Multitarget

General

Multitarget directed ligand (MTDL). In case of Alzheimer disease enzymes or pathways targeted include: Inhibition of AChE and or BCHE, Inhibition of glycogen synthase kinase-3 (GSK-3 kinase), BACE1-inhibitor (beta-secretase-1), antioxidant, Cannabinoid-Receptor-ligand, Sigma1R, Histamine-Receptor3-H3-Antagonist, H1-antihistamine, 5-HT-receptor-agonist, NMDA-ligand, Ca2+ channels block, Abeta aggregation, Metal ion chelator. Inhibition of multiple enzymes of the arachidonic acid cascade leads to synergistic anti-inflammatory effects. The targets include in these cases soluble epoxide hydrolase (sEH), 5-lipoxygenase (5-LOX), LTA4-hydrolase-inhibitor, dual sEH\/FAAH
Inhibitor Main targeted enzyme familyes Type Structure
MR33317 ACHE Multitarget 5-HT-receptor-ligand Piperidine
AP2238 Multitarget Coumarin anti-Abeta-aggregation Chromen
VN-19 Monoamine-oxidase-inhibitor Multitarget Pyrrolidine Chromen
ChEs-MAOs-IN-1 Monoamine-oxidase-inhibitor Multitarget Benzodioxo Carboxamide
JW8 Multitarget BACE1-inhibitor Benzamide
Hydrazide-Hydrazone-Cpd12 Carbonic anhydrase inhibitor Multitarget Derivative of Nicotine Benzoate Naphthalen
Biphenyl-oxo-triazine-S-12 Multitarget Triazine
Biphenyl-oxo-triazine-piperazine-cpd6g Piperazine Multitarget Triazine
Phenyl-phenylpyridin-oxadiazol-cpd5a Oxadiazol Multitarget Pyridine
Embelin Multitarget Not A\/B H target Natural
Cannabidiol-amide-CB7 Cannabinoid-Receptor-ligand Multitarget Carbamate
TAC-PhBTA-Cpd16 Derivative of Tacrine Sulfur Compound Multitarget Benzothiazol
Coumarin-phosphazide-Cpd8b Multitarget Coumarin anti-Abeta-aggregation Chromen
CHEMBL4292235 Multitarget Monoamine-oxidase-inhibitor Chromen
BuChE-IN-TM-10 Feruloyl Hydroxycinnamic-ester Multitarget Isoquinoline Monoamine-oxidase-inhibitor
Tacrine-dehydrozingerone Derivative of Tacrine Multitarget
PyrTac-5f Derivative of Tacrine Multitarget Protein Phosphatase activator Pyridine
6-(4-4-phenethylpiperazin-1-yl)heptyl-THAI-14d Indole Azepine Piperazine Multitarget Alkyl linked bis-ligand
BChE-HDAC6-IN-2 BCHE Multitarget
sEH-HDAC6-IN-M9 Epoxide_hydrolase Multitarget Adamantyl Urea derivative
CHEMBL4177075-INDY Multitarget Benzothiazol Carbamate Quinoline
ADS031 Histamine-Receptor3-H3-Antagonist Multitarget Piperidine Naphthalen
CHEMBL459756 ACHE BCHE Histamine-Receptor3-H3-Antagonist Multitarget Piperidine
FUB833 ACHE BCHE Acridine Derivative of Tacrine Alkyl linked bis-ligand Histamine-Receptor3-H3-Antagonist Multitarget Piperidine
Isosorbide-2-butylcarbamate-5-lipoic-acid-ester BCHE Isosorbide Carbamate Multitarget Antioxidant
Aurone-Donepezil-Cpd5g ACHE Flavonoid Benzofuran Multitarget Derivative of Donepezil
Aurone-Donepezil-Cpd6b Flavonoid Benzofuran Multitarget Derivative of Donepezil
Rivastigmine-Donepezil-COR783 Cannabinoid-Receptor-ligand Derivative of Rivastigmine Multitarget Sulfur Compound Derivative of Donepezil Carbamate Adamantyl
Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k BCHE ACHE Monoamine-oxidase-inhibitor Multitarget Urea derivative Benzothiazol Sulfur Compound Sulfonamide
Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5b BCHE ACHE Multitarget Indole Carboxamide Sulfur Compound Sulfonamide
Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b BCHE ACHE Multitarget Indole Carboxamide Piperidin Derivative of Donepezil Sulfur Compound
Dimethoxy-phenyl-pyrazino-indol-cpd5i Multitarget Indole
Tacrine-Sibiriline-Cpd7 BCHE ACHE Multitarget Acridine Derivative of Tacrine Alkyl linked bis-ligand Pyridine Carbamate Pyrrolidine
Tacrine-selegiline-8g BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand
Tacrine-selegiline-7d BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand
Di-tert-butyl-phenol-octylamino-acridine-17d ACHE Multitarget Acridine Derivative of Tacrine Antioxidant tert-Butyl Alkyl linked bis-ligand
Di-tert-butyl-phenol-octylamino-cycloheptaquinolin-18d BCHE Multitarget Derivative of Tacrine Quinoline Antioxidant tert-Butyl Alkyl linked bis-ligand
7-Methyloxyde-PhO-cpd-I52 Multitarget NMDA-Ligand Derivative of Tacrine
7-PhO-THA Multitarget NMDA-Ligand Derivative of Tacrine
Indole-piperidine-amide-cpd23a ACHE Multitarget Indole Carboxamide Derivative of Donepezil BACE1-inhibitor Piperidine
SB-1448 BCHE ACHE Multitarget Derivative of Donepezil BACE1-inhibitor Piperidine
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget
CHEMBL5206601 ACHE anti-Abeta-aggregation Multitarget Pyridine
Genistein-O-alkylbenzylamine-25d ACHE Multitarget Monoamine-oxidase-inhibitor anti-Abeta-aggregation Chromen
tacrine-isatin-Cpd7k ACHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
tacrine-isatin-Cpd7d BCHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide
Compound19n-quinolinol ACHE Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
ZINC22029744 ACHE BCHE Multitarget Sulfur Compound Derivative of Donepezil BACE1-inhibitor Piperazine Oxadiazol
Melatonin-alkylbenzylamine-Cpd5 BCHE Antioxidant Derivative of Tryptamine Indole Multitarget Alkyl linked bis-ligand
JS0-7ZPB BCHE Quinoline Piperazine Multitarget Monoamine-oxidase-inhibitor
WMY90-5f ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Derivative of Donepezil
DPH6 BCHE ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Derivative of Donepezil
AI6-7QBR BCHE Quinoline Piperazine tert-Butyl Multitarget Monoamine-oxidase-inhibitor
AI0-7QBQ BCHE Quinoline Multitarget Monoamine-oxidase-inhibitor
4c2-AChE-IN-24 ACHE Sulfur Compound Multitarget Piperidine
Dihydroquinazoline-carboxamide-34 Epoxide_hydrolase Carboxamide Multitarget 5-Lipoxygenase inhibitor Sulfur Compound Quinazoline
Dihydroindole-thiourea-73 Epoxide_hydrolase Indole Urea derivative Multitarget 5-Lipoxygenase inhibitor Sulfur Compound
Di-tert-butyl-4-Amino-2,3-cycloheptaquinoline-8c BCHE Quinoline Multitarget Antioxidant tert-Butyl
DFAH-12 BCHE ACHE Piperidine Hydroxycinnamic-ester Multitarget Antioxidant Derivative of Donepezil
ZTL-11 ACHE GSK-3 kinase inhibitor Carboxamide Multitarget Triazol Indole Cyclopropyl beta-carboline
ZLWH-23 ACHE Piperidine GSK-3 kinase inhibitor Carboxamide Multitarget Indole Cyclopropyl beta-carboline
Quinone-polyamine-NSAID-4 BCHE Multitarget 5-Lipoxygenase inhibitor Alkyl linked bis-ligand
Propargyl-Tacrine-15 BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Derivative of Tacrine Alkyne
TFAH-tacrine-ferulic-acid-hybrid-10n BCHE Multitarget Acrylate Antioxidant Derivative of Tacrine Hydroxycinnamic-ester Alkyl linked bis-ligand
Tacrine-dihydropyrimidine-4e ACHE Multitarget Derivative of Tacrine Calcium Channel Antagonist Sulfur Compound Quinoline Pyrimidine
3,5-dihydroxybenzamido-huprine-hybrid-11 BCHE ACHE Multitarget Derivative of Huperzine BACE1-inhibitor Alkyl linked bis-ligand
Donepezil-idebenone-cpd9 BCHE Multitarget Antioxidant anti-Abeta-aggregation Derivative of Donepezil
Phenothiazine-Tacrine-1dC ACHE Phenothiazine Multitarget Derivative of Tacrine Antioxidant Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Sulfur Compound
CHEMBL4442990 BCHE Cannabinoid-Receptor-ligand Benzofuran Multitarget
Diclofenac-derivative-39 ACHE Monoamine-oxidase-inhibitor Multitarget 5-Lipoxygenase inhibitor Sulfur Compound Sulfonamide Pyrazole
Amantadine-M30D-hybrid5e BCHE Monoamine-oxidase-inhibitor Multitarget Carbamate Adamantyl Alkyl linked bis-ligand
M30D ACHE Monoamine-oxidase-inhibitor Multitarget Carbamate Quinoline
JM-20 Benzodiazepin Not A\/B H target Pyridine Multitarget 2-nitrophenyl Azepine
Fluoropezil ACHE Multitarget Derivative of Donepezil Sulfur Compound Antioxidant
2-tolylazo-1,3-aminoenketone-tacrine-7a Multitarget Derivative of Tacrine Alkyl linked bis-ligand Antioxidant
Salicylamide-8-Tacrine ACHE BCHE Multitarget Derivative of Tacrine Alkyl linked bis-ligand Antioxidant Salicylic
3-butyl-6-benzyloxyphthalide-Mannich-base-7d ACHE Monoamine-oxidase-inhibitor Multitarget Piperidine Benzofuran
TPPU-6-Chlorotacrine-12c Epoxide_hydrolase ACHE Multitarget Derivative of Tacrine Trifluoro Piperidine Urea derivative Alkyl linked bis-ligand
7QAK-Cpd1 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen
7QB4-Cpd2 ACHE Monoamine-oxidase-inhibitor Multitarget Coumarin Chromen Derivative of Donepezil
MT-031 ACHE BCHE Monoamine-oxidase-inhibitor Multitarget Carbamate
PTUPB Epoxide_hydrolase Multitarget Trifluoro Urea derivative Sulfur Compound Sulfonamide Pyrazole
FL217 Epoxide_hydrolase Multitarget PPARgamma ligand Cyclopropyl Sulfur Compound Sulfonamide Indole
Tacrine-dipicolylamine-13a ACHE Derivative of Tacrine Alkyl linked bis-ligand Multitarget anti-Abeta-aggregation
8U2-7AIX7AY-compound5i ACHE BCHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8U5-7AIW-compound5g ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UE-7AIV-compound5f ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UQ-7AIU-compound5d ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UK-7AIT-compound5c ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
8UH-7AIS-compound5b ACHE Derivative of Huperzine Quinoline Alkyl linked bis-ligand Multitarget Derivative of Capsaicin Antioxidant
CHEMBL3585776 ACHE Carbamate Sulfur Compound Sulfonamide Carbonic anhydrase inhibitor Multitarget
Cpd14-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Indole Alkyl linked bis-ligand
Cpd17-Tacrine-5-HT6 ACHE BCHE Acridine Derivative of Tacrine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand anti-Abeta-aggregation
Cpd54-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand tert-Butyloxycarbonyl tert-Butyl
Cpd70-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Indole Alkyl linked bis-ligand
Cpd27-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand
Cpd35-Rivastigmine-5-HT6 BCHE Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Carbamate Alkyl linked bis-ligand anti-Abeta-aggregation
TK90 Epoxide_hydrolase Butyrate Carboxamide Trifluoro Multitarget PPARgamma ligand
PE154 ACHE BCHE Derivative of Tacrine Multitarget Hydrazide Coumarin Chromen
Evodiamine BCHE Derivative of Evodiamine Natural beta-carboline Not A\/B H target Multitarget
CHEMBL440526 BCHE ACHE Multitarget Carbamate Coumarin Chromen
ACHE-GSK-3-27g ACHE GSK-3 kinase inhibitor Derivative of Tacrine Multitarget
Cpd37-Fluoroindol-carbamate Monoglyceridelipase_lysophospholip Multitarget Carbamate Indole FAAH inhibitor Alkyl linked bis-ligand
SPB01403 Monoglyceridelipase_lysophospholip Carbamate FAAH inhibitor Multitarget Sulfur Compound
Idalopirdine-rivastigmine BCHE Drug Pro-Drug Carbamate Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand
Tacrine-methylanacardate-cpd5 BCHE Multitarget Derivative of Tacrine Salicylic Alkyl linked bis-ligand Benzoate
6o-5-HT3 BCHE ACHE Multitarget 5-HT-receptor-ligand Derivative of Tacrine Carboxamide Alkyl linked bis-ligand
MTDL-cpd51-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide
MTDL-cpd36-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide tert-Butyl
Ass-IN-10 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl
BIGI-3h ACHE BCHE Multitarget Monoamine-oxidase-inhibitor GSK-3 kinase inhibitor Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil
OWW-6YL4 Epoxide_hydrolase Trifluoro Multitarget 5-Lipoxygenase inhibitor
6ZWE-Cpd3 BCHE ACHE Multitarget Antioxidant Benzodioxo Alkyl linked bis-ligand
6SAM-cpd13 BCHE Multitarget Piperidine Inden Monoamine-oxidase-inhibitor Carbamate
11a-quinoxaline ACHE BCHE Cholinesterase Multitarget Histamine-Receptor3-H3-Antagonist Quinoxaline
18-E100 ACHE BCHE Cholinesterase Multitarget Azepane Histamine-Receptor3-H3-Antagonist
UW-MD-71 ACHE BCHE Cholinesterase Piperidine Quinazoline Multitarget Histamine-Receptor3-H3-Antagonist
Taxifolin ACHE Natural Flavonoid Carbonic anhydrase inhibitor Multitarget Chromen
Methylene-blue-carboline-2 ACHE BCHE Cholinesterase Dye Multitarget Indole Phenothiazine beta-carboline Sulfur Compound
6H12-(R)2 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
6H13-(R)3 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
FG1912 GSK-3 kinase inhibitor Multitarget Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GD29 ACHE GSK-3 kinase inhibitor Multitarget Thiazole Pyridine Piperidine Cyclopropyl Carboxamide Derivative of Donepezil
GT15 ACHE Derivative of Tacrine GSK-3 kinase inhibitor Multitarget Carboxamide Pyridine Thiazole Cyclopropyl
6H14-(S)6 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
sEH-LTA4H-14 Epoxide_hydrolase Urea derivative LTA4-hydrolase-inhibitor Multitarget Sulfur Compound
15d-PGJ2 Epoxide_hydrolase Prostaglandin PPARgamma ligand Multitarget
Donecopride ACHE Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
RS67333 ACHE Multitarget 5-HT-receptor-ligand Piperidine
Phenolic-deriv-Donecopride-4 Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Phenolic-deriv-Donecopride-20 Carbamate Multitarget 5-HT-receptor-ligand Derivative of Donepezil Piperidine
Sigma1R-ACHE-6a ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R Indole Derivative of Donepezil
Sigma1R-ACHE-6b ACHE Multitarget 5-HT-receptor-ligand Piperidine Sigma1R Indole Derivative of Donepezil
6F7Q-cpd11 BCHE Multitarget Antioxidant Piperidine Quinoline Metal ion chelator Inden Carboxamide
Chlorotacrine-tryptophan-hybrid ACHE BCHE Derivative of Tacrine Multitarget Indole anti-Abeta-aggregation Alkyl linked bis-ligand
BIA-10-2474 Carb_B_Chordata ABHD6-Lip Pyridine Imidazole FAAH inhibitor Multitarget Carboxamide
Memoquin ACHE Multitarget BACE1-inhibitor Antioxidant Alkyl linked bis-ligand
Lipocrine ACHE Multitarget Derivative of Tacrine Antioxidant Sulfur Compound Alkyl linked bis-ligand
PGN33 BCHE Multitarget Cannabinoid-Receptor-ligand
Donepezil-8-Hydroxyquinoline-2b BCHE Quinoline Multitarget Antioxidant Derivative of Donepezil
QTC-4-MeOBnE ACHE Multitarget BACE1-inhibitor Triazol Derivative of Tacrine
Memagal ACHE Multitarget Derivative of Galanthamine NMDA-Ligand Alkyl linked bis-ligand Benzazepin Azepine
Carbacrine BCHE ACHE Alkyl linked bis-ligand Multitarget Derivative of Tacrine NMDA-Ligand
ARN14140-doubleboundlink ACHE Adamantyl Alkyl linked bis-ligand Multitarget Derivative of Galanthamine NMDA-Ligand Azepine
ARN14140 ACHE Adamantyl Multitarget Derivative of Galanthamine NMDA-Ligand Alkyl linked bis-ligand
benzohomoadamantane-chlorotacrine-18a ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine
benzohomoadamantane-chlorotacrine-18b BCHE ACHE Multitarget NMDA-Ligand Adamantyl Derivative of Tacrine Alkyl linked bis-ligand
triazole-aryl-adamantane-Cpd32 ACHE Multitarget NMDA-Ligand Adamantyl Triazol
7-methoxytacrine-memantine-Cpd4 ACHE Multitarget NMDA-Ligand Adamantyl Urea derivative Alkyl linked bis-ligand Sulfur Compound Derivative of Tacrine
NMDA-BCHE-C-2h BCHE Multitarget NMDA-Ligand Carbazol Adamantyl
Tacrine-Resveratrol-12 ACHE Multitarget Antioxidant Derivative of Tacrine
Tacrine-Trolox-7u ACHE Multitarget Antioxidant Derivative of Tacrine Carboxamide Alkyl linked bis-ligand Chromen
CB1R-ACHE-20 ACHE Multitarget Cannabinoid-Receptor-ligand Derivative of Tacrine Imidazole Carboxamide Alkyl linked bis-ligand
CB2R-BCHE-x BCHE Multitarget Cannabinoid-Receptor-ligand Piperidine Imidazole Carboxamide
CB2R-BCHE-20a BCHE Multitarget Cannabinoid-Receptor-ligand Piperidine Imidazole Carboxamide
Contilisant ACHE BCHE Multitarget Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor Piperidine Indole
ASS234 ACHE Multitarget Monoamine-oxidase-inhibitor Alkyl linked bis-ligand Piperidine Indole
Mebbpp ACHE Derivative of Donepezil Multitarget Sulfur Compound Piperidine
Donepezil-Melatonin-4u ACHE Derivative of Donepezil Derivative of Tryptamine Indole Alkyl linked bis-ligand Multitarget Antioxidant
Tacrine-Melatonin-Feruloyl-5c BCHE Derivative of Tacrine Derivative of Tryptamine Indole Multitarget Feruloyl Acrylate Antioxidant Hydroxycinnamic-ester Alkyl linked bis-ligand
SCHEMBL19358888 Epoxide_hydrolase Urea derivative Benzoate FAAH inhibitor Multitarget
t-AUCMB Epoxide_hydrolase Urea derivative Multitarget Adamantyl
t-MTUCB-NH Epoxide_hydrolase Urea derivative Multitarget
t-MTUCB Epoxide_hydrolase Urea derivative Multitarget
t-TUCB Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor
Methylene-blue ACHE BCHE Dye Drug Phenothiazine anti-tau-aggregation Multitarget Sulfur Compound
JZL195 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperazine FAAH inhibitor Multitarget pNP Phenoxyphenyl
JZL184 Monoglyceridelipase_lysophospholip Carb_B_Chordata ABHD6-Lip Piperidine Benzodioxo FAAH inhibitor Multitarget pNP
AM6701 ABHD6-Lip Monoglyceridelipase_lysophospholip Biphenyl Urea derivative Cannabinoid-Receptor-ligand FAAH inhibitor Multitarget Carboxamide Tetrazol
40V BCHE Piperidine Quinoline Multitarget Carboxamide Metal ion chelator Inden
Methyl-arachidonyl-fluorophosphonate CGI-58_ABHD5_ABHD4 PC-sterol_acyltransferase Monoglyceridelipase_lysophospholip Cannabinoid-Receptor-ligand Organophosphate FAAH inhibitor Multitarget
Ladostigil ACHE BCHE Monoamine-oxidase-inhibitor Multitarget Carbamate Drug Inden
Pyridophen-10 ACHE Muscarinic antagonist Propionate Carbamate Pro-Drug Multitarget Not A\/B H target PET probe
Dimethylhydroxycarbaphen BCHE Muscarinic antagonist Propionate Carbamate Pro-Drug Multitarget Not A\/B H target
Tacrine-Benzofuran ACHE Multitarget BACE1-inhibitor Derivative of Tacrine Acridine Alkyl linked bis-ligand Benzofuran
Quinolinetrione-tacrine-Cpd3 ACHE Quinoline Multitarget Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation
Chlorotacrine-juglone ACHE Multitarget Antioxidant Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Naphthalen
Chlorpromazine ACHE BCHE Not A\/B H target Phenothiazine Multitarget Drug Sulfur Compound
IDFP PC-sterol_acyltransferase Monoglyceridelipase_lysophospholip Organophosphate FAAH inhibitor Multitarget
IDFPen PC-sterol_acyltransferase Organophosphate Multitarget FAAH inhibitor
hAChE-IN-6 Pyridine Pyrazole GSK-3 kinase inhibitor Multitarget
Phenothiazine ACHE Phenothiazine Not A\/B H target Multitarget Drug Sulfur Compound
LY2183240 Monoglyceridelipase_lysophospholip Arylacetamide_deacetylase ABHD6-Lip Cannabinoid-Receptor-ligand Biphenyl Urea derivative FAAH inhibitor Multitarget Carboxamide Tetrazol
URB597 Monoglyceridelipase_lysophospholip Carbamate Biphenyl FAAH inhibitor Multitarget