Topiramate-phenolicacid-cpdT4
T4 competitively inhibited pancreatic lipase human-PNLIP with IC50 value of 8.96 M || Derivative of Topiramate. Topiramate is a hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine
General
Type : Not AlphaBeta Hydrolase target, Sulfur Compound
Chemical_Nomenclature : (2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4,5-d]pyran-3a-yl)methyl (3-(4-hydroxy-3-methoxyphenyl)acryloyl)sulfamate
Canonical SMILES : [S](NC(C=CC1=CC(=C(C=C1)O)OC)=O)(OCC24C(C3C(CO2)OC(O3)(C)C)OC(O4)(C)C)(=O)=O
InChI : InChI=1S\/C22H29NO11S\/c1-20(2)31-16-11-29-22(19(18(16)32-20)33-21(3,4)34-22)12-30-35(26,27)23-17(25)9-7-13-6-8-14(24)15(10-13)28-5\/h6-10,16,18-19,24H,11-12H2,1-5H3,(H,23,25)
InChIKey : NXMCHFFRHHBQCF-UHFFFAOYSA-N
Other name(s) : Compound T4
Target
Families : Topiramate-phenolicacid-cpdT4 ligand of proteins in family
Pancreatic_lipase
Protein :
human-PNLIP
References (1)
| Title : Antilipase and antioxidant activities of topiramate-phenolic acid conjugates: Computational modelling, synthesis, and in-vitro investigations - Padhy_2024_Biochem.Biophys.Res.Commun_745_151200 |
| Author(s) : Padhy I , Banerjee B , Sharma T , Achary PGR , Singh N , Chandra A |
| Ref : Biochemical & Biophysical Research Communications , 745 :151200 , 2024 |
| Abstract : |
| PubMedSearch : Padhy_2024_Biochem.Biophys.Res.Commun_745_151200 |
| PubMedID: 39729676 |
| Gene_locus related to this paper: human-PNLIP |