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Alkaloid

General

Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom, produced by a large variety of organisms including bacteria, fungi, plants, and animals. The boundary between alkaloids and other nitrogen-containing natural compounds is not clear-cut.
Inhibitor Main targeted enzyme families Type Structure
CHEMBL4204057 Thioesterase Natural_modified Alkaloid Benzodioxo Phenanthridinium
Ungeremine ACHE BCHE Natural Alkaloid Phenanthrene Phenanthridinium
Huptremule-D ACHE Derivative of Huperzine Natural Alkaloid
Avicine ACHE BCHE Alkaloid Natural Phenanthrene Benzodioxo Phenanthridinium
Nitidine ACHE Alkaloid Natural Phenanthrene Benzodioxo Phenanthridinium
Juliflorine ACHE BCHE Indole Alkaloid Natural
CHEMBL4797670 Isoquinoline Alkaloid Quinoline
CHEMBL550075 ACHE Oxoisoaporphine Alkaloid Piperidine
CHEMBL245470 ACHE BCHE Oxoisoaporphine Alkaloid Pyrrolidine
AChE-IN-7 ACHE Oxoisoaporphine Alkaloid
Corydaline ACHE Alkaloid Natural Quinoline Isoquinoline
1-(((piperidin)ethyl)amino)pentyl)-Caffeine-Cpd28 ACHE Purine Alkaloid
Theobromine Purine Alkaloid Natural Not AlphaBeta Hydrolase target
Salidroside Pancreatic_lipase Canar_LipB Natural Alkaloid Glycoside Antioxidant
Verbascoside S9N_PPCE_Peptidase_S9 Pancreatic_lipase Natural Hydroxycinnamic-ester Alkaloid Glycoside Dihydroxyphenyl Antioxidant
Galantamine-benzylpyridine-C2 ACHE BCHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Pyridine Benzazepin Azepane
Tabersonine Plant_carboxylesterase Indole Alkaloid Natural
Catharanthine Plant_carboxylesterase Indole Alkaloid Natural
(S)Aporphine-N-benzylpyridinium ACHE Isoquinoline Pyridine Alkaloid Organochlorine
O-Methyl-Dauracine DPP4N_Peptidase_S9 Alkaloid Natural Quinoline Isoquinoline
Carltonine-A BCHE Alkaloid Natural
Carltonine-B BCHE Alkaloid Natural
XB8-8CGO BCHE Alkaloid Natural_modified Cyclobutyl
Lycocasuarine-C ACHE Derivative of Huperzine Natural Alkaloid
Lycocasuarinine-D ACHE Derivative of Huperzine Natural Alkaloid
N-demethylhuperzinine BCHE ACHE Derivative of Huperzine Natural Alkaloid
Cinchonidine BCHE Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo Quinuclidine
Cinchonine BCHE Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo Quinuclidine
CD-Bzl BCHE Alkaloid Derivative of Cinchonine Quinoline Natural_modified
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not AlphaBeta Hydrolase target
Emetine Hydrolase_RBBP9_YdeN Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
Chelerythrine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Benzodioxo Phenanthridinium Phenanthrene
Sanguinarine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Benzodioxo Phenanthridinium
Columbamine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Palmatine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Berberine ACHE BCHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Benzodioxo Antioxidant Derivative of berberine
8-Hydroxydihydrochelerythrine ACHE Alkaloid Benzodioxo Phenanthridinium Phenanthrene
Harmine Natural Alkaloid Indole beta-carboline Not AlphaBeta Hydrolase target
Caffeine Pectinacetylesterase-Notum Lipase_3 Purine Alkaloid Natural Drug Not AlphaBeta Hydrolase target
18-carboxymethoxy-cleaviminium Plant_carboxylesterase Natural Alkaloid
Theophylline Pectinacetylesterase-Notum Alkaloid Natural Purine Not AlphaBeta Hydrolase target
Canadine ACHE BCHE Cholinesterase Natural Alkaloid Derivative of berberine
sEH-inhibitor-19 Epoxide_hydrolase Natural Alkaloid Isoquinoline Trifluoro Urea derivative Derivative of berberine
Thalictricavine ACHE BCHE Cholinesterase Natural Alkaloid Derivative of berberine
N-piperidinopropylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Benzazepin Azepane
N-saccharinohexylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Sulfur Compound Benzazepin Azepane
16-epi-Vellosimine Hydroxynitrile_lyase Alkaloid
Vinblastine Arylacetamide_deacetylase Carb_B_Chordata Alkaloid
Psilocybin ACHE BCHE Organophosphate Natural Alkaloid Indole
Memogain ACHE Carb_B_Chordata Derivative of Galanthamine Alkaloid Benzoate Natural_modified Benzazepin Azepane
Phthalimido-Galanthaminium-4d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Phthalimido-Galanthaminium-8d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Galanthaminium ACHE Derivative of Galanthamine Alkaloid Natural_modified Benzazepin Azepane
Peganine ACHE BCHE Not AlphaBeta Hydrolase target beta-carboline Natural Alkaloid Natural_modified
Desoxypeganine ACHE BCHE Not AlphaBeta Hydrolase target beta-carboline Natural Alkaloid Quinazoline
Gramine ACHE BCHE Alkaloid Natural Not AlphaBeta Hydrolase target Indole
Atropine ACHE Not AlphaBeta Hydrolase target Muscarinic antagonist Drug Alkaloid Natural Azabicyclo Propionate
Cocaine BCHE Natural Not AlphaBeta Hydrolase target Drug Alkaloid Benzoate
D-tubocurarine ACHE Natural Alkaloid Neuromuscular Nondepolarizing Agents Not AlphaBeta Hydrolase target Drug Organochlorine
Sanguinine ACHE Derivative of Galanthamine Natural Alkaloid Benzazepin Azepane
Mahanimbine ACHE Natural Alkaloid
Galanthamine ACHE Derivative of Galanthamine Natural Alkaloid Drug Benzazepin Azepane Multitarget Nicotinic agonist Azocine
Bis-galanthamine ACHE Derivative of Galanthamine Alkaloid Alkyl linked bis-ligand Benzazepin Azepane Natural_modified
HuperzineA ACHE Derivative of Huperzine Natural Alkaloid
HuperzineB ACHE Derivative of Huperzine Natural Alkaloid
P11149 BCHE ACHE Adamantyl Derivative of Galanthamine Alkaloid Benzazepin Azepane Natural_modified Organochlorine
Jatrorrhizine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Nicotinic agonist Natural Alkaloid Drug Not AlphaBeta Hydrolase target
Solanidine BCHE Natural Alkaloid Steroid
alpha-Chaconine BCHE Natural Alkaloid Glycoside
Solanine BCHE Natural Alkaloid Carbohydrate Glycoside
CHEMBL4204057 Thioesterase Natural_modified Alkaloid Benzodioxo Phenanthridinium Indole
Ungeremine ACHE BCHE Natural Alkaloid Phenanthrene Phenanthridinium
Huptremule-D ACHE Derivative of Huperzine Natural Alkaloid
Avicine ACHE BCHE Alkaloid Natural Phenanthrene Benzodioxo Phenanthridinium
Nitidine ACHE Alkaloid Natural Phenanthrene Benzodioxo Phenanthridinium
Huptremule-C Alkaloid Natural Derivative of Huperzine
Huptremule-A Alkaloid Natural Derivative of Huperzine
Petrosamine Alkaloid Natural Acridine Ammonium
Juliflorine ACHE BCHE Indole Alkaloid Natural
CHEMBL4797670 Isoquinoline Alkaloid Quinoline
CHEMBL550075 ACHE Oxoisoaporphine Alkaloid Piperidine
CHEMBL245470 ACHE BCHE Oxoisoaporphine Alkaloid Pyrrolidine
AChE-IN-7 ACHE Oxoisoaporphine Alkaloid
Corydaline ACHE Alkaloid Natural Quinoline Isoquinoline
1-(((piperidin)ethyl)amino)pentyl)-Caffeine-Cpd28 ACHE Purine Alkaloid
Theobromine Purine Alkaloid Natural Not AlphaBeta Hydrolase target
Salidroside Pancreatic_lipase Canar_LipB Natural Alkaloid Glycoside Antioxidant
Verbascoside S9N_PPCE_Peptidase_S9 Pancreatic_lipase Natural Hydroxycinnamic-ester Alkaloid Glycoside Dihydroxyphenyl Antioxidant
Galantamine-benzylpyridine-C2 ACHE BCHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Pyridine Benzazepin Azepane
Tabersonine Plant_carboxylesterase Indole Alkaloid Natural
Catharanthine Plant_carboxylesterase Indole Alkaloid Natural
(S)Aporphine-N-benzylpyridinium ACHE Isoquinoline Pyridine Alkaloid Organochlorine
O-Methyl-Dauracine DPP4N_Peptidase_S9 Alkaloid Natural Quinoline Isoquinoline
Carltonine-A BCHE Alkaloid Natural
Carltonine-B BCHE Alkaloid Natural
XB8-8CGO BCHE Alkaloid Natural_modified Cyclobutyl
Lycocasuarine-C ACHE Derivative of Huperzine Natural Alkaloid
Lycocasuarinine-D ACHE Derivative of Huperzine Natural Alkaloid
N-demethylhuperzinine BCHE ACHE Derivative of Huperzine Natural Alkaloid
Cinchonidine BCHE Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo Quinuclidine
Cinchonine BCHE Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo Quinuclidine
CD-Bzl BCHE Alkaloid Derivative of Cinchonine Quinoline Natural_modified
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not AlphaBeta Hydrolase target
Emetine Hydrolase_RBBP9_YdeN Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
Chelerythrine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Benzodioxo Phenanthridinium Phenanthrene
Sanguinarine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Benzodioxo Phenanthridinium
Columbamine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Palmatine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Berberine ACHE BCHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Benzodioxo Antioxidant Derivative of berberine Ammonium
8-Hydroxydihydrochelerythrine ACHE Alkaloid Benzodioxo Phenanthridinium Phenanthrene
Harmine Natural Alkaloid Indole beta-carboline Not AlphaBeta Hydrolase target
Caffeine Pectinacetylesterase-Notum Lipase_3 Purine Alkaloid Natural Drug Not AlphaBeta Hydrolase target
18-carboxymethoxy-cleaviminium Plant_carboxylesterase Natural Alkaloid
Theophylline Pectinacetylesterase-Notum Alkaloid Natural Purine Not AlphaBeta Hydrolase target
Canadine ACHE BCHE Cholinesterase Natural Alkaloid Derivative of berberine
sEH-inhibitor-19 Epoxide_hydrolase Natural Alkaloid Isoquinoline Trifluoro Urea derivative Derivative of berberine
Thalictricavine ACHE BCHE Cholinesterase Natural Alkaloid Derivative of berberine
N-piperidinopropylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Benzazepin Azepane
N-saccharinohexylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Sulfur compound Benzazepin Azepane
16-epi-Vellosimine Hydroxynitrile_lyase Alkaloid
Vinblastine Arylacetamide_deacetylase Carb_B_Chordata Alkaloid
Psilocybin ACHE BCHE Organophosphate Natural Alkaloid Indole
Memogain ACHE Carb_B_Chordata Derivative of Galanthamine Alkaloid Benzoate Natural_modified Benzazepin Azepane
Phthalimido-Galanthaminium-4d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Phthalimido-Galanthaminium-8d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Galanthaminium ACHE Derivative of Galanthamine Alkaloid Natural_modified Benzazepin Azepane
Peganine ACHE BCHE Not AlphaBeta Hydrolase target beta-carboline Natural Alkaloid Natural_modified
Desoxypeganine ACHE BCHE Not AlphaBeta Hydrolase target beta-carboline Natural Alkaloid Quinazoline
Gramine ACHE BCHE Alkaloid Natural Not AlphaBeta Hydrolase target Indole
Atropine ACHE Not AlphaBeta Hydrolase target Muscarinic antagonist Drug Alkaloid Natural Azabicyclo Propionate
Cocaine BCHE Natural Not AlphaBeta Hydrolase target Drug Alkaloid Benzoate
D-tubocurarine ACHE Natural Alkaloid Neuromuscular Nondepolarizing Agents Not AlphaBeta Hydrolase target Drug Organochlorine
Sanguinine ACHE Derivative of Galanthamine Natural Alkaloid Benzazepin Azepane
Mahanimbine ACHE Natural Alkaloid
Galanthamine ACHE Derivative of Galanthamine Natural Alkaloid Drug Benzazepin Azepane Multitarget Nicotinic agonist Azocine
Bis-galanthamine ACHE Derivative of Galanthamine Alkaloid Alkyl linked bis-ligand Benzazepin Azepane Natural_modified
HuperzineA ACHE Derivative of Huperzine Natural Alkaloid
HuperzineB ACHE Derivative of Huperzine Natural Alkaloid
P11149 BCHE ACHE Adamantyl Derivative of Galanthamine Alkaloid Benzazepin Azepane Natural_modified Organochlorine
Jatrorrhizine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Nicotinic agonist Natural Alkaloid Drug Not AlphaBeta Hydrolase target
Solanidine BCHE Natural Alkaloid Steroid
alpha-Chaconine BCHE Natural Alkaloid Glycoside
Solanine BCHE Natural Alkaloid Carbohydrate Glycoside
CHEMBL4204057 Thioesterase Natural_modified Alkaloid Benzodioxo Phenanthridinium Indole
Ungeremine ACHE BCHE Natural Alkaloid Phenanthrene Phenanthridinium
Huptremule-D ACHE Derivative of Huperzine Natural Alkaloid
Avicine ACHE BCHE Alkaloid Natural Phenanthrene Benzodioxo Phenanthridinium
Nitidine ACHE Alkaloid Natural Phenanthrene Benzodioxo Phenanthridinium
Huptremule-C Alkaloid Natural Derivative of Huperzine
Huptremule-A Alkaloid Natural Derivative of Huperzine
Petrosamine Alkaloid Natural Acridine Ammonium
Juliflorine ACHE BCHE Indole Alkaloid Natural
CHEMBL4797670 Isoquinoline Alkaloid Quinoline
CHEMBL550075 ACHE Oxoisoaporphine Alkaloid Piperidine
CHEMBL245470 ACHE BCHE Oxoisoaporphine Alkaloid Pyrrolidine
AChE-IN-7 ACHE Oxoisoaporphine Alkaloid
Corydaline ACHE Alkaloid Natural Quinoline Isoquinoline
1-(((piperidin)ethyl)amino)pentyl)-Caffeine-Cpd28 ACHE Purine Alkaloid
Theobromine Purine Alkaloid Natural Not AlphaBeta Hydrolase target
Salidroside Pancreatic_lipase Canar_LipB Natural Alkaloid Glycoside Antioxidant
Verbascoside S9N_PPCE_Peptidase_S9 Pancreatic_lipase Natural Hydroxycinnamic-ester Alkaloid Glycoside Dihydroxyphenyl Antioxidant
Galantamine-benzylpyridine-C2 ACHE BCHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Pyridine Benzazepin Azepane
Tabersonine Plant_carboxylesterase Indole Alkaloid Natural
Catharanthine Plant_carboxylesterase Indole Alkaloid Natural
(S)Aporphine-N-benzylpyridinium ACHE Isoquinoline Pyridine Alkaloid Organochlorine
O-Methyl-Dauracine DPP4N_Peptidase_S9 Alkaloid Natural Quinoline Isoquinoline
Carltonine-A BCHE Alkaloid Natural
Carltonine-B BCHE Alkaloid Natural
XB8-8CGO BCHE Alkaloid Natural_modified Cyclobutyl
Lycocasuarine-C ACHE Derivative of Huperzine Natural Alkaloid
Lycocasuarinine-D ACHE Derivative of Huperzine Natural Alkaloid
N-demethylhuperzinine BCHE ACHE Derivative of Huperzine Natural Alkaloid
Cinchonidine BCHE Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo Quinuclidine
Cinchonine BCHE Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo Quinuclidine
CD-Bzl BCHE Alkaloid Derivative of Cinchonine Quinoline Natural_modified
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not AlphaBeta Hydrolase target
Emetine Hydrolase_RBBP9_YdeN Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
Chelerythrine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Benzodioxo Phenanthridinium Phenanthrene
Sanguinarine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Benzodioxo Phenanthridinium
Columbamine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Palmatine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Berberine ACHE BCHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Benzodioxo Antioxidant Derivative of berberine Ammonium
8-Hydroxydihydrochelerythrine ACHE Alkaloid Benzodioxo Phenanthridinium Phenanthrene
Harmine Natural Alkaloid Indole beta-carboline Not AlphaBeta Hydrolase target
Caffeine Pectinacetylesterase-Notum Lipase_3 Purine Alkaloid Natural Drug Not AlphaBeta Hydrolase target
18-carboxymethoxy-cleaviminium Plant_carboxylesterase Natural Alkaloid
Theophylline Pectinacetylesterase-Notum Alkaloid Natural Purine Not AlphaBeta Hydrolase target
Canadine ACHE BCHE Cholinesterase Natural Alkaloid Derivative of berberine
sEH-inhibitor-19 Epoxide_hydrolase Natural Alkaloid Isoquinoline Trifluoro Urea derivative Derivative of berberine
Thalictricavine ACHE BCHE Cholinesterase Natural Alkaloid Derivative of berberine
N-piperidinopropylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Benzazepin Azepane
N-saccharinohexylgalanthamine ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Sulfur compound Benzazepin Azepane
16-epi-Vellosimine Hydroxynitrile_lyase Alkaloid
Vinblastine Arylacetamide_deacetylase Carb_B_Chordata Alkaloid
Psilocybin ACHE BCHE Organophosphate Natural Alkaloid Indole
Memogain ACHE Carb_B_Chordata Derivative of Galanthamine Alkaloid Benzoate Natural_modified Benzazepin Azepane
Phthalimido-Galanthaminium-4d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Phthalimido-Galanthaminium-8d ACHE Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Galanthaminium ACHE Derivative of Galanthamine Alkaloid Natural_modified Benzazepin Azepane
Peganine ACHE BCHE Not AlphaBeta Hydrolase target beta-carboline Natural Alkaloid Natural_modified
Desoxypeganine ACHE BCHE Not AlphaBeta Hydrolase target beta-carboline Natural Alkaloid Quinazoline
Gramine ACHE BCHE Alkaloid Natural Not AlphaBeta Hydrolase target Indole
Atropine ACHE Not AlphaBeta Hydrolase target Muscarinic antagonist Drug Alkaloid Natural Azabicyclo Propionate
Cocaine BCHE Natural Not AlphaBeta Hydrolase target Drug Alkaloid Benzoate
D-tubocurarine ACHE Natural Alkaloid Neuromuscular Nondepolarizing Agents Not AlphaBeta Hydrolase target Drug Organochlorine
Sanguinine ACHE Derivative of Galanthamine Natural Alkaloid Benzazepin Azepane
Mahanimbine ACHE Natural Alkaloid
Galanthamine ACHE Derivative of Galanthamine Natural Alkaloid Drug Benzazepin Azepane Multitarget Nicotinic agonist Azocine
Bis-galanthamine ACHE Derivative of Galanthamine Alkaloid Alkyl linked bis-ligand Benzazepin Azepane Natural_modified
HuperzineA ACHE Derivative of Huperzine Natural Alkaloid
HuperzineB ACHE Derivative of Huperzine Natural Alkaloid
P11149 BCHE ACHE Adamantyl Derivative of Galanthamine Alkaloid Benzazepin Azepane Natural_modified Organochlorine
Jatrorrhizine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Nicotinic agonist Natural Alkaloid Drug Not AlphaBeta Hydrolase target
Solanidine BCHE Natural Alkaloid Steroid
alpha-Chaconine BCHE Natural Alkaloid Glycoside
Solanine BCHE Natural Alkaloid Carbohydrate Glycoside