Triazole-tethered-benzothiazole-cpd10l
IC50 0.11 +/- 0.01microM || 10f hAChE IC50 110 nM
General
Type : Triazol, Benzothiazol, Sulfur Compound, Multitarget, Organochlorine
Chemical_Nomenclature :
Canonical SMILES : C1=C(C=CC(=C1)[N](=O)=O)C([H])=C([H])C(=O)OCC4=C[N](CC(=NC3=NC2=C(C=C(C=C2)Cl)S3)O[H])N=N4
InChI : InChI=1S\/C21H15ClN6O5S\/c22-14-4-7-17-18(9-14)34-21(23-17)24-19(29)11-27-10-15(25-26-27)12-33-20(30)8-3-13-1-5-16(6-2-13)28(31)32\/h1-10H,11-12H2,(H,23,24,29)\/b8-3+
InChIKey : MCHGNFCUVLDWPW-FPYGCLRLSA-N
Other name(s) : Compound 10l
Target
Families : Triazole-tethered-benzothiazole-cpd10l ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Click Chemistry-Aided Synthesis of Triazole-Tethered Benzothiazoles as Novel Multifunctional Agents Against Alzheimer's Disease - Elbadawi_2025_Arch.Pharm.(Weinheim)_358_e70046 |
| Author(s) : Elbadawi MM , Elgazar AA , Hefny AA , Abdulla MH , Bin Traiki T , Roshdy E , Al-Sanea MM , Abe M , Eldehna WM , Rao PPN , Hamdi A |
| Ref : Arch Pharm (Weinheim) , 358 :e70046 , 2025 |
| Abstract : |
| PubMedSearch : Elbadawi_2025_Arch.Pharm.(Weinheim)_358_e70046 |
| PubMedID: 40641142 |