Huptremule-C
Biotransformation of Huperzine A by Ceriporia lacerate HS-ZJUT-C13A : IC50 = 0.11 microM AChE
General
Type : Alkaloid, Natural, Derivative of Huperzine
Chemical_Nomenclature : (1R,9R,13E)-1-[[(5R,6R,6aS)-3a,5-dihydroxy-6,8,8-trimethyl-1,3,4,5,6,6a,7,9-octahydroazuleno[4,5-c]furan-3-yl]amino]-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one
Canonical SMILES : C\/C=C\/1\\[C@@H]2CC3=C([C@]1(CC(=C2)C)NC4C5(C[C@H]([C@@H]([C@@H]6CC(CC6=C5CO4)(C)C)C)O)O)C=CC(=O)N3
InChI : InChI=1S\/C30H40N2O4\/c1-6-21-18-9-16(2)11-29(21,22-7-8-26(34)31-24(22)10-18)32-27-30(35)14-25(33)17(3)19-12-28(4,5)13-20(19)23(30)15-36-27\/h6-9,17-19,25,27,32-33,35H,10-15H2,1-5H3,(H,31,34)\/b21-6+\/t17-,18+,19+,25-,27?,29-,30?\/m1\/s1
InChIKey : SJYVGYLWIJIYHJ-LIUSGKPXSA-N
Other name(s) : Huptremule C || Huptremules C || RefChem:146919 || CHEMBL3338388
MW : 492.6
Formula : C30H40N2O4
CAS_number :
PubChem : 118715261
UniChem : SJYVGYLWIJIYHJ-LIUSGKPXSA-N
Target
References (6)
| Title : Natural alkaloids with therapeutic potential against Alzheimer's disease through cholinesterase inhibition - Khan_2025_Eur.J.Med.Chem_302_118371 |
| Author(s) : Khan U , Ahmad M , Tuba M , Naaz R , Qayum F , Khatoon S , Sanobar , Ahamad S , Saquib M , Hussain MK |
| Ref : Eur Journal of Medicinal Chemistry , 302 :118371 , 2025 |
| Abstract : |
| PubMedSearch : Khan_2025_Eur.J.Med.Chem_302_118371 |
| PubMedID: 41240614 |
| Title : Natural alkaloids with therapeutic potential against Alzheimer's disease through cholinesterase inhibition - Khan_2025_Eur.J.Med.Chem_302_118371 |
| Author(s) : Khan U , Ahmad M , Tuba M , Naaz R , Qayum F , Khatoon S , Sanobar , Ahamad S , Saquib M , Hussain MK |
| Ref : Eur Journal of Medicinal Chemistry , 302 :118371 , 2025 |
| Abstract : |
| PubMedSearch : Khan_2025_Eur.J.Med.Chem_302_118371 |
| PubMedID: 41240614 |
| Title : Natural alkaloids with therapeutic potential against Alzheimer's disease through cholinesterase inhibition - Khan_2025_Eur.J.Med.Chem_302_118371 |
| Author(s) : Khan U , Ahmad M , Tuba M , Naaz R , Qayum F , Khatoon S , Sanobar , Ahamad S , Saquib M , Hussain MK |
| Ref : Eur Journal of Medicinal Chemistry , 302 :118371 , 2025 |
| Abstract : |
| PubMedSearch : Khan_2025_Eur.J.Med.Chem_302_118371 |
| PubMedID: 41240614 |
| Title : Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids - Ying_2014_J.Nat.Prod_77_2054 |
| Author(s) : Ying YM , Shan WG , Zhan ZJ |
| Ref : Journal of Natural Products , 77 :2054 , 2014 |
| Abstract : |
| PubMedSearch : Ying_2014_J.Nat.Prod_77_2054 |
| PubMedID: 25222040 |
| Title : Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids - Ying_2014_J.Nat.Prod_77_2054 |
| Author(s) : Ying YM , Shan WG , Zhan ZJ |
| Ref : Journal of Natural Products , 77 :2054 , 2014 |
| Abstract : |
| PubMedSearch : Ying_2014_J.Nat.Prod_77_2054 |
| PubMedID: 25222040 |
| Title : Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids - Ying_2014_J.Nat.Prod_77_2054 |
| Author(s) : Ying YM , Shan WG , Zhan ZJ |
| Ref : Journal of Natural Products , 77 :2054 , 2014 |
| Abstract : |
| PubMedSearch : Ying_2014_J.Nat.Prod_77_2054 |
| PubMedID: 25222040 |