It End the Hegemony of (18)F-FDG in Oncology? - Hicks_2021_J.Nucl.Med_62_296 |
| Author(s) : Hicks RJ , Roselt PJ , Kallur KG , Tothill RW , Mileshkin L |
| Ref : J Nucl Med , 62 :296 , 2021 |
| Abstract : |
| PubMedSearch : Hicks_2021_J.Nucl.Med_62_296 |
| PubMedID: 33277397 |
| Gene_locus related to this paper: human-FAP |
| Title : New Frontiers in Cancer Imaging and Therapy Based on Radiolabeled Fibroblast Activation Protein Inhibitors: A Rational Review and Current Progress - Imlimthan_2021_Pharmaceuticals.(Basel)_14_ |
| Author(s) : Imlimthan S , Moon ES , Rathke H , Afshar-Oromieh A , Rosch F , Rominger A , Gourni E |
| Ref : Pharmaceuticals (Basel) , 14 : , 2021 |
| Abstract : |
| PubMedSearch : Imlimthan_2021_Pharmaceuticals.(Basel)_14_ |
| PubMedID: 34681246 |
| Gene_locus related to this paper: human-FAP |
| Title : A Trifunctional Theranostic Ligand Targeting Fibroblast Activation Protein-alpha (FAPalpha) - Kelly_2021_Mol.Imaging.Biol_23_686 |
| Author(s) : Kelly JM , Jeitner TM , Ponnala S , Williams C, Jr. , Nikolopoulou A , DiMagno SG , Babich JW |
| Ref : Mol Imaging Biol , 23 :686 , 2021 |
| Abstract : |
| PubMedSearch : Kelly_2021_Mol.Imaging.Biol_23_686 |
| PubMedID: 33721173 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast-Activated Protein Inhibitor PET\/CT: Cancer Diagnosis and Management - Kuyumcu_2021_Front.Oncol_11_758958 |
| Author(s) : Kuyumcu S , Sanli Y , Subramaniam RM |
| Ref : Front Oncol , 11 :758958 , 2021 |
| Abstract : |
| PubMedSearch : Kuyumcu_2021_Front.Oncol_11_758958 |
| PubMedID: 34858834 |
| Gene_locus related to this paper: human-FAP |
| Title : Rational Design, Pharmacomodulation, and Synthesis of [(68)Ga]Ga-Alb-FAPtp-01, a Selective Tumor-Associated Fibroblast Activation Protein Tracer for PET Imaging of Glioma - Lin_2021_ACS.Sens_6_3424 |
| Author(s) : Lin JJ , Chuang CP , Lin JY , Huang FT , Huang CW |
| Ref : ACS Sens , 6 :3424 , 2021 |
| Abstract : |
| PubMedSearch : Lin_2021_ACS.Sens_6_3424 |
| PubMedID: 34415143 |
| Gene_locus related to this paper: human-FAP |
| Title : Targeting Fibroblast Activation Protein: Radiosynthesis and Preclinical Evaluation of an (18)F-Labeled FAP Inhibitor - Toms_2020_J.Nucl.Med_61_1806 |
| Author(s) : Toms J , Kogler J , Maschauer S , Daniel C , Schmidkonz C , Kuwert T , Prante O |
| Ref : J Nucl Med , 61 :1806 , 2020 |
| Abstract : |
| PubMedSearch : Toms_2020_J.Nucl.Med_61_1806 |
| PubMedID: 32332144 |
| Gene_locus related to this paper: human-FAP |
| Title : High expression of fibroblast activation protein (FAP) predicts poor outcome in high-grade serous ovarian cancer - Li_2020_BMC.Cancer_20_1032 |
| Author(s) : Li M , Cheng X , Rong R , Gao Y , Tang X , Chen Y |
| Ref : BMC Cancer , 20 :1032 , 2020 |
| Abstract : |
| PubMedSearch : Li_2020_BMC.Cancer_20_1032 |
| PubMedID: 33109151 |
| Gene_locus related to this paper: human-FAP |
| Title : Imaging of Fibroblast Activation Protein Alpha Expression in a Preclinical Mouse Model of Glioma Using Positron Emission Tomography - Pandya_2020_Molecules_25_3672 |
| Author(s) : Pandya DN , Sinha A , Yuan H , Mutkus L , Stumpf K , Marini FC , Wadas TJ |
| Ref : Molecules , 25 :3672 , 2020 |
| Abstract : |
| PubMedSearch : Pandya_2020_Molecules_25_3672 |
| PubMedID: 32806623 |
| Gene_locus related to this paper: human-FAP |
| Title : RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-alpha - Wang_2020_J.Immunol_205_1653 |
| Author(s) : Wang X , Gessier F , Perozzo R , Stojkov D , Hosseini A , Amirshahrokhi K , Kuchen S , Yousefi S , Lotscher P , Simon HU |
| Ref : J Immunol , 205 :1653 , 2020 |
| Abstract : |
| PubMedSearch : Wang_2020_J.Immunol_205_1653 |
| PubMedID: 32796025 |
| Gene_locus related to this paper: human-FAP |
| Title : High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes - Coto-Llerena_2020_Front.Oncol_10_979 |
| Author(s) : Coto-Llerena M , Ercan C , Kancherla V , Taha-Mehlitz S , Eppenberger-Castori S , Soysal SD , Ng CKY , Bolli M , von Flue M , Nicolas GP , Terracciano LM , Fani M , Piscuoglio S |
| Ref : Front Oncol , 10 :979 , 2020 |
| Abstract : |
| PubMedSearch : Coto-Llerena_2020_Front.Oncol_10_979 |
| PubMedID: 32733792 |
| Gene_locus related to this paper: human-FAP |
| Title : Altered expression of fibroblast activation protein-alpha (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases - Solano-Iturri_2020_Aging.(Albany.NY)_12_10337 |
| Author(s) : Solano-Iturri JD , Beitia M , Errarte P , Calvete-Candenas J , Etxezarraga MC , Loizate A , Echevarria E , Badiola I , Larrinaga G |
| Ref : Aging (Albany NY) , 12 :10337 , 2020 |
| Abstract : |
| PubMedSearch : Solano-Iturri_2020_Aging.(Albany.NY)_12_10337 |
| PubMedID: 32428869 |
| Gene_locus related to this paper: human-FAP |
| Title : FAP-specific PET signaling shows a moderately positive correlation with relative CBV and no correlation with ADC in 13 IDH wildtype glioblastomas - Rohrich_2020_Eur.J.Radiol_127_109021 |
| Author(s) : Rohrich M , Floca R , Loi L , Adeberg S , Windisch P , Giesel FL , Kratochwil C , Flechsig P , Rathke H , Lindner T , Loktev A , Schlemmer HP , Haberkorn U , Paech D |
| Ref : Eur J Radiol , 127 :109021 , 2020 |
| Abstract : |
| PubMedSearch : Rohrich_2020_Eur.J.Radiol_127_109021 |
| PubMedID: 32344293 |
| Gene_locus related to this paper: human-FAP |
| Title : MiR-30a suppresses metastasis of gastric adenocarcinoma via targeting FAPalpha - Yu_2020_Cancer.Biomark_27_471 |
| Author(s) : Yu T , Gong L , Li W , Zuo Q , Cai D , Mao H , Wang L , Lin J , Xiao B |
| Ref : Cancer Biomark , 27 :471 , 2020 |
| Abstract : |
| PubMedSearch : Yu_2020_Cancer.Biomark_27_471 |
| PubMedID: 32116236 |
| Gene_locus related to this paper: human-FAP |
| Title : microRNA-30a attenuates TGF-beta1-induced activation of pulmonary fibroblast cell by targeting FAP-alpha - Wu_2020_J.Cell.Mol.Med_24_3745 |
| Author(s) : Wu G , Xie B , Lu C , Chen C , Zhou J , Deng Z |
| Ref : J Cell Mol Med , 24 :3745 , 2020 |
| Abstract : |
| PubMedSearch : Wu_2020_J.Cell.Mol.Med_24_3745 |
| PubMedID: 31991519 |
| Gene_locus related to this paper: human-FAP |
| Title : Expression of fibroblast activation protein and the clinicopathological relevance in distal cholangiocarcinoma - Byrling_2020_Scand.J.Gastroenterol_55_82 |
| Author(s) : Byrling J , Sasor A , Nilsson J , Said Hilmersson K , Andersson R , Andersson B |
| Ref : Scand J Gastroenterol , 55 :82 , 2020 |
| Abstract : |
| PubMedSearch : Byrling_2020_Scand.J.Gastroenterol_55_82 |
| PubMedID: 31917931 |
| Gene_locus related to this paper: human-FAP |
| Title : Molecular recognition of fibroblast activation protein for diagnostic and therapeutic applications - Simkova_2020_Biochim.Biophys.Acta.Proteins.Proteom_1868_140409 |
| Author(s) : Simkova A , Busek P , Sedo A , Konvalinka J |
| Ref : Biochimica & Biophysica Acta Proteins Proteom , 1868 :140409 , 2020 |
| Abstract : |
| PubMedSearch : Simkova_2020_Biochim.Biophys.Acta.Proteins.Proteom_1868_140409 |
| PubMedID: 32171757 |
| Gene_locus related to this paper: human-FAP |
| Title : The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma - Bracke_2019_Clin.Chim.Acta_495_154 |
| Author(s) : Bracke A , Van Elzen R , Van der Veken P , Augustyns K , De Meester I , Lambeir AM |
| Ref : Clinica Chimica Acta , 495 :154 , 2019 |
| Abstract : |
| PubMedSearch : Bracke_2019_Clin.Chim.Acta_495_154 |
| PubMedID: 30981844 |
| Gene_locus related to this paper: human-FAP , human-PREP |
| Title : Inhibitor-conjugated harmonic nanoparticles targeting fibroblast activation protein - De Matos_2019_RSC.Adv_9_31659 |
| Author(s) : De Matos R , Vuilleumier J , Mas C , Constant S , Staedler D , Gerber-Lemaire S |
| Ref : RSC Adv , 9 :31659 , 2019 |
| Abstract : |
| PubMedSearch : De Matos_2019_RSC.Adv_9_31659 |
| PubMedID: 35527932 |
| Gene_locus related to this paper: human-FAP |
| Title : A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts - Loktev_2018_J.Nucl.Med_59_1423 |
| Author(s) : Loktev A , Lindner T , Mier W , Debus J , Altmann A , Jager D , Giesel F , Kratochwil C , Barthe P , Roumestand C , Haberkorn U |
| Ref : J Nucl Med , 59 :1423 , 2018 |
| Abstract : |
| PubMedSearch : Loktev_2018_J.Nucl.Med_59_1423 |
| PubMedID: 29626120 |
| Gene_locus related to this paper: human-FAP |
| Title : Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein - Lindner_2018_J.Nucl.Med_59_1415 |
| Author(s) : Lindner T , Loktev A , Altmann A , Giesel F , Kratochwil C , Debus J , Jager D , Mier W , Haberkorn U |
| Ref : J Nucl Med , 59 :1415 , 2018 |
| Abstract : |
| PubMedSearch : Lindner_2018_J.Nucl.Med_59_1415 |
| PubMedID: 29626119 |
| Gene_locus related to this paper: human-FAP |
| Title : Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP) - Bainbridge_2017_Sci.Rep_7_12524 |
| Author(s) : Bainbridge TW , Dunshee DR , Kljavin NM , Skelton NJ , Sonoda J , Ernst JA |
| Ref : Sci Rep , 7 :12524 , 2017 |
| Abstract : |
| PubMedSearch : Bainbridge_2017_Sci.Rep_7_12524 |
| PubMedID: 28970566 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein-alpha in fibrogenic disorders and cancer: more than a prolyl-specific peptidase? - Juillerat-Jeanneret_2017_Expert.Opin.Ther.Targets_21_977 |
| Author(s) : Juillerat-Jeanneret L , Tafelmeyer P , Golshayan D |
| Ref : Expert Opin Ther Targets , 21 :977 , 2017 |
| Abstract : |
| PubMedSearch : Juillerat-Jeanneret_2017_Expert.Opin.Ther.Targets_21_977 |
| PubMedID: 28829211 |
| Gene_locus related to this paper: human-FAP |
| Title : Circulating FGF21 proteolytic processing mediated by fibroblast activation protein - Zhen_2016_Biochem.J_473_605 |
| Author(s) : Zhen EY , Jin Z , Ackermann BL , Thomas MK , Gutierrez JA |
| Ref : Biochemical Journal , 473 :605 , 2016 |
| Abstract : |
| PubMedSearch : Zhen_2016_Biochem.J_473_605 |
| PubMedID: 26635356 |
| Gene_locus related to this paper: human-FAP |
| Title : A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice - Fang_2016_Int.J.Cancer_138_1013 |
| Author(s) : Fang J , Xiao L , Joo KI , Liu Y , Zhang C , Liu S , Conti PS , Li Z , Wang P |
| Ref : International Journal of Cancer , 138 :1013 , 2016 |
| Abstract : |
| PubMedSearch : Fang_2016_Int.J.Cancer_138_1013 |
| PubMedID: 26334777 |
| Gene_locus related to this paper: human-FAP |
| Title : A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation - Osborne_2014_Biochim.Biophys.Acta_1844_1248 |
| Author(s) : Osborne B , Yao TW , Wang XM , Chen Y , Kotan LD , Nadvi NA , Herdem M , McCaughan GW , Allen JD , Yu DM , Topaloglu AK , Gorrell MD |
| Ref : Biochimica & Biophysica Acta , 1844 :1248 , 2014 |
| Abstract : |
| PubMedSearch : Osborne_2014_Biochim.Biophys.Acta_1844_1248 |
| PubMedID: 24717288 |
| Gene_locus related to this paper: human-FAP |
| Title : Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP) - Jansen_2014_J.Med.Chem_57_3053 |
| Author(s) : Jansen K , Heirbaut L , Verkerk R , Cheng JD , Joossens J , Cos P , Maes L , Lambeir AM , De Meester I , Augustyns K , Van der Veken P |
| Ref : Journal of Medicinal Chemistry , 57 :3053 , 2014 |
| Abstract : |
| PubMedSearch : Jansen_2014_J.Med.Chem_57_3053 |
| PubMedID: 24617858 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation - Chung_2014_PLoS.One_9_e88772 |
| Author(s) : Chung KM , Hsu SC , Chu YR , Lin MY , Jiaang WT , Chen RH , Chen X |
| Ref : PLoS ONE , 9 :e88772 , 2014 |
| Abstract : |
| PubMedSearch : Chung_2014_PLoS.One_9_e88772 |
| PubMedID: 24551161 |
| Gene_locus related to this paper: human-FAP |
| Title : Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs - Keane_2013_FEBS.Open.Bio_4_43 |
| Author(s) : Keane FM , Yao TW , Seelk S , Gall MG , Chowdhury S , Poplawski SE , Lai JH , Li Y , Wu W , Farrell P , Vieira de Ribeiro AJ , Osborne B , Yu DM , Seth D , Rahman K , Haber P , Topaloglu AK , Wang C , Thomson S , Hennessy A , Prins J , Twigg SM , McLennan SV , McCaughan GW , Bachovchin WW , Gorrell MD |
| Ref : FEBS Open Bio , 4 :43 , 2013 |
| Abstract : |
| PubMedSearch : Keane_2013_FEBS.Open.Bio_4_43 |
| PubMedID: 24371721 |
| Gene_locus related to this paper: human-FAP |
| Title : Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold - Jansen_2013_ACS.Med.Chem.Lett_4_491 |
| Author(s) : Jansen K , Heirbaut L , Cheng JD , Joossens J , Ryabtsova O , Cos P , Maes L , Lambeir AM , De Meester I , Augustyns K , Van der Veken P |
| Ref : ACS Med Chem Lett , 4 :491 , 2013 |
| Abstract : |
| PubMedSearch : Jansen_2013_ACS.Med.Chem.Lett_4_491 |
| PubMedID: 24900696 |
| Gene_locus related to this paper: human-FAP |
| Title : Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP\/prolyl oligopeptidase (PREP)-selectivity - Ryabtsova_2012_Bioorg.Med.Chem.Lett_22_3412 |
| Author(s) : Ryabtsova O , Jansen K , Van Goethem S , Joossens J , Cheng JD , Lambeir AM , De Meester I , Augustyns K , Van der Veken P |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :3412 , 2012 |
| Abstract : |
| PubMedSearch : Ryabtsova_2012_Bioorg.Med.Chem.Lett_22_3412 |
| PubMedID: 22525314 |
| Gene_locus related to this paper: human-FAP |
| Title : Expression and role of the cell surface protease seprase\/fibroblast activation protein-alpha (FAP-alpha) in astroglial tumors - Mentlein_2011_Biol.Chem_392_199 |
| Author(s) : Mentlein R , Hattermann K , Hemion C , Jungbluth AA , Held-Feindt J |
| Ref : Biol Chem , 392 :199 , 2011 |
| Abstract : |
| PubMedSearch : Mentlein_2011_Biol.Chem_392_199 |
| PubMedID: 20707604 |
| Gene_locus related to this paper: human-FAP |
| Title : Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha - Keane_2011_Febs.j_278_1316 |
| Author(s) : Keane FM , Nadvi NA , Yao TW , Gorrell MD |
| Ref : Febs J , 278 :1316 , 2011 |
| Abstract : |
| PubMedSearch : Keane_2011_Febs.j_278_1316 |
| PubMedID: 21314817 |
| Gene_locus related to this paper: human-FAP |
| Title : Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate - Huang_2011_J.Biochem_149_685 |
| Author(s) : Huang CH , Suen CS , Lin CT , Chien CH , Lee HY , Chung KM , Tsai TY , Jiaang WT , Hwang MJ , Chen X |
| Ref : J Biochem , 149 :685 , 2011 |
| Abstract : |
| PubMedSearch : Huang_2011_J.Biochem_149_685 |
| PubMedID: 21288888 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites - Aggarwal_2008_Biochemistry_47_1076 |
| Author(s) : Aggarwal S , Brennen WN , Kole TP , Schneider E , Topaloglu O , Yates M , Cotter RJ , Denmeade SR |
| Ref : Biochemistry , 47 :1076 , 2008 |
| Abstract : |
| PubMedSearch : Aggarwal_2008_Biochemistry_47_1076 |
| PubMedID: 18095711 |
| Gene_locus related to this paper: human-FAP |
| Title : Seprase: an overview of an important matrix serine protease - O'Brien_2008_Biochim.Biophys.Acta_1784_1130 |
| Author(s) : O'Brien P , O'Connor BF |
| Ref : Biochimica & Biophysica Acta , 1784 :1130 , 2008 |
| Abstract : |
| PubMedSearch : O'Brien_2008_Biochim.Biophys.Acta_1784_1130 |
| PubMedID: 18262497 |
| Gene_locus related to this paper: human-FAP |
| Title : Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization - Meadows_2007_Biochemistry_46_4598 |
| Author(s) : Meadows SA , Edosada CY , Mayeda M , Tran T , Quan C , Raab H , Wiesmann C , Wolf BB |
| Ref : Biochemistry , 46 :4598 , 2007 |
| Abstract : |
| PubMedSearch : Meadows_2007_Biochemistry_46_4598 |
| PubMedID: 17381073 |
| Gene_locus related to this paper: human-FAP |
| Title : Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity - Edosada_2006_J.Biol.Chem_281_7437 |
| Author(s) : Edosada CY , Quan C , Wiesmann C , Tran T , Sutherlin D , Reynolds M , Elliott JM , Raab H , Fairbrother W , Wolf BB |
| Ref : Journal of Biological Chemistry , 281 :7437 , 2006 |
| Abstract : |
| PubMedSearch : Edosada_2006_J.Biol.Chem_281_7437 |
| PubMedID: 16410248 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes - Bauer_2006_Arthritis.Res.Ther_8_R171 |
| Author(s) : Bauer S , Jendro MC , Wadle A , Kleber S , Stenner F , Dinser R , Reich A , Faccin E , Godde S , Dinges H , Muller-Ladner U , Renner C |
| Ref : Arthritis Res Ther , 8 :R171 , 2006 |
| Abstract : |
| PubMedSearch : Bauer_2006_Arthritis.Res.Ther_8_R171 |
| PubMedID: 17105646 |
| Gene_locus related to this paper: human-FAP |
| Title : The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices - Ghersi_2006_Cancer.Res_66_4652 |
| Author(s) : Ghersi G , Zhao Q , Salamone M , Yeh Y , Zucker S , Chen WT |
| Ref : Cancer Research , 66 :4652 , 2006 |
| Abstract : |
| PubMedSearch : Ghersi_2006_Cancer.Res_66_4652 |
| PubMedID: 16651416 |
| Gene_locus related to this paper: human-FAP |
| Title : Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity - Edosada_2006_FEBS.Lett_580_1581 |
| Author(s) : Edosada CY , Quan C , Tran T , Pham V , Wiesmann C , Fairbrother W , Wolf BB |
| Ref : FEBS Letters , 580 :1581 , 2006 |
| Abstract : |
| PubMedSearch : Edosada_2006_FEBS.Lett_580_1581 |
| PubMedID: 16480718 |
| Gene_locus related to this paper: human-FAP |
| Title : Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein - Lee_2006_Blood_107_1397 |
| Author(s) : Lee KN , Jackson KW , Christiansen VJ , Lee CS , Chun JG , McKee PA |
| Ref : Blood , 107 :1397 , 2006 |
| Abstract : |
| PubMedSearch : Lee_2006_Blood_107_1397 |
| PubMedID: 16223769 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line - Wang_2005_Hepatology_42_935 |
| Author(s) : Wang XM , Yu DM , McCaughan GW , Gorrell MD |
| Ref : Hepatology , 42 :935 , 2005 |
| Abstract : |
| PubMedSearch : Wang_2005_Hepatology_42_935 |
| PubMedID: 16175601 |
| Gene_locus related to this paper: human-FAP |
| Title : Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha - Aertgeerts_2005_J.Biol.Chem_280_19441 |
| Author(s) : Aertgeerts K , Levin I , Shi L , Snell GP , Jennings A , Prasad GS , Zhang Y , Kraus ML , Salakian S , Sridhar V , Wijnands R , Tennant MG |
| Ref : Journal of Biological Chemistry , 280 :19441 , 2005 |
| Abstract : |
| PubMedSearch : Aertgeerts_2005_J.Biol.Chem_280_19441 |
| PubMedID: 15809306 |
| Gene_locus related to this paper: human-FAP |
| Title : Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform - Goldstein_2000_J.Biol.Chem_275_2554 |
| Author(s) : Goldstein LA , Chen WT |
| Ref : Journal of Biological Chemistry , 275 :2554 , 2000 |
| Abstract : |
| PubMedSearch : Goldstein_2000_J.Biol.Chem_275_2554 |
| PubMedID: 10644713 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts - Park_1999_J.Biol.Chem_274_36505 |
| Author(s) : Park JE , Lenter MC , Zimmermann RN , Garin-Chesa P , Old LJ , Rettig WJ |
| Ref : Journal of Biological Chemistry , 274 :36505 , 1999 |
| Abstract : |
| PubMedSearch : Park_1999_J.Biol.Chem_274_36505 |
| PubMedID: 10593948 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis - Levy_1999_Hepatology_29_1768 |
| Author(s) : Levy MT , McCaughan GW , Abbott CA , Park JE , Cunningham AM , Muller E , Rettig WJ , Gorrell MD |
| Ref : Hepatology , 29 :1768 , 1999 |
| Abstract : |
| PubMedSearch : Levy_1999_Hepatology_29_1768 |
| PubMedID: 10347120 |
| Gene_locus related to this paper: human-FAP |
| Title : Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease - Pineiro-Sanchez_1997_J.Biol.Chem_272_7595 |
| Author(s) : Pineiro-Sanchez ML , Goldstein LA , Dodt J , Howard L , Yeh Y , Tran H , Argraves WS , Chen WT |
| Ref : Journal of Biological Chemistry , 272 :7595 , 1997 |
| Abstract : |
| PubMedSearch : Pineiro-Sanchez_1997_J.Biol.Chem_272_7595 |
| PubMedID: 9065413 |
| Gene_locus related to this paper: human-FAP |
| Title : Fibroblast activation protein: purification, epitope mapping and induction by growth factors - Rettig_1994_Int.J.Cancer_58_385 |
| Author(s) : Rettig WJ , Su SL , Fortunato SR , Scanlan MJ , Raj BK , Garin-Chesa P , Healey JH , Old LJ |
| Ref : International Journal of Cancer , 58 :385 , 1994 |
| Abstract : |
| PubMedSearch : Rettig_1994_Int.J.Cancer_58_385 |
| PubMedID: 7519584 |
| Gene_locus related to this paper: human-FAP |
| Title : A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells - Monsky_1994_Cancer.Res_54_5702 |
| Author(s) : Monsky WL , Lin CY , Aoyama A , Kelly T , Akiyama SK , Mueller SC , Chen WT |
| Ref : Cancer Research , 54 :5702 , 1994 |
| Abstract : |
| PubMedSearch : Monsky_1994_Cancer.Res_54_5702 |
| PubMedID: 7923219 |
| Gene_locus related to this paper: human-FAP |
| Title : Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers - Scanlan_1994_Proc.Natl.Acad.Sci.U.S.A_91_5657 |
| Author(s) : Scanlan MJ , Raj BK , Calvo B , Garin-Chesa P , Sanz-Moncasi MP , Healey JH , Old LJ , Rettig WJ |
| Ref : Proc Natl Acad Sci U S A , 91 :5657 , 1994 |
| Abstract : |
| PubMedSearch : Scanlan_1994_Proc.Natl.Acad.Sci.U.S.A_91_5657 |
| PubMedID: 7911242 |
| Gene_locus related to this paper: human-FAP |
| Title : A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells - Aoyama_1990_Proc.Natl.Acad.Sci.U.S.A_87_8296 |
| Author(s) : Aoyama A , Chen WT |
| Ref : Proc Natl Acad Sci U S A , 87 :8296 , 1990 |
| Abstract : |
| PubMedSearch : Aoyama_1990_Proc.Natl.Acad.Sci.U.S.A_87_8296 |
| PubMedID: 2172980 |
| Gene_locus related to this paper: human-FAP |