human-FAP

Homo sapiens (Human) fibroblast activation protein alpha FAPalpha, integral membrane serine protease seprase FAPA, FAP, SEPR

Comment

Fibroblast activation protein (FAP). However, FAP is not expressed in normal fibroblasts, normal or malignant epithelial cells, or the stroma of benign epithelial tumors. FAP is a cell membrane-bound serine peptidase overexpressed on the surface of cancer-associated fibroblasts. Serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala\/Ser-Gly-Pro-Ser\/Asn\/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein. FAP can hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY cleavage product proangiogenic FAP enhances tumor growth progression), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB). Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner

Relationship

Family : DPP4N_Peptidase_S9

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Database

Sequence

Peptide

MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP FQITFNGREN KIFNGIPDWV YEEEMLPTKY ALWWSPNGKF LAYAEFNDKD IPVIAYSYYG DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSRPVFSYD AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD

References (12)

Title : Cell-specific expression of the FAP gene is regulated by enhancer elements - Antonova_2023_Front.Mol.Biosci_10_1111511
Author(s) : Antonova DV , Gnatenko DA , Kotova ES , Pleshkan VV , Kuzmich AI , Didych DA , Sverdlov ED , Alekseenko IV
Ref : Front Mol Biosci , 10 :1111511 , 2023
Abstract :
PubMedSearch : Antonova_2023_Front.Mol.Biosci_10_1111511
PubMedID: 36825204
Gene_locus related to this paper: human-FAP

Title : Fibroblast Activation Protein Inhibitor Theranostics: Preclinical Considerations - Kaneda-Nakashima_2023_PET.Clin_18_397
Author(s) : Kaneda-Nakashima K , Shirakami Y , Kadonaga Y , Watabe T
Ref : PET Clin , 18 :397 , 2023
Abstract :
PubMedSearch : Kaneda-Nakashima_2023_PET.Clin_18_397
PubMedID: 36997365
Gene_locus related to this paper: human-FAP

Title : A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein - Schnapp_2021_ChemMedChem_16_630
Author(s) : Schnapp G , Hoevels Y , Bakker RA , Schreiner P , Klein T , Nar H
Ref : ChemMedChem , 16 :630 , 2021
Abstract :
PubMedSearch : Schnapp_2021_ChemMedChem_16_630
PubMedID: 33030297
Gene_locus related to this paper: human-FAP

Title : The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma - Bracke_2019_Clin.Chim.Acta_495_154
Author(s) : Bracke A , Van Elzen R , Van der Veken P , Augustyns K , De Meester I , Lambeir AM
Ref : Clinica Chimica Acta , 495 :154 , 2019
Abstract :
PubMedSearch : Bracke_2019_Clin.Chim.Acta_495_154
PubMedID: 30981844
Gene_locus related to this paper: human-FAP , human-PREP

Title : A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts - Loktev_2018_J.Nucl.Med_59_1423
Author(s) : Loktev A , Lindner T , Mier W , Debus J , Altmann A , Jager D , Giesel F , Kratochwil C , Barthe P , Roumestand C , Haberkorn U
Ref : J Nucl Med , 59 :1423 , 2018
Abstract :
PubMedSearch : Loktev_2018_J.Nucl.Med_59_1423
PubMedID: 29626120
Gene_locus related to this paper: human-FAP

Title : Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein - Lindner_2018_J.Nucl.Med_59_1415
Author(s) : Lindner T , Loktev A , Altmann A , Giesel F , Kratochwil C , Debus J , Jager D , Mier W , Haberkorn U
Ref : J Nucl Med , 59 :1415 , 2018
Abstract :
PubMedSearch : Lindner_2018_J.Nucl.Med_59_1415
PubMedID: 29626119
Gene_locus related to this paper: human-FAP

Title : Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP) - Bainbridge_2017_Sci.Rep_7_12524
Author(s) : Bainbridge TW , Dunshee DR , Kljavin NM , Skelton NJ , Sonoda J , Ernst JA
Ref : Sci Rep , 7 :12524 , 2017
Abstract :
PubMedSearch : Bainbridge_2017_Sci.Rep_7_12524
PubMedID: 28970566
Gene_locus related to this paper: human-FAP

Title : Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein - Lee_2006_Blood_107_1397
Author(s) : Lee KN , Jackson KW , Christiansen VJ , Lee CS , Chun JG , McKee PA
Ref : Blood , 107 :1397 , 2006
Abstract :
PubMedSearch : Lee_2006_Blood_107_1397
PubMedID: 16223769
Gene_locus related to this paper: human-FAP

Title : Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha - Aertgeerts_2005_J.Biol.Chem_280_19441
Author(s) : Aertgeerts K , Levin I , Shi L , Snell GP , Jennings A , Prasad GS , Zhang Y , Kraus ML , Salakian S , Sridhar V , Wijnands R , Tennant MG
Ref : Journal of Biological Chemistry , 280 :19441 , 2005
Abstract :
PubMedSearch : Aertgeerts_2005_J.Biol.Chem_280_19441
PubMedID: 15809306
Gene_locus related to this paper: human-FAP

Title : Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform - Goldstein_2000_J.Biol.Chem_275_2554
Author(s) : Goldstein LA , Chen WT
Ref : Journal of Biological Chemistry , 275 :2554 , 2000
Abstract :
PubMedSearch : Goldstein_2000_J.Biol.Chem_275_2554
PubMedID: 10644713
Gene_locus related to this paper: human-FAP

Title : Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease - Pineiro-Sanchez_1997_J.Biol.Chem_272_7595
Author(s) : Pineiro-Sanchez ML , Goldstein LA , Dodt J , Howard L , Yeh Y , Tran H , Argraves WS , Chen WT
Ref : Journal of Biological Chemistry , 272 :7595 , 1997
Abstract :
PubMedSearch : Pineiro-Sanchez_1997_J.Biol.Chem_272_7595
PubMedID: 9065413
Gene_locus related to this paper: human-FAP

Title : Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers - Scanlan_1994_Proc.Natl.Acad.Sci.U.S.A_91_5657
Author(s) : Scanlan MJ , Raj BK , Calvo B , Garin-Chesa P , Sanz-Moncasi MP , Healey JH , Old LJ , Rettig WJ
Ref : Proc Natl Acad Sci U S A , 91 :5657 , 1994
Abstract :
PubMedSearch : Scanlan_1994_Proc.Natl.Acad.Sci.U.S.A_91_5657
PubMedID: 7911242
Gene_locus related to this paper: human-FAP