Tetraethylpyrophosphate
First synthetized organophosphate cholinesterase inhibitor (tetraethyl pyrophosphate, TEPP) by Philippe de Clermont and Wladimir P. Moshin. Willy Lange,in Berlin prepared sodium monofluorophosphate in 1929. Attempts to isolate the free monofluophosphoric acid led to the preparation of some of its esters, in 1932, with one of his graduate students, Gerda von Krueger. They recognized the toxicity of these esters. Insecticide
General
Type : Organophosphate
Chemical_Nomenclature : diethoxyphosphoryl diethyl phosphate
Canonical SMILES : CCOP(=O)(OCC)OP(=O)(OCC)OCC
InChI : InChI=1S\/C8H20O7P2\/c1-5-11-16(9,12-6-2)15-17(10,13-7-3)14-8-4\/h5-8H2,1-4H3
InChIKey : IDCBOTIENDVCBQ-UHFFFAOYSA-N
Other name(s) : Diphosphoric acid tetraethyl ester, TEPP, Nifos T, Vapatone, Killax, Tetron, Moropal, Hepthexamite, Tetrastigmine, Mortopal, Lirohex
MW : 290.19
Formula : C8H20O7P2
CAS_number : 107-49-3
PubChem : 7873
UniChem : IDCBOTIENDVCBQ-UHFFFAOYSA-N
References (4)
| Title : Synthesis of tetraethyl pyrophosphate (TEPP): from physician Abbot and pharmacist Riegel to chemist Nylen - Petroianu_2015_Pharmazie_70_427 |
| Author(s) : Petroianu GA |
| Ref : Pharmazie , 70 :427 , 2015 |
| PubMedID: 26189307 |
| Title : Toxicity of phosphor esters: Willy Lange (1900-1976) and Gerda von Krueger (1907-after 1970) - Petroianu_2010_Pharmazie_65_776 |
| Author(s) : Petroianu GA |
| Ref : Pharmazie , 65 :776 , 2010 |
| PubMedID: 21105582 |
| Title : The history of cholinesterase inhibitors: who was Moschnin(e)? - Petroianu_2008_Pharmazie_63_325 |
| Author(s) : Petroianu GA |
| Ref : Pharmazie , 63 :325 , 2008 |
| PubMedID: 18468398 |
| Title : Note sur la preparation de quelques ethers - |
| Author(s) : De Clermont P |
| Ref : Comptes Rendus de l Academie des Sciences , 39 :338 , 1854 |
| PubMedID: |