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Oroxylin-A

It has a role as an antineoplastic agent and an EC 1.14.13.39 (nitric oxide synthase) inhibitor. Natural product found in Scutellaria likiangensis

General

Type : Natural, Flavonoid

Chemical_Nomenclature : 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one

Canonical SMILES : COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=CC=C3)O

InChI : InChI=1S\/C16H12O5\/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9\/h2-8,18-19H,1H3

InChIKey : LKOJGSWUMISDOF-UHFFFAOYSA-N

Other name(s) : Oroxylin A, Oroxylin, 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one, 5,7-dihydroxy-6-methoxyflavone

MW : 284.26

Formula : C16H12O5

CAS_number : 480-11-5

PubChem : 5320315

UniChem : LKOJGSWUMISDOF-UHFFFAOYSA-N

Target

Families : Oroxylin-A ligand of proteins in family
Carb_B_Chordata

References (4)

Title : Elucidation of Carboxylesterase Mediated Pharmacokinetic Interactions between Irinotecan and Oroxylin A in Rats via Physiologically Based Pharmacokinetic Modeling - Zhang_2023_Pharm.Res__
Author(s) : Zhang J , Zhang Y , Lai YS , Song Q , Xiao M , Ji X , Yan X , Zuo Z
Ref : Pharm Res , : , 2023
PubMedID: 37667147

Title : Biotransformation to synthesize the methylated derivatives of baicalein using engineered Escherichia coli - Zhang_2023_Bioprocess.Biosyst.Eng_46_735
Author(s) : Zhang X , Zhang H , Shen T , Pei J , Zhao L
Ref : Bioprocess Biosyst Eng , 46 :735 , 2023
PubMedID: 36932217

Title : Inhibition of Radix Scutellariae flavones on carboxylesterase mediated activations of prodrugs - Zhang_2022_Life.Sci_305_120743
Author(s) : Zhang J , Xiao M , Ji X , Lai YS , Song Q , Zhang Y , Ip CM , Ng WL , Zuo Z
Ref : Life Sciences , 305 :120743 , 2022
PubMedID: 35780840

Title : An efficient strategy based on two-stage chromatography and in vitro evaluation for rapid screening and isolation of acetylcholinesterase inhibitors from Scutellaria baicalensis Georgi - Hou_2022_J.Sep.Sci__
Author(s) : Hou W , Liu C , Li S , Zhang Y , Jin Y , Li X , Liu Z , Niu H , Xia J
Ref : J Sep Sci , : , 2022
PubMedID: 34990521