Hydroxyphenyl-methyl-dimethylaminomethyl-triazole-thione-Cpd5b
AChE IC50 0.136 +/- 0.006 microM; Ki 0.149 microM and MAO-B IC50 0.108 +/- 0.005 microM Ki 0.052 microM
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Triazol, Sulfur Compound
Chemical_Nomenclature : 5-(4-Hydroxyphenyl)-4-methyl-2-(dimethylaminomethyl)-3H-1,2,4-triazole-3-thione
Canonical SMILES : C1(=CC=C(C=C1)O)C2=NN(C(N2C)=S)CN(C)C
InChI : InChI=1S\/C12H16N4OS\/c1-14(2)8-16-12(18)15(3)11(13-16)9-4-6-10(17)7-5-9\/h4-7,17H,8H2,1-3H3
InChIKey : LSVBGHQEOATYAA-UHFFFAOYSA-N
Other name(s) : Compound 5b || 1-[(Dimethylamino)methyl]-3-(p-hydroxyphenyl)-4-methyl-1,4-dihydro-5H-1,2,4-triazole-5-thione
Target
Families : Hydroxyphenyl-methyl-dimethylaminomethyl-triazole-thione-Cpd5b ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Structure-Guided Optimization of 1,2,4-Triazole-Thione-Based Mannich Derivatives as Dual-Target Modulators: AChE\/MAO-B - Sellitepe_2026_Chem.Biol.Drug.Des_108_e70347 |
| Author(s) : Sellitepe HE , Aksel AB , Zivali H , Pehlivanlar Yavrucu E , Saglik Ozkan BN , Dogan I S , Ozcan Kosif K |
| Ref : Chemical Biology Drug Des , 108 :e70347 , 2026 |
| Abstract : |
| PubMedSearch : Sellitepe_2026_Chem.Biol.Drug.Des_108_e70347 |
| PubMedID: 42444499 |