Alkaloid

General

Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom, produced by a large variety of organisms including bacteria, fungi, plants, and animals. The boundary between alkaloids and other nitrogen-containing natural compounds is not clear-cut.

Inhibitor	Main targeted enzyme families	Type
Verbascoside	S9N_PPCE_Peptidase_S9	Natural Hydroxycinnamic-ester Alkaloid Glycoside
Galantamine-benzylpyridine-C2	ACHE BCHE	Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Pyridine Benzazepin Azepane
Tabersonine	Plant_carboxylesterase	Indole Alkaloid Natural
Catharanthine	Plant_carboxylesterase	Indole Alkaloid Natural
(S)Aporphine-N-benzylpyridinium	ACHE	Isoquinoline Pyridine Alkaloid
O-Methyl-Dauracine	DPP4N_Peptidase_S9	Alkaloid Natural Quinoline
Carltonine-A	BCHE	Alkaloid Natural
Carltonine-B	BCHE	Alkaloid Natural
XB8-8CGO	BCHE	Alkaloid Natural_modified
Cinchonidine	BCHE	Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo
Cinchonine	BCHE	Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo
CD-Bzl	BCHE	Alkaloid Derivative of Cinchonine Quinoline Natural_modified
Cotinine	Pectinacetylesterase-Notum	Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not AlphaBeta Hydrolase target
Emetine	Hydrolase_RBBP9_YdeN	Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
Chelerythrine	ACHE	Natural Alkaloid Not AlphaBeta Hydrolase target Benzodioxo Phenanthridinium
Sanguinarine	ACHE	Natural Alkaloid Not AlphaBeta Hydrolase target Benzodioxo Phenanthridinium
Palmatine	ACHE	Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline
Berberine	ACHE BCHE	Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Benzodioxo Antioxidant
8-Hydroxydihydrochelerythrine	ACHE	Alkaloid Benzodioxo Phenanthridinium
Harmine		Natural Alkaloid Indole beta-carboline Not AlphaBeta Hydrolase target
Caffeine	Pectinacetylesterase-Notum Lipase_3	Purine Alkaloid Natural Drug Not AlphaBeta Hydrolase target
18-carboxymethoxy-cleaviminium	Plant_carboxylesterase	Natural Alkaloid
Theophylline	Pectinacetylesterase-Notum	Alkaloid Natural Purine Not AlphaBeta Hydrolase target
Canadine	ACHE BCHE Cholinesterase	Natural Alkaloid
Thalictricavine	ACHE BCHE Cholinesterase	Natural Alkaloid
N-piperidinopropylgalanthamine	ACHE	Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Benzazepin Azepane
N-saccharinohexylgalanthamine	ACHE	Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Sulfur Compound Benzazepin Azepane
16-epi-Vellosimine	Hydroxynitrile_lyase	Alkaloid
Vinblastine	Arylacetamide_deacetylase Carb_B_Chordata	Alkaloid
Psilocybin	ACHE BCHE	Organophosphate Natural Alkaloid Indole
Memogain	ACHE Carb_B_Chordata	Derivative of Galanthamine Alkaloid Benzoate Natural_modified Benzazepin Azepane
Phthalimido-Galanthaminium-4d	ACHE	Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Phthalimido Benzazepin Azepane
Phthalimido-Galanthaminium-8d	ACHE	Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepane
Galanthaminium	ACHE	Derivative of Galanthamine Alkaloid Natural_modified Benzazepin Azepane
Peganine	ACHE BCHE	Not AlphaBeta Hydrolase target Alkaloid Natural_modified
Desoxypeganine	ACHE BCHE	Not AlphaBeta Hydrolase target Alkaloid Natural Quinazoline
Gramine	ACHE BCHE	Alkaloid Natural Not AlphaBeta Hydrolase target Indole
Atropine	ACHE	Not AlphaBeta Hydrolase target Muscarinic antagonist Drug Alkaloid Natural Azabicyclo Propionate
Cocaine	BCHE	Natural Not AlphaBeta Hydrolase target Drug Alkaloid Benzoate
D-tubocurarine	ACHE	Natural Alkaloid Neuromuscular Nondepolarizing Agents Not AlphaBeta Hydrolase target Drug
Sanguinine	ACHE	Derivative of Galanthamine Natural Alkaloid Benzazepin Azepane
Mahanimbine	ACHE	Natural Alkaloid
Galanthamine	ACHE	Derivative of Galanthamine Natural Alkaloid Drug Benzazepin Azepane Multitarget Nicotinic agonist
Bis-galanthamine	ACHE	Derivative of Galanthamine Alkaloid Alkyl linked bis-ligand Benzazepin Azepane Natural_modified
HuperzineA	ACHE	Derivative of Huperzine Natural Alkaloid
HuperzineB	ACHE	Derivative of Huperzine Natural Alkaloid
P11149	BCHE ACHE	Adamantyl Derivative of Galanthamine Alkaloid Benzazepin Azepane Natural_modified
Jatrorrhizine		Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline
Nicotine	ACHE BCHE Pectinacetylesterase-Notum	Derivative of Nicotine Pyrrolidine Nicotinic agonist Natural Alkaloid Drug Not AlphaBeta Hydrolase target
Solanidine	BCHE	Natural Alkaloid Steroid
alpha-Chaconine	BCHE	Natural Alkaloid Glycoside
Solanine	BCHE	Natural Alkaloid Carbohydrate Glycoside