Alkaloid

General

Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom, produced by a large variety of organisms including bacteria, fungi, plants, and animals. The boundary between alkaloids and other nitrogen-containing natural compounds is not clear-cut.
Inhibitor Main targeted enzyme familyes Type Structure
Tabersonine Plant_carboxylesterase Indole Alkaloid Natural
Catharanthine Plant_carboxylesterase Indole Alkaloid Natural
(S)Aporphine-N-benzylpyridinium Isoquinoline Alkaloid
O-Methyl-Dauracine DPP4N_Peptidase_S9 Alkaloid Natural Quinoline
Carltonine-A BCHE Alkaloid Natural
Carltonine-B BCHE Alkaloid Natural
XB8-8CGO BCHE Alkaloid Natural_modified
Cinchonidine BCHE Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo
Cinchonine BCHE Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo
CD-Bzl BCHE Alkaloid Derivative of Cinchonine Quinoline Natural_modified
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not A\/B H target
Emetine Hydrolase_RBBP9_YdeN Natural Alkaloid Drug Isoquinoline Quinoline
Chelerythrine ACHE Natural Alkaloid Not A\/B H target Benzodioxo Phenanthridinium
Sanguinarine Natural Alkaloid Not A\/B H target Benzodioxo Phenanthridinium
Palmatine Natural Alkaloid Not A\/B H target Isoquinoline
Berberine ACHE BCHE Natural Alkaloid Not A\/B H target Isoquinoline Benzodioxo
8-Hydroxydihydrochelerythrine ACHE Alkaloid Benzodioxo Phenanthridinium
Harmine Natural Alkaloid Indole beta-carboline Not A\/B H target
Caffeine Pectinacetylesterase-Notum Lipase_3 Purine Alkaloid Natural Drug Not A\/B H target
18-carboxymethoxy-cleaviminium Plant_carboxylesterase Natural Alkaloid
Theophylline Pectinacetylesterase-Notum Alkaloid Natural Purine Not A\/B H target
Canadine ACHE BCHE Cholinesterase Natural Alkaloid
Thalictricavine ACHE BCHE Cholinesterase Natural Alkaloid
N-piperidinopropylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Benzazepin Azepine
N-saccharinohexylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Sulfur Compound
16-epi-Vellosimine Hydroxynitrile_lyase Alkaloid
Vinblastine Arylacetamide_deacetylase Carb_B_Chordata Alkaloid
Psilocybin ACHE BCHE Organophosphate Natural Alkaloid Indole
Memogain ACHE Carb_B_Chordata Derivative of Galanthamine Alkaloid Benzoate Natural_modified Benzazepin Azepine
Phthalimido-Galanthaminium-4d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Phthalimido Benzazepin Azepine
Phthalimido-Galanthaminium-8d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepine
Galanthaminium ACHE Derivative of Galanthamine Alkaloid Natural_modified Benzazepin Azepine
Peganine ACHE BCHE Not A\/B H target Alkaloid Natural_modified
Desoxypeganine ACHE BCHE Not A\/B H target Alkaloid Natural Quinazoline
Gramine ACHE BCHE Alkaloid Natural Not A\/B H target Indole
Atropine ACHE Not A\/B H target Muscarinic antagonist Drug Alkaloid Natural Azabicyclo Propionate
Cocaine BCHE Natural Not A\/B H target Drug Alkaloid Benzoate
D-tubocurarine ACHE Natural Alkaloid Neuromuscular Nondepolarizing Agents Not A\/B H target Drug
Sanguinine ACHE Derivative of Galanthamine Natural Alkaloid
Mahanimbine Natural Alkaloid
Galanthamine ACHE Derivative of Galanthamine Natural Alkaloid Drug Benzazepin Azepine
Bis-galanthamine ACHE Derivative of Galanthamine Alkaloid Alkyl linked bis-ligand Benzazepin Azepine Natural_modified
HuperzineA ACHE Derivative of Huperzine Natural Alkaloid
HuperzineB ACHE Derivative of Huperzine Natural Alkaloid
P11149 Adamantyl Derivative of Galanthamine Alkaloid Benzazepin Azepine Natural_modified
Jatrorrhizine Natural Alkaloid Not A\/B H target Isoquinoline
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not A\/B H target
Solanidine BCHE Natural Alkaloid Steroid
alpha-Chaconine BCHE Natural Alkaloid Glycoside
Solanine BCHE Natural Alkaloid Carbohydrate Glycoside