IMS-48
ACHE IC50 IMS48 0.31 +/- 0.04; BCHE 1.85 +/- 0.05
General
Type : Benzimidazole
Chemical_Nomenclature :
Canonical SMILES : C1=CC=C2C(=C1)[N](C=[N+]2CC(NC3=CC(=CC=C3)Cl)=O)CC4=CC=CC=C4.[Cl-]
InChI : InChI=1S\/C22H18ClN3O.ClH\/c23-18-9-6-10-19(13-18)24-22(27)15-26-16-25(14-17-7-2-1-3-8-17)20-11-4-5-12-21(20)26\;\/h1-13,16H,14-15H2\;1H
InChIKey : OXIJDPITXKSSLU-UHFFFAOYSA-N
Other name(s) :
Target
Families : IMS-48 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Discovery of a novel IMS48 as a dual inhibitor of acetylcholinesterase and butyrylcholinesterase: In vitro and in vivo study for Alzheimer Therapy - Munir_2026_Neuropharmacol__110856 |
| Author(s) : Munir S , Chaudhary Z , Khan IA , Ahmad M , Khurshid M , Ashfaq UA |
| Ref : Neuropharmacology , :110856 , 2026 |
| Abstract : |
| PubMedSearch : Munir_2026_Neuropharmacol__110856 |
| PubMedID: 41628818 |