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Trifluoro

General

Building block for many synthetic inhibitors of enzymes. The trifluoromethyl group is a functional group that has the formula -CF3. The naming of is group is derived from the methyl group (which has the formula -CH3). The trifluoromethyl group is often used as a bioisostere to create derivatives by replacing a chloride or a methyl group. This can be used to adjust the steric and electronic properties of a lead compound, or to protect a reactive methyl group from metabolic oxidation.
Inhibitor Main targeted enzyme families Type Structure
3-[4-(trifluoromethyl)phenyl]propanoic-acid Trifluoro Propionate
2-Oxoindolin-thiazoline-Cpd3i ACHE BCHE Sulfur Compound Thiazole Trifluoro Multitarget PPARgamma ligand Indole
2-Oxoindolin-thiazoline-Cpd4i ACHE BCHE Thiazolidine Thiazole Sulfur Compound Trifluoro Multitarget PPARgamma ligand Indole Hydrazide
t-TUCB-PROTAC-P3 Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor Triazol Trifluoro Piperidine Indole Isoindole PROTAC
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
ATFMK Monoglyceridelipase_lysophospholip ketone Trifluoro
Amiridine-Aminomethylidene-5b Derivative of Amiridine Trifluoro
PPARd-sEH-Cpd30 Epoxide_hydrolase Multitarget Trifluoro PPARdelta ligand
FP30 Epoxide_hydrolase Imidazole Cyclopropyl Trifluoro Carboxamide
8-mercapto-1,1,1-tri-fluoro-2-octanone Juvenile_hormone_esterase Trifluoro Sulfur Compound Halo ketone
ELF8-8D5 Monoglyceridelipase_lysophospholip Trifluoro Pyrrolidine Oxazole
Methoxyphenylsulfonamide-indol-thiosemicarbazone-bis(trifluoromethyl)-benzene-cpd5l ACHE BCHE Monoamine-oxidase-inhibitor Trifluoro Urea derivative Multitarget Sulfur Compound Sulfonamide Indole
CHEMBL5192349 Epoxide_hydrolase Trifluoro Urea derivative Oxadiazol Carboxamide
HY-148573 Epoxide_hydrolase Trifluoro Urea derivative Benzoxazol
DJ-89 Epoxide_hydrolase Urea derivative Trifluoro Piperidine Dimethoxyphenyl
HSL-IN-1 Hormone-sensitive_lipase_like Boron compound Pyridine Trifluoro
Penfluridol Not AlphaBeta Hydrolase target Trifluoro Piperidine
SP-C01 Epoxide_hydrolase Urea derivative Trifluoro Multitarget PPARgamma ligand
MGL-Inhibitor-candidate1 Monoglyceridelipase_lysophospholip Trifluoro Piperazine
SCHEMBL4415503 ACHE Trifluoro Phthalimido Isoindole Indole
FP9 Epoxide_hydrolase Pyridazine Urea derivative Trifluoro
Oxoimidazolidin-trifluoromethyl-thiazole-5-carboxamide-Cpd50 Epoxide_hydrolase Imidazole Trifluoro Thiazole Carboxamide Sulfur Compound
PROTAC-FL412 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperidine Isoindole Indole
PROTAC-JSF67 Epoxide_hydrolase PROTAC Multitarget Trifluoro Piperidine Indole Isoindole Triazol Sulfur Compound Sulfonamide Carboxamide
PROTAC-JSF234 Epoxide_hydrolase PROTAC Multitarget Sulfur Compound Sulfonamide Trifluoro Indole Carboxamide
JW912 Carbamate BODIPY-derivative Boranuidatricyclo Boron compound Trifluoro Near-Infrared fluorescent Probe Fluorescent Probe
Imidazo-thiadiazole-cpd20aa ACHE Triazol Thiadiazol Sulfur Compound Trifluoro Imidazole
Dichlorophenyl-trifluoroethanol Carb_B_Chordata Trifluoro Organochlorine
Chlorophenyl-trifluoroethanol Carb_B_Chordata Trifluoro
CHEMBL5176915 Monoglyceridelipase_lysophospholip Pyridine Piperidine Trifluoro
MAGL-IN-10-Cpd28 Monoglyceridelipase_lysophospholip Pyridine Piperidine Trifluoro Sulfur Compound
(R)-14i Epoxide_hydrolase Urea derivative Trifluoro
Nonafluoro-[(methylphenyl)hydrazinylidene]-oxoheptanoic-acid Carb_B_Chordata Trifluoro Hydrazinylidene
SCHEMBL22488617 Monoglyceridelipase_lysophospholip Piperidine Trifluoro Oxazine
SCHEMBL22488357 Monoglyceridelipase_lysophospholip Trifluoro Piperidine Oxazine
SCHEMBL22462763 Monoglyceridelipase_lysophospholip Piperidine Trifluoro Oxazine
DJ-53 Epoxide_hydrolase Urea derivative Quinoline Trifluoro Dimethoxyphenyl
Trifluoromethyl-thiophene-boronic-acid 6_AlphaBeta_hydrolase CarbLipBact_1 Trifluoro Boron compound Sulfur Compound Thiophen
TI45b ACHE Trifluoro Triazol Thiazole Sulfur Compound Indazole
MGLL-IN-Cpd118 Monoglyceridelipase_lysophospholip Triazol Azaspiro Trifluoro Pyrazole
Adamantyl-trifluoromethoxy-phenyl-sulfonylurea-4f Epoxide_hydrolase Sulfur Compound Urea derivative Trifluoro Adamantyl
Retagliptin DPP4N_Peptidase_S9 Drug Gliptin Triazol Trifluoro Pro-Drug Imidazole
ABD-1970 Monoglyceridelipase_lysophospholip Carbamate Trifluoro Piperazine Azabicyclo
Cofrogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Pyrazole Sulfonamide Sulfur Compound
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Piperidine Indole Isoindole Multitarget
LE-463 Monoglyceridelipase_lysophospholip Trifluoro Indole Piperazine Triazol Fluorescent Probe
KBR-2822 Sulfur Compound Organophosphate Trifluoro Cyclobutyl Not AlphaBeta Hydrolase target
Compound19n-quinolinol ACHE Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
DCJW Carb_B_Arthropoda Insecticide Carboxamide Trifluoro Not AlphaBeta Hydrolase target
M513 Insecticide Carboxamide Carbamate Trifluoro Not AlphaBeta Hydrolase target
Indoxacarb Carb_B_Arthropoda Insecticide Carboxamide Carbamate Trifluoro Not AlphaBeta Hydrolase target
SCHEMBL19582562 ABHD6-Lip Morpholine Carbamate Trifluoro Azaspiro
SCHEMBL22462761 Monoglyceridelipase_lysophospholip PET probe Trifluoro Urea derivative Azetidin Oxazine
ARUK3004876 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006560 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006561 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006562 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3000438 Pectinacetylesterase-Notum Fragment inhibitor of Notum Triazol Trifluoro
FEPAD Monoglyceridelipase_lysophospholip Piperazine Azetidin Trifluoro Thiazolidine Sulfur Compound PET probe Biphenyl
CHEMBL3793506 PAF-Acetylhydrolase Trifluoro Cyanide Pyrimidine Morpholine
6M08-BWL PAF-Acetylhydrolase Trifluoro Pyrrolidine
6M07-BWO PAF-Acetylhydrolase Trifluoro Pyrrolidine
Prusogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Cyanide Pyrrolidine
ARUK3001043 Pectinacetylesterase-Notum Fragment inhibitor of Notum Triazol Trifluoro
TPPU-6-Chlorotacrine-12c Epoxide_hydrolase ACHE Multitarget Derivative of Tacrine Acridine Trifluoro Piperidine Urea derivative Alkyl linked bis-ligand
ARUK3000223 Pectinacetylesterase-Notum Fragment inhibitor of Notum Trifluoro Triazol
Riluzole Pectinacetylesterase-Notum Drug Benzothiazol Trifluoro Sulfur Compound Not AlphaBeta Hydrolase target Fragment inhibitor of Notum Thiazole
PTUPB Epoxide_hydrolase Cyclooxygenase-2 Inhibitor Multitarget Trifluoro Urea derivative Sulfur Compound Sulfonamide Pyrazole
ARUK3003909 Pectinacetylesterase-Notum Fragment inhibitor of Notum Triazol Trifluoro Pyridazine Sulfur Compound
CHEMBL2313198 Epoxide_hydrolase Piperidine Sulfur Compound Sulfonamide Carboxamide Trifluoro
CHEMBL442384-S0E-3WK8 Epoxide_hydrolase Benzothiazol Not AlphaBeta Hydrolase target Trifluoro Sulfur Compound Thiazole
CHEMBL45663-49N-4Y2Q Epoxide_hydrolase Piperazine Pyridine Trifluoro
CHEMBL3402236-49P-4Y2S Epoxide_hydrolase Trifluoro Pyrazole
CHEMBL4649188 Epoxide_hydrolase LTA4-hydrolase-inhibitor Multitarget Trifluoro Oxazole
TK90 Epoxide_hydrolase Butyrate Carboxamide Trifluoro Multitarget PPARgamma ligand
HT-01 Lipase_3 ABHD6-Lip Fluorescent Probe BODIPY-derivative Boranuidatricyclo Carboxamide Triazol Trifluoro Boron compound
ZINC11996936 ACHE Trifluoro Derivative of Donepezil
ZINC11709541 ACHE Trifluoro Derivative of Donepezil
ABD957 ABHD17-depalmitoylase Trifluoro Sulfur Compound Sulfonamide Piperazine Pyrazole Azabicyclo
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
OWW-6YL4 Epoxide_hydrolase Trifluoro Multitarget 5-Lipoxygenase inhibitor Alkyne
SCHEMBL21776992 Pectinacetylesterase-Notum Trifluoro Oxadiazolone Oxadiazol
Pyrrole-5-6YUY Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Trifluoro
Pyrrole-26-6YSK Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Trifluoro
62-mEH Epoxide_hydrolase Sulfur Compound Trifluoro
SR-3420 CGI-58_ABHD5_ABHD4 Urea derivative Sulfur Compound Benzothiazepine Azepane Trifluoro
CHEMBL4076292 PAF-Acetylhydrolase Sulfur Compound Cyanide Trifluoro
XEN445 Lipoprotein_Lipase Pyridine Trifluoro
Soporidine RsbQ-like Alkyne Piperidine Trifluoro Strigolactone receptors ligand
TUPS Epoxide_hydrolase Piperidine Urea derivative Trifluoro Sulfur Compound Sulfonamide
Regorafenib Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Trifluoro Carboxamide multi-kinase inhibitor
Sorafenib Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Trifluoro Carboxamide multi-kinase inhibitor
sEH-inhibitor-19 Epoxide_hydrolase Natural Alkaloid Isoquinoline Trifluoro Urea derivative Derivative of berberine
HL2 DPP4N_Peptidase_S9 Cyanide Trifluoro
SCHEMBL21862936 DPP4N_Peptidase_S9 Gliptin Trifluoro Azabicyclo Oxadiazol
Neogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Cyanide Azabicyclo
DA-12166 DPP4N_Peptidase_S9 Gliptin Trifluoro
DA-12228 DPP4N_Peptidase_S9 Gliptin Trifluoro Piperazine
6N3Z-4 Epoxide_hydrolase Urea derivative Trifluoro
KK073 RsbQ-like Urea derivative Trifluoro Triazol
LK864 Epoxide_hydrolase Azaspiro Sulfur Compound Sulfonyl Urea derivative Trifluoro
ML348 LYsophospholipase_carboxylesterase Trifluoro Piperazine
5LP1-71H PAF-Acetylhydrolase Trifluoro Pyrimidine Sulfur Compound
Cpd227 Epoxide_hydrolase Urea derivative Trifluoro
D3C DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Carboxamide
CHEMBL3087815 ACHE Trifluoro Sulfur Compound Sulfonamide Benzenesulfonamide
Carboxamide-triflurophenyl-D5C DPP4N_Peptidase_S9 Trifluoro Carboxamide Biphenyl
Sulfonamide-D1C DPP4N_Peptidase_S9 Sulfur Compound Sulfonamide Trifluoro Benzenesulfonamide
Triazol-triflurophenyl-DC3 DPP4N_Peptidase_S9 Triazol Trifluoro
CHEMBL2147710 DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Thiazolidine Sulfur Compound Pyrazole
CHEMBL2058971 DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Quinoline Thiazolidine Sulfur Compound
SCHEMBL19305555 DPP4N_Peptidase_S9 Trifluoro Chromen
beta-aminoacyl-thiazolidine-2da DPP4N_Peptidase_S9 Trifluoro Sulfur Compound Thiazolidine
PF-06795071 Monoglyceridelipase_lysophospholip Trifluoro Carbamate PET probe Pyrazole Azabicyclo
TPPU-methyl Epoxide_hydrolase Trifluoro Piperidine Urea derivative
SCHEMBL15272467 Epoxide_hydrolase Trifluoro Piperidine Urea derivative
TPAU Trifluoro Piperidine Urea derivative
TPPU Epoxide_hydrolase Trifluoro Piperidine Urea derivative
Fulvestrant Epoxide_hydrolase Trifluoro Sulfur Compound Drug Not AlphaBeta Hydrolase target Phenanthrene
CHEMBL2392714 Epoxide_hydrolase Trifluoro Piperidine Carboxamide Triazine
Piperidine-fused-benzimidazole-25 DPP4N_Peptidase_S9 Trifluoro Piperidine Sulfur Compound Imidazole Benzimidazole Sulfonyl
Piperidine-fused-benzimidazole-34 DPP4N_Peptidase_S9 Trifluoro Piperidine Benzimidazole
Gemigliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin Trifluoro Delta-lactam
CHEMBL233360 DPP4N_Peptidase_S9 Trifluoro Triazol
Diazepan-AJH DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
PETFP Cutinase Trifluoro Sulfur Compound
5ALR-8TM Epoxide_hydrolase Sulfur Compound Trifluoro Quinazoline
CHEMBL4451596 Epoxide_hydrolase Sulfonamide Pyridine Trifluoro Sulfur Compound
Nitrophenyl-trifluoroethyl-arsenocholine ACHE Trifluoro 2-nitrophenyl
Triazolopiperazine-based-beta-amino-acid DPP4N_Peptidase_S9 Piperidine Trifluoro Triazol
3-amino-4-phenyl-pyrrolidine-15B DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Pyridine Pyrimidine
Piperidinone-constrained-phenethylamine-31 DPP4N_Peptidase_S9 Benzodioxo Trifluoro Piperidine Delta-lactam
Piperidine-constrained-phenethylamine-42 DPP4N_Peptidase_S9 Trifluoro Sulfur Compound Pyrimidine Piperidine
Cyclic-Hydrazine-Derivative DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
DLI DPP4N_Peptidase_S9 Trifluoro Sulfur Compound Pyrrolidine Pyrimidine
Diazepanone-Analog-18 DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
Diazepanone-Analog-1 DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
ABT-341 DPP4N_Peptidase_S9 Trifluoro Triazol
Benzyl-2-triazole-linked-tryptamine-paeonol-Cpd896 BCHE Triazol Trifluoro Derivative of Tryptamine Indole Monoamine-oxidase-inhibitor
6AX1-cp3 Monoglyceridelipase_lysophospholip Halo ketone Trifluoro Carbamate Azetidin Oxadiazol
Hexafluoracetone Hydroxynitrile_lyase Trifluoro Halo ketone
Tr-EH-urea-13 Epoxide_hydrolase Urea derivative Trifluoro
OTFP Juvenile_hormone_esterase Cutinase Trifluoro Halo ketone Sulfur Compound
DETFP Juvenile_hormone_esterase Carb_B_Chordata Carboxylesterase Trifluoro Sulfur Compound Halo ketone
OTFPdOHSO2 Juvenile_hormone_esterase Trifluoro Sulfur Compound Sulfonyl Halo ketone
ARUK3001185 Pectinacetylesterase-Notum Trifluoro Triazol Organochlorine
SCHEMBL19358888 Epoxide_hydrolase Urea derivative Trifluoro Benzoate FAAH inhibitor Multitarget
EC5026 Epoxide_hydrolase Urea derivative Trifluoro Piperidine Drug
Darapladib PAF-Acetylhydrolase Trifluoro Pyrimidine Sulfur Compound
CHEMBL3792924 PAF-Acetylhydrolase Trifluoro Sulfur Compound Thiomorpholine
GTPL9797 PAF-Acetylhydrolase Trifluoro Piperidine Sulfur Compound Sulfonamide Benzenesulfonamide Cyanide
Rilapladib PAF-Acetylhydrolase Trifluoro Piperidine Sulfur Compound
Evogliptin DPP4N_Peptidase_S9 Drug Gliptin Trifluoro
Sitagliptin DPP4N_Peptidase_S9 Drug Piperidine Gliptin Triazol Trifluoro
ZINC02141756 Carb_B_Chordata Trifluoro Sulfur Compound Thiophen Hydrazinylidene
SZC Epoxide_hydrolase Sulfur Compound Sulfonamide Trifluoro Imidazole Benzimidazole
CHEMBL238787 Hormone-sensitive_lipase_like Carb_B_Chordata ABHD6-Lip Trifluoro Carbamate Piperidine
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro Organochlorine
DO34 Lipase_3 Trifluoro Piperazine Carbamate tert-Butyloxycarbonyl tert-Butyl
QST-0837 Monoglyceridelipase_lysophospholip PET probe Carbamate Trifluoro Azetidin Pyrazole
ABX-1431 Monoglyceridelipase_lysophospholip Piperazine Carbamate Pyrrolidine Trifluoro
KML29 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Halo ketone Piperidine Benzodioxo Carbamate Trifluoro
CHEMBL3087809 ACHE Sulfonamide Sulfur Compound Trifluoro
Zifrosilone ACHE Halo ketone Transition state analogue Trifluoro
FBQ ACHE Trifluoro Transition state analogue Quinoline Derivative of Tacrine Sulfur Compound
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate BCHE Trifluoro Organophosphate Halo ketone Coumarin Chromen
Bisuracil-pentylammonium-2h ACHE Trifluoro Ammonium Uracil derivative
CHEMBL4793341 ACHE BCHE Trifluoro Pyrrolidine Multitarget BACE1-inhibitor
Fluphenazine Phenothiazine Sulfur Compound Not AlphaBeta Hydrolase target Trifluoro
Trifluoperazine Phenothiazine Sulfur Compound Trifluoro Not AlphaBeta Hydrolase target
Triflupromazine Phenothiazine Sulfur Compound Trifluoro Not AlphaBeta Hydrolase target
TBTFA ACHE BCHE Halo ketone Transition state analogue Trifluoro tert-Butyl
NAF ACHE Trifluoro Quaternary compound Trimethylammonium Ammonium Transition state analogue
MBTFP Cutinase Juvenile_hormone_esterase Trifluoro Transition state analogue Halo ketone Sulfur Compound
TMTFA ACHE Trifluoro Trimethylammonium Ammonium Quaternary compound Transition state analogue Halo ketone
Trifluoro-6-dimethyl-2-heptanone BCHE ACHE Trifluoro Halo ketone
A1480LS Lipase_3 Trifluoro Piperazine Indazole Urea derivative
SCHEMBL31549744 Monoglyceridelipase_lysophospholip Trifluoro Azaspiro Urea derivative Sulfur compound
3-[4-(trifluoromethyl)phenyl]propanoic-acid Trifluoro Propionate
2-Oxoindolin-thiazoline-Cpd3i ACHE BCHE Sulfur compound Thiazole Trifluoro Multitarget PPARgamma ligand Indole
2-Oxoindolin-thiazoline-Cpd4i ACHE BCHE Thiazolidine Thiazole Sulfur compound Trifluoro Multitarget PPARgamma ligand Indole Hydrazide
t-TUCB-PROTAC-P3 Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor Triazol Trifluoro Piperidine Indole Isoindole PROTAC
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
ATFMK Monoglyceridelipase_lysophospholip ketone Trifluoro
Amiridine-Aminomethylidene-5b Derivative of Amiridine Trifluoro
PPARd-sEH-Cpd30 Epoxide_hydrolase Multitarget Trifluoro PPARdelta ligand
FP30 Epoxide_hydrolase Imidazole Cyclopropyl Trifluoro Carboxamide
8-mercapto-1,1,1-tri-fluoro-2-octanone Juvenile_hormone_esterase Trifluoro Sulfur compound Halo ketone
ELF8-8D5 Monoglyceridelipase_lysophospholip Trifluoro Pyrrolidine Oxazole
Methoxyphenylsulfonamide-indol-thiosemicarbazone-bis(trifluoromethyl)-benzene-cpd5l ACHE BCHE Monoamine-oxidase-inhibitor Trifluoro Urea derivative Multitarget Sulfur compound Sulfonamide Indole
CHEMBL5192349 Epoxide_hydrolase Trifluoro Urea derivative Oxadiazol Carboxamide
HY-148573 Epoxide_hydrolase Trifluoro Urea derivative Benzoxazol
DJ-89 Epoxide_hydrolase Urea derivative Trifluoro Piperidine Dimethoxyphenyl
HSL-IN-1 Hormone-sensitive_lipase_like Boron compound Pyridine Trifluoro
Penfluridol Not AlphaBeta Hydrolase target Trifluoro Piperidine
SP-C01 Epoxide_hydrolase Urea derivative Trifluoro Multitarget PPARgamma ligand
MGL-Inhibitor-candidate1 Monoglyceridelipase_lysophospholip Trifluoro Piperazine
SCHEMBL4415503 ACHE Trifluoro Phthalimido Isoindole Indole
FP9 Epoxide_hydrolase Pyridazine Urea derivative Trifluoro
Oxoimidazolidin-trifluoromethyl-thiazole-5-carboxamide-Cpd50 Epoxide_hydrolase Imidazole Trifluoro Thiazole Carboxamide Sulfur compound
PROTAC-FL412 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperidine Isoindole Indole
PROTAC-JSF67 Epoxide_hydrolase PROTAC Multitarget Trifluoro Piperidine Indole Isoindole Triazol Sulfur compound Sulfonamide Carboxamide
PROTAC-JSF234 Epoxide_hydrolase PROTAC Multitarget Sulfur compound Sulfonamide Trifluoro Indole Carboxamide
JW912 Carbamate BODIPY-derivative Boranuidatricyclo Boron compound Trifluoro Near-Infrared fluorescent Probe Fluorescent Probe
Imidazo-thiadiazole-cpd20aa ACHE Triazol Thiadiazol Sulfur compound Trifluoro Imidazole
Dichlorophenyl-trifluoroethanol Carb_B_Chordata Trifluoro Organochlorine
Chlorophenyl-trifluoroethanol Carb_B_Chordata Trifluoro
CHEMBL5176915 Monoglyceridelipase_lysophospholip Pyridine Piperidine Trifluoro
MAGL-IN-10-Cpd28 Monoglyceridelipase_lysophospholip Pyridine Piperidine Trifluoro Sulfur compound
(R)-14i Epoxide_hydrolase Urea derivative Trifluoro
Nonafluoro-[(methylphenyl)hydrazinylidene]-oxoheptanoic-acid Carb_B_Chordata Trifluoro Hydrazinylidene
SCHEMBL22488617 Monoglyceridelipase_lysophospholip Piperidine Trifluoro Oxazine
SCHEMBL22488357 Monoglyceridelipase_lysophospholip Trifluoro Piperidine Oxazine
SCHEMBL22462763 Monoglyceridelipase_lysophospholip Piperidine Trifluoro Oxazine
DJ-53 Epoxide_hydrolase Urea derivative Quinoline Trifluoro Dimethoxyphenyl
Trifluoromethyl-thiophene-boronic-acid 6_AlphaBeta_hydrolase CarbLipBact_1 Trifluoro Boron compound Sulfur compound Thiophen
TI45b ACHE Trifluoro Triazol Thiazole Sulfur compound Indazole
MGLL-IN-Cpd118 Monoglyceridelipase_lysophospholip Triazol Azaspiro Trifluoro Pyrazole
Adamantyl-trifluoromethoxy-phenyl-sulfonylurea-4f Epoxide_hydrolase Sulfur compound Urea derivative Trifluoro Adamantyl
Retagliptin DPP4N_Peptidase_S9 Drug Gliptin Triazol Trifluoro Pro-Drug Imidazole
ABD-1970 Monoglyceridelipase_lysophospholip Carbamate Trifluoro Piperazine Azabicyclo
Cofrogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Pyrazole Sulfonamide Sulfur compound
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Piperidine Indole Isoindole Multitarget
LEI-463 Monoglyceridelipase_lysophospholip Trifluoro Indole Piperazine Triazol Fluorescent Probe
KBR-2822 Sulfur compound Organophosphate Trifluoro Cyclobutyl Not AlphaBeta Hydrolase target
Compound19n-quinolinol ACHE Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
DCJW Carb_B_Arthropoda Insecticide Carboxamide Trifluoro Not AlphaBeta Hydrolase target
M513 Insecticide Carboxamide Carbamate Trifluoro Not AlphaBeta Hydrolase target
Indoxacarb Carb_B_Arthropoda Insecticide Carboxamide Carbamate Trifluoro Not AlphaBeta Hydrolase target
SCHEMBL19582562 ABHD6-Lip Morpholine Carbamate Trifluoro Azaspiro
SCHEMBL22462761 Monoglyceridelipase_lysophospholip PET probe Trifluoro Urea derivative Azetidin Oxazine
ARUK3004876 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006560 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006561 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006562 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3000438 Pectinacetylesterase-Notum Fragment inhibitor of Notum Triazol Trifluoro
FEPAD Monoglyceridelipase_lysophospholip Piperazine Azetidin Trifluoro Thiazolidine Sulfur compound PET probe Biphenyl
CHEMBL3793506 PAF-Acetylhydrolase Trifluoro Cyanide Pyrimidine Morpholine
6M08-BWL PAF-Acetylhydrolase Trifluoro Pyrrolidine
6M07-BWO PAF-Acetylhydrolase Trifluoro Pyrrolidine
Prusogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Cyanide Pyrrolidine
ARUK3001043 Pectinacetylesterase-Notum Fragment inhibitor of Notum Triazol Trifluoro
TPPU-6-Chlorotacrine-12c Epoxide_hydrolase ACHE Multitarget Derivative of Tacrine Acridine Trifluoro Piperidine Urea derivative Alkyl linked bis-ligand
ARUK3000223 Pectinacetylesterase-Notum Fragment inhibitor of Notum Trifluoro Triazol
Riluzole Pectinacetylesterase-Notum Drug Benzothiazol Trifluoro Sulfur compound Not AlphaBeta Hydrolase target Fragment inhibitor of Notum Thiazole
PTUPB Epoxide_hydrolase Cyclooxygenase-2 Inhibitor Multitarget Trifluoro Urea derivative Sulfur compound Sulfonamide Pyrazole
ARUK3003909 Pectinacetylesterase-Notum Fragment inhibitor of Notum Triazol Trifluoro Pyridazine Sulfur compound
CHEMBL2313198 Epoxide_hydrolase Piperidine Sulfur compound Sulfonamide Carboxamide Trifluoro
CHEMBL442384-S0E-3WK8 Epoxide_hydrolase Benzothiazol Not AlphaBeta Hydrolase target Trifluoro Sulfur compound Thiazole
CHEMBL45663-49N-4Y2Q Epoxide_hydrolase Piperazine Pyridine Trifluoro
CHEMBL3402236-49P-4Y2S Epoxide_hydrolase Trifluoro Pyrazole
CHEMBL4649188 Epoxide_hydrolase LTA4-hydrolase-inhibitor Multitarget Trifluoro Oxazole
TK90 Epoxide_hydrolase Butyrate Carboxamide Trifluoro Multitarget PPARgamma ligand
HT-01 Lipase_3 ABHD6-Lip Fluorescent Probe BODIPY-derivative Boranuidatricyclo Carboxamide Triazol Trifluoro Boron compound
ZINC11996936 ACHE Trifluoro Derivative of Donepezil
ZINC11709541 ACHE Trifluoro Derivative of Donepezil
ABD957 ABHD17-depalmitoylase Trifluoro Sulfur compound Sulfonamide Piperazine Pyrazole Azabicyclo
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
OWW-6YL4 Epoxide_hydrolase Trifluoro Multitarget 5-Lipoxygenase inhibitor Alkyne
SCHEMBL21776992 Pectinacetylesterase-Notum Trifluoro Oxadiazolone Oxadiazol
Pyrrole-5-6YUY Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Trifluoro
Pyrrole-26-6YSK Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Trifluoro
62-mEH Epoxide_hydrolase Sulfur compound Trifluoro
SR-3420 CGI-58_ABHD5_ABHD4 Urea derivative Sulfur compound Benzothiazepine Azepane Trifluoro
CHEMBL4076292 PAF-Acetylhydrolase Sulfur compound Cyanide Trifluoro
XEN445 Lipoprotein_Lipase Pyridine Trifluoro
Soporidine RsbQ-like Alkyne Piperidine Trifluoro Strigolactone receptors ligand
TUPS Epoxide_hydrolase Piperidine Urea derivative Trifluoro Sulfur compound Sulfonamide
Regorafenib Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Trifluoro Carboxamide multi-kinase inhibitor
Sorafenib Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Trifluoro Carboxamide multi-kinase inhibitor
sEH-inhibitor-19 Epoxide_hydrolase Natural Alkaloid Isoquinoline Trifluoro Urea derivative Derivative of berberine
HL2 DPP4N_Peptidase_S9 Cyanide Trifluoro
SCHEMBL21862936 DPP4N_Peptidase_S9 Gliptin Trifluoro Azabicyclo Oxadiazol
Neogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Cyanide Azabicyclo
DA-12166 DPP4N_Peptidase_S9 Gliptin Trifluoro
DA-12228 DPP4N_Peptidase_S9 Gliptin Trifluoro Piperazine
6N3Z-4 Epoxide_hydrolase Urea derivative Trifluoro
KK073 RsbQ-like Urea derivative Trifluoro Triazol
LK864 Epoxide_hydrolase Azaspiro Sulfur compound Sulfonyl Urea derivative Trifluoro
ML348 LYsophospholipase_carboxylesterase Trifluoro Piperazine
5LP1-71H PAF-Acetylhydrolase Trifluoro Pyrimidine Sulfur compound
Cpd227 Epoxide_hydrolase Urea derivative Trifluoro
D3C DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Carboxamide
CHEMBL3087815 ACHE Trifluoro Sulfur compound Sulfonamide Benzenesulfonamide
Carboxamide-triflurophenyl-D5C DPP4N_Peptidase_S9 Trifluoro Carboxamide Biphenyl
Sulfonamide-D1C DPP4N_Peptidase_S9 Sulfur compound Sulfonamide Trifluoro Benzenesulfonamide
Triazol-triflurophenyl-DC3 DPP4N_Peptidase_S9 Triazol Trifluoro
CHEMBL2147710 DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Thiazolidine Sulfur compound Pyrazole
CHEMBL2058971 DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Quinoline Thiazolidine Sulfur compound
SCHEMBL19305555 DPP4N_Peptidase_S9 Trifluoro Chromen
beta-aminoacyl-thiazolidine-2da DPP4N_Peptidase_S9 Trifluoro Sulfur compound Thiazolidine
PF-06795071 Monoglyceridelipase_lysophospholip Trifluoro Carbamate PET probe Pyrazole Azabicyclo
TPPU-methyl Epoxide_hydrolase Trifluoro Piperidine Urea derivative
SCHEMBL15272467 Epoxide_hydrolase Trifluoro Piperidine Urea derivative
TPAU Trifluoro Piperidine Urea derivative
TPPU Epoxide_hydrolase Trifluoro Piperidine Urea derivative
Fulvestrant Epoxide_hydrolase Trifluoro Sulfur compound Drug Not AlphaBeta Hydrolase target Phenanthrene
CHEMBL2392714 Epoxide_hydrolase Trifluoro Piperidine Carboxamide Triazine
Piperidine-fused-benzimidazole-25 DPP4N_Peptidase_S9 Trifluoro Piperidine Sulfur compound Imidazole Benzimidazole Sulfonyl
Piperidine-fused-benzimidazole-34 DPP4N_Peptidase_S9 Trifluoro Piperidine Benzimidazole
Gemigliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin Trifluoro Delta-lactam
CHEMBL233360 DPP4N_Peptidase_S9 Trifluoro Triazol
Diazepan-AJH DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
PETFP Cutinase Trifluoro Sulfur compound
5ALR-8TM Epoxide_hydrolase Sulfur compound Trifluoro Quinazoline
CHEMBL4451596 Epoxide_hydrolase Sulfonamide Pyridine Trifluoro Sulfur compound
Nitrophenyl-trifluoroethyl-arsenocholine ACHE Trifluoro 2-nitrophenyl
Triazolopiperazine-based-beta-amino-acid DPP4N_Peptidase_S9 Piperidine Trifluoro Triazol
3-amino-4-phenyl-pyrrolidine-15B DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Pyridine Pyrimidine
Piperidinone-constrained-phenethylamine-31 DPP4N_Peptidase_S9 Benzodioxo Trifluoro Piperidine Delta-lactam
Piperidine-constrained-phenethylamine-42 DPP4N_Peptidase_S9 Trifluoro Sulfur compound Pyrimidine Piperidine
Cyclic-Hydrazine-Derivative DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
DLI DPP4N_Peptidase_S9 Trifluoro Sulfur compound Pyrrolidine Pyrimidine
Diazepanone-Analog-18 DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
Diazepanone-Analog-1 DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
ABT-341 DPP4N_Peptidase_S9 Trifluoro Triazol
Benzyl-2-triazole-linked-tryptamine-paeonol-Cpd896 BCHE Triazol Trifluoro Derivative of Tryptamine Indole Monoamine-oxidase-inhibitor
6AX1-cp3 Monoglyceridelipase_lysophospholip Halo ketone Trifluoro Carbamate Azetidin Oxadiazol
Hexafluoracetone Hydroxynitrile_lyase Trifluoro Halo ketone
Tr-EH-urea-13 Epoxide_hydrolase Urea derivative Trifluoro
OTFP Juvenile_hormone_esterase Cutinase Trifluoro Halo ketone Sulfur compound
DETFP Juvenile_hormone_esterase Carb_B_Chordata Carboxylesterase Trifluoro Sulfur compound Halo ketone
OTFPdOHSO2 Juvenile_hormone_esterase Trifluoro Sulfur compound Sulfonyl Halo ketone
ARUK3001185 Pectinacetylesterase-Notum Trifluoro Triazol Organochlorine
SCHEMBL19358888 Epoxide_hydrolase Urea derivative Trifluoro Benzoate FAAH inhibitor Multitarget
EC5026 Epoxide_hydrolase Urea derivative Trifluoro Piperidine Drug
Darapladib PAF-Acetylhydrolase Trifluoro Pyrimidine Sulfur compound
CHEMBL3792924 PAF-Acetylhydrolase Trifluoro Sulfur compound Thiomorpholine
GTPL9797 PAF-Acetylhydrolase Trifluoro Piperidine Sulfur compound Sulfonamide Benzenesulfonamide Cyanide
Rilapladib PAF-Acetylhydrolase Trifluoro Piperidine Sulfur compound
Evogliptin DPP4N_Peptidase_S9 Drug Gliptin Trifluoro
Sitagliptin DPP4N_Peptidase_S9 Drug Piperidine Gliptin Triazol Trifluoro
ZINC02141756 Carb_B_Chordata Trifluoro Sulfur compound Thiophen Hydrazinylidene
SZC Epoxide_hydrolase Sulfur compound Sulfonamide Trifluoro Imidazole Benzimidazole
CHEMBL238787 Hormone-sensitive_lipase_like Carb_B_Chordata ABHD6-Lip Trifluoro Carbamate Piperidine
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro Organochlorine
DO34 Lipase_3 Trifluoro Piperazine Carbamate tert-Butyloxycarbonyl tert-Butyl
QST-0837 Monoglyceridelipase_lysophospholip PET probe Carbamate Trifluoro Azetidin Pyrazole
ABX-1431 Monoglyceridelipase_lysophospholip Piperazine Carbamate Pyrrolidine Trifluoro
KML29 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Halo ketone Piperidine Benzodioxo Carbamate Trifluoro
CHEMBL3087809 ACHE Sulfonamide Sulfur compound Trifluoro
Zifrosilone ACHE Halo ketone Transition state analogue Trifluoro
FBQ ACHE Trifluoro Transition state analogue Quinoline Derivative of Tacrine Sulfur compound
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate BCHE Trifluoro Organophosphate Halo ketone Coumarin Chromen
Bisuracil-pentylammonium-2h ACHE Trifluoro Ammonium Uracil derivative
CHEMBL4793341 ACHE BCHE Trifluoro Pyrrolidine Multitarget BACE1-inhibitor
Fluphenazine Phenothiazine Sulfur compound Not AlphaBeta Hydrolase target Trifluoro
Trifluoperazine Phenothiazine Sulfur compound Trifluoro Not AlphaBeta Hydrolase target
Triflupromazine Phenothiazine Sulfur compound Trifluoro Not AlphaBeta Hydrolase target
TBTFA ACHE BCHE Halo ketone Transition state analogue Trifluoro tert-Butyl
NAF ACHE Trifluoro Quaternary compound Trimethylammonium Ammonium Transition state analogue
MBTFP Cutinase Juvenile_hormone_esterase Trifluoro Transition state analogue Halo ketone Sulfur compound
TMTFA ACHE Trifluoro Trimethylammonium Ammonium Quaternary compound Transition state analogue Halo ketone
Trifluoro-6-dimethyl-2-heptanone BCHE ACHE Trifluoro Halo ketone
A1480LS Lipase_3 Trifluoro Piperazine Indazole Urea derivative
SCHEMBL31549744 Monoglyceridelipase_lysophospholip Trifluoro Azaspiro Urea derivative Sulfur compound
3-[4-(trifluoromethyl)phenyl]propanoic-acid Trifluoro Propionate
2-Oxoindolin-thiazoline-Cpd3i ACHE BCHE Sulfur compound Thiazole Trifluoro Multitarget PPARgamma ligand Indole
2-Oxoindolin-thiazoline-Cpd4i ACHE BCHE Thiazolidine Thiazole Sulfur compound Trifluoro Multitarget PPARgamma ligand Indole Hydrazide
t-TUCB-PROTAC-P3 Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor Triazol Trifluoro Piperidine Indole Isoindole PROTAC
t-TUCB-PROTAC-P4 Epoxide_hydrolase Urea derivative Triazol Trifluoro Piperidine Indole Piperazine Multitarget Isoindole FAAH inhibitor PROTAC
ATFMK Monoglyceridelipase_lysophospholip ketone Trifluoro
Amiridine-Aminomethylidene-5b Derivative of Amiridine Trifluoro
PPARd-sEH-Cpd30 Epoxide_hydrolase Multitarget Trifluoro PPARdelta ligand
FP30 Epoxide_hydrolase Imidazole Cyclopropyl Trifluoro Carboxamide
8-mercapto-1,1,1-tri-fluoro-2-octanone Juvenile_hormone_esterase Trifluoro Sulfur compound Halo ketone
ELF8-8D5 Monoglyceridelipase_lysophospholip Trifluoro Pyrrolidine Oxazole
Methoxyphenylsulfonamide-indol-thiosemicarbazone-bis(trifluoromethyl)-benzene-cpd5l ACHE BCHE Monoamine-oxidase-inhibitor Trifluoro Urea derivative Multitarget Sulfur compound Sulfonamide Indole
CHEMBL5192349 Epoxide_hydrolase Trifluoro Urea derivative Oxadiazol Carboxamide
HY-148573 Epoxide_hydrolase Trifluoro Urea derivative Benzoxazol
DJ-89 Epoxide_hydrolase Urea derivative Trifluoro Piperidine Dimethoxyphenyl
HSL-IN-1 Hormone-sensitive_lipase_like Boron compound Pyridine Trifluoro
Penfluridol Not AlphaBeta Hydrolase target Trifluoro Piperidine
SP-C01 Epoxide_hydrolase Urea derivative Trifluoro Multitarget PPARgamma ligand
MGL-Inhibitor-candidate1 Monoglyceridelipase_lysophospholip Trifluoro Piperazine
SCHEMBL4415503 ACHE Trifluoro Phthalimido Isoindole Indole
FP9 Epoxide_hydrolase Pyridazine Urea derivative Trifluoro
Oxoimidazolidin-trifluoromethyl-thiazole-5-carboxamide-Cpd50 Epoxide_hydrolase Imidazole Trifluoro Thiazole Carboxamide Sulfur compound
PROTAC-FL412 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperidine Isoindole Indole
PROTAC-JSF67 Epoxide_hydrolase PROTAC Multitarget Trifluoro Piperidine Indole Isoindole Triazol Sulfur compound Sulfonamide Carboxamide
PROTAC-JSF234 Epoxide_hydrolase PROTAC Multitarget Sulfur compound Sulfonamide Trifluoro Indole Carboxamide
JW912 Carbamate BODIPY-derivative Boranuidatricyclo Boron compound Trifluoro Near-Infrared fluorescent Probe Fluorescent Probe
Imidazo-thiadiazole-cpd20aa ACHE Triazol Thiadiazol Sulfur compound Trifluoro Imidazole
Dichlorophenyl-trifluoroethanol Carb_B_Chordata Trifluoro Organochlorine
Chlorophenyl-trifluoroethanol Carb_B_Chordata Trifluoro
CHEMBL5176915 Monoglyceridelipase_lysophospholip Pyridine Piperidine Trifluoro
MAGL-IN-10-Cpd28 Monoglyceridelipase_lysophospholip Pyridine Piperidine Trifluoro Sulfur compound
(R)-14i Epoxide_hydrolase Urea derivative Trifluoro
Nonafluoro-[(methylphenyl)hydrazinylidene]-oxoheptanoic-acid Carb_B_Chordata Trifluoro Hydrazinylidene
SCHEMBL22488617 Monoglyceridelipase_lysophospholip Piperidine Trifluoro Oxazine
SCHEMBL22488357 Monoglyceridelipase_lysophospholip Trifluoro Piperidine Oxazine
SCHEMBL22462763 Monoglyceridelipase_lysophospholip Piperidine Trifluoro Oxazine
DJ-53 Epoxide_hydrolase Urea derivative Quinoline Trifluoro Dimethoxyphenyl
Trifluoromethyl-thiophene-boronic-acid 6_AlphaBeta_hydrolase CarbLipBact_1 Trifluoro Boron compound Sulfur compound Thiophen
TI45b ACHE Trifluoro Triazol Thiazole Sulfur compound Indazole
MGLL-IN-Cpd118 Monoglyceridelipase_lysophospholip Triazol Azaspiro Trifluoro Pyrazole
Adamantyl-trifluoromethoxy-phenyl-sulfonylurea-4f Epoxide_hydrolase Sulfur compound Urea derivative Trifluoro Adamantyl
Retagliptin DPP4N_Peptidase_S9 Drug Gliptin Triazol Trifluoro Pro-Drug Imidazole
ABD-1970 Monoglyceridelipase_lysophospholip Carbamate Trifluoro Piperazine Azabicyclo
Cofrogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Pyrazole Sulfonamide Sulfur compound
t-TUCB-PROTAC-Cpd8 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget Piperazine
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Piperidine Indole Isoindole Multitarget
LEI-463 Monoglyceridelipase_lysophospholip Trifluoro Indole Piperazine Triazol Fluorescent Probe
KBR-2822 Sulfur compound Organophosphate Trifluoro Cyclobutyl Not AlphaBeta Hydrolase target
Compound19n-quinolinol ACHE Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
DCJW Carb_B_Arthropoda Insecticide Carboxamide Trifluoro Not AlphaBeta Hydrolase target
M513 Insecticide Carboxamide Carbamate Trifluoro Not AlphaBeta Hydrolase target
Indoxacarb Carb_B_Arthropoda Insecticide Carboxamide Carbamate Trifluoro Not AlphaBeta Hydrolase target
SCHEMBL19582562 ABHD6-Lip Morpholine Carbamate Trifluoro Azaspiro
SCHEMBL22462761 Monoglyceridelipase_lysophospholip PET probe Trifluoro Urea derivative Azetidin Oxazine
ARUK3004876 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006560 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006561 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3006562 Pectinacetylesterase-Notum Fragment inhibitor of Notum Indole Trifluoro
ARUK3000438 Pectinacetylesterase-Notum Fragment inhibitor of Notum Triazol Trifluoro
FEPAD Monoglyceridelipase_lysophospholip Piperazine Azetidin Trifluoro Thiazolidine Sulfur compound PET probe Biphenyl
CHEMBL3793506 PAF-Acetylhydrolase Trifluoro Cyanide Pyrimidine Morpholine
6M08-BWL PAF-Acetylhydrolase Trifluoro Pyrrolidine
6M07-BWO PAF-Acetylhydrolase Trifluoro Pyrrolidine
Prusogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Cyanide Pyrrolidine
ARUK3001043 Pectinacetylesterase-Notum Fragment inhibitor of Notum Triazol Trifluoro
TPPU-6-Chlorotacrine-12c Epoxide_hydrolase ACHE Multitarget Derivative of Tacrine Acridine Trifluoro Piperidine Urea derivative Alkyl linked bis-ligand
ARUK3000223 Pectinacetylesterase-Notum Fragment inhibitor of Notum Trifluoro Triazol
Riluzole Pectinacetylesterase-Notum Drug Benzothiazol Trifluoro Sulfur compound Not AlphaBeta Hydrolase target Fragment inhibitor of Notum Thiazole
PTUPB Epoxide_hydrolase Cyclooxygenase-2 Inhibitor Multitarget Trifluoro Urea derivative Sulfur compound Sulfonamide Pyrazole
ARUK3003909 Pectinacetylesterase-Notum Fragment inhibitor of Notum Triazol Trifluoro Pyridazine Sulfur compound
CHEMBL2313198 Epoxide_hydrolase Piperidine Sulfur compound Sulfonamide Carboxamide Trifluoro
CHEMBL442384-S0E-3WK8 Epoxide_hydrolase Benzothiazol Not AlphaBeta Hydrolase target Trifluoro Sulfur compound Thiazole
CHEMBL45663-49N-4Y2Q Epoxide_hydrolase Piperazine Pyridine Trifluoro
CHEMBL3402236-49P-4Y2S Epoxide_hydrolase Trifluoro Pyrazole
CHEMBL4649188 Epoxide_hydrolase LTA4-hydrolase-inhibitor Multitarget Trifluoro Oxazole
TK90 Epoxide_hydrolase Butyrate Carboxamide Trifluoro Multitarget PPARgamma ligand
HT-01 Lipase_3 ABHD6-Lip Fluorescent Probe BODIPY-derivative Boranuidatricyclo Carboxamide Triazol Trifluoro Boron compound
ZINC11996936 ACHE Trifluoro Derivative of Donepezil
ZINC11709541 ACHE Trifluoro Derivative of Donepezil
ABD957 ABHD17-depalmitoylase Trifluoro Sulfur compound Sulfonamide Piperazine Pyrazole Azabicyclo
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
OWW-6YL4 Epoxide_hydrolase Trifluoro Multitarget 5-Lipoxygenase inhibitor Alkyne
SCHEMBL21776992 Pectinacetylesterase-Notum Trifluoro Oxadiazolone Oxadiazol
Pyrrole-5-6YUY Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Trifluoro
Pyrrole-26-6YSK Pectinacetylesterase-Notum Pyrrole_Pyrrolidine-derivative Trifluoro
62-mEH Epoxide_hydrolase Sulfur compound Trifluoro
SR-3420 CGI-58_ABHD5_ABHD4 Urea derivative Sulfur compound Benzothiazepine Azepane Trifluoro
CHEMBL4076292 PAF-Acetylhydrolase Sulfur compound Cyanide Trifluoro
XEN445 Lipoprotein_Lipase Pyridine Trifluoro
Soporidine RsbQ-like Alkyne Piperidine Trifluoro Strigolactone receptors ligand
TUPS Epoxide_hydrolase Piperidine Urea derivative Trifluoro Sulfur compound Sulfonamide
Regorafenib Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Trifluoro Carboxamide multi-kinase inhibitor
Sorafenib Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Trifluoro Carboxamide multi-kinase inhibitor
sEH-inhibitor-19 Epoxide_hydrolase Natural Alkaloid Isoquinoline Trifluoro Urea derivative Derivative of berberine
HL2 DPP4N_Peptidase_S9 Cyanide Trifluoro
SCHEMBL21862936 DPP4N_Peptidase_S9 Gliptin Trifluoro Azabicyclo Oxadiazol
Neogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Cyanide Azabicyclo
DA-12166 DPP4N_Peptidase_S9 Gliptin Trifluoro
DA-12228 DPP4N_Peptidase_S9 Gliptin Trifluoro Piperazine
6N3Z-4 Epoxide_hydrolase Urea derivative Trifluoro
KK073 RsbQ-like Urea derivative Trifluoro Triazol
LK864 Epoxide_hydrolase Azaspiro Sulfur compound Sulfonyl Urea derivative Trifluoro
ML348 LYsophospholipase_carboxylesterase Trifluoro Piperazine
5LP1-71H PAF-Acetylhydrolase Trifluoro Pyrimidine Sulfur compound
Cpd227 Epoxide_hydrolase Urea derivative Trifluoro
D3C DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Carboxamide
CHEMBL3087815 ACHE Trifluoro Sulfur compound Sulfonamide Benzenesulfonamide
Carboxamide-triflurophenyl-D5C DPP4N_Peptidase_S9 Trifluoro Carboxamide Biphenyl
Sulfonamide-D1C DPP4N_Peptidase_S9 Sulfur compound Sulfonamide Trifluoro Benzenesulfonamide
Triazol-triflurophenyl-DC3 DPP4N_Peptidase_S9 Triazol Trifluoro
CHEMBL2147710 DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Thiazolidine Sulfur compound Pyrazole
CHEMBL2058971 DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Quinoline Thiazolidine Sulfur compound
SCHEMBL19305555 DPP4N_Peptidase_S9 Trifluoro Chromen
beta-aminoacyl-thiazolidine-2da DPP4N_Peptidase_S9 Trifluoro Sulfur compound Thiazolidine
PF-06795071 Monoglyceridelipase_lysophospholip Trifluoro Carbamate PET probe Pyrazole Azabicyclo
TPPU-methyl Epoxide_hydrolase Trifluoro Piperidine Urea derivative
SCHEMBL15272467 Epoxide_hydrolase Trifluoro Piperidine Urea derivative
TPAU Trifluoro Piperidine Urea derivative
TPPU Epoxide_hydrolase Trifluoro Piperidine Urea derivative
Fulvestrant Epoxide_hydrolase Trifluoro Sulfur compound Drug Not AlphaBeta Hydrolase target Phenanthrene
CHEMBL2392714 Epoxide_hydrolase Trifluoro Piperidine Carboxamide Triazine
Piperidine-fused-benzimidazole-25 DPP4N_Peptidase_S9 Trifluoro Piperidine Sulfur compound Imidazole Benzimidazole Sulfonyl
Piperidine-fused-benzimidazole-34 DPP4N_Peptidase_S9 Trifluoro Piperidine Benzimidazole
Gemigliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin Trifluoro Delta-lactam
CHEMBL233360 DPP4N_Peptidase_S9 Trifluoro Triazol
Diazepan-AJH DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
PETFP Cutinase Trifluoro Sulfur compound
5ALR-8TM Epoxide_hydrolase Sulfur compound Trifluoro Quinazoline
CHEMBL4451596 Epoxide_hydrolase Sulfonamide Pyridine Trifluoro Sulfur compound
Nitrophenyl-trifluoroethyl-arsenocholine ACHE Trifluoro 2-nitrophenyl
Triazolopiperazine-based-beta-amino-acid DPP4N_Peptidase_S9 Piperidine Trifluoro Triazol
3-amino-4-phenyl-pyrrolidine-15B DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Pyridine Pyrimidine
Piperidinone-constrained-phenethylamine-31 DPP4N_Peptidase_S9 Benzodioxo Trifluoro Piperidine Delta-lactam
Piperidine-constrained-phenethylamine-42 DPP4N_Peptidase_S9 Trifluoro Sulfur compound Pyrimidine Piperidine
Cyclic-Hydrazine-Derivative DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
DLI DPP4N_Peptidase_S9 Trifluoro Sulfur compound Pyrrolidine Pyrimidine
Diazepanone-Analog-18 DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
Diazepanone-Analog-1 DPP4N_Peptidase_S9 Trifluoro Diazepan Azepane
ABT-341 DPP4N_Peptidase_S9 Trifluoro Triazol
Benzyl-2-triazole-linked-tryptamine-paeonol-Cpd896 BCHE Triazol Trifluoro Derivative of Tryptamine Indole Monoamine-oxidase-inhibitor
6AX1-cp3 Monoglyceridelipase_lysophospholip Halo ketone Trifluoro Carbamate Azetidin Oxadiazol
Hexafluoracetone Hydroxynitrile_lyase Trifluoro Halo ketone
Tr-EH-urea-13 Epoxide_hydrolase Urea derivative Trifluoro
OTFP Juvenile_hormone_esterase Cutinase Trifluoro Halo ketone Sulfur compound
DETFP Juvenile_hormone_esterase Carb_B_Chordata Carboxylesterase Trifluoro Sulfur compound Halo ketone
OTFPdOHSO2 Juvenile_hormone_esterase Trifluoro Sulfur compound Sulfonyl Halo ketone
ARUK3001185 Pectinacetylesterase-Notum Trifluoro Triazol Organochlorine
SCHEMBL19358888 Epoxide_hydrolase Urea derivative Trifluoro Benzoate FAAH inhibitor Multitarget
EC5026 Epoxide_hydrolase Urea derivative Trifluoro Piperidine Drug
Darapladib PAF-Acetylhydrolase Trifluoro Pyrimidine Sulfur compound
CHEMBL3792924 PAF-Acetylhydrolase Trifluoro Sulfur compound Thiomorpholine
GTPL9797 PAF-Acetylhydrolase Trifluoro Piperidine Sulfur compound Sulfonamide Benzenesulfonamide Cyanide
Rilapladib PAF-Acetylhydrolase Trifluoro Piperidine Sulfur compound
Evogliptin DPP4N_Peptidase_S9 Drug Gliptin Trifluoro
Sitagliptin DPP4N_Peptidase_S9 Drug Piperidine Gliptin Triazol Trifluoro
ZINC02141756 Carb_B_Chordata Trifluoro Sulfur compound Thiophen Hydrazinylidene
SZC Epoxide_hydrolase Sulfur compound Sulfonamide Trifluoro Imidazole Benzimidazole
CHEMBL238787 Hormone-sensitive_lipase_like Carb_B_Chordata ABHD6-Lip Trifluoro Carbamate Piperidine
JW651 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Piperazine Halo ketone Carbamate Trifluoro Organochlorine
DO34 Lipase_3 Trifluoro Piperazine Carbamate tert-Butyloxycarbonyl tert-Butyl
QST-0837 Monoglyceridelipase_lysophospholip PET probe Carbamate Trifluoro Azetidin Pyrazole
ABX-1431 Monoglyceridelipase_lysophospholip Piperazine Carbamate Pyrrolidine Trifluoro
KML29 Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A Halo ketone Piperidine Benzodioxo Carbamate Trifluoro
CHEMBL3087809 ACHE Sulfonamide Sulfur compound Trifluoro
Zifrosilone ACHE Halo ketone Transition state analogue Trifluoro
FBQ ACHE Trifluoro Transition state analogue Quinoline Derivative of Tacrine Sulfur compound
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate BCHE Trifluoro Organophosphate Halo ketone Coumarin Chromen
Bisuracil-pentylammonium-2h ACHE Trifluoro Ammonium Uracil derivative
CHEMBL4793341 ACHE BCHE Trifluoro Pyrrolidine Multitarget BACE1-inhibitor
Fluphenazine Phenothiazine Sulfur compound Not AlphaBeta Hydrolase target Trifluoro
Trifluoperazine Phenothiazine Sulfur compound Trifluoro Not AlphaBeta Hydrolase target
Triflupromazine Phenothiazine Sulfur compound Trifluoro Not AlphaBeta Hydrolase target
TBTFA ACHE BCHE Halo ketone Transition state analogue Trifluoro tert-Butyl
NAF ACHE Trifluoro Quaternary compound Trimethylammonium Ammonium Transition state analogue
MBTFP Cutinase Juvenile_hormone_esterase Trifluoro Transition state analogue Halo ketone Sulfur compound
TMTFA ACHE Trifluoro Trimethylammonium Ammonium Quaternary compound Transition state analogue Halo ketone
Trifluoro-6-dimethyl-2-heptanone BCHE ACHE Trifluoro Halo ketone