Fluphenazine

antipsychotic agent which is no longer in common use. Fluphenazine can cause mild and transient serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. blocking postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia. This prevents the actions of dopamine, thereby reducing the hallucinations and delusions that are associated with schizophrenia

General

Type : Phenothiazine, Sulfur Compound, Not A\/B H target, Trifluoro

Chemical_Nomenclature : 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol

Canonical SMILES : C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO

InChI : InChI=1S\/C22H26F3N3OS\/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29\/h1-2,4-7,16,29H,3,8-15H2

InChIKey : PLDUPXSUYLZYBN-UHFFFAOYSA-N

Other name(s) : Triflumethazine  ||  Fluorophenazine  ||  Fluorphenazine  ||  CHEBI:5123  ||  ZINC19203912  ||  DB00623  ||  CHEMBL726  ||  SCHEMBL19221


MW : 437.5

Formula : C22H26F3N3OS

CAS_number : 69-23-8

PubChem : 3372

UniChem : PLDUPXSUYLZYBN-UHFFFAOYSA-N

Target

References (8)

Title : Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review - Otreba_2020_Eur.J.Pharmacol_887_173553
Author(s) : Otreba M , Kosmider L , Rzepecka-Stojko A
Ref : European Journal of Pharmacology , 887 :173553 , 2020
Abstract :
PubMedSearch : Otreba_2020_Eur.J.Pharmacol_887_173553
PubMedID: 32949606

Title : Treatment of psychotic symptoms in patients with Parkinson disease - Chen_2017_Ment.Health.Clin_7_262
Author(s) : Chen JJ
Ref : Ment Health Clin , 7 :262 , 2017
Abstract :
PubMedSearch : Chen_2017_Ment.Health.Clin_7_262
PubMedID: 29955532

Title : In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure - Mosnaim_2003_Pharmacology_67_6
Author(s) : Mosnaim AD , Puente J , Saavedra R , Diamond S , Wolf ME
Ref : Pharmacology , 67 :6 , 2003
Abstract :
PubMedSearch : Mosnaim_2003_Pharmacology_67_6
PubMedID: 12444298

Title : A comparative study of the anticholinesterase activity of several antipsychotic agents - Nasello_2003_Pharmacol.Biochem.Behav_75_895
Author(s) : Nasello AG , Gidali D , Felicio LF
Ref : Pharmacol Biochem Behav , 75 :895 , 2003
Abstract :
PubMedSearch : Nasello_2003_Pharmacol.Biochem.Behav_75_895
PubMedID: 12957233

Title : Inhibition of butyrylcholinesterase by phenothiazine derivatives - Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
Author(s) : Debord J , Merle L , Bollinger JC , Dantoine T
Ref : J Enzyme Inhib Med Chem , 17 :197 , 2002
Abstract :
PubMedSearch : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
PubMedID: 12443046

Title : A highly sensitive and specific radioimmunoassay for quantitation of plasma fluphenazine - Lo_1988_J.Pharm.Sci_77_255
Author(s) : Lo ES , Fein M , Hunter C , Suckow RF , Cooper TB
Ref : J Pharm Sci , 77 :255 , 1988
Abstract :
PubMedSearch : Lo_1988_J.Pharm.Sci_77_255
PubMedID: 3373431

Title : Effects of the Combined Treatment of Rats with Fluphenazine and Choline or Lecithin on the Striatal Cholinergic and Dopaminergic System -
Author(s) : Flentge F , Arst D , Westerink BH , Zigmond MJ , Hanin I
Ref : Advances in Behavioral Biology , 30 :859 , 1986
PubMedID:

Title : Fluphenazine-induced decline in striatal acetylcholine content is not abolished by exogenous choline -
Author(s) : Sherman KA , Zigmond MJ , Hanin I
Ref : Neuropharmacology , 20 :921 , 1981
PubMedID: 7301054