Oroxylin-A
It has a role as an antineoplastic agent and an EC 1.14.13.39 (nitric oxide synthase) inhibitor. Natural product found in Scutellaria likiangensis
General
Type : Natural, Flavonoid, Chromen
Chemical_Nomenclature : 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
Canonical SMILES : COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=CC=C3)O
InChI : InChI=1S\/C16H12O5\/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9\/h2-8,18-19H,1H3
InChIKey : LKOJGSWUMISDOF-UHFFFAOYSA-N
Other name(s) : Oroxylin A || Oroxylin || 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one || 5,7-dihydroxy-6-methoxyflavone
MW : 284.26
Formula : C16H12O5
CAS_number : 480-11-5
PubChem : 5320315
UniChem : LKOJGSWUMISDOF-UHFFFAOYSA-N
Target
Families : Oroxylin-A ligand of proteins in family
Carb_B_Chordata
References (4)
| Title : Elucidation of Carboxylesterase Mediated Pharmacokinetic Interactions between Irinotecan and Oroxylin A in Rats via Physiologically Based Pharmacokinetic Modeling - Zhang_2023_Pharm.Res__ |
| Author(s) : Zhang J , Zhang Y , Lai YS , Song Q , Xiao M , Ji X , Yan X , Zuo Z |
| Ref : Pharm Res , : , 2023 |
| Abstract : |
| PubMedSearch : Zhang_2023_Pharm.Res__ |
| PubMedID: 37667147 |
| Title : Biotransformation to synthesize the methylated derivatives of baicalein using engineered Escherichia coli - Zhang_2023_Bioprocess.Biosyst.Eng_46_735 |
| Author(s) : Zhang X , Zhang H , Shen T , Pei J , Zhao L |
| Ref : Bioprocess Biosyst Eng , 46 :735 , 2023 |
| Abstract : |
| PubMedSearch : Zhang_2023_Bioprocess.Biosyst.Eng_46_735 |
| PubMedID: 36932217 |
| Title : Inhibition of Radix Scutellariae flavones on carboxylesterase mediated activations of prodrugs - Zhang_2022_Life.Sci_305_120743 |
| Author(s) : Zhang J , Xiao M , Ji X , Lai YS , Song Q , Zhang Y , Ip CM , Ng WL , Zuo Z |
| Ref : Life Sciences , 305 :120743 , 2022 |
| Abstract : |
| PubMedSearch : Zhang_2022_Life.Sci_305_120743 |
| PubMedID: 35780840 |
| Title : An efficient strategy based on two-stage chromatography and in vitro evaluation for rapid screening and isolation of acetylcholinesterase inhibitors from Scutellaria baicalensis Georgi - Hou_2022_J.Sep.Sci__ |
| Author(s) : Hou W , Liu C , Li S , Zhang Y , Jin Y , Li X , Liu Z , Niu H , Xia J |
| Ref : J Sep Sci , : , 2022 |
| Abstract : |
| PubMedSearch : Hou_2022_J.Sep.Sci__ |
| PubMedID: 34990521 |