product of hydrolysis of GPI anchor. Portion of the GPI anchor. GPI, lipid anchor that binds a variety of proteins via the C-terminus to a phosphoethanolamine unit at the end of a complex glycosyl moiety. The phospholipid part is embedded in the membrane of the cell.. GPIs have a common pentasaccharide core structure 6-O-NEtP-ManAlpha1-2-ManAlpha1-6-ManAlpha1-4-GlcNAlpha1-6-Ino-1-P. Additional phosphorylations, glycosylations, or acylations at the 2-O position of the myo-inositol occur in a cell-type dependent manner. GPIs are heterogeneous in the glycan as well as the lipid part. Inositol can bear sn-1-alkyl-2-acylglycerol, sn-1,2-diacylglycerol, or ceramide adorned with lipid chains of different lengths and degrees of saturation.
Type : Phospholipid
Chemical_Nomenclature : (2S)-2-amino-3-[[(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropoxy]-hydroxyphosphoryl]oxypropanoic acid
Canonical SMILES : CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC(C(=O)O)N)OC(=O)CCCCCCCC=CCCCCCCCC
InChI : InChI=1S\/C40H76NO10P\/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-39(43)51-36(34-49-52(46,47)50-35-37(41)40(44)45)33-48-38(42)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2\/h17-18,36-37H,3-16,19-35,41H2,1-2H3,(H,44,45)(H,46,47)\/b18-17-\/t36-,37+\/m1\/s1
InChIKey : OIWCYIUQAVBPGV-DAQGAKHBSA-N
Other name(s) : D39 || 16:0-18:1 PS (Pops) || 1-Palmitoyl-2-oleoylphosphatidylserine || 1-palmitoyl-2-oleoylglycero-3-phosphoserine || 1-Palmitoyl-2-oleoyl-glycero-3-phosphoserine || PS(16:0\/18:1(9Z)) || PS(16:0\/18:1) || Palmitoyloleoyl-gps || SCHEMBL234216 || CHEBI:34086
Title : Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis - Hong_2024_Nat.Commun_15_8 |
Author(s) : Hong J , Li T , Chao Y , Xu Y , Zhu Z , Zhou Z , Gu W , Qu Q , Li D |
Ref : Nat Commun , 15 :8 , 2024 |
Abstract : |
PubMedSearch : Hong_2024_Nat.Commun_15_8 |
PubMedID: 38167496 |
Gene_locus related to this paper: chatd-g0s652 , human-PGAP1 |