Alkaloid

General

Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom, produced by a large variety of organisms including bacteria, fungi, plants, and animals. The boundary between alkaloids and other nitrogen-containing natural compounds is not clear-cut.

Inhibitor	Main targeted enzyme familyes	Type
D-tubocurarine	ACHE	Natural Alkaloid Neuromuscular Nondepolarizing Agents Not A\/B H target Drug
Cocaine	BCHE	Natural Not A\/B H target Drug Alkaloid Benzoate
HuperzineA	ACHE	Derivative of Huperzine Natural Alkaloid
Solanine	BCHE	Natural Alkaloid Carbohydrate Glycoside
Tabersonine	Plant_carboxylesterase	Indole Alkaloid Natural
Catharanthine	Plant_carboxylesterase	Indole Alkaloid Natural
(S)Aporphine-N-benzylpyridinium		Isoquinoline Alkaloid
O-Methyl-Dauracine	DPP4N_Peptidase_S9	Alkaloid Natural Quinoline
Carltonine-A	BCHE	Alkaloid Natural
Carltonine-B	BCHE	Alkaloid Natural
XB8-8CGO	BCHE	Alkaloid Natural_modified
Cinchonidine	BCHE	Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo
Cinchonine	BCHE	Natural Alkaloid Derivative of Cinchonine Quinoline Azabicyclo
CD-Bzl	BCHE	Alkaloid Derivative of Cinchonine Quinoline Natural_modified
Cotinine	Pectinacetylesterase-Notum	Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not A\/B H target
Emetine	Hydrolase_RBBP9_YdeN	Natural Alkaloid Drug Isoquinoline Quinoline
Chelerythrine	ACHE	Natural Alkaloid Not A\/B H target Benzodioxo Phenanthridinium
Sanguinarine		Natural Alkaloid Not A\/B H target Benzodioxo Phenanthridinium
Palmatine		Natural Alkaloid Not A\/B H target Isoquinoline
Berberine	ACHE BCHE	Natural Alkaloid Not A\/B H target Isoquinoline Benzodioxo
8-Hydroxydihydrochelerythrine	ACHE	Alkaloid Benzodioxo Phenanthridinium
Harmine		Natural Alkaloid Indole beta-carboline Not A\/B H target
Caffeine	Pectinacetylesterase-Notum Lipase_3	Purine Alkaloid Natural Drug Not A\/B H target
18-carboxymethoxy-cleaviminium	Plant_carboxylesterase	Natural Alkaloid
Theophylline	Pectinacetylesterase-Notum	Alkaloid Natural Purine Not A\/B H target
Canadine	ACHE BCHE Cholinesterase	Natural Alkaloid
Thalictricavine	ACHE BCHE Cholinesterase	Natural Alkaloid
N-piperidinopropylgalanthamine	ACHE	Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Piperidine Benzazepin Azepine
N-saccharinohexylgalanthamine	ACHE	Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Sulfur Compound
16-epi-Vellosimine	Hydroxynitrile_lyase	Alkaloid
Vinblastine	Arylacetamide_deacetylase Carb_B_Chordata	Alkaloid
Psilocybin	ACHE BCHE	Organophosphate Natural Alkaloid Indole
Memogain	ACHE Carb_B_Chordata	Derivative of Galanthamine Alkaloid Benzoate Natural_modified Benzazepin Azepine
Phthalimido-Galanthaminium-4d	ACHE	Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Phthalimido Benzazepin Azepine
Phthalimido-Galanthaminium-8d	ACHE	Derivative of Galanthamine Alkaloid Natural_modified Alkyl linked bis-ligand Isoindole Indole Phthalimido Benzazepin Azepine
Galanthaminium	ACHE	Derivative of Galanthamine Alkaloid Natural_modified Benzazepin Azepine
Peganine	ACHE BCHE	Not A\/B H target Alkaloid Natural_modified
Desoxypeganine	ACHE BCHE	Not A\/B H target Alkaloid Natural Quinazoline
Gramine	ACHE BCHE	Alkaloid Natural Not A\/B H target Indole
Atropine	ACHE	Not A\/B H target Muscarinic antagonist Drug Alkaloid Natural Azabicyclo Propionate
Sanguinine	ACHE	Derivative of Galanthamine Natural Alkaloid
Mahanimbine		Natural Alkaloid
Galanthamine	ACHE	Derivative of Galanthamine Natural Alkaloid Drug Benzazepin Azepine
Bis-galanthamine	ACHE	Derivative of Galanthamine Alkaloid Alkyl linked bis-ligand Benzazepin Azepine Natural_modified
HuperzineB	ACHE	Derivative of Huperzine Natural Alkaloid
P11149		Adamantane Derivative of Galanthamine Alkaloid Benzazepin Azepine Natural_modified
Jatrorrhizine		Natural Alkaloid Not AB H target Isoquinoline
Nicotine	ACHE BCHE Pectinacetylesterase-Notum	Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not A\/B H target
Solanidine	BCHE	Natural Alkaloid Steroid
alpha-Chaconine	BCHE	Natural Alkaloid Glycoside