Triazole-thiazolidinedione-benzothiazole-cpd7k
7k exhibited the strongest AChE inhibition with an IC50 = 0.083 microM
General
Type : Triazol, Thiazolidine, Benzothiazol, Dioxothiazolidine, Sulfur Compound
Chemical_Nomenclature : (Z)-N-(6-chlorobenzo[d]thiazol-2-yl)-2-(4-((5-(4-fluorobenzylidene)-2,4-dioxothiazolidin-3-yl)methyl)-1H-1,2,3-triazol-1-yl)acetamide
Canonical SMILES : C1(=CC=C(C=C1)C=C5C(N(CC2=C[N](N=N2)CC(=O)NC4=NC3=CC=C(C=C3S4)Cl)C(S5)=O)=O)F
InChI : InChI=1S\/C22H14ClFN6O3S2\/c23-13-3-6-16-17(8-13)34-21(25-16)26-19(31)11-29-9-15(27-28-29)10-30-20(32)18(35-22(30)33)7-12-1-4-14(24)5-2-12\/h1-9H,10-11H2,(H,25,26,31)
InChIKey : MNXVBRIORWRMIT-UHFFFAOYSA-N
Other name(s) : Compound 7k
Target
References (1)
| Title : Triazole-linked thiazolidinedione-Benzothiazole hybrids: Design and biological evaluation as AChE inhibitors - Almatary_2025_Bioorg.Chem_157_108295 |
| Author(s) : Almatary AM , Al-Sanea MM , Nasr EE , Haikal A , Thompson GS , Abood A , Ibrahim MAA , Elgazar AA , Hamdi A |
| Ref : Bioorg Chem , 157 :108295 , 2025 |
| Abstract : |
| PubMedSearch : Almatary_2025_Bioorg.Chem_157_108295 |
| PubMedID: 40010133 |