Pancreatic_lipase

Relationship

Family: Pancreatic_lipase

Block: L

Parent Family: No family

Comment

Pancreatic, hepatic and gastric/lingual lipase are closely related to each other and to lipoprotein lipase (EC: 3.1.1.34), which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL). Pancreatic lipase (triacylglycerol acylhydrolase, EC: 3.1.1.3) plays a key role in dietary fat absorption by hydrolysing dietary long chain triacyl-glycerol to free fatty acids and monoacylglycerols in the intestinal lumen. The activity of lipase is stimulated by colipase in the presence of bile acids. Congenital pancreatic lipase deficiency is a rare, monoenzymatic form of exocrine pancreatic failure. Patients have oily/greasy stools from infancy or early childhood and the absence of discernable pancreatic disease. The pancreatic lipase-related protein show no significant catalytic activity on any of the substrates tested di and tri-glycerides phospholipids. Introducing the double mutation Val 178 Ala and Ala 180 Pro into the human pancreatic RP1 HPLRP1 gene yielded an enzyme is kinetically active on triglycerides. The guinea pig pancreatic lipase-related protein 2 (GPLRP2) differs from classical pancreatic lipases in that it displays both lipase and phospholipase A1 activities; classical pancreatic lipases have no phospholipase activity. human-PNLIPRP2 adopt in solution an open lid conformation which creates a large cavity capable of accommodating the galactose polar head of galactolipids (galactolipase)

Database

Interpro : IPR000734 Lipase , IPR002331 Pancreatic lipase , IPR016272 Lipase, LIPH-type , IPR013818 Lipase

PIRSF : PIRSF000865 lipoprotein lipase, LIPH type

Pdoc : PDOC00110

Pfam : PF00151 Lipase

Prints : PR00821 , PR00823

EC Number : 3.1.1.3

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (12)

Genes Proteins in Pancreatic_lipase family (488)

Fragments of genes in Pancreatic_lipase family (103)

Structures in Pancreatic_lipase family (12)

Substrates in Pancreatic_lipase family (18)

Inhibitors in Pancreatic_lipase family (16)

References (14)

Title : Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes - Tang_2022_Front.Genet_13_909091
Author(s) : Tang SL , Liang XF , He S , Li L , Alam MS , Wu J
Ref : Front Genet , 13 :909091 , 2022
PubMedID: 35991544

Title : Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States - Zhu_2021_Front.Genet_12_693538
Author(s) : Zhu G , Fang Q , Zhu F , Huang D , Yang C
Ref : Front Genet , 12 :693538 , 2021
PubMedID: 34290745
Gene_locus related to this paper: human-PNLIPRP2

Title : Pancreatic lipase inhibitors: The road voyaged and successes - Kumar_2021_Life.Sci__119115
Author(s) : Kumar A , Chauhan S
Ref : Life Sciences , :119115 , 2021
PubMedID: 33515565

Title : The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2) - Xiao_2015_J.Biol.Chem_290_28847
Author(s) : Xiao X , Lowe ME
Ref : Journal of Biological Chemistry , 290 :28847 , 2015
PubMedID: 26494624
Gene_locus related to this paper: human-PNLIP , human-PNLIPRP2

Title : Inhibition of phospholipase A1, lipase and galactolipase activities of pancreatic lipase-related protein 2 by methyl arachidonyl fluorophosphonate (MAFP) - Amara_2012_Biochim.Biophys.Acta_1821_1379
Author(s) : Amara S , Delorme V , Record M , Carriere F
Ref : Biochimica & Biophysica Acta , 1821 :1379 , 2012
PubMedID: 22835523
Gene_locus related to this paper: human-PNLIPRP2

Title : Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation - Eydoux_2008_Biochemistry_47_9553
Author(s) : Eydoux C , Spinelli S , Davis TL , Walker JR , Seitova A , Dhe-Paganon S , de Caro A , Cambillau C , Carriere F
Ref : Biochemistry , 47 :9553 , 2008
PubMedID: 18702514
Gene_locus related to this paper: human-PNLIPRP2

Title : Human pancreatic lipase-related protein 2 is a galactolipase - Sias_2004_Biochemistry_43_10138
Author(s) : Sias B , Ferrato F , Grandval P , Lafont D , Boullanger P , de Caro A , Leboeuf B , Verger R , Carriere F
Ref : Biochemistry , 43 :10138 , 2004
PubMedID: 15287741
Gene_locus related to this paper: human-PNLIPRP2

Title : Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations - Roussel_1998_Proteins_32_523
Author(s) : Roussel A , De Caro J , Bezzine S , Gastinel L , de Caro A , Carriere F , Leydier S , Verger R , Cambillau C
Ref : Proteins , 32 :523 , 1998
PubMedID: 9726421
Gene_locus related to this paper: canfa-1plip

Title : A pancreatic lipase with a phospholipase A1 activity: crystal structure of a chimeric pancreatic lipase-related protein 2 from guinea pig - Withers-Martinez_1996_Structure_4_1363
Author(s) : Withers-Martinez C , Carriere F , Verger R , Bourgeois D , Cambillau C
Ref : Structure , 4 :1363 , 1996
PubMedID: 8939760
Gene_locus related to this paper: human-PNLIP

Title : Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity - Giller_1992_J.Biol.Chem_267_16509
Author(s) : Giller T , Buchwald P , Blum-Kaelin D , Hunziker W
Ref : Journal of Biological Chemistry , 267 :16509 , 1992
PubMedID: 1379598
Gene_locus related to this paper: human-LPL , human-PNLIPRP1 , human-PNLIPRP2

Title : Minireview on pancreatic lipase and colipase - Chapus_1988_Biochimie_70_1223
Author(s) : Chapus C , Rovery M , Sarda L , Verger R
Ref : Biochimie , 70 :1223 , 1988
PubMedID: 3147715

Title : Congenital pancreatic lipase deficiency - Figarella_1980_J.Pediatr_96_412
Author(s) : Figarella C , de Caro A , Leupold D , Poley JR
Ref : J Pediatr , 96 :412 , 1980
PubMedID: 6153713
Gene_locus related to this paper: human-PNLIP , human-PNLIPRP1

Title : [Congenital absence of pancreatic lipase] -
Author(s) : Rey J , Frezal J , Royer P , Lamy M
Ref : Arch Fr Pediatr , 23 :5 , 1966
PubMedID: 5902779
Gene_locus related to this paper: human-PNLIP

Title : CONGENITAL PANCREATIC LIPASE DEFICIENCY -
Author(s) : Sheldon W
Ref : Arch Dis Child , 39 :268 , 1964
PubMedID: 14169458
Gene_locus related to this paper: human-PNLIP